Amino acid dipepetide frequency for Actinomarinicola tropica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.544AlaAla: 20.544 ± 0.203
0.997AlaCys: 0.997 ± 0.031
8.923AlaAsp: 8.923 ± 0.094
8.659AlaGlu: 8.659 ± 0.101
3.391AlaPhe: 3.391 ± 0.057
12.021AlaGly: 12.021 ± 0.118
2.723AlaHis: 2.723 ± 0.052
4.883AlaIle: 4.883 ± 0.073
1.749AlaLys: 1.749 ± 0.057
13.586AlaLeu: 13.586 ± 0.125
2.669AlaMet: 2.669 ± 0.052
1.866AlaAsn: 1.866 ± 0.045
6.736AlaPro: 6.736 ± 0.092
2.958AlaGln: 2.958 ± 0.064
10.294AlaArg: 10.294 ± 0.129
6.273AlaSer: 6.273 ± 0.085
7.702AlaThr: 7.702 ± 0.095
12.521AlaVal: 12.521 ± 0.122
1.882AlaTrp: 1.882 ± 0.048
2.134AlaTyr: 2.134 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.831CysAla: 0.831 ± 0.029
0.093CysCys: 0.093 ± 0.009
0.531CysAsp: 0.531 ± 0.019
0.398CysGlu: 0.398 ± 0.022
0.192CysPhe: 0.192 ± 0.013
0.863CysGly: 0.863 ± 0.031
0.211CysHis: 0.211 ± 0.014
0.241CysIle: 0.241 ± 0.015
0.071CysLys: 0.071 ± 0.007
0.572CysLeu: 0.572 ± 0.022
0.107CysMet: 0.107 ± 0.01
0.116CysAsn: 0.116 ± 0.011
0.516CysPro: 0.516 ± 0.026
0.18CysGln: 0.18 ± 0.012
0.662CysArg: 0.662 ± 0.026
0.375CysSer: 0.375 ± 0.018
0.418CysThr: 0.418 ± 0.019
0.54CysVal: 0.54 ± 0.027
0.114CysTrp: 0.114 ± 0.01
0.132CysTyr: 0.132 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
9.718AspAla: 9.718 ± 0.103
0.349AspCys: 0.349 ± 0.016
5.847AspAsp: 5.847 ± 0.077
5.593AspGlu: 5.593 ± 0.078
1.344AspPhe: 1.344 ± 0.033
7.592AspGly: 7.592 ± 0.102
1.828AspHis: 1.828 ± 0.047
1.825AspIle: 1.825 ± 0.047
0.71AspLys: 0.71 ± 0.027
7.828AspLeu: 7.828 ± 0.086
0.975AspMet: 0.975 ± 0.03
0.737AspAsn: 0.737 ± 0.032
5.387AspPro: 5.387 ± 0.072
1.735AspGln: 1.735 ± 0.037
5.872AspArg: 5.872 ± 0.087
1.896AspSer: 1.896 ± 0.044
2.786AspThr: 2.786 ± 0.051
6.849AspVal: 6.849 ± 0.094
0.934AspTrp: 0.934 ± 0.029
0.932AspTyr: 0.932 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
7.709GluAla: 7.709 ± 0.091
0.298GluCys: 0.298 ± 0.017
3.309GluAsp: 3.309 ± 0.064
3.891GluGlu: 3.891 ± 0.063
1.27GluPhe: 1.27 ± 0.033
4.886GluGly: 4.886 ± 0.076
1.645GluHis: 1.645 ± 0.043
2.663GluIle: 2.663 ± 0.055
0.912GluLys: 0.912 ± 0.032
7.613GluLeu: 7.613 ± 0.096
1.236GluMet: 1.236 ± 0.036
0.794GluAsn: 0.794 ± 0.026
3.863GluPro: 3.863 ± 0.066
2.091GluGln: 2.091 ± 0.045
6.432GluArg: 6.432 ± 0.092
2.635GluSer: 2.635 ± 0.052
2.552GluThr: 2.552 ± 0.049
6.627GluVal: 6.627 ± 0.083
0.982GluTrp: 0.982 ± 0.031
0.823GluTyr: 0.823 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.548PheAla: 3.548 ± 0.055
0.262PheCys: 0.262 ± 0.015
2.249PheAsp: 2.249 ± 0.047
1.827PheGlu: 1.827 ± 0.045
0.842PhePhe: 0.842 ± 0.033
2.893PheGly: 2.893 ± 0.054
0.628PheHis: 0.628 ± 0.023
0.828PheIle: 0.828 ± 0.03
0.372PheLys: 0.372 ± 0.017
2.433PheLeu: 2.433 ± 0.048
0.405PheMet: 0.405 ± 0.021
0.517PheAsn: 0.517 ± 0.024
1.353PhePro: 1.353 ± 0.035
0.587PheGln: 0.587 ± 0.024
1.761PheArg: 1.761 ± 0.04
1.317PheSer: 1.317 ± 0.034
1.626PheThr: 1.626 ± 0.037
2.699PheVal: 2.699 ± 0.053
0.385PheTrp: 0.385 ± 0.022
0.497PheTyr: 0.497 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
11.139GlyAla: 11.139 ± 0.115
0.737GlyCys: 0.737 ± 0.024
6.193GlyAsp: 6.193 ± 0.085
5.461GlyGlu: 5.461 ± 0.09
2.922GlyPhe: 2.922 ± 0.058
8.736GlyGly: 8.736 ± 0.098
2.282GlyHis: 2.282 ± 0.041
3.866GlyIle: 3.866 ± 0.058
1.431GlyLys: 1.431 ± 0.042
8.724GlyLeu: 8.724 ± 0.094
2.005GlyMet: 2.005 ± 0.044
1.333GlyAsn: 1.333 ± 0.039
5.183GlyPro: 5.183 ± 0.072
2.258GlyGln: 2.258 ± 0.043
8.186GlyArg: 8.186 ± 0.089
5.159GlySer: 5.159 ± 0.07
5.597GlyThr: 5.597 ± 0.083
8.019GlyVal: 8.019 ± 0.083
1.868GlyTrp: 1.868 ± 0.044
1.856GlyTyr: 1.856 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.599HisAla: 2.599 ± 0.053
0.186HisCys: 0.186 ± 0.014
1.805HisAsp: 1.805 ± 0.043
1.423HisGlu: 1.423 ± 0.037
0.565HisPhe: 0.565 ± 0.026
2.419HisGly: 2.419 ± 0.045
0.871HisHis: 0.871 ± 0.033
0.641HisIle: 0.641 ± 0.023
0.243HisLys: 0.243 ± 0.015
2.81HisLeu: 2.81 ± 0.059
0.312HisMet: 0.312 ± 0.016
0.316HisAsn: 0.316 ± 0.017
1.806HisPro: 1.806 ± 0.049
0.622HisGln: 0.622 ± 0.024
2.379HisArg: 2.379 ± 0.043
0.751HisSer: 0.751 ± 0.027
1.002HisThr: 1.002 ± 0.032
2.145HisVal: 2.145 ± 0.047
0.324HisTrp: 0.324 ± 0.02
0.364HisTyr: 0.364 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.988IleAla: 4.988 ± 0.068
0.298IleCys: 0.298 ± 0.014
3.467IleAsp: 3.467 ± 0.055
2.915IleGlu: 2.915 ± 0.05
0.772IlePhe: 0.772 ± 0.028
4.101IleGly: 4.101 ± 0.071
0.783IleHis: 0.783 ± 0.028
1.088IleIle: 1.088 ± 0.036
0.476IleLys: 0.476 ± 0.023
2.768IleLeu: 2.768 ± 0.049
0.454IleMet: 0.454 ± 0.021
0.62IleAsn: 0.62 ± 0.024
1.839IlePro: 1.839 ± 0.04
0.759IleGln: 0.759 ± 0.031
2.492IleArg: 2.492 ± 0.048
1.714IleSer: 1.714 ± 0.042
2.206IleThr: 2.206 ± 0.046
3.524IleVal: 3.524 ± 0.06
0.396IleTrp: 0.396 ± 0.02
0.563IleTyr: 0.563 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
1.655LysAla: 1.655 ± 0.057
0.07LysCys: 0.07 ± 0.008
0.773LysAsp: 0.773 ± 0.028
0.761LysGlu: 0.761 ± 0.032
0.29LysPhe: 0.29 ± 0.015
1.299LysGly: 1.299 ± 0.046
0.234LysHis: 0.234 ± 0.017
0.6LysIle: 0.6 ± 0.028
0.43LysLys: 0.43 ± 0.03
1.306LysLeu: 1.306 ± 0.04
0.287LysMet: 0.287 ± 0.017
0.261LysAsn: 0.261 ± 0.016
0.704LysPro: 0.704 ± 0.026
0.377LysGln: 0.377 ± 0.021
0.99LysArg: 0.99 ± 0.034
0.663LysSer: 0.663 ± 0.027
0.683LysThr: 0.683 ± 0.026
1.58LysVal: 1.58 ± 0.045
0.163LysTrp: 0.163 ± 0.012
0.225LysTyr: 0.225 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
15.053LeuAla: 15.053 ± 0.153
0.694LeuCys: 0.694 ± 0.024
8.377LeuAsp: 8.377 ± 0.108
5.66LeuGlu: 5.66 ± 0.078
2.544LeuPhe: 2.544 ± 0.051
9.716LeuGly: 9.716 ± 0.112
2.285LeuHis: 2.285 ± 0.046
2.769LeuIle: 2.769 ± 0.058
1.173LeuLys: 1.173 ± 0.036
10.241LeuLeu: 10.241 ± 0.128
1.487LeuMet: 1.487 ± 0.036
1.361LeuAsn: 1.361 ± 0.035
5.519LeuPro: 5.519 ± 0.078
2.07LeuGln: 2.07 ± 0.047
8.195LeuArg: 8.195 ± 0.089
4.703LeuSer: 4.703 ± 0.067
5.5LeuThr: 5.5 ± 0.072
10.935LeuVal: 10.935 ± 0.118
1.183LeuTrp: 1.183 ± 0.035
1.408LeuTyr: 1.408 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.546MetAla: 2.546 ± 0.05
0.137MetCys: 0.137 ± 0.012
0.919MetAsp: 0.919 ± 0.027
0.87MetGlu: 0.87 ± 0.027
0.526MetPhe: 0.526 ± 0.023
1.574MetGly: 1.574 ± 0.041
0.364MetHis: 0.364 ± 0.017
0.671MetIle: 0.671 ± 0.026
0.305MetLys: 0.305 ± 0.018
1.671MetLeu: 1.671 ± 0.043
0.329MetMet: 0.329 ± 0.017
0.369MetAsn: 0.369 ± 0.016
1.119MetPro: 1.119 ± 0.034
0.428MetGln: 0.428 ± 0.02
1.445MetArg: 1.445 ± 0.037
1.334MetSer: 1.334 ± 0.033
1.467MetThr: 1.467 ± 0.034
1.541MetVal: 1.541 ± 0.034
0.229MetTrp: 0.229 ± 0.014
0.25MetTyr: 0.25 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
1.814AsnAla: 1.814 ± 0.045
0.137AsnCys: 0.137 ± 0.01
0.903AsnAsp: 0.903 ± 0.03
0.811AsnGlu: 0.811 ± 0.029
0.431AsnPhe: 0.431 ± 0.021
1.39AsnGly: 1.39 ± 0.04
0.385AsnHis: 0.385 ± 0.019
0.583AsnIle: 0.583 ± 0.025
0.249AsnLys: 0.249 ± 0.014
1.635AsnLeu: 1.635 ± 0.041
0.253AsnMet: 0.253 ± 0.015
0.292AsnAsn: 0.292 ± 0.02
1.184AsnPro: 1.184 ± 0.033
0.445AsnGln: 0.445 ± 0.02
1.244AsnArg: 1.244 ± 0.034
0.578AsnSer: 0.578 ± 0.025
0.758AsnThr: 0.758 ± 0.024
1.448AsnVal: 1.448 ± 0.037
0.228AsnTrp: 0.228 ± 0.014
0.304AsnTyr: 0.304 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.351ProAla: 7.351 ± 0.096
0.322ProCys: 0.322 ± 0.018
5.136ProAsp: 5.136 ± 0.07
4.161ProGlu: 4.161 ± 0.059
1.619ProPhe: 1.619 ± 0.04
5.828ProGly: 5.828 ± 0.087
1.431ProHis: 1.431 ± 0.038
2.081ProIle: 2.081 ± 0.05
0.79ProLys: 0.79 ± 0.03
4.999ProLeu: 4.999 ± 0.064
1.006ProMet: 1.006 ± 0.025
0.903ProAsn: 0.903 ± 0.034
4.092ProPro: 4.092 ± 0.092
1.269ProGln: 1.269 ± 0.031
3.946ProArg: 3.946 ± 0.073
3.546ProSer: 3.546 ± 0.06
3.767ProThr: 3.767 ± 0.065
5.24ProVal: 5.24 ± 0.076
0.916ProTrp: 0.916 ± 0.031
0.966ProTyr: 0.966 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.973GlnAla: 2.973 ± 0.048
0.15GlnCys: 0.15 ± 0.011
1.061GlnAsp: 1.061 ± 0.031
1.257GlnGlu: 1.257 ± 0.039
0.613GlnPhe: 0.613 ± 0.02
1.827GlnGly: 1.827 ± 0.036
0.542GlnHis: 0.542 ± 0.024
1.094GlnIle: 1.094 ± 0.034
0.395GlnLys: 0.395 ± 0.019
3.017GlnLeu: 3.017 ± 0.059
0.504GlnMet: 0.504 ± 0.025
0.357GlnAsn: 0.357 ± 0.013
1.445GlnPro: 1.445 ± 0.034
0.834GlnGln: 0.834 ± 0.029
2.364GlnArg: 2.364 ± 0.051
1.032GlnSer: 1.032 ± 0.027
1.069GlnThr: 1.069 ± 0.031
2.611GlnVal: 2.611 ± 0.048
0.336GlnTrp: 0.336 ± 0.015
0.426GlnTyr: 0.426 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
9.831ArgAla: 9.831 ± 0.097
0.657ArgCys: 0.657 ± 0.024
4.879ArgAsp: 4.879 ± 0.076
4.244ArgGlu: 4.244 ± 0.057
2.771ArgPhe: 2.771 ± 0.055
5.936ArgGly: 5.936 ± 0.07
2.345ArgHis: 2.345 ± 0.052
3.479ArgIle: 3.479 ± 0.059
1.036ArgLys: 1.036 ± 0.031
8.596ArgLeu: 8.596 ± 0.118
1.785ArgMet: 1.785 ± 0.04
1.278ArgAsn: 1.278 ± 0.041
5.244ArgPro: 5.244 ± 0.084
2.246ArgGln: 2.246 ± 0.044
9.571ArgArg: 9.571 ± 0.148
4.71ArgSer: 4.71 ± 0.067
4.826ArgThr: 4.826 ± 0.067
6.465ArgVal: 6.465 ± 0.078
1.719ArgTrp: 1.719 ± 0.039
1.695ArgTyr: 1.695 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.636SerAla: 5.636 ± 0.073
0.405SerCys: 0.405 ± 0.019
3.081SerAsp: 3.081 ± 0.055
2.505SerGlu: 2.505 ± 0.048
1.633SerPhe: 1.633 ± 0.034
5.08SerGly: 5.08 ± 0.068
1.008SerHis: 1.008 ± 0.028
2.094SerIle: 2.094 ± 0.042
0.702SerLys: 0.702 ± 0.029
4.537SerLeu: 4.537 ± 0.066
1.245SerMet: 1.245 ± 0.035
0.842SerAsn: 0.842 ± 0.03
2.931SerPro: 2.931 ± 0.053
1.14SerGln: 1.14 ± 0.032
3.605SerArg: 3.605 ± 0.055
2.916SerSer: 2.916 ± 0.061
3.3SerThr: 3.3 ± 0.054
4.141SerVal: 4.141 ± 0.066
0.878SerTrp: 0.878 ± 0.028
0.921SerTyr: 0.921 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.881ThrAla: 6.881 ± 0.093
0.399ThrCys: 0.399 ± 0.018
3.646ThrAsp: 3.646 ± 0.059
3.137ThrGlu: 3.137 ± 0.057
1.949ThrPhe: 1.949 ± 0.043
5.5ThrGly: 5.5 ± 0.07
1.161ThrHis: 1.161 ± 0.035
2.564ThrIle: 2.564 ± 0.053
0.773ThrLys: 0.773 ± 0.03
5.178ThrLeu: 5.178 ± 0.066
1.063ThrMet: 1.063 ± 0.031
1.018ThrAsn: 1.018 ± 0.036
3.502ThrPro: 3.502 ± 0.052
1.096ThrGln: 1.096 ± 0.031
3.685ThrArg: 3.685 ± 0.06
3.282ThrSer: 3.282 ± 0.059
4.234ThrThr: 4.234 ± 0.085
5.334ThrVal: 5.334 ± 0.073
0.952ThrTrp: 0.952 ± 0.03
1.181ThrTyr: 1.181 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
14.146ValAla: 14.146 ± 0.166
0.642ValCys: 0.642 ± 0.027
7.477ValAsp: 7.477 ± 0.082
6.698ValGlu: 6.698 ± 0.085
2.233ValPhe: 2.233 ± 0.05
8.495ValGly: 8.495 ± 0.101
2.131ValHis: 2.131 ± 0.045
3.174ValIle: 3.174 ± 0.061
1.092ValLys: 1.092 ± 0.038
9.898ValLeu: 9.898 ± 0.111
1.424ValMet: 1.424 ± 0.038
1.54ValAsn: 1.54 ± 0.035
5.322ValPro: 5.322 ± 0.077
1.935ValGln: 1.935 ± 0.039
7.19ValArg: 7.19 ± 0.092
3.97ValSer: 3.97 ± 0.053
5.248ValThr: 5.248 ± 0.077
11.749ValVal: 11.749 ± 0.134
1.084ValTrp: 1.084 ± 0.032
1.235ValTyr: 1.235 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.648TrpAla: 1.648 ± 0.041
0.193TrpCys: 0.193 ± 0.014
0.898TrpAsp: 0.898 ± 0.03
0.803TrpGlu: 0.803 ± 0.028
0.605TrpPhe: 0.605 ± 0.024
1.113TrpGly: 1.113 ± 0.034
0.359TrpHis: 0.359 ± 0.018
0.664TrpIle: 0.664 ± 0.022
0.208TrpLys: 0.208 ± 0.014
1.64TrpLeu: 1.64 ± 0.043
0.33TrpMet: 0.33 ± 0.015
0.305TrpAsn: 0.305 ± 0.015
0.752TrpPro: 0.752 ± 0.029
0.402TrpGln: 0.402 ± 0.02
1.471TrpArg: 1.471 ± 0.039
0.998TrpSer: 0.998 ± 0.034
0.957TrpThr: 0.957 ± 0.026
1.199TrpVal: 1.199 ± 0.031
0.388TrpTrp: 0.388 ± 0.019
0.295TrpTyr: 0.295 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.898TyrAla: 1.898 ± 0.045
0.136TyrCys: 0.136 ± 0.011
1.262TyrAsp: 1.262 ± 0.037
1.154TyrGlu: 1.154 ± 0.032
0.52TyrPhe: 0.52 ± 0.022
1.684TyrGly: 1.684 ± 0.04
0.366TyrHis: 0.366 ± 0.018
0.413TyrIle: 0.413 ± 0.022
0.236TyrLys: 0.236 ± 0.014
1.825TyrLeu: 1.825 ± 0.044
0.217TyrMet: 0.217 ± 0.016
0.246TyrAsn: 0.246 ± 0.014
0.87TyrPro: 0.87 ± 0.029
0.476TyrGln: 0.476 ± 0.021
1.532TyrArg: 1.532 ± 0.033
0.747TyrSer: 0.747 ± 0.027
0.839TyrThr: 0.839 ± 0.028
1.517TyrVal: 1.517 ± 0.035
0.267TyrTrp: 0.267 ± 0.016
0.337TyrTyr: 0.337 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3559 proteins (1144291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski