Amino acid dipepetide frequency for Candidatus Thioglobus autotrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.475AlaAla: 5.475 ± 0.14
0.868AlaCys: 0.868 ± 0.048
4.261AlaAsp: 4.261 ± 0.101
4.108AlaGlu: 4.108 ± 0.103
3.277AlaPhe: 3.277 ± 0.088
5.34AlaGly: 5.34 ± 0.131
1.8AlaHis: 1.8 ± 0.068
6.075AlaIle: 6.075 ± 0.125
5.85AlaLys: 5.85 ± 0.133
8.628AlaLeu: 8.628 ± 0.166
2.365AlaMet: 2.365 ± 0.087
3.792AlaAsn: 3.792 ± 0.091
2.32AlaPro: 2.32 ± 0.072
3.884AlaGln: 3.884 ± 0.106
2.968AlaArg: 2.968 ± 0.091
4.937AlaSer: 4.937 ± 0.112
4.188AlaThr: 4.188 ± 0.105
4.806AlaVal: 4.806 ± 0.121
0.717AlaTrp: 0.717 ± 0.036
2.418AlaTyr: 2.418 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.76CysAla: 0.76 ± 0.041
0.128CysCys: 0.128 ± 0.018
0.614CysAsp: 0.614 ± 0.038
0.657CysGlu: 0.657 ± 0.04
0.353CysPhe: 0.353 ± 0.025
0.902CysGly: 0.902 ± 0.051
0.359CysHis: 0.359 ± 0.038
0.708CysIle: 0.708 ± 0.043
0.501CysLys: 0.501 ± 0.034
0.923CysLeu: 0.923 ± 0.052
0.213CysMet: 0.213 ± 0.019
0.463CysAsn: 0.463 ± 0.034
0.579CysPro: 0.579 ± 0.039
0.469CysGln: 0.469 ± 0.036
0.398CysArg: 0.398 ± 0.03
0.698CysSer: 0.698 ± 0.044
0.517CysThr: 0.517 ± 0.03
0.737CysVal: 0.737 ± 0.042
0.071CysTrp: 0.071 ± 0.013
0.266CysTyr: 0.266 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.328AspAla: 4.328 ± 0.112
0.605AspCys: 0.605 ± 0.039
3.162AspAsp: 3.162 ± 0.09
4.264AspGlu: 4.264 ± 0.128
2.894AspPhe: 2.894 ± 0.082
3.535AspGly: 3.535 ± 0.092
1.069AspHis: 1.069 ± 0.052
4.857AspIle: 4.857 ± 0.096
4.167AspLys: 4.167 ± 0.099
5.752AspLeu: 5.752 ± 0.128
1.527AspMet: 1.527 ± 0.059
2.819AspAsn: 2.819 ± 0.087
1.644AspPro: 1.644 ± 0.066
2.615AspGln: 2.615 ± 0.085
2.18AspArg: 2.18 ± 0.077
3.471AspSer: 3.471 ± 0.101
2.942AspThr: 2.942 ± 0.08
3.808AspVal: 3.808 ± 0.097
0.843AspTrp: 0.843 ± 0.047
2.258AspTyr: 2.258 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.628GluAla: 4.628 ± 0.114
0.538GluCys: 0.538 ± 0.036
3.039GluAsp: 3.039 ± 0.089
3.11GluGlu: 3.11 ± 0.089
2.745GluPhe: 2.745 ± 0.087
3.398GluGly: 3.398 ± 0.089
1.397GluHis: 1.397 ± 0.058
4.726GluIle: 4.726 ± 0.105
4.376GluLys: 4.376 ± 0.105
6.153GluLeu: 6.153 ± 0.112
1.784GluMet: 1.784 ± 0.074
2.878GluAsn: 2.878 ± 0.09
1.573GluPro: 1.573 ± 0.063
3.194GluGln: 3.194 ± 0.093
2.505GluArg: 2.505 ± 0.081
3.501GluSer: 3.501 ± 0.09
2.732GluThr: 2.732 ± 0.085
4.422GluVal: 4.422 ± 0.12
0.566GluTrp: 0.566 ± 0.038
1.772GluTyr: 1.772 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.176PheAla: 3.176 ± 0.093
0.492PheCys: 0.492 ± 0.034
3.231PheAsp: 3.231 ± 0.091
2.796PheGlu: 2.796 ± 0.077
2.02PhePhe: 2.02 ± 0.076
3.089PheGly: 3.089 ± 0.086
0.772PheHis: 0.772 ± 0.042
3.233PheIle: 3.233 ± 0.098
2.805PheLys: 2.805 ± 0.084
3.746PheLeu: 3.746 ± 0.127
1.078PheMet: 1.078 ± 0.054
2.297PheAsn: 2.297 ± 0.077
1.298PhePro: 1.298 ± 0.057
1.204PheGln: 1.204 ± 0.046
1.317PheArg: 1.317 ± 0.06
3.432PheSer: 3.432 ± 0.094
2.079PheThr: 2.079 ± 0.076
2.821PheVal: 2.821 ± 0.096
0.488PheTrp: 0.488 ± 0.037
1.47PheTyr: 1.47 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
5.388GlyAla: 5.388 ± 0.123
0.95GlyCys: 0.95 ± 0.041
3.753GlyAsp: 3.753 ± 0.104
4.062GlyGlu: 4.062 ± 0.109
3.419GlyPhe: 3.419 ± 0.094
4.918GlyGly: 4.918 ± 0.147
1.523GlyHis: 1.523 ± 0.064
4.967GlyIle: 4.967 ± 0.115
4.44GlyLys: 4.44 ± 0.123
6.601GlyLeu: 6.601 ± 0.138
2.056GlyMet: 2.056 ± 0.073
2.562GlyAsn: 2.562 ± 0.078
1.493GlyPro: 1.493 ± 0.058
2.434GlyGln: 2.434 ± 0.076
2.581GlyArg: 2.581 ± 0.083
4.234GlySer: 4.234 ± 0.094
3.057GlyThr: 3.057 ± 0.08
5.663GlyVal: 5.663 ± 0.114
0.799GlyTrp: 0.799 ± 0.048
2.349GlyTyr: 2.349 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.619HisAla: 1.619 ± 0.063
0.305HisCys: 0.305 ± 0.027
1.044HisAsp: 1.044 ± 0.052
1.122HisGlu: 1.122 ± 0.051
0.898HisPhe: 0.898 ± 0.045
1.509HisGly: 1.509 ± 0.066
0.719HisHis: 0.719 ± 0.048
1.656HisIle: 1.656 ± 0.064
1.193HisLys: 1.193 ± 0.058
2.31HisLeu: 2.31 ± 0.071
0.566HisMet: 0.566 ± 0.039
1.042HisAsn: 1.042 ± 0.041
1.246HisPro: 1.246 ± 0.058
1.262HisGln: 1.262 ± 0.061
0.921HisArg: 0.921 ± 0.05
1.443HisSer: 1.443 ± 0.059
1.211HisThr: 1.211 ± 0.055
1.204HisVal: 1.204 ± 0.053
0.318HisTrp: 0.318 ± 0.032
0.953HisTyr: 0.953 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
6.638IleAla: 6.638 ± 0.126
0.74IleCys: 0.74 ± 0.04
5.427IleAsp: 5.427 ± 0.116
5.289IleGlu: 5.289 ± 0.107
2.97IlePhe: 2.97 ± 0.105
5.234IleGly: 5.234 ± 0.128
1.619IleHis: 1.619 ± 0.061
5.347IleIle: 5.347 ± 0.121
5.523IleLys: 5.523 ± 0.121
6.773IleLeu: 6.773 ± 0.135
1.759IleMet: 1.759 ± 0.07
4.161IleAsn: 4.161 ± 0.092
2.702IlePro: 2.702 ± 0.075
2.814IleGln: 2.814 ± 0.083
2.626IleArg: 2.626 ± 0.089
5.299IleSer: 5.299 ± 0.113
4.277IleThr: 4.277 ± 0.087
4.68IleVal: 4.68 ± 0.118
0.579IleTrp: 0.579 ± 0.037
2.079IleTyr: 2.079 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
5.262LysAla: 5.262 ± 0.107
0.479LysCys: 0.479 ± 0.029
3.881LysAsp: 3.881 ± 0.106
3.76LysGlu: 3.76 ± 0.1
2.29LysPhe: 2.29 ± 0.083
4.119LysGly: 4.119 ± 0.117
1.573LysHis: 1.573 ± 0.06
5.36LysIle: 5.36 ± 0.125
4.875LysLys: 4.875 ± 0.128
5.933LysLeu: 5.933 ± 0.119
1.781LysMet: 1.781 ± 0.065
3.799LysAsn: 3.799 ± 0.113
2.393LysPro: 2.393 ± 0.067
3.217LysGln: 3.217 ± 0.081
2.81LysArg: 2.81 ± 0.074
4.36LysSer: 4.36 ± 0.105
4.174LysThr: 4.174 ± 0.098
4.403LysVal: 4.403 ± 0.101
0.556LysTrp: 0.556 ± 0.036
2.059LysTyr: 2.059 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
8.186LeuAla: 8.186 ± 0.141
0.84LeuCys: 0.84 ± 0.049
6.34LeuAsp: 6.34 ± 0.134
6.315LeuGlu: 6.315 ± 0.112
4.074LeuPhe: 4.074 ± 0.111
6.553LeuGly: 6.553 ± 0.133
1.836LeuHis: 1.836 ± 0.058
7.433LeuIle: 7.433 ± 0.165
6.714LeuLys: 6.714 ± 0.124
9.585LeuLeu: 9.585 ± 0.183
2.764LeuMet: 2.764 ± 0.08
4.939LeuAsn: 4.939 ± 0.114
3.877LeuPro: 3.877 ± 0.104
2.986LeuGln: 2.986 ± 0.084
3.384LeuArg: 3.384 ± 0.093
8.177LeuSer: 8.177 ± 0.152
5.317LeuThr: 5.317 ± 0.118
6.379LeuVal: 6.379 ± 0.123
0.863LeuTrp: 0.863 ± 0.051
2.636LeuTyr: 2.636 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
2.292MetAla: 2.292 ± 0.068
0.197MetCys: 0.197 ± 0.024
1.484MetAsp: 1.484 ± 0.05
1.2MetGlu: 1.2 ± 0.06
0.971MetPhe: 0.971 ± 0.045
2.052MetGly: 2.052 ± 0.073
0.575MetHis: 0.575 ± 0.032
1.873MetIle: 1.873 ± 0.061
1.852MetLys: 1.852 ± 0.063
2.553MetLeu: 2.553 ± 0.079
0.82MetMet: 0.82 ± 0.047
1.321MetAsn: 1.321 ± 0.056
1.214MetPro: 1.214 ± 0.053
1.255MetGln: 1.255 ± 0.054
1.147MetArg: 1.147 ± 0.058
2.134MetSer: 2.134 ± 0.072
1.456MetThr: 1.456 ± 0.061
1.878MetVal: 1.878 ± 0.067
0.174MetTrp: 0.174 ± 0.019
0.534MetTyr: 0.534 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.627AsnAla: 3.627 ± 0.089
0.506AsnCys: 0.506 ± 0.032
2.395AsnAsp: 2.395 ± 0.077
2.622AsnGlu: 2.622 ± 0.073
2.088AsnPhe: 2.088 ± 0.063
2.72AsnGly: 2.72 ± 0.081
1.168AsnHis: 1.168 ± 0.048
4.353AsnIle: 4.353 ± 0.116
3.375AsnLys: 3.375 ± 0.098
4.355AsnLeu: 4.355 ± 0.101
1.138AsnMet: 1.138 ± 0.051
2.748AsnAsn: 2.748 ± 0.091
2.274AsnPro: 2.274 ± 0.071
2.404AsnGln: 2.404 ± 0.081
1.857AsnArg: 1.857 ± 0.073
2.812AsnSer: 2.812 ± 0.093
3.112AsnThr: 3.112 ± 0.089
2.489AsnVal: 2.489 ± 0.07
0.531AsnTrp: 0.531 ± 0.038
1.619AsnTyr: 1.619 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.363ProAla: 2.363 ± 0.076
0.376ProCys: 0.376 ± 0.03
2.036ProAsp: 2.036 ± 0.071
2.558ProGlu: 2.558 ± 0.078
1.564ProPhe: 1.564 ± 0.058
2.184ProGly: 2.184 ± 0.083
0.758ProHis: 0.758 ± 0.045
2.835ProIle: 2.835 ± 0.083
2.308ProLys: 2.308 ± 0.072
3.297ProLeu: 3.297 ± 0.094
1.088ProMet: 1.088 ± 0.051
1.745ProAsn: 1.745 ± 0.064
0.921ProPro: 0.921 ± 0.048
1.177ProGln: 1.177 ± 0.048
0.994ProArg: 0.994 ± 0.048
2.246ProSer: 2.246 ± 0.071
1.898ProThr: 1.898 ± 0.072
2.388ProVal: 2.388 ± 0.069
0.417ProTrp: 0.417 ± 0.029
1.152ProTyr: 1.152 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
4.195GlnAla: 4.195 ± 0.104
0.366GlnCys: 0.366 ± 0.031
2.299GlnAsp: 2.299 ± 0.075
2.253GlnGlu: 2.253 ± 0.071
1.472GlnPhe: 1.472 ± 0.055
2.805GlnGly: 2.805 ± 0.075
1.078GlnHis: 1.078 ± 0.054
3.05GlnIle: 3.05 ± 0.086
2.842GlnLys: 2.842 ± 0.078
4.461GlnLeu: 4.461 ± 0.113
1.159GlnMet: 1.159 ± 0.049
1.77GlnAsn: 1.77 ± 0.067
1.2GlnPro: 1.2 ± 0.062
2.395GlnGln: 2.395 ± 0.085
1.619GlnArg: 1.619 ± 0.068
2.59GlnSer: 2.59 ± 0.077
2.503GlnThr: 2.503 ± 0.069
3.238GlnVal: 3.238 ± 0.085
0.387GlnTrp: 0.387 ± 0.03
1.349GlnTyr: 1.349 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
2.832ArgAla: 2.832 ± 0.09
0.405ArgCys: 0.405 ± 0.034
2.104ArgAsp: 2.104 ± 0.067
2.288ArgGlu: 2.288 ± 0.067
1.857ArgPhe: 1.857 ± 0.071
2.393ArgGly: 2.393 ± 0.097
0.959ArgHis: 0.959 ± 0.051
2.816ArgIle: 2.816 ± 0.067
2.306ArgLys: 2.306 ± 0.074
3.968ArgLeu: 3.968 ± 0.094
1.069ArgMet: 1.069 ± 0.058
1.564ArgAsn: 1.564 ± 0.056
1.257ArgPro: 1.257 ± 0.055
1.713ArgGln: 1.713 ± 0.063
1.633ArgArg: 1.633 ± 0.059
2.363ArgSer: 2.363 ± 0.072
1.662ArgThr: 1.662 ± 0.059
2.734ArgVal: 2.734 ± 0.087
0.392ArgTrp: 0.392 ± 0.034
1.486ArgTyr: 1.486 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
5.409SerAla: 5.409 ± 0.119
0.698SerCys: 0.698 ± 0.042
3.712SerAsp: 3.712 ± 0.089
3.936SerGlu: 3.936 ± 0.087
2.816SerPhe: 2.816 ± 0.082
5.017SerGly: 5.017 ± 0.119
1.532SerHis: 1.532 ± 0.059
5.31SerIle: 5.31 ± 0.125
4.355SerLys: 4.355 ± 0.116
6.727SerLeu: 6.727 ± 0.128
1.8SerMet: 1.8 ± 0.061
3.08SerAsn: 3.08 ± 0.072
1.953SerPro: 1.953 ± 0.067
2.59SerGln: 2.59 ± 0.079
2.482SerArg: 2.482 ± 0.077
4.454SerSer: 4.454 ± 0.102
3.407SerThr: 3.407 ± 0.09
4.667SerVal: 4.667 ± 0.096
0.662SerTrp: 0.662 ± 0.039
1.93SerTyr: 1.93 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
3.59ThrAla: 3.59 ± 0.095
0.515ThrCys: 0.515 ± 0.034
3.201ThrAsp: 3.201 ± 0.092
2.42ThrGlu: 2.42 ± 0.085
2.001ThrPhe: 2.001 ± 0.073
4.069ThrGly: 4.069 ± 0.099
1.472ThrHis: 1.472 ± 0.062
3.948ThrIle: 3.948 ± 0.089
2.94ThrLys: 2.94 ± 0.097
6.29ThrLeu: 6.29 ± 0.135
1.227ThrMet: 1.227 ± 0.054
2.377ThrAsn: 2.377 ± 0.086
2.633ThrPro: 2.633 ± 0.077
2.862ThrGln: 2.862 ± 0.084
1.949ThrArg: 1.949 ± 0.067
3.055ThrSer: 3.055 ± 0.076
3.08ThrThr: 3.08 ± 0.088
3.213ThrVal: 3.213 ± 0.09
0.54ThrTrp: 0.54 ± 0.038
1.562ThrTyr: 1.562 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.37ValAla: 5.37 ± 0.11
0.746ValCys: 0.746 ± 0.039
4.502ValAsp: 4.502 ± 0.114
4.3ValGlu: 4.3 ± 0.096
3.034ValPhe: 3.034 ± 0.083
4.616ValGly: 4.616 ± 0.116
1.214ValHis: 1.214 ± 0.054
5.331ValIle: 5.331 ± 0.117
4.28ValLys: 4.28 ± 0.093
6.462ValLeu: 6.462 ± 0.122
1.756ValMet: 1.756 ± 0.055
3.052ValAsn: 3.052 ± 0.084
2.184ValPro: 2.184 ± 0.067
2.02ValGln: 2.02 ± 0.065
2.562ValArg: 2.562 ± 0.082
4.797ValSer: 4.797 ± 0.122
3.261ValThr: 3.261 ± 0.094
5.402ValVal: 5.402 ± 0.144
0.554ValTrp: 0.554 ± 0.04
1.905ValTyr: 1.905 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.634TrpAla: 0.634 ± 0.04
0.165TrpCys: 0.165 ± 0.02
0.547TrpAsp: 0.547 ± 0.038
0.479TrpGlu: 0.479 ± 0.034
0.485TrpPhe: 0.485 ± 0.041
0.692TrpGly: 0.692 ± 0.044
0.327TrpHis: 0.327 ± 0.024
0.774TrpIle: 0.774 ± 0.047
0.485TrpLys: 0.485 ± 0.033
1.138TrpLeu: 1.138 ± 0.058
0.337TrpMet: 0.337 ± 0.029
0.382TrpAsn: 0.382 ± 0.032
0.229TrpPro: 0.229 ± 0.021
0.591TrpGln: 0.591 ± 0.039
0.501TrpArg: 0.501 ± 0.037
0.598TrpSer: 0.598 ± 0.036
0.44TrpThr: 0.44 ± 0.035
0.714TrpVal: 0.714 ± 0.044
0.121TrpTrp: 0.121 ± 0.02
0.332TrpTyr: 0.332 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.304TyrAla: 2.304 ± 0.072
0.398TyrCys: 0.398 ± 0.032
1.708TyrAsp: 1.708 ± 0.071
1.498TyrGlu: 1.498 ± 0.057
1.617TyrPhe: 1.617 ± 0.06
2.102TyrGly: 2.102 ± 0.079
0.788TyrHis: 0.788 ± 0.043
1.887TyrIle: 1.887 ± 0.07
1.896TyrLys: 1.896 ± 0.07
3.542TyrLeu: 3.542 ± 0.103
0.692TyrMet: 0.692 ± 0.044
1.404TyrAsn: 1.404 ± 0.06
1.314TyrPro: 1.314 ± 0.052
1.944TyrGln: 1.944 ± 0.074
1.369TyrArg: 1.369 ± 0.059
1.937TyrSer: 1.937 ± 0.08
1.63TyrThr: 1.63 ± 0.064
1.704TyrVal: 1.704 ± 0.066
0.394TyrTrp: 0.394 ± 0.031
1.14TyrTyr: 1.14 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1488 proteins (436720 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski