Amino acid dipepetide frequency for Kwoniella pini CBS 10737

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.181AlaAla: 6.181 ± 0.062	0.752AlaCys: 0.752 ± 0.014	3.118AlaAsp: 3.118 ± 0.031	4.361AlaGlu: 4.361 ± 0.042	2.546AlaPhe: 2.546 ± 0.032	4.797AlaGly: 4.797 ± 0.041	1.377AlaHis: 1.377 ± 0.02	4.122AlaIle: 4.122 ± 0.032	3.981AlaLys: 3.981 ± 0.034	6.565AlaLeu: 6.565 ± 0.047	1.54AlaMet: 1.54 ± 0.021	2.657AlaAsn: 2.657 ± 0.028	3.962AlaPro: 3.962 ± 0.05	2.954AlaGln: 2.954 ± 0.039	3.722AlaArg: 3.722 ± 0.033	6.648AlaSer: 6.648 ± 0.062	4.141AlaThr: 4.141 ± 0.04	3.921AlaVal: 3.921 ± 0.036	0.898AlaTrp: 0.898 ± 0.014	1.847AlaTyr: 1.847 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.621CysAla: 0.621 ± 0.015	0.165CysCys: 0.165 ± 0.007	0.498CysAsp: 0.498 ± 0.012	0.509CysGlu: 0.509 ± 0.013	0.414CysPhe: 0.414 ± 0.01	0.745CysGly: 0.745 ± 0.019	0.243CysHis: 0.243 ± 0.009	0.612CysIle: 0.612 ± 0.013	0.491CysLys: 0.491 ± 0.012	1.037CysLeu: 1.037 ± 0.018	0.21CysMet: 0.21 ± 0.008	0.342CysAsn: 0.342 ± 0.01	0.516CysPro: 0.516 ± 0.016	0.383CysGln: 0.383 ± 0.012	0.479CysArg: 0.479 ± 0.01	0.763CysSer: 0.763 ± 0.014	0.539CysThr: 0.539 ± 0.013	0.554CysVal: 0.554 ± 0.011	0.16CysTrp: 0.16 ± 0.006	0.289CysTyr: 0.289 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.285AspAla: 3.285 ± 0.031	0.494AspCys: 0.494 ± 0.012	4.212AspAsp: 4.212 ± 0.048	5.113AspGlu: 5.113 ± 0.048	1.925AspPhe: 1.925 ± 0.02	3.592AspGly: 3.592 ± 0.035	1.226AspHis: 1.226 ± 0.018	3.253AspIle: 3.253 ± 0.029	2.902AspLys: 2.902 ± 0.036	5.229AspLeu: 5.229 ± 0.046	1.124AspMet: 1.124 ± 0.019	2.283AspAsn: 2.283 ± 0.027	3.014AspPro: 3.014 ± 0.027	2.207AspGln: 2.207 ± 0.027	2.723AspArg: 2.723 ± 0.037	4.07AspSer: 4.07 ± 0.03	2.662AspThr: 2.662 ± 0.028	3.24AspVal: 3.24 ± 0.03	0.844AspTrp: 0.844 ± 0.015	1.48AspTyr: 1.48 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.357GluAla: 4.357 ± 0.039	0.541GluCys: 0.541 ± 0.012	4.755GluAsp: 4.755 ± 0.043	7.018GluGlu: 7.018 ± 0.069	1.892GluPhe: 1.892 ± 0.024	4.261GluGly: 4.261 ± 0.037	1.183GluHis: 1.183 ± 0.018	4.16GluIle: 4.16 ± 0.042	4.633GluLys: 4.633 ± 0.055	5.257GluLeu: 5.257 ± 0.046	1.491GluMet: 1.491 ± 0.021	3.314GluAsn: 3.314 ± 0.037	2.379GluPro: 2.379 ± 0.028	2.4GluGln: 2.4 ± 0.027	3.814GluArg: 3.814 ± 0.044	4.577GluSer: 4.577 ± 0.037	3.061GluThr: 3.061 ± 0.028	3.484GluVal: 3.484 ± 0.034	0.928GluTrp: 0.928 ± 0.017	1.681GluTyr: 1.681 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.536PheAla: 2.536 ± 0.027	0.434PheCys: 0.434 ± 0.011	2.212PheAsp: 2.212 ± 0.023	2.127PheGlu: 2.127 ± 0.024	1.405PhePhe: 1.405 ± 0.022	2.751PheGly: 2.751 ± 0.035	0.773PheHis: 0.773 ± 0.013	1.964PheIle: 1.964 ± 0.026	1.806PheLys: 1.806 ± 0.021	3.105PheLeu: 3.105 ± 0.035	0.67PheMet: 0.67 ± 0.013	1.641PheAsn: 1.641 ± 0.023	1.851PhePro: 1.851 ± 0.021	1.195PheGln: 1.195 ± 0.016	1.609PheArg: 1.609 ± 0.017	3.014PheSer: 3.014 ± 0.028	2.027PheThr: 2.027 ± 0.021	1.96PheVal: 1.96 ± 0.027	0.534PheTrp: 0.534 ± 0.013	0.951PheTyr: 0.951 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	3.994GlyAla: 3.994 ± 0.042	0.701GlyCys: 0.701 ± 0.016	3.247GlyAsp: 3.247 ± 0.031	4.042GlyGlu: 4.042 ± 0.032	2.506GlyPhe: 2.506 ± 0.027	6.127GlyGly: 6.127 ± 0.077	1.457GlyHis: 1.457 ± 0.018	3.975GlyIle: 3.975 ± 0.035	4.358GlyLys: 4.358 ± 0.037	6.116GlyLeu: 6.116 ± 0.048	1.63GlyMet: 1.63 ± 0.027	2.962GlyAsn: 2.962 ± 0.03	3.006GlyPro: 3.006 ± 0.033	2.669GlyGln: 2.669 ± 0.032	3.595GlyArg: 3.595 ± 0.033	5.966GlySer: 5.966 ± 0.047	3.617GlyThr: 3.617 ± 0.037	3.776GlyVal: 3.776 ± 0.037	1.246GlyTrp: 1.246 ± 0.02	2.088GlyTyr: 2.088 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.381HisAla: 1.381 ± 0.02	0.226HisCys: 0.226 ± 0.007	1.086HisAsp: 1.086 ± 0.019	1.168HisGlu: 1.168 ± 0.018	0.797HisPhe: 0.797 ± 0.014	1.326HisGly: 1.326 ± 0.018	0.846HisHis: 0.846 ± 0.02	1.222HisIle: 1.222 ± 0.02	0.951HisLys: 0.951 ± 0.015	2.326HisLeu: 2.326 ± 0.029	0.382HisMet: 0.382 ± 0.01	0.923HisAsn: 0.923 ± 0.017	1.713HisPro: 1.713 ± 0.024	1.011HisGln: 1.011 ± 0.018	1.264HisArg: 1.264 ± 0.018	2.033HisSer: 2.033 ± 0.026	1.297HisThr: 1.297 ± 0.019	1.138HisVal: 1.138 ± 0.017	0.265HisTrp: 0.265 ± 0.007	0.597HisTyr: 0.597 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.12IleAla: 4.12 ± 0.035	0.707IleCys: 0.707 ± 0.014	3.423IleAsp: 3.423 ± 0.031	3.757IleGlu: 3.757 ± 0.033	2.065IlePhe: 2.065 ± 0.024	3.769IleGly: 3.769 ± 0.038	1.348IleHis: 1.348 ± 0.021	3.661IleIle: 3.661 ± 0.036	3.454IleLys: 3.454 ± 0.037	5.26IleLeu: 5.26 ± 0.043	1.043IleMet: 1.043 ± 0.018	2.893IleAsn: 2.893 ± 0.031	4.16IlePro: 4.16 ± 0.032	2.267IleGln: 2.267 ± 0.023	3.009IleArg: 3.009 ± 0.032	5.461IleSer: 5.461 ± 0.042	3.349IleThr: 3.349 ± 0.027	3.05IleVal: 3.05 ± 0.032	0.827IleTrp: 0.827 ± 0.017	1.523IleTyr: 1.523 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.299LysAla: 4.299 ± 0.04	0.47LysCys: 0.47 ± 0.013	3.348LysAsp: 3.348 ± 0.032	4.632LysGlu: 4.632 ± 0.052	1.66LysPhe: 1.66 ± 0.021	3.959LysGly: 3.959 ± 0.035	1.065LysHis: 1.065 ± 0.018	3.327LysIle: 3.327 ± 0.034	4.57LysLys: 4.57 ± 0.053	4.703LysLeu: 4.703 ± 0.037	1.109LysMet: 1.109 ± 0.016	2.488LysAsn: 2.488 ± 0.029	2.988LysPro: 2.988 ± 0.032	2.079LysGln: 2.079 ± 0.023	3.783LysArg: 3.783 ± 0.033	4.977LysSer: 4.977 ± 0.048	2.991LysThr: 2.991 ± 0.028	3.156LysVal: 3.156 ± 0.028	0.801LysTrp: 0.801 ± 0.016	1.477LysTyr: 1.477 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	6.608LeuAla: 6.608 ± 0.046	0.915LeuCys: 0.915 ± 0.018	4.913LeuAsp: 4.913 ± 0.036	5.351LeuGlu: 5.351 ± 0.049	3.13LeuPhe: 3.13 ± 0.035	5.759LeuGly: 5.759 ± 0.04	1.982LeuHis: 1.982 ± 0.026	5.162LeuIle: 5.162 ± 0.046	5.063LeuLys: 5.063 ± 0.04	8.169LeuLeu: 8.169 ± 0.072	1.612LeuMet: 1.612 ± 0.02	4.373LeuAsn: 4.373 ± 0.036	6.409LeuPro: 6.409 ± 0.046	3.291LeuGln: 3.291 ± 0.034	4.723LeuArg: 4.723 ± 0.041	8.381LeuSer: 8.381 ± 0.054	5.069LeuThr: 5.069 ± 0.04	4.594LeuVal: 4.594 ± 0.043	0.992LeuTrp: 0.992 ± 0.016	2.181LeuTyr: 2.181 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.536MetAla: 1.536 ± 0.02	0.18MetCys: 0.18 ± 0.007	1.098MetAsp: 1.098 ± 0.017	1.159MetGlu: 1.159 ± 0.018	0.658MetPhe: 0.658 ± 0.013	1.418MetGly: 1.418 ± 0.025	0.313MetHis: 0.313 ± 0.01	1.155MetIle: 1.155 ± 0.016	1.105MetLys: 1.105 ± 0.02	1.552MetLeu: 1.552 ± 0.02	0.547MetMet: 0.547 ± 0.013	0.906MetAsn: 0.906 ± 0.019	1.12MetPro: 1.12 ± 0.018	0.66MetGln: 0.66 ± 0.015	1.064MetArg: 1.064 ± 0.016	2.145MetSer: 2.145 ± 0.024	1.3MetThr: 1.3 ± 0.018	1.047MetVal: 1.047 ± 0.019	0.217MetTrp: 0.217 ± 0.007	0.458MetTyr: 0.458 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.893AsnAla: 2.893 ± 0.028	0.377AsnCys: 0.377 ± 0.011	2.667AsnAsp: 2.667 ± 0.029	3.092AsnGlu: 3.092 ± 0.033	1.511AsnPhe: 1.511 ± 0.022	3.688AsnGly: 3.688 ± 0.035	1.083AsnHis: 1.083 ± 0.019	2.505AsnIle: 2.505 ± 0.03	2.549AsnLys: 2.549 ± 0.03	4.389AsnLeu: 4.389 ± 0.041	0.776AsnMet: 0.776 ± 0.017	2.895AsnAsn: 2.895 ± 0.05	2.743AsnPro: 2.743 ± 0.028	2.187AsnGln: 2.187 ± 0.028	2.136AsnArg: 2.136 ± 0.029	4.475AsnSer: 4.475 ± 0.043	2.677AsnThr: 2.677 ± 0.03	2.382AsnVal: 2.382 ± 0.025	0.603AsnTrp: 0.603 ± 0.011	1.177AsnTyr: 1.177 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.248ProAla: 4.248 ± 0.052	0.39ProCys: 0.39 ± 0.012	2.732ProAsp: 2.732 ± 0.024	3.354ProGlu: 3.354 ± 0.029	2.169ProPhe: 2.169 ± 0.025	3.236ProGly: 3.236 ± 0.036	1.38ProHis: 1.38 ± 0.021	3.86ProIle: 3.86 ± 0.031	3.061ProLys: 3.061 ± 0.03	5.28ProLeu: 5.28 ± 0.045	0.938ProMet: 0.938 ± 0.016	2.841ProAsn: 2.841 ± 0.028	5.945ProPro: 5.945 ± 0.089	2.379ProGln: 2.379 ± 0.039	2.879ProArg: 2.879 ± 0.028	7.838ProSer: 7.838 ± 0.069	4.648ProThr: 4.648 ± 0.045	3.018ProVal: 3.018 ± 0.034	0.581ProTrp: 0.581 ± 0.015	1.544ProTyr: 1.544 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.237GlnAla: 3.237 ± 0.037	0.345GlnCys: 0.345 ± 0.011	1.987GlnAsp: 1.987 ± 0.025	2.248GlnGlu: 2.248 ± 0.026	1.165GlnPhe: 1.165 ± 0.018	2.366GlnGly: 2.366 ± 0.03	0.959GlnHis: 0.959 ± 0.017	2.349GlnIle: 2.349 ± 0.028	1.942GlnLys: 1.942 ± 0.024	3.261GlnLeu: 3.261 ± 0.032	0.825GlnMet: 0.825 ± 0.019	2.069GlnAsn: 2.069 ± 0.025	2.615GlnPro: 2.615 ± 0.038	2.653GlnGln: 2.653 ± 0.091	2.163GlnArg: 2.163 ± 0.026	3.723GlnSer: 3.723 ± 0.035	2.272GlnThr: 2.272 ± 0.022	2.071GlnVal: 2.071 ± 0.026	0.487GlnTrp: 0.487 ± 0.012	1.096GlnTyr: 1.096 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	3.596ArgAla: 3.596 ± 0.033	0.499ArgCys: 0.499 ± 0.012	2.831ArgAsp: 2.831 ± 0.031	3.449ArgGlu: 3.449 ± 0.04	1.779ArgPhe: 1.779 ± 0.022	3.3ArgGly: 3.3 ± 0.033	1.198ArgHis: 1.198 ± 0.019	2.968ArgIle: 2.968 ± 0.026	3.643ArgLys: 3.643 ± 0.035	4.7ArgLeu: 4.7 ± 0.039	1.139ArgMet: 1.139 ± 0.017	2.277ArgAsn: 2.277 ± 0.029	3.18ArgPro: 3.18 ± 0.036	2.263ArgGln: 2.263 ± 0.026	4.308ArgArg: 4.308 ± 0.046	5.022ArgSer: 5.022 ± 0.049	2.845ArgThr: 2.845 ± 0.027	2.617ArgVal: 2.617 ± 0.027	0.733ArgTrp: 0.733 ± 0.014	1.438ArgTyr: 1.438 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.511SerAla: 6.511 ± 0.058	0.708SerCys: 0.708 ± 0.017	4.459SerAsp: 4.459 ± 0.038	4.677SerGlu: 4.677 ± 0.037	3.259SerPhe: 3.259 ± 0.029	5.877SerGly: 5.877 ± 0.048	2.117SerHis: 2.117 ± 0.024	5.711SerIle: 5.711 ± 0.045	5.075SerLys: 5.075 ± 0.044	7.997SerLeu: 7.997 ± 0.049	1.656SerMet: 1.656 ± 0.022	4.984SerAsn: 4.984 ± 0.052	6.665SerPro: 6.665 ± 0.064	3.603SerGln: 3.603 ± 0.036	5.048SerArg: 5.048 ± 0.051	13.42SerSer: 13.42 ± 0.143	7.426SerThr: 7.426 ± 0.061	4.301SerVal: 4.301 ± 0.037	1.023SerTrp: 1.023 ± 0.015	2.24SerTyr: 2.24 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	4.278ThrAla: 4.278 ± 0.041	0.593ThrCys: 0.593 ± 0.013	2.61ThrAsp: 2.61 ± 0.028	2.916ThrGlu: 2.916 ± 0.029	2.232ThrPhe: 2.232 ± 0.027	3.77ThrGly: 3.77 ± 0.039	1.31ThrHis: 1.31 ± 0.02	3.657ThrIle: 3.657 ± 0.032	2.879ThrLys: 2.879 ± 0.028	5.351ThrLeu: 5.351 ± 0.04	1.004ThrMet: 1.004 ± 0.016	2.675ThrAsn: 2.675 ± 0.032	4.916ThrPro: 4.916 ± 0.055	2.057ThrGln: 2.057 ± 0.023	2.749ThrArg: 2.749 ± 0.028	6.947ThrSer: 6.947 ± 0.059	4.354ThrThr: 4.354 ± 0.05	3.017ThrVal: 3.017 ± 0.029	0.693ThrTrp: 0.693 ± 0.015	1.606ThrTyr: 1.606 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	3.726ValAla: 3.726 ± 0.031	0.569ValCys: 0.569 ± 0.012	3.253ValAsp: 3.253 ± 0.029	3.798ValGlu: 3.798 ± 0.046	1.901ValPhe: 1.901 ± 0.028	3.586ValGly: 3.586 ± 0.035	1.109ValHis: 1.109 ± 0.017	3.226ValIle: 3.226 ± 0.031	3.249ValLys: 3.249 ± 0.031	4.642ValLeu: 4.642 ± 0.04	1.093ValMet: 1.093 ± 0.019	2.35ValAsn: 2.35 ± 0.029	3.124ValPro: 3.124 ± 0.036	2.02ValGln: 2.02 ± 0.024	2.62ValArg: 2.62 ± 0.032	4.077ValSer: 4.077 ± 0.034	2.936ValThr: 2.936 ± 0.029	3.283ValVal: 3.283 ± 0.038	0.742ValTrp: 0.742 ± 0.014	1.412ValTyr: 1.412 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.881TrpAla: 0.881 ± 0.016	0.172TrpCys: 0.172 ± 0.006	0.818TrpAsp: 0.818 ± 0.015	0.892TrpGlu: 0.892 ± 0.016	0.482TrpPhe: 0.482 ± 0.012	0.873TrpGly: 0.873 ± 0.015	0.263TrpHis: 0.263 ± 0.007	0.802TrpIle: 0.802 ± 0.016	0.886TrpLys: 0.886 ± 0.016	1.175TrpLeu: 1.175 ± 0.017	0.319TrpMet: 0.319 ± 0.009	0.66TrpAsn: 0.66 ± 0.013	0.485TrpPro: 0.485 ± 0.012	0.474TrpGln: 0.474 ± 0.01	0.777TrpArg: 0.777 ± 0.017	1.072TrpSer: 1.072 ± 0.018	0.799TrpThr: 0.799 ± 0.015	0.733TrpVal: 0.733 ± 0.014	0.282TrpTrp: 0.282 ± 0.008	0.39TrpTyr: 0.39 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.801TyrAla: 1.801 ± 0.021	0.332TyrCys: 0.332 ± 0.011	1.61TyrAsp: 1.61 ± 0.022	1.525TyrGlu: 1.525 ± 0.022	1.068TyrPhe: 1.068 ± 0.016	1.883TyrGly: 1.883 ± 0.024	0.718TyrHis: 0.718 ± 0.013	1.458TyrIle: 1.458 ± 0.02	1.286TyrLys: 1.286 ± 0.019	2.563TyrLeu: 2.563 ± 0.026	0.528TyrMet: 0.528 ± 0.014	1.272TyrAsn: 1.272 ± 0.018	1.531TyrPro: 1.531 ± 0.023	1.08TyrGln: 1.08 ± 0.017	1.319TyrArg: 1.319 ± 0.02	2.15TyrSer: 2.15 ± 0.026	1.604TyrThr: 1.604 ± 0.022	1.371TyrVal: 1.371 ± 0.02	0.378TyrTrp: 0.378 ± 0.01	0.794TyrTyr: 0.794 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7827 proteins (4033902 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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