Amino acid dipepetide frequency for Flavobacterium micromati

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.686AlaAla: 4.686 ± 0.096	0.496AlaCys: 0.496 ± 0.023	3.298AlaAsp: 3.298 ± 0.084	3.847AlaGlu: 3.847 ± 0.072	3.447AlaPhe: 3.447 ± 0.061	4.246AlaGly: 4.246 ± 0.072	0.983AlaHis: 0.983 ± 0.034	5.979AlaIle: 5.979 ± 0.08	5.047AlaLys: 5.047 ± 0.117	6.228AlaLeu: 6.228 ± 0.095	1.597AlaMet: 1.597 ± 0.046	3.715AlaAsn: 3.715 ± 0.068	1.899AlaPro: 1.899 ± 0.059	2.373AlaGln: 2.373 ± 0.057	1.957AlaArg: 1.957 ± 0.056	4.08AlaSer: 4.08 ± 0.076	4.201AlaThr: 4.201 ± 0.125	4.513AlaVal: 4.513 ± 0.075	0.552AlaTrp: 0.552 ± 0.023	2.143AlaTyr: 2.143 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.024	0.104CysCys: 0.104 ± 0.01	0.417CysAsp: 0.417 ± 0.02	0.428CysGlu: 0.428 ± 0.022	0.432CysPhe: 0.432 ± 0.022	0.578CysGly: 0.578 ± 0.027	0.184CysHis: 0.184 ± 0.015	0.608CysIle: 0.608 ± 0.023	0.494CysLys: 0.494 ± 0.025	0.662CysLeu: 0.662 ± 0.026	0.133CysMet: 0.133 ± 0.011	0.459CysAsn: 0.459 ± 0.022	0.33CysPro: 0.33 ± 0.022	0.212CysGln: 0.212 ± 0.014	0.199CysArg: 0.199 ± 0.013	0.568CysSer: 0.568 ± 0.028	0.449CysThr: 0.449 ± 0.032	0.43CysVal: 0.43 ± 0.02	0.062CysTrp: 0.062 ± 0.008	0.294CysTyr: 0.294 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.621AspAla: 3.621 ± 0.086	0.402AspCys: 0.402 ± 0.021	2.589AspAsp: 2.589 ± 0.062	3.41AspGlu: 3.41 ± 0.073	3.708AspPhe: 3.708 ± 0.067	3.331AspGly: 3.331 ± 0.085	0.778AspHis: 0.778 ± 0.028	4.134AspIle: 4.134 ± 0.066	4.373AspLys: 4.373 ± 0.072	5.371AspLeu: 5.371 ± 0.081	0.971AspMet: 0.971 ± 0.029	3.072AspAsn: 3.072 ± 0.06	1.532AspPro: 1.532 ± 0.044	1.52AspGln: 1.52 ± 0.037	1.769AspArg: 1.769 ± 0.043	2.981AspSer: 2.981 ± 0.057	2.52AspThr: 2.52 ± 0.052	3.315AspVal: 3.315 ± 0.063	0.641AspTrp: 0.641 ± 0.025	2.544AspTyr: 2.544 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	3.972GluAla: 3.972 ± 0.085	0.356GluCys: 0.356 ± 0.02	3.024GluAsp: 3.024 ± 0.069	4.103GluGlu: 4.103 ± 0.09	2.953GluPhe: 2.953 ± 0.058	3.197GluGly: 3.197 ± 0.064	0.973GluHis: 0.973 ± 0.037	6.184GluIle: 6.184 ± 0.081	6.19GluLys: 6.19 ± 0.1	5.942GluLeu: 5.942 ± 0.091	1.678GluMet: 1.678 ± 0.042	4.915GluAsn: 4.915 ± 0.075	1.416GluPro: 1.416 ± 0.04	2.21GluGln: 2.21 ± 0.05	2.228GluArg: 2.228 ± 0.05	3.4GluSer: 3.4 ± 0.057	3.519GluThr: 3.519 ± 0.061	3.925GluVal: 3.925 ± 0.068	0.53GluTrp: 0.53 ± 0.023	2.259GluTyr: 2.259 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.422PheAla: 3.422 ± 0.062	0.491PheCys: 0.491 ± 0.023	3.414PheAsp: 3.414 ± 0.063	3.676PheGlu: 3.676 ± 0.064	2.931PhePhe: 2.931 ± 0.073	3.739PheGly: 3.739 ± 0.064	0.804PheHis: 0.804 ± 0.028	4.423PheIle: 4.423 ± 0.079	3.788PheLys: 3.788 ± 0.066	4.917PheLeu: 4.917 ± 0.08	1.133PheMet: 1.133 ± 0.035	3.233PheAsn: 3.233 ± 0.073	1.762PhePro: 1.762 ± 0.045	1.751PheGln: 1.751 ± 0.045	1.646PheArg: 1.646 ± 0.043	4.178PheSer: 4.178 ± 0.073	3.359PheThr: 3.359 ± 0.072	3.206PheVal: 3.206 ± 0.057	0.553PheTrp: 0.553 ± 0.021	2.279PheTyr: 2.279 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.006GlyAla: 4.006 ± 0.073	0.587GlyCys: 0.587 ± 0.041	2.925GlyAsp: 2.925 ± 0.056	3.159GlyGlu: 3.159 ± 0.066	3.745GlyPhe: 3.745 ± 0.062	4.182GlyGly: 4.182 ± 0.102	1.044GlyHis: 1.044 ± 0.033	5.722GlyIle: 5.722 ± 0.092	5.031GlyLys: 5.031 ± 0.081	5.517GlyLeu: 5.517 ± 0.073	1.541GlyMet: 1.541 ± 0.046	3.573GlyAsn: 3.573 ± 0.063	1.173GlyPro: 1.173 ± 0.037	1.831GlyGln: 1.831 ± 0.046	1.922GlyArg: 1.922 ± 0.048	3.938GlySer: 3.938 ± 0.066	4.014GlyThr: 4.014 ± 0.121	3.995GlyVal: 3.995 ± 0.075	0.642GlyTrp: 0.642 ± 0.025	2.52GlyTyr: 2.52 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.854HisAla: 0.854 ± 0.029	0.163HisCys: 0.163 ± 0.013	0.774HisAsp: 0.774 ± 0.026	0.875HisGlu: 0.875 ± 0.03	1.158HisPhe: 1.158 ± 0.034	0.928HisGly: 0.928 ± 0.03	0.391HisHis: 0.391 ± 0.023	1.345HisIle: 1.345 ± 0.036	1.071HisLys: 1.071 ± 0.036	1.609HisLeu: 1.609 ± 0.046	0.246HisMet: 0.246 ± 0.015	0.976HisAsn: 0.976 ± 0.031	0.762HisPro: 0.762 ± 0.032	0.676HisGln: 0.676 ± 0.028	0.577HisArg: 0.577 ± 0.023	1.067HisSer: 1.067 ± 0.037	0.794HisThr: 0.794 ± 0.026	0.794HisVal: 0.794 ± 0.031	0.172HisTrp: 0.172 ± 0.014	0.764HisTyr: 0.764 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.406IleAla: 6.406 ± 0.099	0.686IleCys: 0.686 ± 0.029	5.094IleAsp: 5.094 ± 0.063	5.937IleGlu: 5.937 ± 0.079	4.043IlePhe: 4.043 ± 0.073	5.288IleGly: 5.288 ± 0.088	1.414IleHis: 1.414 ± 0.041	7.365IleIle: 7.365 ± 0.108	6.502IleLys: 6.502 ± 0.084	7.776IleLeu: 7.776 ± 0.084	1.594IleMet: 1.594 ± 0.041	5.21IleAsn: 5.21 ± 0.091	3.381IlePro: 3.381 ± 0.06	2.853IleGln: 2.853 ± 0.059	2.576IleArg: 2.576 ± 0.044	5.952IleSer: 5.952 ± 0.084	5.204IleThr: 5.204 ± 0.108	5.398IleVal: 5.398 ± 0.077	0.739IleTrp: 0.739 ± 0.029	3.016IleTyr: 3.016 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.938LysAla: 4.938 ± 0.1	0.369LysCys: 0.369 ± 0.021	4.091LysAsp: 4.091 ± 0.077	5.918LysGlu: 5.918 ± 0.099	3.28LysPhe: 3.28 ± 0.065	4.483LysGly: 4.483 ± 0.07	1.173LysHis: 1.173 ± 0.036	7.494LysIle: 7.494 ± 0.104	7.242LysLys: 7.242 ± 0.116	6.969LysLeu: 6.969 ± 0.107	2.364LysMet: 2.364 ± 0.048	5.954LysAsn: 5.954 ± 0.102	2.407LysPro: 2.407 ± 0.053	2.77LysGln: 2.77 ± 0.055	2.582LysArg: 2.582 ± 0.054	5.056LysSer: 5.056 ± 0.085	4.849LysThr: 4.849 ± 0.066	4.875LysVal: 4.875 ± 0.078	0.755LysTrp: 0.755 ± 0.029	3.072LysTyr: 3.072 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.991LeuAla: 5.991 ± 0.082	0.694LeuCys: 0.694 ± 0.028	4.898LeuAsp: 4.898 ± 0.076	6.082LeuGlu: 6.082 ± 0.093	5.262LeuPhe: 5.262 ± 0.085	5.535LeuGly: 5.535 ± 0.082	1.514LeuHis: 1.514 ± 0.044	7.473LeuIle: 7.473 ± 0.087	7.75LeuLys: 7.75 ± 0.103	8.981LeuLeu: 8.981 ± 0.113	2.082LeuMet: 2.082 ± 0.049	5.954LeuAsn: 5.954 ± 0.093	3.435LeuPro: 3.435 ± 0.066	3.38LeuGln: 3.38 ± 0.064	3.029LeuArg: 3.029 ± 0.054	6.582LeuSer: 6.582 ± 0.08	5.125LeuThr: 5.125 ± 0.086	5.319LeuVal: 5.319 ± 0.087	0.735LeuTrp: 0.735 ± 0.029	3.165LeuTyr: 3.165 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.503MetAla: 1.503 ± 0.043	0.135MetCys: 0.135 ± 0.012	1.106MetAsp: 1.106 ± 0.033	1.364MetGlu: 1.364 ± 0.036	0.862MetPhe: 0.862 ± 0.035	1.376MetGly: 1.376 ± 0.041	0.392MetHis: 0.392 ± 0.02	1.855MetIle: 1.855 ± 0.045	2.331MetLys: 2.331 ± 0.052	1.892MetLeu: 1.892 ± 0.043	0.606MetMet: 0.606 ± 0.028	1.434MetAsn: 1.434 ± 0.035	0.809MetPro: 0.809 ± 0.03	0.897MetGln: 0.897 ± 0.033	0.803MetArg: 0.803 ± 0.031	1.414MetSer: 1.414 ± 0.039	1.257MetThr: 1.257 ± 0.033	1.283MetVal: 1.283 ± 0.036	0.177MetTrp: 0.177 ± 0.016	0.737MetTyr: 0.737 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.981AsnAla: 3.981 ± 0.065	0.531AsnCys: 0.531 ± 0.028	3.429AsnAsp: 3.429 ± 0.067	3.954AsnGlu: 3.954 ± 0.058	3.5AsnPhe: 3.5 ± 0.076	4.05AsnGly: 4.05 ± 0.088	1.01AsnHis: 1.01 ± 0.029	4.997AsnIle: 4.997 ± 0.081	4.838AsnLys: 4.838 ± 0.075	5.892AsnLeu: 5.892 ± 0.084	1.286AsnMet: 1.286 ± 0.035	4.228AsnAsn: 4.228 ± 0.092	2.826AsnPro: 2.826 ± 0.052	2.553AsnGln: 2.553 ± 0.061	2.13AsnArg: 2.13 ± 0.047	4.308AsnSer: 4.308 ± 0.086	3.513AsnThr: 3.513 ± 0.082	3.647AsnVal: 3.647 ± 0.067	0.841AsnTrp: 0.841 ± 0.03	3.027AsnTyr: 3.027 ± 0.069	0.0AsnXaa: 0.0 ± 0.0
Pro	2.142ProAla: 2.142 ± 0.061	0.212ProCys: 0.212 ± 0.016	1.77ProAsp: 1.77 ± 0.037	2.497ProGlu: 2.497 ± 0.056	1.974ProPhe: 1.974 ± 0.047	1.632ProGly: 1.632 ± 0.046	0.502ProHis: 0.502 ± 0.023	2.757ProIle: 2.757 ± 0.045	2.489ProLys: 2.489 ± 0.052	2.956ProLeu: 2.956 ± 0.059	0.704ProMet: 0.704 ± 0.025	2.257ProAsn: 2.257 ± 0.052	0.756ProPro: 0.756 ± 0.027	1.076ProGln: 1.076 ± 0.034	0.923ProArg: 0.923 ± 0.031	2.069ProSer: 2.069 ± 0.052	2.029ProThr: 2.029 ± 0.062	2.206ProVal: 2.206 ± 0.053	0.298ProTrp: 0.298 ± 0.015	1.313ProTyr: 1.313 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.997GlnAla: 1.997 ± 0.04	0.212GlnCys: 0.212 ± 0.017	1.639GlnAsp: 1.639 ± 0.038	2.254GlnGlu: 2.254 ± 0.051	1.83GlnPhe: 1.83 ± 0.041	1.677GlnGly: 1.677 ± 0.039	0.568GlnHis: 0.568 ± 0.026	3.058GlnIle: 3.058 ± 0.055	3.157GlnLys: 3.157 ± 0.066	3.524GlnLeu: 3.524 ± 0.067	0.84GlnMet: 0.84 ± 0.029	2.557GlnAsn: 2.557 ± 0.056	1.039GlnPro: 1.039 ± 0.034	1.481GlnGln: 1.481 ± 0.041	1.16GlnArg: 1.16 ± 0.03	2.141GlnSer: 2.141 ± 0.053	1.951GlnThr: 1.951 ± 0.046	1.93GlnVal: 1.93 ± 0.044	0.353GlnTrp: 0.353 ± 0.019	1.352GlnTyr: 1.352 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.958ArgAla: 1.958 ± 0.045	0.183ArgCys: 0.183 ± 0.014	1.625ArgAsp: 1.625 ± 0.039	2.058ArgGlu: 2.058 ± 0.052	1.855ArgPhe: 1.855 ± 0.043	1.821ArgGly: 1.821 ± 0.042	0.553ArgHis: 0.553 ± 0.022	2.973ArgIle: 2.973 ± 0.053	2.674ArgLys: 2.674 ± 0.056	2.962ArgLeu: 2.962 ± 0.059	0.826ArgMet: 0.826 ± 0.026	2.243ArgAsn: 2.243 ± 0.052	0.994ArgPro: 0.994 ± 0.03	1.022ArgGln: 1.022 ± 0.036	1.131ArgArg: 1.131 ± 0.036	1.876ArgSer: 1.876 ± 0.043	1.787ArgThr: 1.787 ± 0.049	1.939ArgVal: 1.939 ± 0.046	0.327ArgTrp: 0.327 ± 0.017	1.356ArgTyr: 1.356 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.869SerAla: 3.869 ± 0.068	0.626SerCys: 0.626 ± 0.031	3.37SerAsp: 3.37 ± 0.058	3.749SerGlu: 3.749 ± 0.059	4.035SerPhe: 4.035 ± 0.068	4.455SerGly: 4.455 ± 0.073	1.075SerHis: 1.075 ± 0.03	5.615SerIle: 5.615 ± 0.081	5.286SerLys: 5.286 ± 0.096	5.943SerLeu: 5.943 ± 0.086	1.305SerMet: 1.305 ± 0.041	4.133SerAsn: 4.133 ± 0.069	2.054SerPro: 2.054 ± 0.051	2.269SerGln: 2.269 ± 0.05	2.237SerArg: 2.237 ± 0.05	4.354SerSer: 4.354 ± 0.073	3.639SerThr: 3.639 ± 0.063	4.025SerVal: 4.025 ± 0.065	0.639SerTrp: 0.639 ± 0.027	2.664SerTyr: 2.664 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.167ThrAla: 4.167 ± 0.121	0.327ThrCys: 0.327 ± 0.025	3.138ThrAsp: 3.138 ± 0.063	3.346ThrGlu: 3.346 ± 0.058	3.24ThrPhe: 3.24 ± 0.066	3.812ThrGly: 3.812 ± 0.098	0.913ThrHis: 0.913 ± 0.031	5.514ThrIle: 5.514 ± 0.098	4.155ThrLys: 4.155 ± 0.079	5.2ThrLeu: 5.2 ± 0.078	1.04ThrMet: 1.04 ± 0.034	3.567ThrAsn: 3.567 ± 0.086	2.324ThrPro: 2.324 ± 0.086	1.939ThrGln: 1.939 ± 0.045	1.572ThrArg: 1.572 ± 0.042	3.731ThrSer: 3.731 ± 0.062	3.759ThrThr: 3.759 ± 0.106	4.017ThrVal: 4.017 ± 0.099	0.497ThrTrp: 0.497 ± 0.025	2.131ThrTyr: 2.131 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.512ValAla: 4.512 ± 0.08	0.528ValCys: 0.528 ± 0.026	3.351ValAsp: 3.351 ± 0.055	3.6ValGlu: 3.6 ± 0.063	3.378ValPhe: 3.378 ± 0.059	3.742ValGly: 3.742 ± 0.065	0.845ValHis: 0.845 ± 0.028	5.33ValIle: 5.33 ± 0.076	4.395ValLys: 4.395 ± 0.077	5.952ValLeu: 5.952 ± 0.085	1.305ValMet: 1.305 ± 0.038	3.763ValAsn: 3.763 ± 0.069	2.074ValPro: 2.074 ± 0.052	1.929ValGln: 1.929 ± 0.046	1.967ValArg: 1.967 ± 0.045	4.289ValSer: 4.289 ± 0.066	3.79ValThr: 3.79 ± 0.109	4.008ValVal: 4.008 ± 0.075	0.528ValTrp: 0.528 ± 0.025	2.157ValTyr: 2.157 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.584TrpAla: 0.584 ± 0.026	0.081TrpCys: 0.081 ± 0.008	0.513TrpAsp: 0.513 ± 0.025	0.578TrpGlu: 0.578 ± 0.025	0.557TrpPhe: 0.557 ± 0.026	0.555TrpGly: 0.555 ± 0.028	0.187TrpHis: 0.187 ± 0.013	0.766TrpIle: 0.766 ± 0.027	0.782TrpLys: 0.782 ± 0.027	0.897TrpLeu: 0.897 ± 0.03	0.282TrpMet: 0.282 ± 0.016	0.711TrpAsn: 0.711 ± 0.029	0.201TrpPro: 0.201 ± 0.016	0.419TrpGln: 0.419 ± 0.02	0.341TrpArg: 0.341 ± 0.017	0.608TrpSer: 0.608 ± 0.026	0.508TrpThr: 0.508 ± 0.024	0.504TrpVal: 0.504 ± 0.022	0.123TrpTrp: 0.123 ± 0.012	0.363TrpTyr: 0.363 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.19TyrAla: 2.19 ± 0.049	0.346TyrCys: 0.346 ± 0.02	2.116TyrAsp: 2.116 ± 0.044	2.14TyrGlu: 2.14 ± 0.047	2.519TyrPhe: 2.519 ± 0.049	2.441TyrGly: 2.441 ± 0.054	0.691TyrHis: 0.691 ± 0.026	2.845TyrIle: 2.845 ± 0.054	3.044TyrLys: 3.044 ± 0.056	3.797TyrLeu: 3.797 ± 0.065	0.701TyrMet: 0.701 ± 0.025	2.588TyrAsn: 2.588 ± 0.053	1.388TyrPro: 1.388 ± 0.039	1.556TyrGln: 1.556 ± 0.042	1.412TyrArg: 1.412 ± 0.041	2.75TyrSer: 2.75 ± 0.052	2.123TyrThr: 2.123 ± 0.063	2.113TyrVal: 2.113 ± 0.049	0.399TyrTrp: 0.399 ± 0.017	1.696TyrTyr: 1.696 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3204 proteins (1040682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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