Amino acid dipepetide frequency for Candidatus Enterovibrio escacola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.744AlaAla: 4.744 ± 0.12
0.986AlaCys: 0.986 ± 0.043
3.56AlaAsp: 3.56 ± 0.08
4.05AlaGlu: 4.05 ± 0.09
3.051AlaPhe: 3.051 ± 0.082
4.254AlaGly: 4.254 ± 0.101
1.305AlaHis: 1.305 ± 0.055
5.164AlaIle: 5.164 ± 0.121
4.091AlaLys: 4.091 ± 0.105
7.364AlaLeu: 7.364 ± 0.131
2.232AlaMet: 2.232 ± 0.063
3.127AlaAsn: 3.127 ± 0.071
1.919AlaPro: 1.919 ± 0.058
2.35AlaGln: 2.35 ± 0.072
3.235AlaArg: 3.235 ± 0.082
3.97AlaSer: 3.97 ± 0.088
3.399AlaThr: 3.399 ± 0.089
4.798AlaVal: 4.798 ± 0.09
0.811AlaTrp: 0.811 ± 0.038
2.016AlaTyr: 2.016 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.653CysAla: 0.653 ± 0.042
0.213CysCys: 0.213 ± 0.019
0.645CysAsp: 0.645 ± 0.035
0.688CysGlu: 0.688 ± 0.037
0.558CysPhe: 0.558 ± 0.034
0.895CysGly: 0.895 ± 0.045
0.66CysHis: 0.66 ± 0.039
1.111CysIle: 1.111 ± 0.044
0.701CysLys: 0.701 ± 0.039
1.561CysLeu: 1.561 ± 0.053
0.338CysMet: 0.338 ± 0.024
0.449CysAsn: 0.449 ± 0.03
0.449CysPro: 0.449 ± 0.028
0.636CysGln: 0.636 ± 0.038
0.768CysArg: 0.768 ± 0.03
1.048CysSer: 1.048 ± 0.046
0.554CysThr: 0.554 ± 0.033
0.722CysVal: 0.722 ± 0.04
0.175CysTrp: 0.175 ± 0.018
0.459CysTyr: 0.459 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.545AspAla: 3.545 ± 0.085
0.58AspCys: 0.58 ± 0.036
2.881AspAsp: 2.881 ± 0.083
3.385AspGlu: 3.385 ± 0.075
2.342AspPhe: 2.342 ± 0.065
3.041AspGly: 3.041 ± 0.09
1.072AspHis: 1.072 ± 0.048
4.282AspIle: 4.282 ± 0.09
3.696AspLys: 3.696 ± 0.091
4.716AspLeu: 4.716 ± 0.109
1.509AspMet: 1.509 ± 0.054
2.415AspAsn: 2.415 ± 0.07
1.809AspPro: 1.809 ± 0.061
1.785AspGln: 1.785 ± 0.057
2.691AspArg: 2.691 ± 0.072
2.806AspSer: 2.806 ± 0.072
2.749AspThr: 2.749 ± 0.074
3.987AspVal: 3.987 ± 0.089
0.569AspTrp: 0.569 ± 0.034
1.762AspTyr: 1.762 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.158GluAla: 4.158 ± 0.096
0.643GluCys: 0.643 ± 0.036
2.445GluAsp: 2.445 ± 0.075
3.386GluGlu: 3.386 ± 0.09
2.31GluPhe: 2.31 ± 0.072
3.319GluGly: 3.319 ± 0.087
1.296GluHis: 1.296 ± 0.045
4.235GluIle: 4.235 ± 0.1
3.853GluLys: 3.853 ± 0.087
6.448GluLeu: 6.448 ± 0.105
2.096GluMet: 2.096 ± 0.063
2.422GluAsn: 2.422 ± 0.063
1.456GluPro: 1.456 ± 0.055
2.588GluGln: 2.588 ± 0.075
3.485GluArg: 3.485 ± 0.098
3.073GluSer: 3.073 ± 0.073
3.267GluThr: 3.267 ± 0.081
4.628GluVal: 4.628 ± 0.09
0.733GluTrp: 0.733 ± 0.029
1.751GluTyr: 1.751 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.378PheAla: 2.378 ± 0.073
0.735PheCys: 0.735 ± 0.038
2.516PheAsp: 2.516 ± 0.071
2.031PheGlu: 2.031 ± 0.058
1.717PhePhe: 1.717 ± 0.068
2.734PheGly: 2.734 ± 0.079
1.177PheHis: 1.177 ± 0.049
3.558PheIle: 3.558 ± 0.089
2.719PheLys: 2.719 ± 0.078
3.709PheLeu: 3.709 ± 0.092
1.193PheMet: 1.193 ± 0.048
2.079PheAsn: 2.079 ± 0.072
1.537PhePro: 1.537 ± 0.055
1.223PheGln: 1.223 ± 0.046
1.781PheArg: 1.781 ± 0.062
3.355PheSer: 3.355 ± 0.08
2.46PheThr: 2.46 ± 0.069
2.946PheVal: 2.946 ± 0.082
0.578PheTrp: 0.578 ± 0.032
1.602PheTyr: 1.602 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
3.802GlyAla: 3.802 ± 0.101
1.024GlyCys: 1.024 ± 0.046
3.435GlyAsp: 3.435 ± 0.084
3.429GlyGlu: 3.429 ± 0.086
3.222GlyPhe: 3.222 ± 0.08
4.097GlyGly: 4.097 ± 0.116
1.496GlyHis: 1.496 ± 0.055
5.742GlyIle: 5.742 ± 0.122
4.505GlyLys: 4.505 ± 0.103
5.978GlyLeu: 5.978 ± 0.107
2.098GlyMet: 2.098 ± 0.062
2.627GlyAsn: 2.627 ± 0.072
1.188GlyPro: 1.188 ± 0.049
2.094GlyGln: 2.094 ± 0.077
3.151GlyArg: 3.151 ± 0.082
3.726GlySer: 3.726 ± 0.089
3.388GlyThr: 3.388 ± 0.083
5.078GlyVal: 5.078 ± 0.1
0.897GlyTrp: 0.897 ± 0.04
2.743GlyTyr: 2.743 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.441HisAla: 1.441 ± 0.049
0.448HisCys: 0.448 ± 0.026
1.001HisAsp: 1.001 ± 0.05
1.173HisGlu: 1.173 ± 0.044
1.317HisPhe: 1.317 ± 0.051
1.632HisGly: 1.632 ± 0.059
0.867HisHis: 0.867 ± 0.037
1.606HisIle: 1.606 ± 0.053
1.309HisLys: 1.309 ± 0.052
2.67HisLeu: 2.67 ± 0.071
0.565HisMet: 0.565 ± 0.029
1.262HisAsn: 1.262 ± 0.054
1.108HisPro: 1.108 ± 0.053
1.479HisGln: 1.479 ± 0.063
1.49HisArg: 1.49 ± 0.058
1.397HisSer: 1.397 ± 0.054
1.083HisThr: 1.083 ± 0.044
1.555HisVal: 1.555 ± 0.051
0.373HisTrp: 0.373 ± 0.027
0.774HisTyr: 0.774 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.837IleAla: 5.837 ± 0.12
0.998IleCys: 0.998 ± 0.044
4.472IleAsp: 4.472 ± 0.092
4.878IleGlu: 4.878 ± 0.087
2.969IlePhe: 2.969 ± 0.078
4.651IleGly: 4.651 ± 0.112
1.96IleHis: 1.96 ± 0.06
5.154IleIle: 5.154 ± 0.124
4.658IleLys: 4.658 ± 0.091
6.48IleLeu: 6.48 ± 0.122
1.816IleMet: 1.816 ± 0.052
3.892IleAsn: 3.892 ± 0.096
2.892IlePro: 2.892 ± 0.079
2.351IleGln: 2.351 ± 0.064
3.767IleArg: 3.767 ± 0.071
6.226IleSer: 6.226 ± 0.104
4.53IleThr: 4.53 ± 0.103
4.643IleVal: 4.643 ± 0.082
0.748IleTrp: 0.748 ± 0.039
2.055IleTyr: 2.055 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.035LysAla: 4.035 ± 0.087
0.584LysCys: 0.584 ± 0.031
2.672LysAsp: 2.672 ± 0.08
3.638LysGlu: 3.638 ± 0.077
1.872LysPhe: 1.872 ± 0.059
4.584LysGly: 4.584 ± 0.109
1.766LysHis: 1.766 ± 0.059
4.153LysIle: 4.153 ± 0.088
3.978LysLys: 3.978 ± 0.097
6.87LysLeu: 6.87 ± 0.099
1.939LysMet: 1.939 ± 0.068
3.062LysAsn: 3.062 ± 0.076
2.607LysPro: 2.607 ± 0.073
2.902LysGln: 2.902 ± 0.09
3.961LysArg: 3.961 ± 0.08
3.502LysSer: 3.502 ± 0.078
3.491LysThr: 3.491 ± 0.08
4.899LysVal: 4.899 ± 0.101
0.641LysTrp: 0.641 ± 0.039
1.896LysTyr: 1.896 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
7.584LeuAla: 7.584 ± 0.133
1.404LeuCys: 1.404 ± 0.049
5.302LeuAsp: 5.302 ± 0.108
5.846LeuGlu: 5.846 ± 0.104
3.827LeuPhe: 3.827 ± 0.094
6.031LeuGly: 6.031 ± 0.113
2.383LeuHis: 2.383 ± 0.064
7.577LeuIle: 7.577 ± 0.139
6.42LeuLys: 6.42 ± 0.106
9.779LeuLeu: 9.779 ± 0.166
3.67LeuMet: 3.67 ± 0.095
4.682LeuAsn: 4.682 ± 0.102
4.483LeuPro: 4.483 ± 0.093
3.373LeuGln: 3.373 ± 0.09
5.732LeuArg: 5.732 ± 0.11
7.69LeuSer: 7.69 ± 0.126
6.01LeuThr: 6.01 ± 0.119
7.213LeuVal: 7.213 ± 0.118
1.212LeuTrp: 1.212 ± 0.047
2.816LeuTyr: 2.816 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.316MetAla: 2.316 ± 0.07
0.283MetCys: 0.283 ± 0.024
1.434MetAsp: 1.434 ± 0.051
1.566MetGlu: 1.566 ± 0.053
1.091MetPhe: 1.091 ± 0.05
2.156MetGly: 2.156 ± 0.064
0.574MetHis: 0.574 ± 0.033
2.046MetIle: 2.046 ± 0.07
2.199MetLys: 2.199 ± 0.074
3.207MetLeu: 3.207 ± 0.072
1.046MetMet: 1.046 ± 0.049
1.557MetAsn: 1.557 ± 0.048
1.277MetPro: 1.277 ± 0.052
1.322MetGln: 1.322 ± 0.05
1.453MetArg: 1.453 ± 0.053
1.852MetSer: 1.852 ± 0.06
2.092MetThr: 2.092 ± 0.063
2.366MetVal: 2.366 ± 0.07
0.27MetTrp: 0.27 ± 0.022
0.589MetTyr: 0.589 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.075AsnAla: 3.075 ± 0.082
0.522AsnCys: 0.522 ± 0.031
2.348AsnAsp: 2.348 ± 0.064
2.683AsnGlu: 2.683 ± 0.063
1.716AsnPhe: 1.716 ± 0.052
2.849AsnGly: 2.849 ± 0.069
1.052AsnHis: 1.052 ± 0.041
3.537AsnIle: 3.537 ± 0.089
3.252AsnLys: 3.252 ± 0.083
4.69AsnLeu: 4.69 ± 0.093
1.613AsnMet: 1.613 ± 0.059
2.303AsnAsn: 2.303 ± 0.065
1.949AsnPro: 1.949 ± 0.052
1.932AsnGln: 1.932 ± 0.063
2.381AsnArg: 2.381 ± 0.064
2.598AsnSer: 2.598 ± 0.071
2.368AsnThr: 2.368 ± 0.063
3.299AsnVal: 3.299 ± 0.064
0.679AsnTrp: 0.679 ± 0.04
1.484AsnTyr: 1.484 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.034ProAla: 2.034 ± 0.069
0.416ProCys: 0.416 ± 0.031
1.9ProAsp: 1.9 ± 0.067
2.506ProGlu: 2.506 ± 0.07
1.488ProPhe: 1.488 ± 0.053
1.318ProGly: 1.318 ± 0.057
0.779ProHis: 0.779 ± 0.041
2.553ProIle: 2.553 ± 0.074
2.324ProLys: 2.324 ± 0.061
4.173ProLeu: 4.173 ± 0.092
0.94ProMet: 0.94 ± 0.041
1.65ProAsn: 1.65 ± 0.049
1.104ProPro: 1.104 ± 0.049
1.1ProGln: 1.1 ± 0.051
1.604ProArg: 1.604 ± 0.061
2.779ProSer: 2.779 ± 0.068
2.241ProThr: 2.241 ± 0.067
2.92ProVal: 2.92 ± 0.078
0.364ProTrp: 0.364 ± 0.029
1.113ProTyr: 1.113 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.915GlnAla: 2.915 ± 0.068
0.373GlnCys: 0.373 ± 0.03
1.634GlnAsp: 1.634 ± 0.061
1.88GlnGlu: 1.88 ± 0.063
1.427GlnPhe: 1.427 ± 0.057
2.476GlnGly: 2.476 ± 0.059
0.862GlnHis: 0.862 ± 0.042
2.668GlnIle: 2.668 ± 0.069
2.051GlnLys: 2.051 ± 0.071
4.123GlnLeu: 4.123 ± 0.1
1.022GlnMet: 1.022 ± 0.046
1.289GlnAsn: 1.289 ± 0.049
1.309GlnPro: 1.309 ± 0.052
2.042GlnGln: 2.042 ± 0.074
2.296GlnArg: 2.296 ± 0.079
2.489GlnSer: 2.489 ± 0.058
2.055GlnThr: 2.055 ± 0.063
3.271GlnVal: 3.271 ± 0.08
0.446GlnTrp: 0.446 ± 0.029
1.164GlnTyr: 1.164 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
2.926ArgAla: 2.926 ± 0.086
0.669ArgCys: 0.669 ± 0.037
2.652ArgAsp: 2.652 ± 0.064
3.293ArgGlu: 3.293 ± 0.078
2.547ArgPhe: 2.547 ± 0.07
3.323ArgGly: 3.323 ± 0.086
1.529ArgHis: 1.529 ± 0.05
3.774ArgIle: 3.774 ± 0.103
3.603ArgLys: 3.603 ± 0.089
5.51ArgLeu: 5.51 ± 0.105
1.613ArgMet: 1.613 ± 0.051
2.663ArgAsn: 2.663 ± 0.072
1.596ArgPro: 1.596 ± 0.049
2.394ArgGln: 2.394 ± 0.066
2.862ArgArg: 2.862 ± 0.09
3.056ArgSer: 3.056 ± 0.075
2.355ArgThr: 2.355 ± 0.067
3.399ArgVal: 3.399 ± 0.081
0.619ArgTrp: 0.619 ± 0.035
2.156ArgTyr: 2.156 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
3.884SerAla: 3.884 ± 0.09
0.778SerCys: 0.778 ± 0.035
3.511SerAsp: 3.511 ± 0.082
4.035SerGlu: 4.035 ± 0.074
2.954SerPhe: 2.954 ± 0.079
4.988SerGly: 4.988 ± 0.108
1.434SerHis: 1.434 ± 0.054
4.699SerIle: 4.699 ± 0.092
3.847SerLys: 3.847 ± 0.087
6.838SerLeu: 6.838 ± 0.123
1.852SerMet: 1.852 ± 0.062
2.92SerAsn: 2.92 ± 0.086
2.284SerPro: 2.284 ± 0.063
2.443SerGln: 2.443 ± 0.073
3.157SerArg: 3.157 ± 0.087
4.662SerSer: 4.662 ± 0.103
3.439SerThr: 3.439 ± 0.081
4.983SerVal: 4.983 ± 0.11
0.722SerTrp: 0.722 ± 0.038
2.394SerTyr: 2.394 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
3.899ThrAla: 3.899 ± 0.091
0.768ThrCys: 0.768 ± 0.04
2.663ThrAsp: 2.663 ± 0.081
3.013ThrGlu: 3.013 ± 0.075
2.258ThrPhe: 2.258 ± 0.067
3.95ThrGly: 3.95 ± 0.09
1.576ThrHis: 1.576 ± 0.053
3.985ThrIle: 3.985 ± 0.082
2.851ThrLys: 2.851 ± 0.088
6.529ThrLeu: 6.529 ± 0.131
1.494ThrMet: 1.494 ± 0.048
2.448ThrAsn: 2.448 ± 0.071
2.2ThrPro: 2.2 ± 0.056
1.779ThrGln: 1.779 ± 0.054
2.849ThrArg: 2.849 ± 0.075
3.351ThrSer: 3.351 ± 0.08
2.995ThrThr: 2.995 ± 0.082
4.024ThrVal: 4.024 ± 0.089
0.507ThrTrp: 0.507 ± 0.033
1.852ThrTyr: 1.852 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.776ValAla: 4.776 ± 0.109
1.18ValCys: 1.18 ± 0.051
4.477ValAsp: 4.477 ± 0.103
4.061ValGlu: 4.061 ± 0.095
3.295ValPhe: 3.295 ± 0.077
4.429ValGly: 4.429 ± 0.109
1.38ValHis: 1.38 ± 0.046
5.848ValIle: 5.848 ± 0.106
4.623ValLys: 4.623 ± 0.085
7.062ValLeu: 7.062 ± 0.112
2.462ValMet: 2.462 ± 0.063
3.476ValAsn: 3.476 ± 0.093
2.577ValPro: 2.577 ± 0.076
1.841ValGln: 1.841 ± 0.053
3.107ValArg: 3.107 ± 0.081
5.607ValSer: 5.607 ± 0.117
4.213ValThr: 4.213 ± 0.094
5.087ValVal: 5.087 ± 0.123
0.636ValTrp: 0.636 ± 0.039
2.077ValTyr: 2.077 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.032
0.194TrpCys: 0.194 ± 0.019
0.517TrpAsp: 0.517 ± 0.029
0.662TrpGlu: 0.662 ± 0.034
0.765TrpPhe: 0.765 ± 0.047
0.71TrpGly: 0.71 ± 0.041
0.358TrpHis: 0.358 ± 0.027
0.848TrpIle: 0.848 ± 0.04
0.839TrpLys: 0.839 ± 0.044
1.509TrpLeu: 1.509 ± 0.052
0.349TrpMet: 0.349 ± 0.026
0.533TrpAsn: 0.533 ± 0.035
0.369TrpPro: 0.369 ± 0.027
0.559TrpGln: 0.559 ± 0.037
0.669TrpArg: 0.669 ± 0.037
0.578TrpSer: 0.578 ± 0.033
0.375TrpThr: 0.375 ± 0.027
0.64TrpVal: 0.64 ± 0.035
0.168TrpTrp: 0.168 ± 0.017
0.401TrpTyr: 0.401 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.882TyrAla: 1.882 ± 0.066
0.485TyrCys: 0.485 ± 0.031
1.557TyrAsp: 1.557 ± 0.058
1.389TyrGlu: 1.389 ± 0.052
1.302TyrPhe: 1.302 ± 0.057
2.284TyrGly: 2.284 ± 0.073
1.024TyrHis: 1.024 ± 0.045
2.437TyrIle: 2.437 ± 0.066
1.533TyrLys: 1.533 ± 0.059
3.817TyrLeu: 3.817 ± 0.092
0.85TyrMet: 0.85 ± 0.036
1.471TyrAsn: 1.471 ± 0.056
1.195TyrPro: 1.195 ± 0.047
1.596TyrGln: 1.596 ± 0.055
2.102TyrArg: 2.102 ± 0.068
2.059TyrSer: 2.059 ± 0.066
1.928TyrThr: 1.928 ± 0.057
1.755TyrVal: 1.755 ± 0.055
0.438TyrTrp: 0.438 ± 0.027
1.326TyrTyr: 1.326 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3193 proteins (536259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski