Amino acid dipepetide frequency for Aotus nancymaae (Ma s night monkey)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.667AlaAla: 6.667 ± 0.027	1.365AlaCys: 1.365 ± 0.01	2.942AlaAsp: 2.942 ± 0.014	4.805AlaGlu: 4.805 ± 0.023	2.612AlaPhe: 2.612 ± 0.014	4.643AlaGly: 4.643 ± 0.023	1.542AlaHis: 1.542 ± 0.01	2.789AlaIle: 2.789 ± 0.013	3.498AlaLys: 3.498 ± 0.019	7.028AlaLeu: 7.028 ± 0.028	1.5AlaMet: 1.5 ± 0.009	2.031AlaAsn: 2.031 ± 0.01	4.105AlaPro: 4.105 ± 0.021	3.235AlaGln: 3.235 ± 0.015	3.634AlaArg: 3.634 ± 0.017	5.699AlaSer: 5.699 ± 0.02	3.621AlaThr: 3.621 ± 0.018	4.661AlaVal: 4.661 ± 0.02	0.8AlaTrp: 0.8 ± 0.006	1.526AlaTyr: 1.526 ± 0.009	0.001AlaXaa: 0.001 ± 0.0
Cys	1.205CysAla: 1.205 ± 0.009	0.632CysCys: 0.632 ± 0.009	1.014CysAsp: 1.014 ± 0.01	1.292CysGlu: 1.292 ± 0.011	0.834CysPhe: 0.834 ± 0.007	1.718CysGly: 1.718 ± 0.016	0.665CysHis: 0.665 ± 0.007	0.959CysIle: 0.959 ± 0.008	1.168CysLys: 1.168 ± 0.01	2.176CysLeu: 2.176 ± 0.011	0.421CysMet: 0.421 ± 0.004	0.819CysAsn: 0.819 ± 0.008	1.349CysPro: 1.349 ± 0.013	1.055CysGln: 1.055 ± 0.009	1.276CysArg: 1.276 ± 0.01	1.984CysSer: 1.984 ± 0.012	1.086CysThr: 1.086 ± 0.009	1.275CysVal: 1.275 ± 0.009	0.29CysTrp: 0.29 ± 0.004	0.567CysTyr: 0.567 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.885AspAla: 2.885 ± 0.013	1.065AspCys: 1.065 ± 0.008	2.715AspAsp: 2.715 ± 0.015	3.526AspGlu: 3.526 ± 0.018	2.138AspPhe: 2.138 ± 0.012	3.354AspGly: 3.354 ± 0.02	1.147AspHis: 1.147 ± 0.008	2.644AspIle: 2.644 ± 0.015	2.578AspLys: 2.578 ± 0.013	5.049AspLeu: 5.049 ± 0.019	1.13AspMet: 1.13 ± 0.007	1.718AspAsn: 1.718 ± 0.011	2.896AspPro: 2.896 ± 0.011	1.855AspGln: 1.855 ± 0.01	2.445AspArg: 2.445 ± 0.013	4.239AspSer: 4.239 ± 0.021	2.478AspThr: 2.478 ± 0.011	3.112AspVal: 3.112 ± 0.016	0.624AspTrp: 0.624 ± 0.006	1.519AspTyr: 1.519 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	5.259GluAla: 5.259 ± 0.026	1.477GluCys: 1.477 ± 0.018	4.515GluAsp: 4.515 ± 0.019	8.067GluGlu: 8.067 ± 0.044	2.078GluPhe: 2.078 ± 0.011	4.204GluGly: 4.204 ± 0.016	1.526GluHis: 1.526 ± 0.008	3.207GluIle: 3.207 ± 0.017	5.546GluLys: 5.546 ± 0.028	6.53GluLeu: 6.53 ± 0.031	1.704GluMet: 1.704 ± 0.01	3.201GluAsn: 3.201 ± 0.016	3.205GluPro: 3.205 ± 0.019	3.181GluGln: 3.181 ± 0.018	4.053GluArg: 4.053 ± 0.021	4.418GluSer: 4.418 ± 0.018	3.437GluThr: 3.437 ± 0.014	4.2GluVal: 4.2 ± 0.015	0.716GluTrp: 0.716 ± 0.006	1.648GluTyr: 1.648 ± 0.013	0.001GluXaa: 0.001 ± 0.0
Phe	1.958PheAla: 1.958 ± 0.011	0.898PheCys: 0.898 ± 0.007	1.702PheAsp: 1.702 ± 0.01	2.04PheGlu: 2.04 ± 0.011	1.557PhePhe: 1.557 ± 0.01	2.188PheGly: 2.188 ± 0.013	1.046PheHis: 1.046 ± 0.008	1.813PheIle: 1.813 ± 0.012	1.832PheLys: 1.832 ± 0.01	4.0PheLeu: 4.0 ± 0.018	0.776PheMet: 0.776 ± 0.007	1.358PheAsn: 1.358 ± 0.008	1.98PhePro: 1.98 ± 0.011	1.815PheGln: 1.815 ± 0.01	1.982PheArg: 1.982 ± 0.012	3.419PheSer: 3.419 ± 0.017	2.035PheThr: 2.035 ± 0.013	2.118PheVal: 2.118 ± 0.011	0.488PheTrp: 0.488 ± 0.005	1.158PheTyr: 1.158 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	4.397GlyAla: 4.397 ± 0.024	1.253GlyCys: 1.253 ± 0.011	3.17GlyAsp: 3.17 ± 0.015	4.175GlyGlu: 4.175 ± 0.019	2.401GlyPhe: 2.401 ± 0.014	5.017GlyGly: 5.017 ± 0.032	1.69GlyHis: 1.69 ± 0.012	2.781GlyIle: 2.781 ± 0.014	3.909GlyLys: 3.909 ± 0.019	5.819GlyLeu: 5.819 ± 0.024	1.326GlyMet: 1.326 ± 0.01	2.375GlyAsn: 2.375 ± 0.012	4.166GlyPro: 4.166 ± 0.032	2.754GlyGln: 2.754 ± 0.016	3.765GlyArg: 3.765 ± 0.02	5.777GlySer: 5.777 ± 0.024	3.584GlyThr: 3.584 ± 0.016	3.537GlyVal: 3.537 ± 0.015	0.795GlyTrp: 0.795 ± 0.007	1.754GlyTyr: 1.754 ± 0.012	0.001GlyXaa: 0.001 ± 0.0
His	1.319HisAla: 1.319 ± 0.008	0.729HisCys: 0.729 ± 0.007	0.913HisAsp: 0.913 ± 0.007	1.347HisGlu: 1.347 ± 0.008	1.079HisPhe: 1.079 ± 0.007	1.543HisGly: 1.543 ± 0.01	0.916HisHis: 0.916 ± 0.009	1.264HisIle: 1.264 ± 0.008	1.311HisLys: 1.311 ± 0.009	2.943HisLeu: 2.943 ± 0.015	0.587HisMet: 0.587 ± 0.005	0.866HisAsn: 0.866 ± 0.007	1.653HisPro: 1.653 ± 0.01	1.364HisGln: 1.364 ± 0.013	1.591HisArg: 1.591 ± 0.009	2.323HisSer: 2.323 ± 0.013	1.545HisThr: 1.545 ± 0.015	1.498HisVal: 1.498 ± 0.009	0.352HisTrp: 0.352 ± 0.004	0.808HisTyr: 0.808 ± 0.006	0.001HisXaa: 0.001 ± 0.0
Ile	2.598IleAla: 2.598 ± 0.013	1.062IleCys: 1.062 ± 0.008	2.064IleAsp: 2.064 ± 0.012	2.664IleGlu: 2.664 ± 0.013	1.882IlePhe: 1.882 ± 0.012	2.238IleGly: 2.238 ± 0.013	1.389IleHis: 1.389 ± 0.011	2.378IleIle: 2.378 ± 0.012	2.689IleLys: 2.689 ± 0.013	4.54IleLeu: 4.54 ± 0.019	1.004IleMet: 1.004 ± 0.007	1.863IleAsn: 1.863 ± 0.01	2.622IlePro: 2.622 ± 0.011	2.325IleGln: 2.325 ± 0.011	2.395IleArg: 2.395 ± 0.011	3.713IleSer: 3.713 ± 0.017	2.6IleThr: 2.6 ± 0.016	2.503IleVal: 2.503 ± 0.015	0.515IleTrp: 0.515 ± 0.005	1.375IleTyr: 1.375 ± 0.009	0.0IleXaa: 0.0 ± 0.0
Lys	4.08LysAla: 4.08 ± 0.022	1.195LysCys: 1.195 ± 0.011	3.215LysAsp: 3.215 ± 0.017	5.219LysGlu: 5.219 ± 0.027	1.765LysPhe: 1.765 ± 0.01	3.305LysGly: 3.305 ± 0.019	1.441LysHis: 1.441 ± 0.01	2.867LysIle: 2.867 ± 0.014	4.829LysLys: 4.829 ± 0.029	5.296LysLeu: 5.296 ± 0.022	1.46LysMet: 1.46 ± 0.01	2.453LysAsn: 2.453 ± 0.014	3.176LysPro: 3.176 ± 0.021	2.665LysGln: 2.665 ± 0.015	3.356LysArg: 3.356 ± 0.014	3.923LysSer: 3.923 ± 0.019	3.135LysThr: 3.135 ± 0.014	3.505LysVal: 3.505 ± 0.019	0.612LysTrp: 0.612 ± 0.005	1.595LysTyr: 1.595 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.733LeuAla: 6.733 ± 0.025	2.171LeuCys: 2.171 ± 0.013	4.743LeuAsp: 4.743 ± 0.016	7.266LeuGlu: 7.266 ± 0.031	3.325LeuPhe: 3.325 ± 0.015	5.785LeuGly: 5.785 ± 0.024	2.737LeuHis: 2.737 ± 0.015	3.867LeuIle: 3.867 ± 0.015	5.912LeuLys: 5.912 ± 0.022	10.619LeuLeu: 10.619 ± 0.036	2.021LeuMet: 2.021 ± 0.011	3.528LeuAsn: 3.528 ± 0.017	5.942LeuPro: 5.942 ± 0.024	5.799LeuGln: 5.799 ± 0.028	5.846LeuArg: 5.846 ± 0.023	7.91LeuSer: 7.91 ± 0.023	5.065LeuThr: 5.065 ± 0.016	5.454LeuVal: 5.454 ± 0.021	1.127LeuTrp: 1.127 ± 0.008	2.542LeuTyr: 2.542 ± 0.014	0.001LeuXaa: 0.001 ± 0.0
Met	1.912MetAla: 1.912 ± 0.009	0.4MetCys: 0.4 ± 0.005	1.269MetAsp: 1.269 ± 0.008	1.903MetGlu: 1.903 ± 0.011	0.728MetPhe: 0.728 ± 0.007	1.303MetGly: 1.303 ± 0.008	0.472MetHis: 0.472 ± 0.005	0.857MetIle: 0.857 ± 0.007	1.476MetLys: 1.476 ± 0.009	1.986MetLeu: 1.986 ± 0.01	0.571MetMet: 0.571 ± 0.006	0.925MetAsn: 0.925 ± 0.007	1.116MetPro: 1.116 ± 0.011	0.93MetGln: 0.93 ± 0.007	1.045MetArg: 1.045 ± 0.006	1.563MetSer: 1.563 ± 0.009	1.141MetThr: 1.141 ± 0.008	1.388MetVal: 1.388 ± 0.009	0.242MetTrp: 0.242 ± 0.004	0.553MetTyr: 0.553 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.093AsnAla: 2.093 ± 0.011	0.83AsnCys: 0.83 ± 0.007	1.556AsnAsp: 1.556 ± 0.009	2.278AsnGlu: 2.278 ± 0.013	1.497AsnPhe: 1.497 ± 0.009	2.46AsnGly: 2.46 ± 0.014	0.965AsnHis: 0.965 ± 0.008	2.134AsnIle: 2.134 ± 0.012	2.26AsnLys: 2.26 ± 0.012	3.763AsnLeu: 3.763 ± 0.019	0.927AsnMet: 0.927 ± 0.007	1.533AsnAsn: 1.533 ± 0.01	2.169AsnPro: 2.169 ± 0.011	1.692AsnGln: 1.692 ± 0.01	1.854AsnArg: 1.854 ± 0.009	3.169AsnSer: 3.169 ± 0.016	1.969AsnThr: 1.969 ± 0.012	2.216AsnVal: 2.216 ± 0.011	0.457AsnTrp: 0.457 ± 0.005	1.133AsnTyr: 1.133 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	4.791ProAla: 4.791 ± 0.023	1.13ProCys: 1.13 ± 0.012	2.797ProAsp: 2.797 ± 0.015	4.428ProGlu: 4.428 ± 0.02	1.893ProPhe: 1.893 ± 0.011	5.221ProGly: 5.221 ± 0.045	1.45ProHis: 1.45 ± 0.009	1.914ProIle: 1.914 ± 0.014	2.786ProLys: 2.786 ± 0.02	5.18ProLeu: 5.18 ± 0.022	1.047ProMet: 1.047 ± 0.008	1.828ProAsn: 1.828 ± 0.011	6.036ProPro: 6.036 ± 0.045	2.81ProGln: 2.81 ± 0.015	3.291ProArg: 3.291 ± 0.016	5.677ProSer: 5.677 ± 0.026	3.1ProThr: 3.1 ± 0.017	3.792ProVal: 3.792 ± 0.019	0.686ProTrp: 0.686 ± 0.006	1.552ProTyr: 1.552 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.539GlnAla: 3.539 ± 0.018	0.946GlnCys: 0.946 ± 0.009	2.346GlnAsp: 2.346 ± 0.011	3.929GlnGlu: 3.929 ± 0.022	1.393GlnPhe: 1.393 ± 0.009	2.832GlnGly: 2.832 ± 0.014	1.316GlnHis: 1.316 ± 0.011	2.014GlnIle: 2.014 ± 0.01	2.999GlnLys: 2.999 ± 0.016	4.751GlnLeu: 4.751 ± 0.024	1.129GlnMet: 1.129 ± 0.009	1.876GlnAsn: 1.876 ± 0.01	2.814GlnPro: 2.814 ± 0.017	3.133GlnGln: 3.133 ± 0.029	2.982GlnArg: 2.982 ± 0.014	3.147GlnSer: 3.147 ± 0.018	2.302GlnThr: 2.302 ± 0.01	2.818GlnVal: 2.818 ± 0.012	0.548GlnTrp: 0.548 ± 0.005	1.162GlnTyr: 1.162 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.802ArgAla: 3.802 ± 0.015	1.215ArgCys: 1.215 ± 0.012	2.784ArgAsp: 2.784 ± 0.012	3.996ArgGlu: 3.996 ± 0.018	1.846ArgPhe: 1.846 ± 0.01	3.627ArgGly: 3.627 ± 0.019	1.538ArgHis: 1.538 ± 0.01	2.47ArgIle: 2.47 ± 0.013	3.715ArgLys: 3.715 ± 0.016	5.381ArgLeu: 5.381 ± 0.023	1.202ArgMet: 1.202 ± 0.008	2.124ArgAsn: 2.124 ± 0.01	3.191ArgPro: 3.191 ± 0.016	2.644ArgGln: 2.644 ± 0.014	4.297ArgArg: 4.297 ± 0.019	4.258ArgSer: 4.258 ± 0.023	2.823ArgThr: 2.823 ± 0.015	3.153ArgVal: 3.153 ± 0.018	0.703ArgTrp: 0.703 ± 0.007	1.438ArgTyr: 1.438 ± 0.009	0.001ArgXaa: 0.001 ± 0.0
Ser	5.284SerAla: 5.284 ± 0.021	1.809SerCys: 1.809 ± 0.012	3.931SerAsp: 3.931 ± 0.021	5.238SerGlu: 5.238 ± 0.022	3.03SerPhe: 3.03 ± 0.013	5.63SerGly: 5.63 ± 0.024	2.114SerHis: 2.114 ± 0.013	3.229SerIle: 3.229 ± 0.015	4.122SerLys: 4.122 ± 0.019	8.143SerLeu: 8.143 ± 0.026	1.608SerMet: 1.608 ± 0.009	2.747SerAsn: 2.747 ± 0.012	5.98SerPro: 5.98 ± 0.028	3.883SerGln: 3.883 ± 0.017	4.561SerArg: 4.561 ± 0.023	9.358SerSer: 9.358 ± 0.049	4.476SerThr: 4.476 ± 0.02	4.842SerVal: 4.842 ± 0.016	1.071SerTrp: 1.071 ± 0.007	2.069SerTyr: 2.069 ± 0.012	0.001SerXaa: 0.001 ± 0.0
Thr	3.753ThrAla: 3.753 ± 0.014	1.269ThrCys: 1.269 ± 0.01	2.5ThrAsp: 2.5 ± 0.012	3.56ThrGlu: 3.56 ± 0.015	2.084ThrPhe: 2.084 ± 0.011	3.596ThrGly: 3.596 ± 0.016	1.343ThrHis: 1.343 ± 0.01	2.385ThrIle: 2.385 ± 0.014	2.682ThrLys: 2.682 ± 0.015	5.279ThrLeu: 5.279 ± 0.018	1.12ThrMet: 1.12 ± 0.008	1.767ThrAsn: 1.767 ± 0.01	3.573ThrPro: 3.573 ± 0.02	2.293ThrGln: 2.293 ± 0.011	2.474ThrArg: 2.474 ± 0.011	4.648ThrSer: 4.648 ± 0.021	3.02ThrThr: 3.02 ± 0.022	3.822ThrVal: 3.822 ± 0.019	0.698ThrTrp: 0.698 ± 0.007	1.43ThrTyr: 1.43 ± 0.01	0.001ThrXaa: 0.001 ± 0.0
Val	4.242ValAla: 4.242 ± 0.019	1.414ValCys: 1.414 ± 0.009	2.966ValAsp: 2.966 ± 0.016	3.888ValGlu: 3.888 ± 0.017	2.386ValPhe: 2.386 ± 0.011	3.372ValGly: 3.372 ± 0.015	1.573ValHis: 1.573 ± 0.01	2.903ValIle: 2.903 ± 0.015	3.435ValLys: 3.435 ± 0.018	6.093ValLeu: 6.093 ± 0.02	1.32ValMet: 1.32 ± 0.008	2.28ValAsn: 2.28 ± 0.013	3.593ValPro: 3.593 ± 0.017	2.725ValGln: 2.725 ± 0.012	3.029ValArg: 3.029 ± 0.014	4.847ValSer: 4.847 ± 0.018	3.753ValThr: 3.753 ± 0.022	3.966ValVal: 3.966 ± 0.02	0.711ValTrp: 0.711 ± 0.006	1.619ValTyr: 1.619 ± 0.01	0.001ValXaa: 0.001 ± 0.0
Trp	0.785TrpAla: 0.785 ± 0.006	0.25TrpCys: 0.25 ± 0.004	0.661TrpAsp: 0.661 ± 0.006	0.816TrpGlu: 0.816 ± 0.007	0.435TrpPhe: 0.435 ± 0.004	0.74TrpGly: 0.74 ± 0.007	0.314TrpHis: 0.314 ± 0.004	0.55TrpIle: 0.55 ± 0.005	0.805TrpLys: 0.805 ± 0.006	1.206TrpLeu: 1.206 ± 0.008	0.322TrpMet: 0.322 ± 0.004	0.547TrpAsn: 0.547 ± 0.006	0.534TrpPro: 0.534 ± 0.005	0.544TrpGln: 0.544 ± 0.006	0.728TrpArg: 0.728 ± 0.006	0.873TrpSer: 0.873 ± 0.007	0.671TrpThr: 0.671 ± 0.008	0.689TrpVal: 0.689 ± 0.006	0.199TrpTrp: 0.199 ± 0.003	0.331TrpTyr: 0.331 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.399TyrAla: 1.399 ± 0.008	0.674TyrCys: 0.674 ± 0.007	1.313TyrAsp: 1.313 ± 0.01	1.736TyrGlu: 1.736 ± 0.011	1.201TyrPhe: 1.201 ± 0.009	1.67TyrGly: 1.67 ± 0.011	0.766TyrHis: 0.766 ± 0.006	1.395TyrIle: 1.395 ± 0.011	1.538TyrLys: 1.538 ± 0.017	2.612TyrLeu: 2.612 ± 0.013	0.601TyrMet: 0.601 ± 0.005	1.116TyrAsn: 1.116 ± 0.008	1.309TyrPro: 1.309 ± 0.01	1.277TyrGln: 1.277 ± 0.008	1.605TyrArg: 1.605 ± 0.011	2.18TyrSer: 2.18 ± 0.012	1.452TyrThr: 1.452 ± 0.01	1.567TyrVal: 1.567 ± 0.01	0.366TyrTrp: 0.366 ± 0.006	0.935TyrTyr: 0.935 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.168XaaXaa: 0.168 ± 0.017

Statistics based on 41725 proteins (22903399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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