Amino acid dipepetide frequency for Roseovarius mucosus DSM 17069

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.935AlaAla: 16.935 ± 0.154	1.111AlaCys: 1.111 ± 0.034	6.702AlaAsp: 6.702 ± 0.082	8.499AlaGlu: 8.499 ± 0.107	4.174AlaPhe: 4.174 ± 0.059	10.814AlaGly: 10.814 ± 0.108	2.583AlaHis: 2.583 ± 0.055	5.627AlaIle: 5.627 ± 0.072	3.487AlaLys: 3.487 ± 0.06	14.318AlaLeu: 14.318 ± 0.134	3.83AlaMet: 3.83 ± 0.057	2.698AlaAsn: 2.698 ± 0.048	6.01AlaPro: 6.01 ± 0.093	4.985AlaGln: 4.985 ± 0.078	10.114AlaArg: 10.114 ± 0.117	5.384AlaSer: 5.384 ± 0.068	6.12AlaThr: 6.12 ± 0.078	8.494AlaVal: 8.494 ± 0.086	1.462AlaTrp: 1.462 ± 0.032	2.527AlaTyr: 2.527 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.158CysAla: 1.158 ± 0.036	0.128CysCys: 0.128 ± 0.011	0.62CysAsp: 0.62 ± 0.024	0.451CysGlu: 0.451 ± 0.019	0.306CysPhe: 0.306 ± 0.017	1.019CysGly: 1.019 ± 0.029	0.287CysHis: 0.287 ± 0.015	0.418CysIle: 0.418 ± 0.019	0.208CysLys: 0.208 ± 0.012	0.901CysLeu: 0.901 ± 0.025	0.19CysMet: 0.19 ± 0.012	0.234CysAsn: 0.234 ± 0.013	0.541CysPro: 0.541 ± 0.023	0.253CysGln: 0.253 ± 0.013	0.602CysArg: 0.602 ± 0.022	0.407CysSer: 0.407 ± 0.019	0.472CysThr: 0.472 ± 0.022	0.639CysVal: 0.639 ± 0.024	0.123CysTrp: 0.123 ± 0.01	0.221CysTyr: 0.221 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.116AspAla: 7.116 ± 0.089	0.552AspCys: 0.552 ± 0.022	3.199AspAsp: 3.199 ± 0.09	3.261AspGlu: 3.261 ± 0.057	2.163AspPhe: 2.163 ± 0.044	5.262AspGly: 5.262 ± 0.097	1.405AspHis: 1.405 ± 0.037	3.105AspIle: 3.105 ± 0.05	1.581AspLys: 1.581 ± 0.038	6.744AspLeu: 6.744 ± 0.07	1.727AspMet: 1.727 ± 0.037	1.277AspAsn: 1.277 ± 0.034	3.56AspPro: 3.56 ± 0.06	1.888AspGln: 1.888 ± 0.045	4.21AspArg: 4.21 ± 0.065	2.128AspSer: 2.128 ± 0.047	3.18AspThr: 3.18 ± 0.094	4.251AspVal: 4.251 ± 0.077	1.203AspTrp: 1.203 ± 0.031	1.514AspTyr: 1.514 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.421GluAla: 8.421 ± 0.101	0.365GluCys: 0.365 ± 0.019	3.232GluAsp: 3.232 ± 0.055	3.385GluGlu: 3.385 ± 0.073	1.864GluPhe: 1.864 ± 0.037	4.961GluGly: 4.961 ± 0.075	1.079GluHis: 1.079 ± 0.025	3.76GluIle: 3.76 ± 0.046	1.835GluLys: 1.835 ± 0.044	4.667GluLeu: 4.667 ± 0.059	1.966GluMet: 1.966 ± 0.041	1.645GluAsn: 1.645 ± 0.039	2.471GluPro: 2.471 ± 0.046	1.798GluGln: 1.798 ± 0.037	4.462GluArg: 4.462 ± 0.078	2.279GluSer: 2.279 ± 0.042	3.821GluThr: 3.821 ± 0.057	4.538GluVal: 4.538 ± 0.07	0.689GluTrp: 0.689 ± 0.022	0.99GluTyr: 0.99 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.441PheAla: 4.441 ± 0.054	0.434PheCys: 0.434 ± 0.02	2.824PheAsp: 2.824 ± 0.054	2.18PheGlu: 2.18 ± 0.041	1.429PhePhe: 1.429 ± 0.042	3.617PheGly: 3.617 ± 0.061	0.725PheHis: 0.725 ± 0.023	1.569PheIle: 1.569 ± 0.038	0.863PheLys: 0.863 ± 0.029	3.455PheLeu: 3.455 ± 0.058	0.802PheMet: 0.802 ± 0.024	1.03PheAsn: 1.03 ± 0.032	1.497PhePro: 1.497 ± 0.038	1.032PheGln: 1.032 ± 0.029	2.111PheArg: 2.111 ± 0.04	2.003PheSer: 2.003 ± 0.039	2.058PheThr: 2.058 ± 0.047	2.635PheVal: 2.635 ± 0.051	0.555PheTrp: 0.555 ± 0.021	0.955PheTyr: 0.955 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.493GlyAla: 10.493 ± 0.12	0.906GlyCys: 0.906 ± 0.029	4.835GlyAsp: 4.835 ± 0.088	4.479GlyGlu: 4.479 ± 0.073	3.674GlyPhe: 3.674 ± 0.053	7.57GlyGly: 7.57 ± 0.123	2.066GlyHis: 2.066 ± 0.043	4.33GlyIle: 4.33 ± 0.065	2.817GlyLys: 2.817 ± 0.053	9.573GlyLeu: 9.573 ± 0.094	2.643GlyMet: 2.643 ± 0.05	2.331GlyAsn: 2.331 ± 0.079	3.671GlyPro: 3.671 ± 0.054	3.304GlyGln: 3.304 ± 0.053	6.072GlyArg: 6.072 ± 0.082	4.008GlySer: 4.008 ± 0.06	4.848GlyThr: 4.848 ± 0.106	6.482GlyVal: 6.482 ± 0.079	1.46GlyTrp: 1.46 ± 0.035	2.325GlyTyr: 2.325 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.521HisAla: 2.521 ± 0.048	0.252HisCys: 0.252 ± 0.014	1.324HisAsp: 1.324 ± 0.033	1.068HisGlu: 1.068 ± 0.028	0.869HisPhe: 0.869 ± 0.03	1.965HisGly: 1.965 ± 0.042	0.616HisHis: 0.616 ± 0.029	0.998HisIle: 0.998 ± 0.03	0.516HisLys: 0.516 ± 0.02	2.217HisLeu: 2.217 ± 0.045	0.575HisMet: 0.575 ± 0.023	0.441HisAsn: 0.441 ± 0.019	1.428HisPro: 1.428 ± 0.041	0.599HisGln: 0.599 ± 0.023	1.42HisArg: 1.42 ± 0.031	0.897HisSer: 0.897 ± 0.028	0.87HisThr: 0.87 ± 0.024	1.631HisVal: 1.631 ± 0.04	0.378HisTrp: 0.378 ± 0.014	0.568HisTyr: 0.568 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.944IleAla: 6.944 ± 0.081	0.598IleCys: 0.598 ± 0.022	3.443IleAsp: 3.443 ± 0.058	3.555IleGlu: 3.555 ± 0.055	1.704IlePhe: 1.704 ± 0.046	4.745IleGly: 4.745 ± 0.065	0.904IleHis: 0.904 ± 0.029	2.169IleIle: 2.169 ± 0.049	1.443IleLys: 1.443 ± 0.038	4.99IleLeu: 4.99 ± 0.078	1.058IleMet: 1.058 ± 0.033	1.468IleAsn: 1.468 ± 0.032	2.253IlePro: 2.253 ± 0.046	1.113IleGln: 1.113 ± 0.031	3.166IleArg: 3.166 ± 0.048	2.906IleSer: 2.906 ± 0.05	3.186IleThr: 3.186 ± 0.055	3.625IleVal: 3.625 ± 0.061	0.715IleTrp: 0.715 ± 0.029	1.123IleTyr: 1.123 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.413LysAla: 3.413 ± 0.064	0.21LysCys: 0.21 ± 0.012	1.499LysAsp: 1.499 ± 0.039	1.402LysGlu: 1.402 ± 0.039	0.895LysPhe: 0.895 ± 0.029	2.593LysGly: 2.593 ± 0.052	0.582LysHis: 0.582 ± 0.023	1.543LysIle: 1.543 ± 0.039	1.018LysLys: 1.018 ± 0.034	2.695LysLeu: 2.695 ± 0.047	0.805LysMet: 0.805 ± 0.026	0.672LysAsn: 0.672 ± 0.024	1.717LysPro: 1.717 ± 0.043	0.8LysGln: 0.8 ± 0.029	2.132LysArg: 2.132 ± 0.046	1.706LysSer: 1.706 ± 0.034	1.827LysThr: 1.827 ± 0.038	2.016LysVal: 2.016 ± 0.049	0.367LysTrp: 0.367 ± 0.017	0.636LysTyr: 0.636 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.253LeuAla: 13.253 ± 0.137	1.065LeuCys: 1.065 ± 0.026	6.184LeuAsp: 6.184 ± 0.078	5.39LeuGlu: 5.39 ± 0.067	3.435LeuPhe: 3.435 ± 0.054	8.734LeuGly: 8.734 ± 0.1	2.001LeuHis: 2.001 ± 0.042	5.411LeuIle: 5.411 ± 0.078	2.965LeuLys: 2.965 ± 0.059	9.185LeuLeu: 9.185 ± 0.113	2.838LeuMet: 2.838 ± 0.053	2.688LeuAsn: 2.688 ± 0.042	5.684LeuPro: 5.684 ± 0.072	2.663LeuGln: 2.663 ± 0.05	7.829LeuArg: 7.829 ± 0.075	6.884LeuSer: 6.884 ± 0.081	6.14LeuThr: 6.14 ± 0.077	6.807LeuVal: 6.807 ± 0.082	1.455LeuTrp: 1.455 ± 0.04	1.962LeuTyr: 1.962 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.656MetAla: 3.656 ± 0.059	0.188MetCys: 0.188 ± 0.013	1.368MetAsp: 1.368 ± 0.035	1.263MetGlu: 1.263 ± 0.037	0.802MetPhe: 0.802 ± 0.028	2.477MetGly: 2.477 ± 0.045	0.445MetHis: 0.445 ± 0.021	1.565MetIle: 1.565 ± 0.041	0.926MetLys: 0.926 ± 0.026	2.682MetLeu: 2.682 ± 0.047	0.816MetMet: 0.816 ± 0.026	0.783MetAsn: 0.783 ± 0.027	1.601MetPro: 1.601 ± 0.039	1.073MetGln: 1.073 ± 0.033	1.987MetArg: 1.987 ± 0.044	1.708MetSer: 1.708 ± 0.036	2.12MetThr: 2.12 ± 0.04	1.889MetVal: 1.889 ± 0.042	0.232MetTrp: 0.232 ± 0.012	0.331MetTyr: 0.331 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.074AsnAla: 3.074 ± 0.053	0.253AsnCys: 0.253 ± 0.013	1.591AsnAsp: 1.591 ± 0.08	1.157AsnGlu: 1.157 ± 0.034	0.921AsnPhe: 0.921 ± 0.031	2.38AsnGly: 2.38 ± 0.066	0.502AsnHis: 0.502 ± 0.02	1.343AsnIle: 1.343 ± 0.033	0.617AsnLys: 0.617 ± 0.021	2.543AsnLeu: 2.543 ± 0.046	0.634AsnMet: 0.634 ± 0.023	0.662AsnAsn: 0.662 ± 0.028	1.893AsnPro: 1.893 ± 0.042	0.672AsnGln: 0.672 ± 0.026	1.79AsnArg: 1.79 ± 0.039	1.121AsnSer: 1.121 ± 0.034	1.378AsnThr: 1.378 ± 0.037	1.73AsnVal: 1.73 ± 0.041	0.417AsnTrp: 0.417 ± 0.016	0.589AsnTyr: 0.589 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.649ProAla: 5.649 ± 0.081	0.396ProCys: 0.396 ± 0.016	3.943ProAsp: 3.943 ± 0.059	4.417ProGlu: 4.417 ± 0.058	1.846ProPhe: 1.846 ± 0.038	4.612ProGly: 4.612 ± 0.064	1.076ProHis: 1.076 ± 0.034	2.237ProIle: 2.237 ± 0.041	1.528ProLys: 1.528 ± 0.04	4.905ProLeu: 4.905 ± 0.064	1.348ProMet: 1.348 ± 0.03	1.257ProAsn: 1.257 ± 0.034	2.296ProPro: 2.296 ± 0.052	1.721ProGln: 1.721 ± 0.03	3.021ProArg: 3.021 ± 0.049	2.352ProSer: 2.352 ± 0.043	2.399ProThr: 2.399 ± 0.043	4.28ProVal: 4.28 ± 0.055	0.665ProTrp: 0.665 ± 0.024	1.164ProTyr: 1.164 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.189GlnAla: 4.189 ± 0.06	0.218GlnCys: 0.218 ± 0.012	1.732GlnAsp: 1.732 ± 0.043	1.722GlnGlu: 1.722 ± 0.04	1.125GlnPhe: 1.125 ± 0.03	2.79GlnGly: 2.79 ± 0.053	0.62GlnHis: 0.62 ± 0.024	1.986GlnIle: 1.986 ± 0.041	0.988GlnLys: 0.988 ± 0.03	2.78GlnLeu: 2.78 ± 0.051	1.093GlnMet: 1.093 ± 0.027	0.878GlnAsn: 0.878 ± 0.028	1.584GlnPro: 1.584 ± 0.042	1.065GlnGln: 1.065 ± 0.029	2.106GlnArg: 2.106 ± 0.046	1.898GlnSer: 1.898 ± 0.043	1.879GlnThr: 1.879 ± 0.034	2.454GlnVal: 2.454 ± 0.048	0.407GlnTrp: 0.407 ± 0.017	0.561GlnTyr: 0.561 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.518ArgAla: 9.518 ± 0.11	0.51ArgCys: 0.51 ± 0.021	4.508ArgAsp: 4.508 ± 0.065	3.809ArgGlu: 3.809 ± 0.059	2.729ArgPhe: 2.729 ± 0.049	4.955ArgGly: 4.955 ± 0.068	1.7ArgHis: 1.7 ± 0.039	3.95ArgIle: 3.95 ± 0.059	2.123ArgLys: 2.123 ± 0.044	7.85ArgLeu: 7.85 ± 0.097	2.007ArgMet: 2.007 ± 0.039	1.785ArgAsn: 1.785 ± 0.037	3.423ArgPro: 3.423 ± 0.055	2.327ArgGln: 2.327 ± 0.044	5.294ArgArg: 5.294 ± 0.072	3.121ArgSer: 3.121 ± 0.054	2.849ArgThr: 2.849 ± 0.054	5.111ArgVal: 5.111 ± 0.071	0.959ArgTrp: 0.959 ± 0.027	1.599ArgTyr: 1.599 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.781SerAla: 5.781 ± 0.075	0.439SerCys: 0.439 ± 0.022	3.202SerAsp: 3.202 ± 0.058	2.901SerGlu: 2.901 ± 0.055	2.104SerPhe: 2.104 ± 0.042	5.354SerGly: 5.354 ± 0.081	1.117SerHis: 1.117 ± 0.033	2.349SerIle: 2.349 ± 0.042	1.315SerLys: 1.315 ± 0.033	5.038SerLeu: 5.038 ± 0.067	1.264SerMet: 1.264 ± 0.03	1.266SerAsn: 1.266 ± 0.035	2.499SerPro: 2.499 ± 0.049	1.532SerGln: 1.532 ± 0.038	3.075SerArg: 3.075 ± 0.052	2.335SerSer: 2.335 ± 0.05	2.47SerThr: 2.47 ± 0.05	3.691SerVal: 3.691 ± 0.065	0.649SerTrp: 0.649 ± 0.024	1.292SerTyr: 1.292 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.277ThrAla: 6.277 ± 0.078	0.522ThrCys: 0.522 ± 0.021	3.033ThrAsp: 3.033 ± 0.069	3.054ThrGlu: 3.054 ± 0.055	1.902ThrPhe: 1.902 ± 0.043	5.675ThrGly: 5.675 ± 0.085	1.174ThrHis: 1.174 ± 0.032	2.63ThrIle: 2.63 ± 0.066	1.349ThrLys: 1.349 ± 0.034	6.446ThrLeu: 6.446 ± 0.083	1.227ThrMet: 1.227 ± 0.032	1.266ThrAsn: 1.266 ± 0.037	3.606ThrPro: 3.606 ± 0.062	1.656ThrGln: 1.656 ± 0.04	3.732ThrArg: 3.732 ± 0.057	2.668ThrSer: 2.668 ± 0.047	2.862ThrThr: 2.862 ± 0.068	4.269ThrVal: 4.269 ± 0.096	0.69ThrTrp: 0.69 ± 0.022	1.296ThrTyr: 1.296 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.03ValAla: 9.03 ± 0.087	0.627ValCys: 0.627 ± 0.024	3.847ValAsp: 3.847 ± 0.057	4.305ValGlu: 4.305 ± 0.069	2.829ValPhe: 2.829 ± 0.046	5.23ValGly: 5.23 ± 0.069	1.358ValHis: 1.358 ± 0.032	4.469ValIle: 4.469 ± 0.067	2.018ValLys: 2.018 ± 0.044	7.622ValLeu: 7.622 ± 0.082	2.179ValMet: 2.179 ± 0.048	1.941ValAsn: 1.941 ± 0.043	3.564ValPro: 3.564 ± 0.056	2.222ValGln: 2.222 ± 0.04	4.289ValArg: 4.289 ± 0.059	4.009ValSer: 4.009 ± 0.064	5.014ValThr: 5.014 ± 0.104	5.619ValVal: 5.619 ± 0.082	0.952ValTrp: 0.952 ± 0.03	1.435ValTyr: 1.435 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.438TrpAla: 1.438 ± 0.032	0.149TrpCys: 0.149 ± 0.01	0.687TrpAsp: 0.687 ± 0.021	0.638TrpGlu: 0.638 ± 0.021	0.577TrpPhe: 0.577 ± 0.02	1.051TrpGly: 1.051 ± 0.031	0.374TrpHis: 0.374 ± 0.018	0.726TrpIle: 0.726 ± 0.026	0.387TrpLys: 0.387 ± 0.019	1.662TrpLeu: 1.662 ± 0.037	0.42TrpMet: 0.42 ± 0.019	0.385TrpAsn: 0.385 ± 0.02	0.76TrpPro: 0.76 ± 0.024	0.671TrpGln: 0.671 ± 0.024	1.112TrpArg: 1.112 ± 0.035	0.795TrpSer: 0.795 ± 0.026	0.737TrpThr: 0.737 ± 0.024	0.892TrpVal: 0.892 ± 0.027	0.211TrpTrp: 0.211 ± 0.013	0.277TrpTyr: 0.277 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.046	0.255TyrCys: 0.255 ± 0.016	1.549TyrAsp: 1.549 ± 0.04	1.291TyrGlu: 1.291 ± 0.037	0.866TyrPhe: 0.866 ± 0.03	2.084TyrGly: 2.084 ± 0.04	0.538TyrHis: 0.538 ± 0.023	0.923TyrIle: 0.923 ± 0.029	0.544TyrLys: 0.544 ± 0.022	2.299TyrLeu: 2.299 ± 0.048	0.49TyrMet: 0.49 ± 0.018	0.561TyrAsn: 0.561 ± 0.021	1.054TyrPro: 1.054 ± 0.03	0.703TyrGln: 0.703 ± 0.023	1.603TyrArg: 1.603 ± 0.039	1.065TyrSer: 1.065 ± 0.031	1.103TyrThr: 1.103 ± 0.033	1.507TyrVal: 1.507 ± 0.036	0.361TyrTrp: 0.361 ± 0.015	0.563TyrTyr: 0.563 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4182 proteins (1286318 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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