Amino acid dipepetide frequency for Gordonia paraffinivorans NBRC 108238

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.457AlaAla: 18.457 ± 0.185	0.897AlaCys: 0.897 ± 0.026	9.012AlaAsp: 9.012 ± 0.1	8.416AlaGlu: 8.416 ± 0.103	3.47AlaPhe: 3.47 ± 0.049	11.728AlaGly: 11.728 ± 0.114	2.526AlaHis: 2.526 ± 0.036	5.446AlaIle: 5.446 ± 0.073	2.931AlaLys: 2.931 ± 0.067	11.931AlaLeu: 11.931 ± 0.11	2.722AlaMet: 2.722 ± 0.047	2.218AlaAsn: 2.218 ± 0.039	6.309AlaPro: 6.309 ± 0.09	3.387AlaGln: 3.387 ± 0.054	8.93AlaArg: 8.93 ± 0.087	6.213AlaSer: 6.213 ± 0.07	7.146AlaThr: 7.146 ± 0.067	11.14AlaVal: 11.14 ± 0.123	1.522AlaTrp: 1.522 ± 0.036	2.317AlaTyr: 2.317 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.03	0.087CysCys: 0.087 ± 0.008	0.466CysAsp: 0.466 ± 0.019	0.375CysGlu: 0.375 ± 0.018	0.215CysPhe: 0.215 ± 0.013	0.86CysGly: 0.86 ± 0.027	0.16CysHis: 0.16 ± 0.01	0.252CysIle: 0.252 ± 0.012	0.115CysLys: 0.115 ± 0.009	0.615CysLeu: 0.615 ± 0.022	0.129CysMet: 0.129 ± 0.009	0.152CysAsn: 0.152 ± 0.009	0.429CysPro: 0.429 ± 0.02	0.148CysGln: 0.148 ± 0.009	0.558CysArg: 0.558 ± 0.019	0.453CysSer: 0.453 ± 0.019	0.467CysThr: 0.467 ± 0.019	0.609CysVal: 0.609 ± 0.018	0.114CysTrp: 0.114 ± 0.01	0.151CysTyr: 0.151 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.381AspAla: 8.381 ± 0.102	0.398AspCys: 0.398 ± 0.018	4.864AspAsp: 4.864 ± 0.072	4.801AspGlu: 4.801 ± 0.058	1.816AspPhe: 1.816 ± 0.039	5.94AspGly: 5.94 ± 0.076	1.598AspHis: 1.598 ± 0.031	2.577AspIle: 2.577 ± 0.041	1.342AspLys: 1.342 ± 0.035	6.703AspLeu: 6.703 ± 0.068	0.976AspMet: 0.976 ± 0.028	1.194AspAsn: 1.194 ± 0.031	4.898AspPro: 4.898 ± 0.057	1.564AspGln: 1.564 ± 0.037	5.033AspArg: 5.033 ± 0.066	3.048AspSer: 3.048 ± 0.051	3.412AspThr: 3.412 ± 0.045	5.342AspVal: 5.342 ± 0.066	0.902AspTrp: 0.902 ± 0.025	1.276AspTyr: 1.276 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.584GluAla: 6.584 ± 0.082	0.359GluCys: 0.359 ± 0.018	2.721GluAsp: 2.721 ± 0.05	3.021GluGlu: 3.021 ± 0.061	1.936GluPhe: 1.936 ± 0.04	3.692GluGly: 3.692 ± 0.059	1.569GluHis: 1.569 ± 0.034	3.195GluIle: 3.195 ± 0.055	1.735GluLys: 1.735 ± 0.045	6.718GluLeu: 6.718 ± 0.08	1.207GluMet: 1.207 ± 0.032	1.388GluAsn: 1.388 ± 0.034	3.323GluPro: 3.323 ± 0.059	2.154GluGln: 2.154 ± 0.044	4.849GluArg: 4.849 ± 0.071	3.169GluSer: 3.169 ± 0.054	3.102GluThr: 3.102 ± 0.053	5.07GluVal: 5.07 ± 0.068	0.859GluTrp: 0.859 ± 0.026	1.289GluTyr: 1.289 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.023PheAla: 4.023 ± 0.053	0.295PheCys: 0.295 ± 0.015	2.587PheAsp: 2.587 ± 0.051	1.616PheGlu: 1.616 ± 0.034	0.93PhePhe: 0.93 ± 0.031	3.402PheGly: 3.402 ± 0.06	0.603PheHis: 0.603 ± 0.021	1.06PheIle: 1.06 ± 0.027	0.464PheLys: 0.464 ± 0.021	2.52PheLeu: 2.52 ± 0.047	0.469PheMet: 0.469 ± 0.018	0.64PheAsn: 0.64 ± 0.025	1.402PhePro: 1.402 ± 0.038	0.611PheGln: 0.611 ± 0.024	1.744PheArg: 1.744 ± 0.037	1.633PheSer: 1.633 ± 0.035	1.974PheThr: 1.974 ± 0.039	2.699PheVal: 2.699 ± 0.052	0.4PheTrp: 0.4 ± 0.018	0.702PheTyr: 0.702 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.966GlyAla: 9.966 ± 0.108	0.718GlyCys: 0.718 ± 0.028	5.311GlyAsp: 5.311 ± 0.067	5.026GlyGlu: 5.026 ± 0.061	3.075GlyPhe: 3.075 ± 0.046	7.796GlyGly: 7.796 ± 0.107	2.014GlyHis: 2.014 ± 0.046	4.339GlyIle: 4.339 ± 0.066	2.454GlyLys: 2.454 ± 0.05	8.45GlyLeu: 8.45 ± 0.09	2.008GlyMet: 2.008 ± 0.042	1.895GlyAsn: 1.895 ± 0.045	4.614GlyPro: 4.614 ± 0.075	2.483GlyGln: 2.483 ± 0.049	6.869GlyArg: 6.869 ± 0.079	5.364GlySer: 5.364 ± 0.071	5.419GlyThr: 5.419 ± 0.069	7.9GlyVal: 7.9 ± 0.073	1.466GlyTrp: 1.466 ± 0.036	2.197GlyTyr: 2.197 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.364HisAla: 2.364 ± 0.04	0.172HisCys: 0.172 ± 0.013	1.454HisAsp: 1.454 ± 0.034	1.119HisGlu: 1.119 ± 0.028	0.613HisPhe: 0.613 ± 0.021	1.99HisGly: 1.99 ± 0.048	0.696HisHis: 0.696 ± 0.022	0.864HisIle: 0.864 ± 0.026	0.382HisLys: 0.382 ± 0.019	2.13HisLeu: 2.13 ± 0.039	0.381HisMet: 0.381 ± 0.015	0.421HisAsn: 0.421 ± 0.015	1.623HisPro: 1.623 ± 0.036	0.553HisGln: 0.553 ± 0.022	1.937HisArg: 1.937 ± 0.042	1.044HisSer: 1.044 ± 0.028	1.15HisThr: 1.15 ± 0.03	1.683HisVal: 1.683 ± 0.037	0.322HisTrp: 0.322 ± 0.016	0.466HisTyr: 0.466 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.583IleAla: 6.583 ± 0.082	0.39IleCys: 0.39 ± 0.017	3.476IleAsp: 3.476 ± 0.048	2.723IleGlu: 2.723 ± 0.049	1.03IlePhe: 1.03 ± 0.028	4.712IleGly: 4.712 ± 0.065	0.805IleHis: 0.805 ± 0.024	1.589IleIle: 1.589 ± 0.033	0.889IleLys: 0.889 ± 0.029	3.432IleLeu: 3.432 ± 0.048	0.625IleMet: 0.625 ± 0.021	0.991IleAsn: 0.991 ± 0.028	2.558IlePro: 2.558 ± 0.043	0.856IleGln: 0.856 ± 0.023	2.896IleArg: 2.896 ± 0.046	2.385IleSer: 2.385 ± 0.039	2.771IleThr: 2.771 ± 0.047	4.277IleVal: 4.277 ± 0.059	0.459IleTrp: 0.459 ± 0.018	0.77IleTyr: 0.77 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.896LysAla: 2.896 ± 0.067	0.12LysCys: 0.12 ± 0.008	1.173LysAsp: 1.173 ± 0.034	1.058LysGlu: 1.058 ± 0.037	0.608LysPhe: 0.608 ± 0.026	1.765LysGly: 1.765 ± 0.039	0.456LysHis: 0.456 ± 0.017	1.164LysIle: 1.164 ± 0.033	0.961LysLys: 0.961 ± 0.04	2.147LysLeu: 2.147 ± 0.05	0.486LysMet: 0.486 ± 0.022	0.588LysAsn: 0.588 ± 0.023	1.446LysPro: 1.446 ± 0.038	0.696LysGln: 0.696 ± 0.027	1.668LysArg: 1.668 ± 0.041	1.274LysSer: 1.274 ± 0.036	1.49LysThr: 1.49 ± 0.038	2.177LysVal: 2.177 ± 0.049	0.312LysTrp: 0.312 ± 0.015	0.528LysTyr: 0.528 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.111LeuAla: 13.111 ± 0.118	0.688LeuCys: 0.688 ± 0.023	6.919LeuAsp: 6.919 ± 0.088	4.839LeuGlu: 4.839 ± 0.067	2.646LeuPhe: 2.646 ± 0.049	8.735LeuGly: 8.735 ± 0.082	1.824LeuHis: 1.824 ± 0.042	4.094LeuIle: 4.094 ± 0.055	1.853LeuLys: 1.853 ± 0.043	8.774LeuLeu: 8.774 ± 0.095	1.627LeuMet: 1.627 ± 0.037	1.806LeuAsn: 1.806 ± 0.038	5.42LeuPro: 5.42 ± 0.058	2.168LeuGln: 2.168 ± 0.038	7.41LeuArg: 7.41 ± 0.074	5.429LeuSer: 5.429 ± 0.055	6.013LeuThr: 6.013 ± 0.063	8.617LeuVal: 8.617 ± 0.099	1.074LeuTrp: 1.074 ± 0.027	1.594LeuTyr: 1.594 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.318MetAla: 2.318 ± 0.041	0.181MetCys: 0.181 ± 0.011	0.836MetAsp: 0.836 ± 0.022	0.725MetGlu: 0.725 ± 0.025	0.647MetPhe: 0.647 ± 0.025	1.388MetGly: 1.388 ± 0.036	0.392MetHis: 0.392 ± 0.019	0.979MetIle: 0.979 ± 0.029	0.48MetLys: 0.48 ± 0.022	1.944MetLeu: 1.944 ± 0.037	0.387MetMet: 0.387 ± 0.017	0.495MetAsn: 0.495 ± 0.02	1.119MetPro: 1.119 ± 0.028	0.481MetGln: 0.481 ± 0.018	1.494MetArg: 1.494 ± 0.037	1.736MetSer: 1.736 ± 0.036	1.89MetThr: 1.89 ± 0.036	1.574MetVal: 1.574 ± 0.041	0.256MetTrp: 0.256 ± 0.012	0.335MetTyr: 0.335 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.498AsnAla: 2.498 ± 0.05	0.154AsnCys: 0.154 ± 0.01	1.102AsnAsp: 1.102 ± 0.032	1.032AsnGlu: 1.032 ± 0.028	0.568AsnPhe: 0.568 ± 0.021	1.99AsnGly: 1.99 ± 0.043	0.422AsnHis: 0.422 ± 0.019	0.917AsnIle: 0.917 ± 0.023	0.514AsnLys: 0.514 ± 0.023	1.972AsnLeu: 1.972 ± 0.044	0.383AsnMet: 0.383 ± 0.02	0.518AsnAsn: 0.518 ± 0.02	1.779AsnPro: 1.779 ± 0.036	0.555AsnGln: 0.555 ± 0.021	1.524AsnArg: 1.524 ± 0.032	1.094AsnSer: 1.094 ± 0.026	1.268AsnThr: 1.268 ± 0.025	1.615AsnVal: 1.615 ± 0.035	0.331AsnTrp: 0.331 ± 0.017	0.47AsnTyr: 0.47 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.254ProAla: 7.254 ± 0.091	0.291ProCys: 0.291 ± 0.014	4.788ProAsp: 4.788 ± 0.062	4.325ProGlu: 4.325 ± 0.061	1.617ProPhe: 1.617 ± 0.037	5.834ProGly: 5.834 ± 0.077	1.202ProHis: 1.202 ± 0.034	2.197ProIle: 2.197 ± 0.042	1.361ProLys: 1.361 ± 0.04	4.633ProLeu: 4.633 ± 0.056	1.112ProMet: 1.112 ± 0.027	1.194ProAsn: 1.194 ± 0.029	3.147ProPro: 3.147 ± 0.062	1.59ProGln: 1.59 ± 0.037	3.778ProArg: 3.778 ± 0.062	3.175ProSer: 3.175 ± 0.052	3.636ProThr: 3.636 ± 0.054	5.169ProVal: 5.169 ± 0.078	0.821ProTrp: 0.821 ± 0.024	1.14ProTyr: 1.14 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.107GlnAla: 3.107 ± 0.056	0.163GlnCys: 0.163 ± 0.011	0.998GlnAsp: 0.998 ± 0.025	1.121GlnGlu: 1.121 ± 0.03	0.831GlnPhe: 0.831 ± 0.025	1.842GlnGly: 1.842 ± 0.039	0.573GlnHis: 0.573 ± 0.016	1.5GlnIle: 1.5 ± 0.035	0.729GlnLys: 0.729 ± 0.029	2.812GlnLeu: 2.812 ± 0.058	0.637GlnMet: 0.637 ± 0.024	0.623GlnAsn: 0.623 ± 0.026	1.483GlnPro: 1.483 ± 0.038	1.049GlnGln: 1.049 ± 0.04	2.331GlnArg: 2.331 ± 0.043	1.261GlnSer: 1.261 ± 0.036	1.421GlnThr: 1.421 ± 0.039	2.446GlnVal: 2.446 ± 0.045	0.463GlnTrp: 0.463 ± 0.019	0.55GlnTyr: 0.55 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.451ArgAla: 8.451 ± 0.088	0.563ArgCys: 0.563 ± 0.019	4.484ArgAsp: 4.484 ± 0.059	4.472ArgGlu: 4.472 ± 0.065	2.448ArgPhe: 2.448 ± 0.042	5.308ArgGly: 5.308 ± 0.067	1.814ArgHis: 1.814 ± 0.036	3.571ArgIle: 3.571 ± 0.046	1.85ArgLys: 1.85 ± 0.046	7.334ArgLeu: 7.334 ± 0.073	1.809ArgMet: 1.809 ± 0.032	1.61ArgAsn: 1.61 ± 0.034	4.402ArgPro: 4.402 ± 0.063	2.02ArgGln: 2.02 ± 0.04	7.315ArgArg: 7.315 ± 0.097	4.237ArgSer: 4.237 ± 0.06	4.44ArgThr: 4.44 ± 0.06	5.942ArgVal: 5.942 ± 0.072	1.326ArgTrp: 1.326 ± 0.033	1.781ArgTyr: 1.781 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.956SerAla: 6.956 ± 0.073	0.392SerCys: 0.392 ± 0.019	3.402SerAsp: 3.402 ± 0.052	2.835SerGlu: 2.835 ± 0.055	1.673SerPhe: 1.673 ± 0.035	6.06SerGly: 6.06 ± 0.074	0.979SerHis: 0.979 ± 0.028	2.279SerIle: 2.279 ± 0.041	1.244SerLys: 1.244 ± 0.034	4.67SerLeu: 4.67 ± 0.058	1.338SerMet: 1.338 ± 0.031	1.076SerAsn: 1.076 ± 0.026	3.337SerPro: 3.337 ± 0.055	1.366SerGln: 1.366 ± 0.031	3.902SerArg: 3.902 ± 0.06	3.487SerSer: 3.487 ± 0.057	3.667SerThr: 3.667 ± 0.053	4.809SerVal: 4.809 ± 0.057	0.874SerTrp: 0.874 ± 0.025	1.11SerTyr: 1.11 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.517ThrAla: 7.517 ± 0.086	0.402ThrCys: 0.402 ± 0.015	3.999ThrAsp: 3.999 ± 0.06	3.425ThrGlu: 3.425 ± 0.056	1.737ThrPhe: 1.737 ± 0.036	6.013ThrGly: 6.013 ± 0.062	1.217ThrHis: 1.217 ± 0.028	2.658ThrIle: 2.658 ± 0.048	1.3ThrLys: 1.3 ± 0.035	5.457ThrLeu: 5.457 ± 0.059	1.13ThrMet: 1.13 ± 0.029	1.153ThrAsn: 1.153 ± 0.029	4.246ThrPro: 4.246 ± 0.055	1.329ThrGln: 1.329 ± 0.034	3.932ThrArg: 3.932 ± 0.06	3.565ThrSer: 3.565 ± 0.05	4.178ThrThr: 4.178 ± 0.06	5.882ThrVal: 5.882 ± 0.068	0.837ThrTrp: 0.837 ± 0.024	1.263ThrTyr: 1.263 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	11.602ValAla: 11.602 ± 0.125	0.714ValCys: 0.714 ± 0.022	6.427ValAsp: 6.427 ± 0.077	5.21ValGlu: 5.21 ± 0.074	2.637ValPhe: 2.637 ± 0.05	7.342ValGly: 7.342 ± 0.088	1.817ValHis: 1.817 ± 0.034	4.183ValIle: 4.183 ± 0.058	1.661ValLys: 1.661 ± 0.037	8.669ValLeu: 8.669 ± 0.092	1.59ValMet: 1.59 ± 0.04	1.941ValAsn: 1.941 ± 0.04	4.873ValPro: 4.873 ± 0.063	1.768ValGln: 1.768 ± 0.037	6.014ValArg: 6.014 ± 0.059	4.835ValSer: 4.835 ± 0.064	5.783ValThr: 5.783 ± 0.073	9.117ValVal: 9.117 ± 0.091	1.033ValTrp: 1.033 ± 0.029	1.571ValTyr: 1.571 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.475TrpAla: 1.475 ± 0.033	0.15TrpCys: 0.15 ± 0.01	0.731TrpAsp: 0.731 ± 0.025	0.67TrpGlu: 0.67 ± 0.021	0.565TrpPhe: 0.565 ± 0.024	1.005TrpGly: 1.005 ± 0.026	0.3TrpHis: 0.3 ± 0.014	0.668TrpIle: 0.668 ± 0.022	0.349TrpLys: 0.349 ± 0.015	1.509TrpLeu: 1.509 ± 0.031	0.34TrpMet: 0.34 ± 0.016	0.371TrpAsn: 0.371 ± 0.017	0.721TrpPro: 0.721 ± 0.025	0.519TrpGln: 0.519 ± 0.018	1.161TrpArg: 1.161 ± 0.032	0.906TrpSer: 0.906 ± 0.029	0.867TrpThr: 0.867 ± 0.023	1.095TrpVal: 1.095 ± 0.027	0.364TrpTrp: 0.364 ± 0.018	0.314TrpTyr: 0.314 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.192TyrAla: 2.192 ± 0.04	0.204TyrCys: 0.204 ± 0.013	1.313TyrAsp: 1.313 ± 0.035	1.131TyrGlu: 1.131 ± 0.032	0.708TyrPhe: 0.708 ± 0.025	1.966TyrGly: 1.966 ± 0.043	0.398TyrHis: 0.398 ± 0.015	0.685TyrIle: 0.685 ± 0.021	0.4TyrLys: 0.4 ± 0.018	2.222TyrLeu: 2.222 ± 0.048	0.297TyrMet: 0.297 ± 0.014	0.433TyrAsn: 0.433 ± 0.018	1.135TyrPro: 1.135 ± 0.03	0.643TyrGln: 0.643 ± 0.021	1.829TyrArg: 1.829 ± 0.036	1.148TyrSer: 1.148 ± 0.026	1.148TyrThr: 1.148 ± 0.029	1.623TyrVal: 1.623 ± 0.035	0.35TyrTrp: 0.35 ± 0.014	0.445TyrTyr: 0.445 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4191 proteins (1391700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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