Amino acid dipepetide frequency for Chelatococcus asaccharovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.863AlaAla: 18.863 ± 0.149	1.08AlaCys: 1.08 ± 0.024	7.065AlaAsp: 7.065 ± 0.061	7.297AlaGlu: 7.297 ± 0.066	4.824AlaPhe: 4.824 ± 0.053	11.477AlaGly: 11.477 ± 0.095	2.295AlaHis: 2.295 ± 0.039	7.267AlaIle: 7.267 ± 0.068	3.776AlaLys: 3.776 ± 0.049	14.358AlaLeu: 14.358 ± 0.115	3.601AlaMet: 3.601 ± 0.047	2.76AlaAsn: 2.76 ± 0.039	5.981AlaPro: 5.981 ± 0.068	3.829AlaGln: 3.829 ± 0.042	9.64AlaArg: 9.64 ± 0.089	6.777AlaSer: 6.777 ± 0.062	6.475AlaThr: 6.475 ± 0.066	9.611AlaVal: 9.611 ± 0.076	1.533AlaTrp: 1.533 ± 0.031	2.636AlaTyr: 2.636 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.022	0.097CysCys: 0.097 ± 0.008	0.508CysAsp: 0.508 ± 0.017	0.401CysGlu: 0.401 ± 0.014	0.312CysPhe: 0.312 ± 0.013	0.875CysGly: 0.875 ± 0.024	0.215CysHis: 0.215 ± 0.009	0.399CysIle: 0.399 ± 0.014	0.156CysLys: 0.156 ± 0.008	0.846CysLeu: 0.846 ± 0.02	0.154CysMet: 0.154 ± 0.008	0.192CysAsn: 0.192 ± 0.01	0.426CysPro: 0.426 ± 0.015	0.204CysGln: 0.204 ± 0.01	0.64CysArg: 0.64 ± 0.019	0.399CysSer: 0.399 ± 0.014	0.359CysThr: 0.359 ± 0.014	0.632CysVal: 0.632 ± 0.017	0.109CysTrp: 0.109 ± 0.008	0.168CysTyr: 0.168 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.908AspAla: 6.908 ± 0.066	0.467AspCys: 0.467 ± 0.017	3.044AspAsp: 3.044 ± 0.04	3.244AspGlu: 3.244 ± 0.037	2.141AspPhe: 2.141 ± 0.032	5.043AspGly: 5.043 ± 0.052	1.216AspHis: 1.216 ± 0.028	3.178AspIle: 3.178 ± 0.041	1.587AspLys: 1.587 ± 0.031	5.906AspLeu: 5.906 ± 0.055	1.244AspMet: 1.244 ± 0.026	1.222AspAsn: 1.222 ± 0.025	3.444AspPro: 3.444 ± 0.042	1.547AspGln: 1.547 ± 0.03	4.249AspArg: 4.249 ± 0.053	2.018AspSer: 2.018 ± 0.034	2.415AspThr: 2.415 ± 0.033	4.385AspVal: 4.385 ± 0.043	0.877AspTrp: 0.877 ± 0.021	1.39AspTyr: 1.39 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.933GluAla: 7.933 ± 0.069	0.296GluCys: 0.296 ± 0.012	2.5GluAsp: 2.5 ± 0.037	2.754GluGlu: 2.754 ± 0.044	1.585GluPhe: 1.585 ± 0.03	3.99GluGly: 3.99 ± 0.048	1.08GluHis: 1.08 ± 0.019	3.185GluIle: 3.185 ± 0.04	1.804GluLys: 1.804 ± 0.033	4.934GluLeu: 4.934 ± 0.047	1.297GluMet: 1.297 ± 0.024	1.265GluAsn: 1.265 ± 0.025	2.81GluPro: 2.81 ± 0.042	1.736GluGln: 1.736 ± 0.032	4.993GluArg: 4.993 ± 0.057	2.04GluSer: 2.04 ± 0.031	3.299GluThr: 3.299 ± 0.037	3.556GluVal: 3.556 ± 0.046	0.64GluTrp: 0.64 ± 0.019	0.808GluTyr: 0.808 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.823PheAla: 4.823 ± 0.05	0.358PheCys: 0.358 ± 0.013	2.459PheAsp: 2.459 ± 0.035	1.893PheGlu: 1.893 ± 0.029	1.35PhePhe: 1.35 ± 0.027	3.753PheGly: 3.753 ± 0.046	0.77PheHis: 0.77 ± 0.02	1.865PheIle: 1.865 ± 0.032	0.955PheLys: 0.955 ± 0.025	3.491PheLeu: 3.491 ± 0.043	0.802PheMet: 0.802 ± 0.018	1.021PheAsn: 1.021 ± 0.021	1.781PhePro: 1.781 ± 0.031	1.003PheGln: 1.003 ± 0.02	2.375PheArg: 2.375 ± 0.033	2.214PheSer: 2.214 ± 0.029	2.052PheThr: 2.052 ± 0.027	3.037PheVal: 3.037 ± 0.037	0.543PheTrp: 0.543 ± 0.018	0.849PheTyr: 0.849 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.738GlyAla: 9.738 ± 0.086	0.845GlyCys: 0.845 ± 0.022	4.302GlyAsp: 4.302 ± 0.047	4.702GlyGlu: 4.702 ± 0.05	3.628GlyPhe: 3.628 ± 0.048	7.494GlyGly: 7.494 ± 0.116	1.98GlyHis: 1.98 ± 0.039	4.846GlyIle: 4.846 ± 0.061	2.856GlyLys: 2.856 ± 0.041	9.671GlyLeu: 9.671 ± 0.068	2.173GlyMet: 2.173 ± 0.033	1.968GlyAsn: 1.968 ± 0.031	3.833GlyPro: 3.833 ± 0.046	2.85GlyGln: 2.85 ± 0.041	6.684GlyArg: 6.684 ± 0.062	4.626GlySer: 4.626 ± 0.056	4.536GlyThr: 4.536 ± 0.055	6.36GlyVal: 6.36 ± 0.052	1.319GlyTrp: 1.319 ± 0.026	2.308GlyTyr: 2.308 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.436HisAla: 2.436 ± 0.037	0.224HisCys: 0.224 ± 0.009	1.224HisAsp: 1.224 ± 0.026	0.981HisGlu: 0.981 ± 0.019	0.85HisPhe: 0.85 ± 0.019	1.958HisGly: 1.958 ± 0.033	0.561HisHis: 0.561 ± 0.019	1.018HisIle: 1.018 ± 0.021	0.419HisLys: 0.419 ± 0.014	2.1HisLeu: 2.1 ± 0.034	0.478HisMet: 0.478 ± 0.014	0.43HisAsn: 0.43 ± 0.015	1.363HisPro: 1.363 ± 0.03	0.527HisGln: 0.527 ± 0.017	1.526HisArg: 1.526 ± 0.028	0.885HisSer: 0.885 ± 0.02	0.776HisThr: 0.776 ± 0.021	1.615HisVal: 1.615 ± 0.029	0.333HisTrp: 0.333 ± 0.013	0.539HisTyr: 0.539 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.147IleAla: 8.147 ± 0.076	0.497IleCys: 0.497 ± 0.014	3.598IleAsp: 3.598 ± 0.041	3.227IleGlu: 3.227 ± 0.04	1.75IlePhe: 1.75 ± 0.033	5.196IleGly: 5.196 ± 0.053	0.927IleHis: 0.927 ± 0.022	2.516IleIle: 2.516 ± 0.038	1.337IleLys: 1.337 ± 0.027	4.876IleLeu: 4.876 ± 0.055	1.039IleMet: 1.039 ± 0.025	1.365IleAsn: 1.365 ± 0.027	2.479IlePro: 2.479 ± 0.035	1.162IleGln: 1.162 ± 0.024	3.364IleArg: 3.364 ± 0.034	2.738IleSer: 2.738 ± 0.038	2.755IleThr: 2.755 ± 0.032	4.726IleVal: 4.726 ± 0.05	0.627IleTrp: 0.627 ± 0.017	1.147IleTyr: 1.147 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.167LysAla: 4.167 ± 0.048	0.125LysCys: 0.125 ± 0.008	1.535LysAsp: 1.535 ± 0.029	1.3LysGlu: 1.3 ± 0.031	0.78LysPhe: 0.78 ± 0.022	2.436LysGly: 2.436 ± 0.039	0.499LysHis: 0.499 ± 0.016	1.461LysIle: 1.461 ± 0.03	0.933LysLys: 0.933 ± 0.026	2.956LysLeu: 2.956 ± 0.042	0.593LysMet: 0.593 ± 0.02	0.74LysAsn: 0.74 ± 0.021	1.997LysPro: 1.997 ± 0.037	0.818LysGln: 0.818 ± 0.018	2.234LysArg: 2.234 ± 0.037	1.625LysSer: 1.625 ± 0.029	1.764LysThr: 1.764 ± 0.033	2.211LysVal: 2.211 ± 0.04	0.285LysTrp: 0.285 ± 0.011	0.471LysTyr: 0.471 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.841LeuAla: 14.841 ± 0.109	0.886LeuCys: 0.886 ± 0.019	6.182LeuAsp: 6.182 ± 0.056	4.81LeuGlu: 4.81 ± 0.057	3.657LeuPhe: 3.657 ± 0.048	8.919LeuGly: 8.919 ± 0.076	1.833LeuHis: 1.833 ± 0.032	5.2LeuIle: 5.2 ± 0.05	3.381LeuLys: 3.381 ± 0.041	9.551LeuLeu: 9.551 ± 0.104	2.433LeuMet: 2.433 ± 0.039	2.455LeuAsn: 2.455 ± 0.032	5.936LeuPro: 5.936 ± 0.054	2.597LeuGln: 2.597 ± 0.04	7.097LeuArg: 7.097 ± 0.07	6.449LeuSer: 6.449 ± 0.06	5.822LeuThr: 5.822 ± 0.06	8.043LeuVal: 8.043 ± 0.066	1.132LeuTrp: 1.132 ± 0.026	2.045LeuTyr: 2.045 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	3.169MetAla: 3.169 ± 0.04	0.142MetCys: 0.142 ± 0.008	1.009MetAsp: 1.009 ± 0.024	0.933MetGlu: 0.933 ± 0.02	0.644MetPhe: 0.644 ± 0.017	1.741MetGly: 1.741 ± 0.031	0.422MetHis: 0.422 ± 0.014	1.327MetIle: 1.327 ± 0.027	0.878MetLys: 0.878 ± 0.02	2.494MetLeu: 2.494 ± 0.032	0.619MetMet: 0.619 ± 0.02	0.714MetAsn: 0.714 ± 0.018	1.513MetPro: 1.513 ± 0.028	0.764MetGln: 0.764 ± 0.017	1.897MetArg: 1.897 ± 0.032	1.639MetSer: 1.639 ± 0.028	1.877MetThr: 1.877 ± 0.029	1.771MetVal: 1.771 ± 0.031	0.214MetTrp: 0.214 ± 0.011	0.298MetTyr: 0.298 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.145AsnAla: 3.145 ± 0.04	0.194AsnCys: 0.194 ± 0.01	1.247AsnAsp: 1.247 ± 0.023	1.066AsnGlu: 1.066 ± 0.02	0.918AsnPhe: 0.918 ± 0.02	2.242AsnGly: 2.242 ± 0.035	0.45AsnHis: 0.45 ± 0.014	1.224AsnIle: 1.224 ± 0.025	0.616AsnLys: 0.616 ± 0.019	2.475AsnLeu: 2.475 ± 0.033	0.528AsnMet: 0.528 ± 0.018	0.65AsnAsn: 0.65 ± 0.021	1.76AsnPro: 1.76 ± 0.03	0.649AsnGln: 0.649 ± 0.019	1.741AsnArg: 1.741 ± 0.03	1.128AsnSer: 1.128 ± 0.026	1.171AsnThr: 1.171 ± 0.027	1.854AsnVal: 1.854 ± 0.035	0.392AsnTrp: 0.392 ± 0.013	0.626AsnTyr: 0.626 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.863ProAla: 6.863 ± 0.071	0.316ProCys: 0.316 ± 0.013	3.666ProAsp: 3.666 ± 0.041	3.417ProGlu: 3.417 ± 0.042	2.081ProPhe: 2.081 ± 0.032	4.81ProGly: 4.81 ± 0.05	1.2ProHis: 1.2 ± 0.024	2.493ProIle: 2.493 ± 0.037	1.54ProLys: 1.54 ± 0.035	5.158ProLeu: 5.158 ± 0.059	1.241ProMet: 1.241 ± 0.027	1.346ProAsn: 1.346 ± 0.028	2.939ProPro: 2.939 ± 0.048	1.714ProGln: 1.714 ± 0.026	3.341ProArg: 3.341 ± 0.043	3.093ProSer: 3.093 ± 0.041	2.702ProThr: 2.702 ± 0.036	4.422ProVal: 4.422 ± 0.047	0.74ProTrp: 0.74 ± 0.02	1.269ProTyr: 1.269 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.98GlnAla: 3.98 ± 0.05	0.187GlnCys: 0.187 ± 0.01	1.414GlnAsp: 1.414 ± 0.026	1.32GlnGlu: 1.32 ± 0.028	1.021GlnPhe: 1.021 ± 0.024	2.269GlnGly: 2.269 ± 0.03	0.591GlnHis: 0.591 ± 0.016	1.674GlnIle: 1.674 ± 0.03	0.865GlnLys: 0.865 ± 0.023	2.666GlnLeu: 2.666 ± 0.036	0.819GlnMet: 0.819 ± 0.018	0.789GlnAsn: 0.789 ± 0.019	1.746GlnPro: 1.746 ± 0.031	1.071GlnGln: 1.071 ± 0.029	2.49GlnArg: 2.49 ± 0.035	1.696GlnSer: 1.696 ± 0.031	1.509GlnThr: 1.509 ± 0.027	2.03GlnVal: 2.03 ± 0.032	0.416GlnTrp: 0.416 ± 0.015	0.559GlnTyr: 0.559 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	8.511ArgAla: 8.511 ± 0.067	0.577ArgCys: 0.577 ± 0.02	4.206ArgAsp: 4.206 ± 0.044	4.169ArgGlu: 4.169 ± 0.041	3.047ArgPhe: 3.047 ± 0.037	5.197ArgGly: 5.197 ± 0.049	1.876ArgHis: 1.876 ± 0.031	4.188ArgIle: 4.188 ± 0.044	2.026ArgLys: 2.026 ± 0.03	8.299ArgLeu: 8.299 ± 0.088	1.854ArgMet: 1.854 ± 0.031	1.786ArgAsn: 1.786 ± 0.031	3.959ArgPro: 3.959 ± 0.045	2.664ArgGln: 2.664 ± 0.038	6.297ArgArg: 6.297 ± 0.065	3.928ArgSer: 3.928 ± 0.044	3.353ArgThr: 3.353 ± 0.044	4.915ArgVal: 4.915 ± 0.046	1.002ArgTrp: 1.002 ± 0.023	1.81ArgTyr: 1.81 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.281SerAla: 6.281 ± 0.054	0.402SerCys: 0.402 ± 0.015	2.75SerAsp: 2.75 ± 0.036	2.568SerGlu: 2.568 ± 0.035	2.431SerPhe: 2.431 ± 0.039	5.465SerGly: 5.465 ± 0.057	1.171SerHis: 1.171 ± 0.024	2.807SerIle: 2.807 ± 0.042	1.294SerLys: 1.294 ± 0.029	5.839SerLeu: 5.839 ± 0.055	1.272SerMet: 1.272 ± 0.025	1.218SerAsn: 1.218 ± 0.027	3.049SerPro: 3.049 ± 0.039	1.517SerGln: 1.517 ± 0.028	3.829SerArg: 3.829 ± 0.043	2.961SerSer: 2.961 ± 0.046	2.614SerThr: 2.614 ± 0.033	3.952SerVal: 3.952 ± 0.042	0.751SerTrp: 0.751 ± 0.019	1.269SerTyr: 1.269 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.43ThrAla: 6.43 ± 0.062	0.422ThrCys: 0.422 ± 0.014	2.67ThrAsp: 2.67 ± 0.037	2.424ThrGlu: 2.424 ± 0.033	2.107ThrPhe: 2.107 ± 0.034	4.914ThrGly: 4.914 ± 0.053	1.013ThrHis: 1.013 ± 0.021	3.052ThrIle: 3.052 ± 0.039	1.307ThrLys: 1.307 ± 0.027	5.989ThrLeu: 5.989 ± 0.067	1.214ThrMet: 1.214 ± 0.024	1.211ThrAsn: 1.211 ± 0.023	3.392ThrPro: 3.392 ± 0.043	1.304ThrGln: 1.304 ± 0.025	3.437ThrArg: 3.437 ± 0.038	2.877ThrSer: 2.877 ± 0.036	2.942ThrThr: 2.942 ± 0.044	4.434ThrVal: 4.434 ± 0.046	0.655ThrTrp: 0.655 ± 0.021	1.151ThrTyr: 1.151 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.196ValAla: 10.196 ± 0.073	0.596ValCys: 0.596 ± 0.02	4.168ValAsp: 4.168 ± 0.043	4.369ValGlu: 4.369 ± 0.039	2.931ValPhe: 2.931 ± 0.038	5.847ValGly: 5.847 ± 0.063	1.389ValHis: 1.389 ± 0.024	4.225ValIle: 4.225 ± 0.048	2.271ValLys: 2.271 ± 0.035	7.835ValLeu: 7.835 ± 0.07	1.94ValMet: 1.94 ± 0.031	1.946ValAsn: 1.946 ± 0.032	4.03ValPro: 4.03 ± 0.049	1.925ValGln: 1.925 ± 0.033	4.936ValArg: 4.936 ± 0.049	4.446ValSer: 4.446 ± 0.049	4.671ValThr: 4.671 ± 0.048	6.572ValVal: 6.572 ± 0.06	0.811ValTrp: 0.811 ± 0.017	1.422ValTyr: 1.422 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.158TrpAla: 1.158 ± 0.023	0.129TrpCys: 0.129 ± 0.008	0.609TrpAsp: 0.609 ± 0.02	0.511TrpGlu: 0.511 ± 0.017	0.459TrpPhe: 0.459 ± 0.016	0.932TrpGly: 0.932 ± 0.021	0.319TrpHis: 0.319 ± 0.013	0.648TrpIle: 0.648 ± 0.019	0.389TrpLys: 0.389 ± 0.014	1.616TrpLeu: 1.616 ± 0.031	0.368TrpMet: 0.368 ± 0.013	0.427TrpAsn: 0.427 ± 0.017	0.748TrpPro: 0.748 ± 0.021	0.567TrpGln: 0.567 ± 0.016	1.183TrpArg: 1.183 ± 0.024	0.833TrpSer: 0.833 ± 0.021	0.764TrpThr: 0.764 ± 0.018	0.78TrpVal: 0.78 ± 0.018	0.21TrpTrp: 0.21 ± 0.011	0.285TrpTyr: 0.285 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.581TyrAla: 2.581 ± 0.036	0.226TyrCys: 0.226 ± 0.01	1.37TyrAsp: 1.37 ± 0.027	1.12TyrGlu: 1.12 ± 0.024	0.879TyrPhe: 0.879 ± 0.02	2.16TyrGly: 2.16 ± 0.032	0.434TyrHis: 0.434 ± 0.015	0.902TyrIle: 0.902 ± 0.022	0.54TyrLys: 0.54 ± 0.017	2.21TyrLeu: 2.21 ± 0.035	0.399TyrMet: 0.399 ± 0.014	0.57TyrAsn: 0.57 ± 0.015	1.165TyrPro: 1.165 ± 0.025	0.666TyrGln: 0.666 ± 0.018	1.711TyrArg: 1.711 ± 0.029	1.068TyrSer: 1.068 ± 0.023	1.085TyrThr: 1.085 ± 0.024	1.616TyrVal: 1.616 ± 0.03	0.347TyrTrp: 0.347 ± 0.013	0.576TyrTyr: 0.576 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 6659 proteins (2107697 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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