Amino acid dipepetide frequency for Flaviflexus salsibiostraticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.814AlaAla: 15.814 ± 0.215	0.865AlaCys: 0.865 ± 0.04	7.643AlaAsp: 7.643 ± 0.123	7.968AlaGlu: 7.968 ± 0.117	3.471AlaPhe: 3.471 ± 0.069	10.917AlaGly: 10.917 ± 0.142	2.181AlaHis: 2.181 ± 0.053	6.075AlaIle: 6.075 ± 0.099	3.087AlaLys: 3.087 ± 0.075	12.079AlaLeu: 12.079 ± 0.168	2.867AlaMet: 2.867 ± 0.061	2.331AlaAsn: 2.331 ± 0.059	4.997AlaPro: 4.997 ± 0.114	3.534AlaGln: 3.534 ± 0.071	7.87AlaArg: 7.87 ± 0.134	6.185AlaSer: 6.185 ± 0.093	6.322AlaThr: 6.322 ± 0.098	9.645AlaVal: 9.645 ± 0.134	1.7AlaTrp: 1.7 ± 0.049	2.407AlaTyr: 2.407 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.622CysAla: 0.622 ± 0.028	0.077CysCys: 0.077 ± 0.012	0.359CysAsp: 0.359 ± 0.023	0.432CysGlu: 0.432 ± 0.027	0.194CysPhe: 0.194 ± 0.015	0.74CysGly: 0.74 ± 0.035	0.134CysHis: 0.134 ± 0.013	0.276CysIle: 0.276 ± 0.019	0.094CysLys: 0.094 ± 0.012	0.558CysLeu: 0.558 ± 0.029	0.086CysMet: 0.086 ± 0.01	0.124CysAsn: 0.124 ± 0.014	0.369CysPro: 0.369 ± 0.026	0.155CysGln: 0.155 ± 0.016	0.501CysArg: 0.501 ± 0.025	0.444CysSer: 0.444 ± 0.028	0.42CysThr: 0.42 ± 0.026	0.464CysVal: 0.464 ± 0.027	0.082CysTrp: 0.082 ± 0.01	0.134CysTyr: 0.134 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.626AspAla: 6.626 ± 0.098	0.327AspCys: 0.327 ± 0.021	3.964AspAsp: 3.964 ± 0.087	5.119AspGlu: 5.119 ± 0.085	1.83AspPhe: 1.83 ± 0.05	5.653AspGly: 5.653 ± 0.099	1.43AspHis: 1.43 ± 0.044	3.302AspIle: 3.302 ± 0.064	1.039AspLys: 1.039 ± 0.044	6.371AspLeu: 6.371 ± 0.1	1.381AspMet: 1.381 ± 0.046	1.156AspAsn: 1.156 ± 0.038	3.785AspPro: 3.785 ± 0.076	1.741AspGln: 1.741 ± 0.052	4.812AspArg: 4.812 ± 0.081	3.52AspSer: 3.52 ± 0.082	3.196AspThr: 3.196 ± 0.067	5.237AspVal: 5.237 ± 0.086	1.035AspTrp: 1.035 ± 0.045	1.686AspTyr: 1.686 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	7.53GluAla: 7.53 ± 0.129	0.315GluCys: 0.315 ± 0.023	3.817GluAsp: 3.817 ± 0.089	4.595GluGlu: 4.595 ± 0.091	1.799GluPhe: 1.799 ± 0.041	4.933GluGly: 4.933 ± 0.082	1.592GluHis: 1.592 ± 0.042	3.657GluIle: 3.657 ± 0.066	2.015GluLys: 2.015 ± 0.061	6.592GluLeu: 6.592 ± 0.097	1.453GluMet: 1.453 ± 0.046	1.708GluAsn: 1.708 ± 0.05	3.313GluPro: 3.313 ± 0.083	2.339GluGln: 2.339 ± 0.063	5.198GluArg: 5.198 ± 0.081	3.693GluSer: 3.693 ± 0.075	3.445GluThr: 3.445 ± 0.073	4.771GluVal: 4.771 ± 0.078	0.938GluTrp: 0.938 ± 0.039	1.345GluTyr: 1.345 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.536PheAla: 3.536 ± 0.077	0.195PheCys: 0.195 ± 0.016	2.243PheAsp: 2.243 ± 0.06	1.855PheGlu: 1.855 ± 0.058	1.108PhePhe: 1.108 ± 0.048	2.953PheGly: 2.953 ± 0.084	0.63PheHis: 0.63 ± 0.029	1.546PheIle: 1.546 ± 0.046	0.619PheLys: 0.619 ± 0.03	2.684PheLeu: 2.684 ± 0.064	0.617PheMet: 0.617 ± 0.033	0.764PheAsn: 0.764 ± 0.034	1.316PhePro: 1.316 ± 0.04	0.704PheGln: 0.704 ± 0.033	1.644PheArg: 1.644 ± 0.056	1.996PheSer: 1.996 ± 0.06	2.158PheThr: 2.158 ± 0.056	2.468PheVal: 2.468 ± 0.059	0.415PheTrp: 0.415 ± 0.024	0.69PheTyr: 0.69 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.199GlyAla: 9.199 ± 0.136	0.575GlyCys: 0.575 ± 0.028	5.138GlyAsp: 5.138 ± 0.105	5.469GlyGlu: 5.469 ± 0.086	2.97GlyPhe: 2.97 ± 0.068	7.191GlyGly: 7.191 ± 0.12	1.948GlyHis: 1.948 ± 0.051	5.224GlyIle: 5.224 ± 0.084	2.14GlyLys: 2.14 ± 0.06	8.332GlyLeu: 8.332 ± 0.149	2.33GlyMet: 2.33 ± 0.058	1.915GlyAsn: 1.915 ± 0.056	3.855GlyPro: 3.855 ± 0.069	2.694GlyGln: 2.694 ± 0.065	6.443GlyArg: 6.443 ± 0.094	5.466GlySer: 5.466 ± 0.078	5.669GlyThr: 5.669 ± 0.096	6.938GlyVal: 6.938 ± 0.093	1.439GlyTrp: 1.439 ± 0.042	2.141GlyTyr: 2.141 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.241HisAla: 2.241 ± 0.051	0.177HisCys: 0.177 ± 0.014	1.236HisAsp: 1.236 ± 0.042	1.317HisGlu: 1.317 ± 0.041	0.546HisPhe: 0.546 ± 0.031	1.924HisGly: 1.924 ± 0.05	0.637HisHis: 0.637 ± 0.035	1.006HisIle: 1.006 ± 0.04	0.324HisLys: 0.324 ± 0.024	2.089HisLeu: 2.089 ± 0.049	0.423HisMet: 0.423 ± 0.025	0.424HisAsn: 0.424 ± 0.025	1.381HisPro: 1.381 ± 0.045	0.577HisGln: 0.577 ± 0.027	1.815HisArg: 1.815 ± 0.053	1.22HisSer: 1.22 ± 0.041	1.124HisThr: 1.124 ± 0.038	1.801HisVal: 1.801 ± 0.05	0.275HisTrp: 0.275 ± 0.018	0.518HisTyr: 0.518 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.085IleAla: 7.085 ± 0.113	0.356IleCys: 0.356 ± 0.024	4.316IleAsp: 4.316 ± 0.082	3.604IleGlu: 3.604 ± 0.079	1.516IlePhe: 1.516 ± 0.048	4.954IleGly: 4.954 ± 0.097	1.025IleHis: 1.025 ± 0.036	3.054IleIle: 3.054 ± 0.082	1.115IleLys: 1.115 ± 0.042	4.974IleLeu: 4.974 ± 0.102	1.043IleMet: 1.043 ± 0.042	1.262IleAsn: 1.262 ± 0.038	2.849IlePro: 2.849 ± 0.064	1.188IleGln: 1.188 ± 0.045	3.102IleArg: 3.102 ± 0.057	3.021IleSer: 3.021 ± 0.063	3.203IleThr: 3.203 ± 0.069	4.984IleVal: 4.984 ± 0.081	0.529IleTrp: 0.529 ± 0.027	1.1IleTyr: 1.1 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	2.86LysAla: 2.86 ± 0.074	0.108LysCys: 0.108 ± 0.012	1.551LysAsp: 1.551 ± 0.052	1.483LysGlu: 1.483 ± 0.054	0.502LysPhe: 0.502 ± 0.026	1.813LysGly: 1.813 ± 0.058	0.533LysHis: 0.533 ± 0.026	1.286LysIle: 1.286 ± 0.048	1.114LysLys: 1.114 ± 0.05	2.106LysLeu: 2.106 ± 0.062	0.533LysMet: 0.533 ± 0.028	0.754LysAsn: 0.754 ± 0.037	1.31LysPro: 1.31 ± 0.048	0.708LysGln: 0.708 ± 0.035	1.758LysArg: 1.758 ± 0.055	1.451LysSer: 1.451 ± 0.044	1.527LysThr: 1.527 ± 0.053	1.825LysVal: 1.825 ± 0.054	0.259LysTrp: 0.259 ± 0.018	0.53LysTyr: 0.53 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	13.004LeuAla: 13.004 ± 0.179	0.532LeuCys: 0.532 ± 0.028	6.447LeuAsp: 6.447 ± 0.106	5.898LeuGlu: 5.898 ± 0.099	2.704LeuPhe: 2.704 ± 0.07	8.714LeuGly: 8.714 ± 0.12	1.943LeuHis: 1.943 ± 0.059	5.296LeuIle: 5.296 ± 0.107	2.206LeuLys: 2.206 ± 0.053	9.584LeuLeu: 9.584 ± 0.169	1.938LeuMet: 1.938 ± 0.055	2.012LeuAsn: 2.012 ± 0.053	5.058LeuPro: 5.058 ± 0.08	2.173LeuGln: 2.173 ± 0.058	6.469LeuArg: 6.469 ± 0.104	6.012LeuSer: 6.012 ± 0.105	6.734LeuThr: 6.734 ± 0.109	8.069LeuVal: 8.069 ± 0.118	1.249LeuTrp: 1.249 ± 0.04	1.737LeuTyr: 1.737 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.634MetAla: 2.634 ± 0.063	0.13MetCys: 0.13 ± 0.014	1.084MetAsp: 1.084 ± 0.03	1.161MetGlu: 1.161 ± 0.042	0.653MetPhe: 0.653 ± 0.028	1.681MetGly: 1.681 ± 0.051	0.376MetHis: 0.376 ± 0.019	1.169MetIle: 1.169 ± 0.042	0.76MetLys: 0.76 ± 0.032	2.09MetLeu: 2.09 ± 0.06	0.472MetMet: 0.472 ± 0.027	0.623MetAsn: 0.623 ± 0.029	1.293MetPro: 1.293 ± 0.042	0.524MetGln: 0.524 ± 0.028	1.632MetArg: 1.632 ± 0.043	1.764MetSer: 1.764 ± 0.054	1.931MetThr: 1.931 ± 0.045	1.647MetVal: 1.647 ± 0.054	0.302MetTrp: 0.302 ± 0.021	0.397MetTyr: 0.397 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.457AsnAla: 2.457 ± 0.049	0.149AsnCys: 0.149 ± 0.013	1.269AsnAsp: 1.269 ± 0.047	1.329AsnGlu: 1.329 ± 0.047	0.569AsnPhe: 0.569 ± 0.031	1.967AsnGly: 1.967 ± 0.059	0.513AsnHis: 0.513 ± 0.029	1.094AsnIle: 1.094 ± 0.05	0.44AsnLys: 0.44 ± 0.026	2.177AsnLeu: 2.177 ± 0.059	0.484AsnMet: 0.484 ± 0.024	0.541AsnAsn: 0.541 ± 0.03	1.781AsnPro: 1.781 ± 0.054	0.686AsnGln: 0.686 ± 0.031	1.643AsnArg: 1.643 ± 0.044	1.211AsnSer: 1.211 ± 0.038	1.247AsnThr: 1.247 ± 0.049	1.713AsnVal: 1.713 ± 0.049	0.336AsnTrp: 0.336 ± 0.02	0.571AsnTyr: 0.571 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.079ProAla: 6.079 ± 0.128	0.283ProCys: 0.283 ± 0.019	3.693ProAsp: 3.693 ± 0.071	3.894ProGlu: 3.894 ± 0.07	1.552ProPhe: 1.552 ± 0.047	4.865ProGly: 4.865 ± 0.081	1.143ProHis: 1.143 ± 0.043	2.498ProIle: 2.498 ± 0.054	1.216ProLys: 1.216 ± 0.043	4.56ProLeu: 4.56 ± 0.078	1.076ProMet: 1.076 ± 0.044	1.164ProAsn: 1.164 ± 0.038	2.032ProPro: 2.032 ± 0.071	1.423ProGln: 1.423 ± 0.044	2.946ProArg: 2.946 ± 0.072	3.167ProSer: 3.167 ± 0.072	3.249ProThr: 3.249 ± 0.075	4.419ProVal: 4.419 ± 0.076	0.744ProTrp: 0.744 ± 0.035	1.114ProTyr: 1.114 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.395GlnAla: 3.395 ± 0.07	0.162GlnCys: 0.162 ± 0.013	1.289GlnAsp: 1.289 ± 0.039	1.625GlnGlu: 1.625 ± 0.054	0.851GlnPhe: 0.851 ± 0.034	2.037GlnGly: 2.037 ± 0.05	0.562GlnHis: 0.562 ± 0.027	1.75GlnIle: 1.75 ± 0.05	0.756GlnLys: 0.756 ± 0.031	2.783GlnLeu: 2.783 ± 0.063	0.735GlnMet: 0.735 ± 0.031	0.643GlnAsn: 0.643 ± 0.034	1.391GlnPro: 1.391 ± 0.04	0.985GlnGln: 0.985 ± 0.04	2.234GlnArg: 2.234 ± 0.063	1.655GlnSer: 1.655 ± 0.044	1.542GlnThr: 1.542 ± 0.042	2.352GlnVal: 2.352 ± 0.055	0.42GlnTrp: 0.42 ± 0.022	0.647GlnTyr: 0.647 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.855ArgAla: 7.855 ± 0.124	0.465ArgCys: 0.465 ± 0.026	4.072ArgAsp: 4.072 ± 0.085	4.694ArgGlu: 4.694 ± 0.087	2.201ArgPhe: 2.201 ± 0.059	5.325ArgGly: 5.325 ± 0.087	1.64ArgHis: 1.64 ± 0.05	3.895ArgIle: 3.895 ± 0.075	1.581ArgLys: 1.581 ± 0.051	7.188ArgLeu: 7.188 ± 0.107	1.809ArgMet: 1.809 ± 0.047	1.407ArgAsn: 1.407 ± 0.047	3.551ArgPro: 3.551 ± 0.09	2.251ArgGln: 2.251 ± 0.053	6.493ArgArg: 6.493 ± 0.117	4.565ArgSer: 4.565 ± 0.087	4.149ArgThr: 4.149 ± 0.074	5.215ArgVal: 5.215 ± 0.084	1.108ArgTrp: 1.108 ± 0.044	1.575ArgTyr: 1.575 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.775SerAla: 6.775 ± 0.109	0.38SerCys: 0.38 ± 0.028	3.446SerAsp: 3.446 ± 0.061	3.479SerGlu: 3.479 ± 0.066	2.021SerPhe: 2.021 ± 0.056	5.708SerGly: 5.708 ± 0.087	1.269SerHis: 1.269 ± 0.045	3.281SerIle: 3.281 ± 0.065	1.34SerLys: 1.34 ± 0.046	5.774SerLeu: 5.774 ± 0.088	1.508SerMet: 1.508 ± 0.042	1.251SerAsn: 1.251 ± 0.042	3.216SerPro: 3.216 ± 0.07	1.673SerGln: 1.673 ± 0.054	4.328SerArg: 4.328 ± 0.094	3.782SerSer: 3.782 ± 0.093	3.837SerThr: 3.837 ± 0.058	4.574SerVal: 4.574 ± 0.079	0.953SerTrp: 0.953 ± 0.036	1.439SerTyr: 1.439 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	7.116ThrAla: 7.116 ± 0.112	0.344ThrCys: 0.344 ± 0.023	3.68ThrAsp: 3.68 ± 0.07	3.53ThrGlu: 3.53 ± 0.073	1.995ThrPhe: 1.995 ± 0.057	5.733ThrGly: 5.733 ± 0.092	1.196ThrHis: 1.196 ± 0.044	3.589ThrIle: 3.589 ± 0.077	1.492ThrLys: 1.492 ± 0.048	5.702ThrLeu: 5.702 ± 0.09	1.248ThrMet: 1.248 ± 0.04	1.297ThrAsn: 1.297 ± 0.043	3.515ThrPro: 3.515 ± 0.077	1.429ThrGln: 1.429 ± 0.053	3.69ThrArg: 3.69 ± 0.072	3.514ThrSer: 3.514 ± 0.077	3.625ThrThr: 3.625 ± 0.1	5.794ThrVal: 5.794 ± 0.1	0.917ThrTrp: 0.917 ± 0.036	1.394ThrTyr: 1.394 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.373ValAla: 9.373 ± 0.134	0.557ValCys: 0.557 ± 0.025	5.748ValAsp: 5.748 ± 0.095	5.366ValGlu: 5.366 ± 0.095	2.415ValPhe: 2.415 ± 0.061	6.779ValGly: 6.779 ± 0.107	1.58ValHis: 1.58 ± 0.048	4.589ValIle: 4.589 ± 0.082	1.934ValLys: 1.934 ± 0.058	8.348ValLeu: 8.348 ± 0.105	1.6ValMet: 1.6 ± 0.05	1.854ValAsn: 1.854 ± 0.052	4.273ValPro: 4.273 ± 0.084	1.888ValGln: 1.888 ± 0.05	5.469ValArg: 5.469 ± 0.09	4.884ValSer: 4.884 ± 0.077	5.392ValThr: 5.392 ± 0.101	6.853ValVal: 6.853 ± 0.1	1.03ValTrp: 1.03 ± 0.041	1.653ValTyr: 1.653 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.455TrpAla: 1.455 ± 0.045	0.101TrpCys: 0.101 ± 0.012	0.892TrpAsp: 0.892 ± 0.036	0.791TrpGlu: 0.791 ± 0.033	0.497TrpPhe: 0.497 ± 0.026	1.022TrpGly: 1.022 ± 0.042	0.308TrpHis: 0.308 ± 0.018	0.776TrpIle: 0.776 ± 0.035	0.33TrpLys: 0.33 ± 0.022	1.558TrpLeu: 1.558 ± 0.038	0.351TrpMet: 0.351 ± 0.023	0.445TrpAsn: 0.445 ± 0.03	0.674TrpPro: 0.674 ± 0.029	0.522TrpGln: 0.522 ± 0.025	1.168TrpArg: 1.168 ± 0.045	0.959TrpSer: 0.959 ± 0.037	0.88TrpThr: 0.88 ± 0.04	1.039TrpVal: 1.039 ± 0.042	0.326TrpTrp: 0.326 ± 0.02	0.294TrpTyr: 0.294 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.3TyrAla: 2.3 ± 0.056	0.169TyrCys: 0.169 ± 0.015	1.326TyrAsp: 1.326 ± 0.041	1.437TyrGlu: 1.437 ± 0.046	0.747TyrPhe: 0.747 ± 0.039	2.166TyrGly: 2.166 ± 0.06	0.415TyrHis: 0.415 ± 0.024	0.916TyrIle: 0.916 ± 0.033	0.409TyrLys: 0.409 ± 0.024	2.227TyrLeu: 2.227 ± 0.056	0.371TyrMet: 0.371 ± 0.022	0.5TyrAsn: 0.5 ± 0.031	1.159TyrPro: 1.159 ± 0.041	0.621TyrGln: 0.621 ± 0.027	1.826TyrArg: 1.826 ± 0.056	1.527TyrSer: 1.527 ± 0.044	1.154TyrThr: 1.154 ± 0.04	1.775TyrVal: 1.775 ± 0.058	0.33TyrTrp: 0.33 ± 0.02	0.521TyrTyr: 0.521 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2276 proteins (752478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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