Amino acid dipepetide frequency for Alkalispirochaeta odontotermitis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.296AlaAla: 9.296 ± 0.152	1.011AlaCys: 1.011 ± 0.04	5.02AlaAsp: 5.02 ± 0.077	5.678AlaGlu: 5.678 ± 0.082	3.472AlaPhe: 3.472 ± 0.067	7.59AlaGly: 7.59 ± 0.107	1.433AlaHis: 1.433 ± 0.041	5.76AlaIle: 5.76 ± 0.098	4.098AlaLys: 4.098 ± 0.081	8.876AlaLeu: 8.876 ± 0.118	2.429AlaMet: 2.429 ± 0.057	2.639AlaAsn: 2.639 ± 0.052	2.947AlaPro: 2.947 ± 0.066	2.661AlaGln: 2.661 ± 0.066	5.004AlaArg: 5.004 ± 0.081	4.676AlaSer: 4.676 ± 0.082	3.663AlaThr: 3.663 ± 0.071	6.736AlaVal: 6.736 ± 0.091	1.002AlaTrp: 1.002 ± 0.035	2.444AlaTyr: 2.444 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.871CysAla: 0.871 ± 0.033	0.203CysCys: 0.203 ± 0.018	0.576CysAsp: 0.576 ± 0.024	0.619CysGlu: 0.619 ± 0.03	0.478CysPhe: 0.478 ± 0.023	1.127CysGly: 1.127 ± 0.039	0.309CysHis: 0.309 ± 0.033	0.657CysIle: 0.657 ± 0.026	0.403CysLys: 0.403 ± 0.02	0.974CysLeu: 0.974 ± 0.035	0.235CysMet: 0.235 ± 0.017	0.334CysAsn: 0.334 ± 0.019	0.654CysPro: 0.654 ± 0.034	0.34CysGln: 0.34 ± 0.022	0.844CysArg: 0.844 ± 0.037	0.719CysSer: 0.719 ± 0.033	0.484CysThr: 0.484 ± 0.026	0.659CysVal: 0.659 ± 0.031	0.131CysTrp: 0.131 ± 0.011	0.353CysTyr: 0.353 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.341AspAla: 4.341 ± 0.077	0.593AspCys: 0.593 ± 0.029	3.004AspAsp: 3.004 ± 0.089	3.973AspGlu: 3.973 ± 0.076	2.716AspPhe: 2.716 ± 0.061	3.957AspGly: 3.957 ± 0.077	1.113AspHis: 1.113 ± 0.034	4.163AspIle: 4.163 ± 0.074	2.772AspLys: 2.772 ± 0.061	5.676AspLeu: 5.676 ± 0.092	1.397AspMet: 1.397 ± 0.042	2.0AspAsn: 2.0 ± 0.054	2.936AspPro: 2.936 ± 0.07	1.835AspGln: 1.835 ± 0.047	3.513AspArg: 3.513 ± 0.076	3.236AspSer: 3.236 ± 0.069	2.48AspThr: 2.48 ± 0.058	3.573AspVal: 3.573 ± 0.065	0.776AspTrp: 0.776 ± 0.028	1.959AspTyr: 1.959 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.503GluAla: 5.503 ± 0.095	0.512GluCys: 0.512 ± 0.026	3.307GluAsp: 3.307 ± 0.073	3.902GluGlu: 3.902 ± 0.091	2.512GluPhe: 2.512 ± 0.056	3.806GluGly: 3.806 ± 0.072	1.214GluHis: 1.214 ± 0.038	5.264GluIle: 5.264 ± 0.08	4.293GluLys: 4.293 ± 0.093	6.385GluLeu: 6.385 ± 0.098	1.746GluMet: 1.746 ± 0.05	3.026GluAsn: 3.026 ± 0.065	2.269GluPro: 2.269 ± 0.049	2.227GluGln: 2.227 ± 0.056	3.529GluArg: 3.529 ± 0.07	3.679GluSer: 3.679 ± 0.062	3.453GluThr: 3.453 ± 0.07	4.086GluVal: 4.086 ± 0.069	0.621GluTrp: 0.621 ± 0.029	1.894GluTyr: 1.894 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.367PheAla: 3.367 ± 0.061	0.513PheCys: 0.513 ± 0.024	2.69PheAsp: 2.69 ± 0.061	2.704PheGlu: 2.704 ± 0.061	2.151PhePhe: 2.151 ± 0.064	3.487PheGly: 3.487 ± 0.066	0.843PheHis: 0.843 ± 0.031	2.74PheIle: 2.74 ± 0.056	2.143PheLys: 2.143 ± 0.051	4.19PheLeu: 4.19 ± 0.081	1.069PheMet: 1.069 ± 0.035	1.699PheAsn: 1.699 ± 0.049	1.792PhePro: 1.792 ± 0.049	1.376PheGln: 1.376 ± 0.041	2.259PheArg: 2.259 ± 0.055	3.103PheSer: 3.103 ± 0.065	2.108PheThr: 2.108 ± 0.056	2.741PheVal: 2.741 ± 0.056	0.559PheTrp: 0.559 ± 0.028	1.442PheTyr: 1.442 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.845GlyAla: 5.845 ± 0.09	1.067GlyCys: 1.067 ± 0.034	3.693GlyAsp: 3.693 ± 0.06	4.28GlyGlu: 4.28 ± 0.073	3.486GlyPhe: 3.486 ± 0.067	5.739GlyGly: 5.739 ± 0.096	1.53GlyHis: 1.53 ± 0.034	5.909GlyIle: 5.909 ± 0.082	4.145GlyLys: 4.145 ± 0.075	7.662GlyLeu: 7.662 ± 0.106	2.209GlyMet: 2.209 ± 0.059	2.79GlyAsn: 2.79 ± 0.079	2.459GlyPro: 2.459 ± 0.057	2.596GlyGln: 2.596 ± 0.06	4.59GlyArg: 4.59 ± 0.076	4.578GlySer: 4.578 ± 0.093	3.903GlyThr: 3.903 ± 0.076	5.213GlyVal: 5.213 ± 0.074	1.107GlyTrp: 1.107 ± 0.036	2.598GlyTyr: 2.598 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.437HisAla: 1.437 ± 0.039	0.277HisCys: 0.277 ± 0.017	0.997HisAsp: 0.997 ± 0.035	1.099HisGlu: 1.099 ± 0.039	0.965HisPhe: 0.965 ± 0.032	1.461HisGly: 1.461 ± 0.042	0.524HisHis: 0.524 ± 0.027	1.33HisIle: 1.33 ± 0.044	0.8HisLys: 0.8 ± 0.032	2.133HisLeu: 2.133 ± 0.054	0.451HisMet: 0.451 ± 0.021	0.674HisAsn: 0.674 ± 0.031	1.242HisPro: 1.242 ± 0.041	0.747HisGln: 0.747 ± 0.031	1.236HisArg: 1.236 ± 0.043	1.127HisSer: 1.127 ± 0.034	0.944HisThr: 0.944 ± 0.035	1.139HisVal: 1.139 ± 0.037	0.236HisTrp: 0.236 ± 0.016	0.655HisTyr: 0.655 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.42IleAla: 6.42 ± 0.082	0.828IleCys: 0.828 ± 0.033	4.465IleAsp: 4.465 ± 0.073	4.727IleGlu: 4.727 ± 0.079	2.989IlePhe: 2.989 ± 0.059	5.215IleGly: 5.215 ± 0.083	1.478IleHis: 1.478 ± 0.042	4.559IleIle: 4.559 ± 0.084	3.587IleLys: 3.587 ± 0.071	6.873IleLeu: 6.873 ± 0.113	1.491IleMet: 1.491 ± 0.043	2.763IleAsn: 2.763 ± 0.052	3.472IlePro: 3.472 ± 0.067	2.328IleGln: 2.328 ± 0.062	4.048IleArg: 4.048 ± 0.076	4.858IleSer: 4.858 ± 0.075	3.569IleThr: 3.569 ± 0.071	4.782IleVal: 4.782 ± 0.08	0.792IleTrp: 0.792 ± 0.032	2.021IleTyr: 2.021 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.291LysAla: 4.291 ± 0.074	0.457LysCys: 0.457 ± 0.026	2.796LysAsp: 2.796 ± 0.058	3.402LysGlu: 3.402 ± 0.068	1.837LysPhe: 1.837 ± 0.05	3.384LysGly: 3.384 ± 0.066	0.963LysHis: 0.963 ± 0.033	4.225LysIle: 4.225 ± 0.074	3.849LysLys: 3.849 ± 0.098	5.002LysLeu: 5.002 ± 0.086	1.604LysMet: 1.604 ± 0.046	2.285LysAsn: 2.285 ± 0.055	2.347LysPro: 2.347 ± 0.061	1.777LysGln: 1.777 ± 0.049	2.888LysArg: 2.888 ± 0.052	3.271LysSer: 3.271 ± 0.065	3.07LysThr: 3.07 ± 0.06	3.429LysVal: 3.429 ± 0.065	0.611LysTrp: 0.611 ± 0.029	1.511LysTyr: 1.511 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	9.633LeuAla: 9.633 ± 0.125	0.998LeuCys: 0.998 ± 0.036	5.871LeuAsp: 5.871 ± 0.096	6.664LeuGlu: 6.664 ± 0.09	4.03LeuPhe: 4.03 ± 0.081	7.429LeuGly: 7.429 ± 0.118	1.723LeuHis: 1.723 ± 0.049	6.942LeuIle: 6.942 ± 0.102	6.017LeuLys: 6.017 ± 0.106	9.563LeuLeu: 9.563 ± 0.159	2.479LeuMet: 2.479 ± 0.051	3.919LeuAsn: 3.919 ± 0.071	4.581LeuPro: 4.581 ± 0.079	3.057LeuGln: 3.057 ± 0.065	5.22LeuArg: 5.22 ± 0.087	6.773LeuSer: 6.773 ± 0.099	5.207LeuThr: 5.207 ± 0.091	6.774LeuVal: 6.774 ± 0.088	1.055LeuTrp: 1.055 ± 0.043	2.67LeuTyr: 2.67 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.636MetAla: 2.636 ± 0.058	0.219MetCys: 0.219 ± 0.017	1.474MetAsp: 1.474 ± 0.044	1.51MetGlu: 1.51 ± 0.044	0.752MetPhe: 0.752 ± 0.034	1.997MetGly: 1.997 ± 0.055	0.444MetHis: 0.444 ± 0.024	1.739MetIle: 1.739 ± 0.046	1.521MetLys: 1.521 ± 0.047	2.51MetLeu: 2.51 ± 0.057	0.674MetMet: 0.674 ± 0.027	1.091MetAsn: 1.091 ± 0.036	1.24MetPro: 1.24 ± 0.036	0.89MetGln: 0.89 ± 0.034	1.374MetArg: 1.374 ± 0.041	1.514MetSer: 1.514 ± 0.038	1.415MetThr: 1.415 ± 0.044	1.87MetVal: 1.87 ± 0.051	0.224MetTrp: 0.224 ± 0.016	0.59MetTyr: 0.59 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.966AsnAla: 2.966 ± 0.063	0.459AsnCys: 0.459 ± 0.025	1.787AsnAsp: 1.787 ± 0.053	2.068AsnGlu: 2.068 ± 0.053	1.698AsnPhe: 1.698 ± 0.049	2.659AsnGly: 2.659 ± 0.064	0.75AsnHis: 0.75 ± 0.025	2.79AsnIle: 2.79 ± 0.059	1.711AsnLys: 1.711 ± 0.046	4.444AsnLeu: 4.444 ± 0.079	0.862AsnMet: 0.862 ± 0.032	1.349AsnAsn: 1.349 ± 0.044	2.344AsnPro: 2.344 ± 0.054	1.491AsnGln: 1.491 ± 0.044	2.531AsnArg: 2.531 ± 0.06	2.275AsnSer: 2.275 ± 0.052	1.791AsnThr: 1.791 ± 0.048	2.281AsnVal: 2.281 ± 0.049	0.577AsnTrp: 0.577 ± 0.028	1.247AsnTyr: 1.247 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.907ProAla: 3.907 ± 0.073	0.372ProCys: 0.372 ± 0.021	3.024ProAsp: 3.024 ± 0.06	3.302ProGlu: 3.302 ± 0.066	1.927ProPhe: 1.927 ± 0.051	3.68ProGly: 3.68 ± 0.082	0.917ProHis: 0.917 ± 0.034	2.567ProIle: 2.567 ± 0.054	1.946ProLys: 1.946 ± 0.042	4.246ProLeu: 4.246 ± 0.074	1.045ProMet: 1.045 ± 0.032	1.517ProAsn: 1.517 ± 0.043	1.818ProPro: 1.818 ± 0.051	1.525ProGln: 1.525 ± 0.039	2.081ProArg: 2.081 ± 0.051	2.426ProSer: 2.426 ± 0.058	2.054ProThr: 2.054 ± 0.052	3.498ProVal: 3.498 ± 0.067	0.577ProTrp: 0.577 ± 0.027	1.35ProTyr: 1.35 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.99GlnAla: 2.99 ± 0.055	0.309GlnCys: 0.309 ± 0.021	1.597GlnAsp: 1.597 ± 0.046	2.009GlnGlu: 2.009 ± 0.052	1.401GlnPhe: 1.401 ± 0.042	2.265GlnGly: 2.265 ± 0.052	0.587GlnHis: 0.587 ± 0.029	2.592GlnIle: 2.592 ± 0.062	2.089GlnLys: 2.089 ± 0.054	3.119GlnLeu: 3.119 ± 0.062	0.97GlnMet: 0.97 ± 0.036	1.514GlnAsn: 1.514 ± 0.048	1.431GlnPro: 1.431 ± 0.043	1.314GlnGln: 1.314 ± 0.046	2.025GlnArg: 2.025 ± 0.055	2.011GlnSer: 2.011 ± 0.048	1.778GlnThr: 1.778 ± 0.051	2.284GlnVal: 2.284 ± 0.045	0.483GlnTrp: 0.483 ± 0.023	1.005GlnTyr: 1.005 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.224ArgAla: 4.224 ± 0.074	0.642ArgCys: 0.642 ± 0.028	2.976ArgAsp: 2.976 ± 0.063	3.856ArgGlu: 3.856 ± 0.073	2.647ArgPhe: 2.647 ± 0.063	3.56ArgGly: 3.56 ± 0.078	1.31ArgHis: 1.31 ± 0.043	4.616ArgIle: 4.616 ± 0.072	3.418ArgLys: 3.418 ± 0.062	6.083ArgLeu: 6.083 ± 0.101	1.499ArgMet: 1.499 ± 0.039	2.288ArgAsn: 2.288 ± 0.046	2.27ArgPro: 2.27 ± 0.043	2.411ArgGln: 2.411 ± 0.062	3.842ArgArg: 3.842 ± 0.078	3.318ArgSer: 3.318 ± 0.068	2.549ArgThr: 2.549 ± 0.054	3.772ArgVal: 3.772 ± 0.064	0.747ArgTrp: 0.747 ± 0.026	1.927ArgTyr: 1.927 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.963SerAla: 4.963 ± 0.08	0.668SerCys: 0.668 ± 0.028	3.402SerAsp: 3.402 ± 0.058	3.723SerGlu: 3.723 ± 0.085	2.733SerPhe: 2.733 ± 0.057	5.508SerGly: 5.508 ± 0.092	1.188SerHis: 1.188 ± 0.032	4.368SerIle: 4.368 ± 0.079	2.882SerLys: 2.882 ± 0.058	6.287SerLeu: 6.287 ± 0.101	1.585SerMet: 1.585 ± 0.038	2.169SerAsn: 2.169 ± 0.049	2.638SerPro: 2.638 ± 0.049	2.045SerGln: 2.045 ± 0.046	3.607SerArg: 3.607 ± 0.068	3.744SerSer: 3.744 ± 0.077	2.929SerThr: 2.929 ± 0.066	3.958SerVal: 3.958 ± 0.071	0.809SerTrp: 0.809 ± 0.033	1.817SerTyr: 1.817 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.614ThrAla: 4.614 ± 0.073	0.515ThrCys: 0.515 ± 0.023	2.671ThrAsp: 2.671 ± 0.066	2.849ThrGlu: 2.849 ± 0.067	1.989ThrPhe: 1.989 ± 0.046	4.495ThrGly: 4.495 ± 0.072	1.015ThrHis: 1.015 ± 0.034	3.601ThrIle: 3.601 ± 0.067	1.91ThrLys: 1.91 ± 0.047	5.112ThrLeu: 5.112 ± 0.077	1.186ThrMet: 1.186 ± 0.038	1.636ThrAsn: 1.636 ± 0.051	2.416ThrPro: 2.416 ± 0.058	1.4ThrGln: 1.4 ± 0.048	2.74ThrArg: 2.74 ± 0.055	2.763ThrSer: 2.763 ± 0.055	2.492ThrThr: 2.492 ± 0.064	3.814ThrVal: 3.814 ± 0.073	0.651ThrTrp: 0.651 ± 0.027	1.523ThrTyr: 1.523 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	6.033ValAla: 6.033 ± 0.101	0.802ValCys: 0.802 ± 0.036	4.066ValAsp: 4.066 ± 0.073	4.387ValGlu: 4.387 ± 0.071	3.169ValPhe: 3.169 ± 0.062	4.823ValGly: 4.823 ± 0.086	1.166ValHis: 1.166 ± 0.034	4.775ValIle: 4.775 ± 0.079	3.495ValLys: 3.495 ± 0.059	6.891ValLeu: 6.891 ± 0.091	1.762ValMet: 1.762 ± 0.049	2.665ValAsn: 2.665 ± 0.053	2.97ValPro: 2.97 ± 0.06	1.979ValGln: 1.979 ± 0.048	3.691ValArg: 3.691 ± 0.071	4.325ValSer: 4.325 ± 0.082	3.383ValThr: 3.383 ± 0.07	5.038ValVal: 5.038 ± 0.091	0.719ValTrp: 0.719 ± 0.03	1.988ValTyr: 1.988 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.851TrpAla: 0.851 ± 0.036	0.14TrpCys: 0.14 ± 0.013	0.687TrpAsp: 0.687 ± 0.029	0.747TrpGlu: 0.747 ± 0.031	0.509TrpPhe: 0.509 ± 0.025	0.882TrpGly: 0.882 ± 0.032	0.267TrpHis: 0.267 ± 0.018	0.901TrpIle: 0.901 ± 0.034	0.615TrpLys: 0.615 ± 0.028	1.333TrpLeu: 1.333 ± 0.039	0.338TrpMet: 0.338 ± 0.021	0.558TrpAsn: 0.558 ± 0.024	0.525TrpPro: 0.525 ± 0.028	0.63TrpGln: 0.63 ± 0.028	0.752TrpArg: 0.752 ± 0.029	0.704TrpSer: 0.704 ± 0.033	0.619TrpThr: 0.619 ± 0.025	0.736TrpVal: 0.736 ± 0.029	0.189TrpTrp: 0.189 ± 0.016	0.359TrpTyr: 0.359 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.25TyrAla: 2.25 ± 0.058	0.384TyrCys: 0.384 ± 0.021	1.91TyrAsp: 1.91 ± 0.088	1.732TyrGlu: 1.732 ± 0.049	1.514TyrPhe: 1.514 ± 0.048	2.332TyrGly: 2.332 ± 0.054	0.701TyrHis: 0.701 ± 0.027	1.765TyrIle: 1.765 ± 0.049	1.304TyrLys: 1.304 ± 0.041	3.245TyrLeu: 3.245 ± 0.058	0.654TyrMet: 0.654 ± 0.026	1.16TyrAsn: 1.16 ± 0.042	1.429TyrPro: 1.429 ± 0.04	1.146TyrGln: 1.146 ± 0.033	2.18TyrArg: 2.18 ± 0.052	1.925TyrSer: 1.925 ± 0.051	1.501TyrThr: 1.501 ± 0.052	1.745TyrVal: 1.745 ± 0.05	0.474TyrTrp: 0.474 ± 0.027	1.122TyrTyr: 1.122 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2732 proteins (888817 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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