Amino acid dipepetide frequency for Epibacterium multivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.954AlaAla: 15.954 ± 0.172	1.102AlaCys: 1.102 ± 0.032	6.936AlaAsp: 6.936 ± 0.09	8.237AlaGlu: 8.237 ± 0.119	4.337AlaPhe: 4.337 ± 0.069	10.165AlaGly: 10.165 ± 0.104	2.291AlaHis: 2.291 ± 0.046	5.4AlaIle: 5.4 ± 0.071	4.252AlaLys: 4.252 ± 0.072	13.591AlaLeu: 13.591 ± 0.126	3.651AlaMet: 3.651 ± 0.049	2.878AlaAsn: 2.878 ± 0.049	5.817AlaPro: 5.817 ± 0.099	4.903AlaGln: 4.903 ± 0.072	7.784AlaArg: 7.784 ± 0.094	5.559AlaSer: 5.559 ± 0.077	6.012AlaThr: 6.012 ± 0.076	8.077AlaVal: 8.077 ± 0.094	1.262AlaTrp: 1.262 ± 0.032	2.596AlaTyr: 2.596 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.034	0.136CysCys: 0.136 ± 0.011	0.649CysAsp: 0.649 ± 0.024	0.484CysGlu: 0.484 ± 0.019	0.385CysPhe: 0.385 ± 0.018	0.952CysGly: 0.952 ± 0.033	0.269CysHis: 0.269 ± 0.015	0.409CysIle: 0.409 ± 0.02	0.252CysLys: 0.252 ± 0.014	0.935CysLeu: 0.935 ± 0.024	0.208CysMet: 0.208 ± 0.013	0.231CysAsn: 0.231 ± 0.013	0.507CysPro: 0.507 ± 0.019	0.269CysGln: 0.269 ± 0.015	0.549CysArg: 0.549 ± 0.022	0.485CysSer: 0.485 ± 0.022	0.444CysThr: 0.444 ± 0.02	0.644CysVal: 0.644 ± 0.025	0.1CysTrp: 0.1 ± 0.009	0.219CysTyr: 0.219 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.316AspAla: 7.316 ± 0.092	0.548AspCys: 0.548 ± 0.022	3.316AspAsp: 3.316 ± 0.083	3.342AspGlu: 3.342 ± 0.059	2.456AspPhe: 2.456 ± 0.046	5.461AspGly: 5.461 ± 0.103	1.522AspHis: 1.522 ± 0.043	3.148AspIle: 3.148 ± 0.054	1.806AspLys: 1.806 ± 0.041	6.906AspLeu: 6.906 ± 0.088	1.718AspMet: 1.718 ± 0.041	1.401AspAsn: 1.401 ± 0.04	3.408AspPro: 3.408 ± 0.06	2.235AspGln: 2.235 ± 0.043	3.977AspArg: 3.977 ± 0.054	2.519AspSer: 2.519 ± 0.051	3.135AspThr: 3.135 ± 0.073	4.386AspVal: 4.386 ± 0.068	1.102AspTrp: 1.102 ± 0.031	1.617AspTyr: 1.617 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.271GluAla: 8.271 ± 0.107	0.361GluCys: 0.361 ± 0.018	3.859GluAsp: 3.859 ± 0.061	3.868GluGlu: 3.868 ± 0.074	1.919GluPhe: 1.919 ± 0.041	5.005GluGly: 5.005 ± 0.074	1.142GluHis: 1.142 ± 0.028	3.753GluIle: 3.753 ± 0.059	2.293GluLys: 2.293 ± 0.051	5.538GluLeu: 5.538 ± 0.067	1.775GluMet: 1.775 ± 0.039	1.945GluAsn: 1.945 ± 0.043	2.376GluPro: 2.376 ± 0.057	2.173GluGln: 2.173 ± 0.05	3.807GluArg: 3.807 ± 0.066	2.079GluSer: 2.079 ± 0.043	3.861GluThr: 3.861 ± 0.059	4.611GluVal: 4.611 ± 0.07	0.639GluTrp: 0.639 ± 0.026	1.015GluTyr: 1.015 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.574PheAla: 4.574 ± 0.061	0.462PheCys: 0.462 ± 0.021	2.995PheAsp: 2.995 ± 0.05	2.465PheGlu: 2.465 ± 0.047	1.564PhePhe: 1.564 ± 0.042	3.808PheGly: 3.808 ± 0.067	0.769PheHis: 0.769 ± 0.027	1.571PheIle: 1.571 ± 0.037	1.138PheLys: 1.138 ± 0.037	3.603PheLeu: 3.603 ± 0.072	0.911PheMet: 0.911 ± 0.029	1.108PheAsn: 1.108 ± 0.033	1.515PhePro: 1.515 ± 0.038	1.21PheGln: 1.21 ± 0.031	2.036PheArg: 2.036 ± 0.036	2.238PheSer: 2.238 ± 0.048	2.123PheThr: 2.123 ± 0.051	2.795PheVal: 2.795 ± 0.048	0.622PheTrp: 0.622 ± 0.025	0.99PheTyr: 0.99 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.645GlyAla: 9.645 ± 0.094	0.865GlyCys: 0.865 ± 0.026	5.041GlyAsp: 5.041 ± 0.101	4.696GlyGlu: 4.696 ± 0.07	3.817GlyPhe: 3.817 ± 0.064	7.241GlyGly: 7.241 ± 0.103	1.973GlyHis: 1.973 ± 0.045	4.179GlyIle: 4.179 ± 0.064	3.204GlyLys: 3.204 ± 0.064	9.245GlyLeu: 9.245 ± 0.088	2.41GlyMet: 2.41 ± 0.046	2.252GlyAsn: 2.252 ± 0.051	3.279GlyPro: 3.279 ± 0.048	3.481GlyGln: 3.481 ± 0.063	5.194GlyArg: 5.194 ± 0.068	4.225GlySer: 4.225 ± 0.073	4.601GlyThr: 4.601 ± 0.071	6.221GlyVal: 6.221 ± 0.083	1.376GlyTrp: 1.376 ± 0.033	2.27GlyTyr: 2.27 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.229HisAla: 2.229 ± 0.046	0.249HisCys: 0.249 ± 0.014	1.24HisAsp: 1.24 ± 0.04	1.034HisGlu: 1.034 ± 0.034	0.877HisPhe: 0.877 ± 0.03	1.825HisGly: 1.825 ± 0.046	0.576HisHis: 0.576 ± 0.022	1.014HisIle: 1.014 ± 0.028	0.631HisLys: 0.631 ± 0.023	2.163HisLeu: 2.163 ± 0.039	0.638HisMet: 0.638 ± 0.024	0.528HisAsn: 0.528 ± 0.024	1.307HisPro: 1.307 ± 0.032	0.69HisGln: 0.69 ± 0.026	1.255HisArg: 1.255 ± 0.034	1.039HisSer: 1.039 ± 0.031	0.842HisThr: 0.842 ± 0.025	1.53HisVal: 1.53 ± 0.035	0.371HisTrp: 0.371 ± 0.02	0.567HisTyr: 0.567 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.473IleAla: 6.473 ± 0.079	0.641IleCys: 0.641 ± 0.022	3.317IleAsp: 3.317 ± 0.057	3.334IleGlu: 3.334 ± 0.056	1.808IlePhe: 1.808 ± 0.044	4.531IleGly: 4.531 ± 0.068	0.909IleHis: 0.909 ± 0.029	1.977IleIle: 1.977 ± 0.05	1.553IleLys: 1.553 ± 0.04	4.719IleLeu: 4.719 ± 0.067	1.076IleMet: 1.076 ± 0.036	1.478IleAsn: 1.478 ± 0.031	2.168IlePro: 2.168 ± 0.046	1.39IleGln: 1.39 ± 0.032	2.883IleArg: 2.883 ± 0.05	2.975IleSer: 2.975 ± 0.057	2.853IleThr: 2.853 ± 0.051	3.38IleVal: 3.38 ± 0.064	0.727IleTrp: 0.727 ± 0.026	1.126IleTyr: 1.126 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.193LysAla: 4.193 ± 0.078	0.194LysCys: 0.194 ± 0.013	2.112LysAsp: 2.112 ± 0.045	1.774LysGlu: 1.774 ± 0.042	1.078LysPhe: 1.078 ± 0.033	2.951LysGly: 2.951 ± 0.059	0.666LysHis: 0.666 ± 0.023	1.833LysIle: 1.833 ± 0.037	1.38LysLys: 1.38 ± 0.043	3.229LysLeu: 3.229 ± 0.052	0.975LysMet: 0.975 ± 0.031	0.923LysAsn: 0.923 ± 0.027	1.957LysPro: 1.957 ± 0.045	1.036LysGln: 1.036 ± 0.03	2.248LysArg: 2.248 ± 0.044	1.997LysSer: 1.997 ± 0.043	2.21LysThr: 2.21 ± 0.047	2.495LysVal: 2.495 ± 0.048	0.372LysTrp: 0.372 ± 0.017	0.686LysTyr: 0.686 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.5LeuAla: 12.5 ± 0.126	1.055LeuCys: 1.055 ± 0.032	6.059LeuAsp: 6.059 ± 0.075	5.884LeuGlu: 5.884 ± 0.079	3.72LeuPhe: 3.72 ± 0.074	8.498LeuGly: 8.498 ± 0.092	1.968LeuHis: 1.968 ± 0.038	4.882LeuIle: 4.882 ± 0.072	3.525LeuLys: 3.525 ± 0.056	9.31LeuLeu: 9.31 ± 0.117	2.783LeuMet: 2.783 ± 0.047	2.951LeuAsn: 2.951 ± 0.047	5.717LeuPro: 5.717 ± 0.085	3.188LeuGln: 3.188 ± 0.058	7.201LeuArg: 7.201 ± 0.1	7.04LeuSer: 7.04 ± 0.092	5.993LeuThr: 5.993 ± 0.064	6.825LeuVal: 6.825 ± 0.08	1.38LeuTrp: 1.38 ± 0.041	1.975LeuTyr: 1.975 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.414MetAla: 3.414 ± 0.057	0.202MetCys: 0.202 ± 0.013	1.444MetAsp: 1.444 ± 0.035	1.458MetGlu: 1.458 ± 0.038	0.911MetPhe: 0.911 ± 0.03	2.265MetGly: 2.265 ± 0.049	0.44MetHis: 0.44 ± 0.018	1.481MetIle: 1.481 ± 0.033	1.148MetLys: 1.148 ± 0.031	2.52MetLeu: 2.52 ± 0.044	0.816MetMet: 0.816 ± 0.025	0.836MetAsn: 0.836 ± 0.026	1.432MetPro: 1.432 ± 0.036	1.029MetGln: 1.029 ± 0.026	1.77MetArg: 1.77 ± 0.039	1.77MetSer: 1.77 ± 0.043	2.075MetThr: 2.075 ± 0.041	1.936MetVal: 1.936 ± 0.038	0.248MetTrp: 0.248 ± 0.015	0.332MetTyr: 0.332 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.286AsnAla: 3.286 ± 0.059	0.27AsnCys: 0.27 ± 0.016	1.56AsnAsp: 1.56 ± 0.046	1.277AsnGlu: 1.277 ± 0.032	1.073AsnPhe: 1.073 ± 0.031	2.612AsnGly: 2.612 ± 0.056	0.565AsnHis: 0.565 ± 0.02	1.407AsnIle: 1.407 ± 0.03	0.779AsnLys: 0.779 ± 0.025	2.765AsnLeu: 2.765 ± 0.047	0.745AsnMet: 0.745 ± 0.023	0.794AsnAsn: 0.794 ± 0.028	1.873AsnPro: 1.873 ± 0.037	0.851AsnGln: 0.851 ± 0.024	1.768AsnArg: 1.768 ± 0.04	1.361AsnSer: 1.361 ± 0.038	1.509AsnThr: 1.509 ± 0.037	1.888AsnVal: 1.888 ± 0.039	0.529AsnTrp: 0.529 ± 0.018	0.68AsnTyr: 0.68 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.39ProAla: 5.39 ± 0.08	0.371ProCys: 0.371 ± 0.019	3.685ProAsp: 3.685 ± 0.058	4.177ProGlu: 4.177 ± 0.064	1.943ProPhe: 1.943 ± 0.044	3.961ProGly: 3.961 ± 0.063	1.065ProHis: 1.065 ± 0.032	2.089ProIle: 2.089 ± 0.043	1.936ProLys: 1.936 ± 0.046	4.618ProLeu: 4.618 ± 0.057	1.291ProMet: 1.291 ± 0.03	1.41ProAsn: 1.41 ± 0.033	2.06ProPro: 2.06 ± 0.048	1.881ProGln: 1.881 ± 0.045	2.542ProArg: 2.542 ± 0.053	2.593ProSer: 2.593 ± 0.051	2.499ProThr: 2.499 ± 0.048	4.025ProVal: 4.025 ± 0.054	0.643ProTrp: 0.643 ± 0.025	1.092ProTyr: 1.092 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.361GlnAla: 4.361 ± 0.063	0.231GlnCys: 0.231 ± 0.015	2.066GlnAsp: 2.066 ± 0.04	1.812GlnGlu: 1.812 ± 0.04	1.199GlnPhe: 1.199 ± 0.031	2.802GlnGly: 2.802 ± 0.052	0.63GlnHis: 0.63 ± 0.025	2.21GlnIle: 2.21 ± 0.045	1.283GlnLys: 1.283 ± 0.037	3.376GlnLeu: 3.376 ± 0.056	1.223GlnMet: 1.223 ± 0.032	1.091GlnAsn: 1.091 ± 0.027	1.746GlnPro: 1.746 ± 0.047	1.257GlnGln: 1.257 ± 0.039	2.261GlnArg: 2.261 ± 0.045	2.175GlnSer: 2.175 ± 0.049	2.093GlnThr: 2.093 ± 0.041	2.575GlnVal: 2.575 ± 0.048	0.417GlnTrp: 0.417 ± 0.017	0.643GlnTyr: 0.643 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.418ArgAla: 7.418 ± 0.084	0.484ArgCys: 0.484 ± 0.02	4.036ArgAsp: 4.036 ± 0.054	3.578ArgGlu: 3.578 ± 0.064	2.579ArgPhe: 2.579 ± 0.055	4.246ArgGly: 4.246 ± 0.069	1.371ArgHis: 1.371 ± 0.036	3.355ArgIle: 3.355 ± 0.054	2.379ArgLys: 2.379 ± 0.052	6.901ArgLeu: 6.901 ± 0.089	1.779ArgMet: 1.779 ± 0.042	1.778ArgAsn: 1.778 ± 0.039	3.041ArgPro: 3.041 ± 0.06	2.308ArgGln: 2.308 ± 0.042	4.373ArgArg: 4.373 ± 0.073	3.277ArgSer: 3.277 ± 0.056	2.716ArgThr: 2.716 ± 0.049	4.325ArgVal: 4.325 ± 0.061	0.833ArgTrp: 0.833 ± 0.028	1.45ArgTyr: 1.45 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.098SerAla: 6.098 ± 0.076	0.515SerCys: 0.515 ± 0.021	3.392SerAsp: 3.392 ± 0.055	3.14SerGlu: 3.14 ± 0.059	2.367SerPhe: 2.367 ± 0.053	5.275SerGly: 5.275 ± 0.069	1.178SerHis: 1.178 ± 0.031	2.453SerIle: 2.453 ± 0.046	1.694SerLys: 1.694 ± 0.043	5.334SerLeu: 5.334 ± 0.073	1.342SerMet: 1.342 ± 0.033	1.485SerAsn: 1.485 ± 0.035	2.605SerPro: 2.605 ± 0.044	1.905SerGln: 1.905 ± 0.037	3.18SerArg: 3.18 ± 0.052	2.754SerSer: 2.754 ± 0.053	2.658SerThr: 2.658 ± 0.05	3.824SerVal: 3.824 ± 0.058	0.723SerTrp: 0.723 ± 0.023	1.329SerTyr: 1.329 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.334ThrAla: 6.334 ± 0.083	0.533ThrCys: 0.533 ± 0.021	3.1ThrAsp: 3.1 ± 0.057	3.162ThrGlu: 3.162 ± 0.055	2.048ThrPhe: 2.048 ± 0.051	5.186ThrGly: 5.186 ± 0.068	1.144ThrHis: 1.144 ± 0.026	2.561ThrIle: 2.561 ± 0.049	1.64ThrLys: 1.64 ± 0.037	6.262ThrLeu: 6.262 ± 0.081	1.237ThrMet: 1.237 ± 0.032	1.371ThrAsn: 1.371 ± 0.035	3.427ThrPro: 3.427 ± 0.054	1.868ThrGln: 1.868 ± 0.041	3.255ThrArg: 3.255 ± 0.056	2.893ThrSer: 2.893 ± 0.06	2.864ThrThr: 2.864 ± 0.052	4.113ThrVal: 4.113 ± 0.066	0.703ThrTrp: 0.703 ± 0.028	1.345ThrTyr: 1.345 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.511ValAla: 8.511 ± 0.097	0.635ValCys: 0.635 ± 0.025	4.133ValAsp: 4.133 ± 0.062	4.635ValGlu: 4.635 ± 0.074	2.894ValPhe: 2.894 ± 0.054	5.258ValGly: 5.258 ± 0.074	1.286ValHis: 1.286 ± 0.026	4.01ValIle: 4.01 ± 0.066	2.318ValLys: 2.318 ± 0.049	7.688ValLeu: 7.688 ± 0.106	2.032ValMet: 2.032 ± 0.042	2.044ValAsn: 2.044 ± 0.038	3.39ValPro: 3.39 ± 0.053	2.351ValGln: 2.351 ± 0.045	3.652ValArg: 3.652 ± 0.058	4.262ValSer: 4.262 ± 0.065	4.745ValThr: 4.745 ± 0.07	5.666ValVal: 5.666 ± 0.078	0.906ValTrp: 0.906 ± 0.03	1.414ValTyr: 1.414 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.328TrpAla: 1.328 ± 0.037	0.153TrpCys: 0.153 ± 0.011	0.802TrpAsp: 0.802 ± 0.025	0.656TrpGlu: 0.656 ± 0.021	0.546TrpPhe: 0.546 ± 0.02	1.025TrpGly: 1.025 ± 0.032	0.337TrpHis: 0.337 ± 0.016	0.693TrpIle: 0.693 ± 0.023	0.452TrpLys: 0.452 ± 0.018	1.526TrpLeu: 1.526 ± 0.038	0.431TrpMet: 0.431 ± 0.022	0.433TrpAsn: 0.433 ± 0.02	0.632TrpPro: 0.632 ± 0.025	0.643TrpGln: 0.643 ± 0.023	1.012TrpArg: 1.012 ± 0.032	0.808TrpSer: 0.808 ± 0.025	0.691TrpThr: 0.691 ± 0.024	0.874TrpVal: 0.874 ± 0.027	0.201TrpTrp: 0.201 ± 0.011	0.274TrpTyr: 0.274 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.376TyrAla: 2.376 ± 0.05	0.254TyrCys: 0.254 ± 0.015	1.58TyrAsp: 1.58 ± 0.037	1.278TyrGlu: 1.278 ± 0.036	0.976TyrPhe: 0.976 ± 0.03	2.145TyrGly: 2.145 ± 0.044	0.503TyrHis: 0.503 ± 0.02	0.896TyrIle: 0.896 ± 0.028	0.645TyrLys: 0.645 ± 0.023	2.227TyrLeu: 2.227 ± 0.046	0.482TyrMet: 0.482 ± 0.02	0.655TyrAsn: 0.655 ± 0.025	1.015TyrPro: 1.015 ± 0.029	0.783TyrGln: 0.783 ± 0.026	1.482TyrArg: 1.482 ± 0.038	1.201TyrSer: 1.201 ± 0.033	1.12TyrThr: 1.12 ± 0.039	1.641TyrVal: 1.641 ± 0.038	0.361TyrTrp: 0.361 ± 0.02	0.587TyrTyr: 0.587 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3869 proteins (1235929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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