Amino acid dipepetide frequency for Planomicrobium glaciei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.51AlaAla: 8.51 ± 0.108	0.568AlaCys: 0.568 ± 0.021	4.322AlaAsp: 4.322 ± 0.062	6.528AlaGlu: 6.528 ± 0.087	4.006AlaPhe: 4.006 ± 0.058	6.667AlaGly: 6.667 ± 0.09	1.474AlaHis: 1.474 ± 0.037	6.318AlaIle: 6.318 ± 0.088	5.131AlaLys: 5.131 ± 0.087	8.44AlaLeu: 8.44 ± 0.106	2.473AlaMet: 2.473 ± 0.045	2.824AlaAsn: 2.824 ± 0.054	2.618AlaPro: 2.618 ± 0.056	2.659AlaGln: 2.659 ± 0.049	2.967AlaArg: 2.967 ± 0.046	4.659AlaSer: 4.659 ± 0.072	3.829AlaThr: 3.829 ± 0.061	6.775AlaVal: 6.775 ± 0.091	0.73AlaTrp: 0.73 ± 0.029	2.756AlaTyr: 2.756 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.421CysAla: 0.421 ± 0.02	0.07CysCys: 0.07 ± 0.008	0.328CysAsp: 0.328 ± 0.015	0.392CysGlu: 0.392 ± 0.019	0.249CysPhe: 0.249 ± 0.015	0.646CysGly: 0.646 ± 0.025	0.162CysHis: 0.162 ± 0.012	0.4CysIle: 0.4 ± 0.021	0.251CysLys: 0.251 ± 0.017	0.556CysLeu: 0.556 ± 0.025	0.129CysMet: 0.129 ± 0.011	0.213CysAsn: 0.213 ± 0.013	0.306CysPro: 0.306 ± 0.019	0.212CysGln: 0.212 ± 0.012	0.299CysArg: 0.299 ± 0.016	0.437CysSer: 0.437 ± 0.02	0.315CysThr: 0.315 ± 0.016	0.349CysVal: 0.349 ± 0.018	0.065CysTrp: 0.065 ± 0.007	0.204CysTyr: 0.204 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.172AspAla: 4.172 ± 0.065	0.323AspCys: 0.323 ± 0.017	2.265AspAsp: 2.265 ± 0.049	4.275AspGlu: 4.275 ± 0.069	2.672AspPhe: 2.672 ± 0.049	3.614AspGly: 3.614 ± 0.072	1.154AspHis: 1.154 ± 0.032	3.719AspIle: 3.719 ± 0.06	2.563AspLys: 2.563 ± 0.05	4.975AspLeu: 4.975 ± 0.069	1.442AspMet: 1.442 ± 0.035	1.62AspAsn: 1.62 ± 0.04	2.179AspPro: 2.179 ± 0.04	1.852AspGln: 1.852 ± 0.044	2.454AspArg: 2.454 ± 0.049	2.724AspSer: 2.724 ± 0.052	2.379AspThr: 2.379 ± 0.043	3.794AspVal: 3.794 ± 0.058	0.714AspTrp: 0.714 ± 0.024	2.046AspTyr: 2.046 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.628GluAla: 6.628 ± 0.083	0.313GluCys: 0.313 ± 0.017	3.888GluAsp: 3.888 ± 0.069	7.499GluGlu: 7.499 ± 0.108	2.866GluPhe: 2.866 ± 0.05	4.756GluGly: 4.756 ± 0.072	1.537GluHis: 1.537 ± 0.041	5.113GluIle: 5.113 ± 0.076	5.901GluLys: 5.901 ± 0.085	7.603GluLeu: 7.603 ± 0.103	2.485GluMet: 2.485 ± 0.046	3.34GluAsn: 3.34 ± 0.052	2.393GluPro: 2.393 ± 0.048	3.73GluGln: 3.73 ± 0.065	3.858GluArg: 3.858 ± 0.062	3.73GluSer: 3.73 ± 0.058	4.29GluThr: 4.29 ± 0.056	5.29GluVal: 5.29 ± 0.084	0.941GluTrp: 0.941 ± 0.029	2.047GluTyr: 2.047 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.562PheAla: 3.562 ± 0.062	0.303PheCys: 0.303 ± 0.015	2.561PheAsp: 2.561 ± 0.042	3.136PheGlu: 3.136 ± 0.055	2.4PhePhe: 2.4 ± 0.056	3.691PheGly: 3.691 ± 0.057	0.967PheHis: 0.967 ± 0.033	3.592PheIle: 3.592 ± 0.07	2.199PheLys: 2.199 ± 0.042	4.63PheLeu: 4.63 ± 0.086	1.239PheMet: 1.239 ± 0.038	1.787PheAsn: 1.787 ± 0.04	1.711PhePro: 1.711 ± 0.038	1.554PheGln: 1.554 ± 0.04	1.642PheArg: 1.642 ± 0.039	3.181PheSer: 3.181 ± 0.064	2.578PheThr: 2.578 ± 0.045	3.224PheVal: 3.224 ± 0.054	0.518PheTrp: 0.518 ± 0.023	1.656PheTyr: 1.656 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.763GlyAla: 5.763 ± 0.067	0.521GlyCys: 0.521 ± 0.022	3.429GlyAsp: 3.429 ± 0.065	4.846GlyGlu: 4.846 ± 0.077	3.656GlyPhe: 3.656 ± 0.057	5.285GlyGly: 5.285 ± 0.08	1.543GlyHis: 1.543 ± 0.041	5.987GlyIle: 5.987 ± 0.071	4.943GlyLys: 4.943 ± 0.067	7.002GlyLeu: 7.002 ± 0.091	2.316GlyMet: 2.316 ± 0.049	2.612GlyAsn: 2.612 ± 0.055	1.933GlyPro: 1.933 ± 0.044	2.472GlyGln: 2.472 ± 0.059	2.92GlyArg: 2.92 ± 0.056	4.383GlySer: 4.383 ± 0.06	4.444GlyThr: 4.444 ± 0.062	5.119GlyVal: 5.119 ± 0.068	0.861GlyTrp: 0.861 ± 0.031	2.686GlyTyr: 2.686 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.527HisAla: 1.527 ± 0.035	0.173HisCys: 0.173 ± 0.014	0.962HisAsp: 0.962 ± 0.026	1.395HisGlu: 1.395 ± 0.031	1.003HisPhe: 1.003 ± 0.034	1.487HisGly: 1.487 ± 0.039	0.601HisHis: 0.601 ± 0.025	1.386HisIle: 1.386 ± 0.035	0.921HisLys: 0.921 ± 0.029	2.035HisLeu: 2.035 ± 0.046	0.552HisMet: 0.552 ± 0.022	0.696HisAsn: 0.696 ± 0.025	1.251HisPro: 1.251 ± 0.033	0.815HisGln: 0.815 ± 0.03	0.929HisArg: 0.929 ± 0.028	1.148HisSer: 1.148 ± 0.031	1.065HisThr: 1.065 ± 0.03	1.435HisVal: 1.435 ± 0.037	0.218HisTrp: 0.218 ± 0.014	0.779HisTyr: 0.779 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.406IleAla: 6.406 ± 0.079	0.495IleCys: 0.495 ± 0.022	4.058IleAsp: 4.058 ± 0.059	5.408IleGlu: 5.408 ± 0.075	2.959IlePhe: 2.959 ± 0.064	5.972IleGly: 5.972 ± 0.077	1.461IleHis: 1.461 ± 0.04	4.683IleIle: 4.683 ± 0.087	3.324IleLys: 3.324 ± 0.062	6.589IleLeu: 6.589 ± 0.091	1.596IleMet: 1.596 ± 0.037	2.56IleAsn: 2.56 ± 0.049	3.138IlePro: 3.138 ± 0.055	2.698IleGln: 2.698 ± 0.044	3.149IleArg: 3.149 ± 0.06	4.502IleSer: 4.502 ± 0.066	3.72IleThr: 3.72 ± 0.066	5.222IleVal: 5.222 ± 0.073	0.639IleTrp: 0.639 ± 0.029	2.059IleTyr: 2.059 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.969LysAla: 4.969 ± 0.081	0.225LysCys: 0.225 ± 0.013	3.194LysAsp: 3.194 ± 0.055	6.027LysGlu: 6.027 ± 0.085	1.978LysPhe: 1.978 ± 0.041	4.121LysGly: 4.121 ± 0.069	1.135LysHis: 1.135 ± 0.035	3.815LysIle: 3.815 ± 0.062	4.845LysLys: 4.845 ± 0.07	5.239LysLeu: 5.239 ± 0.067	2.077LysMet: 2.077 ± 0.046	2.679LysAsn: 2.679 ± 0.054	2.193LysPro: 2.193 ± 0.049	2.543LysGln: 2.543 ± 0.05	3.096LysArg: 3.096 ± 0.05	3.106LysSer: 3.106 ± 0.046	3.468LysThr: 3.468 ± 0.057	4.029LysVal: 4.029 ± 0.069	0.733LysTrp: 0.733 ± 0.024	1.762LysTyr: 1.762 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.864LeuAla: 8.864 ± 0.103	0.55LeuCys: 0.55 ± 0.023	4.764LeuAsp: 4.764 ± 0.071	7.177LeuGlu: 7.177 ± 0.086	4.82LeuPhe: 4.82 ± 0.087	6.552LeuGly: 6.552 ± 0.08	1.892LeuHis: 1.892 ± 0.045	6.694LeuIle: 6.694 ± 0.105	6.139LeuLys: 6.139 ± 0.078	10.371LeuLeu: 10.371 ± 0.13	2.676LeuMet: 2.676 ± 0.048	3.856LeuAsn: 3.856 ± 0.065	4.291LeuPro: 4.291 ± 0.067	3.623LeuGln: 3.623 ± 0.058	3.74LeuArg: 3.74 ± 0.064	6.411LeuSer: 6.411 ± 0.078	5.404LeuThr: 5.404 ± 0.071	6.667LeuVal: 6.667 ± 0.083	0.897LeuTrp: 0.897 ± 0.027	3.166LeuTyr: 3.166 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.648MetAla: 2.648 ± 0.047	0.135MetCys: 0.135 ± 0.011	1.689MetAsp: 1.689 ± 0.039	2.229MetGlu: 2.229 ± 0.044	1.083MetPhe: 1.083 ± 0.033	1.859MetGly: 1.859 ± 0.04	0.499MetHis: 0.499 ± 0.02	1.917MetIle: 1.917 ± 0.043	2.446MetLys: 2.446 ± 0.048	2.521MetLeu: 2.521 ± 0.047	0.85MetMet: 0.85 ± 0.029	1.404MetAsn: 1.404 ± 0.035	1.228MetPro: 1.228 ± 0.034	0.983MetGln: 0.983 ± 0.026	1.145MetArg: 1.145 ± 0.035	1.54MetSer: 1.54 ± 0.038	1.783MetThr: 1.783 ± 0.044	1.821MetVal: 1.821 ± 0.039	0.198MetTrp: 0.198 ± 0.014	0.754MetTyr: 0.754 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.992AsnAla: 2.992 ± 0.05	0.277AsnCys: 0.277 ± 0.016	1.853AsnAsp: 1.853 ± 0.043	2.984AsnGlu: 2.984 ± 0.056	1.604AsnPhe: 1.604 ± 0.043	3.215AsnGly: 3.215 ± 0.055	0.796AsnHis: 0.796 ± 0.026	2.6AsnIle: 2.6 ± 0.059	2.156AsnLys: 2.156 ± 0.047	3.55AsnLeu: 3.55 ± 0.057	1.146AsnMet: 1.146 ± 0.03	1.42AsnAsn: 1.42 ± 0.038	2.074AsnPro: 2.074 ± 0.041	1.403AsnGln: 1.403 ± 0.035	1.882AsnArg: 1.882 ± 0.044	2.109AsnSer: 2.109 ± 0.047	1.841AsnThr: 1.841 ± 0.038	2.651AsnVal: 2.651 ± 0.056	0.46AsnTrp: 0.46 ± 0.019	1.341AsnTyr: 1.341 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.265ProAla: 3.265 ± 0.057	0.172ProCys: 0.172 ± 0.013	2.206ProAsp: 2.206 ± 0.041	3.81ProGlu: 3.81 ± 0.053	2.017ProPhe: 2.017 ± 0.037	2.608ProGly: 2.608 ± 0.048	0.861ProHis: 0.861 ± 0.027	2.587ProIle: 2.587 ± 0.054	2.183ProLys: 2.183 ± 0.044	3.724ProLeu: 3.724 ± 0.058	0.944ProMet: 0.944 ± 0.031	1.533ProAsn: 1.533 ± 0.034	1.071ProPro: 1.071 ± 0.03	1.225ProGln: 1.225 ± 0.033	1.134ProArg: 1.134 ± 0.037	2.164ProSer: 2.164 ± 0.04	1.786ProThr: 1.786 ± 0.042	3.322ProVal: 3.322 ± 0.06	0.36ProTrp: 0.36 ± 0.018	1.349ProTyr: 1.349 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.221GlnAla: 3.221 ± 0.057	0.164GlnCys: 0.164 ± 0.012	1.638GlnAsp: 1.638 ± 0.035	2.98GlnGlu: 2.98 ± 0.052	1.587GlnPhe: 1.587 ± 0.036	2.242GlnGly: 2.242 ± 0.054	0.746GlnHis: 0.746 ± 0.025	2.308GlnIle: 2.308 ± 0.048	2.493GlnLys: 2.493 ± 0.049	3.901GlnLeu: 3.901 ± 0.074	1.185GlnMet: 1.185 ± 0.036	1.561GlnAsn: 1.561 ± 0.042	1.349GlnPro: 1.349 ± 0.034	1.927GlnGln: 1.927 ± 0.045	1.542GlnArg: 1.542 ± 0.041	1.953GlnSer: 1.953 ± 0.048	2.041GlnThr: 2.041 ± 0.043	2.451GlnVal: 2.451 ± 0.047	0.448GlnTrp: 0.448 ± 0.02	1.208GlnTyr: 1.208 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.759ArgAla: 2.759 ± 0.045	0.251ArgCys: 0.251 ± 0.016	2.092ArgAsp: 2.092 ± 0.046	3.299ArgGlu: 3.299 ± 0.054	2.093ArgPhe: 2.093 ± 0.044	2.431ArgGly: 2.431 ± 0.05	0.886ArgHis: 0.886 ± 0.033	3.177ArgIle: 3.177 ± 0.052	3.062ArgLys: 3.062 ± 0.056	4.387ArgLeu: 4.387 ± 0.07	1.341ArgMet: 1.341 ± 0.036	1.759ArgAsn: 1.759 ± 0.034	1.494ArgPro: 1.494 ± 0.035	1.712ArgGln: 1.712 ± 0.04	1.885ArgArg: 1.885 ± 0.044	2.384ArgSer: 2.384 ± 0.043	2.205ArgThr: 2.205 ± 0.048	2.816ArgVal: 2.816 ± 0.053	0.401ArgTrp: 0.401 ± 0.018	1.498ArgTyr: 1.498 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.545SerAla: 4.545 ± 0.06	0.342SerCys: 0.342 ± 0.018	2.81SerAsp: 2.81 ± 0.059	3.923SerGlu: 3.923 ± 0.062	3.11SerPhe: 3.11 ± 0.051	5.059SerGly: 5.059 ± 0.081	1.21SerHis: 1.21 ± 0.032	4.312SerIle: 4.312 ± 0.062	3.218SerLys: 3.218 ± 0.058	5.961SerLeu: 5.961 ± 0.086	1.7SerMet: 1.7 ± 0.037	2.119SerAsn: 2.119 ± 0.046	2.111SerPro: 2.111 ± 0.047	1.853SerGln: 1.853 ± 0.043	2.496SerArg: 2.496 ± 0.043	3.713SerSer: 3.713 ± 0.057	2.938SerThr: 2.938 ± 0.047	4.117SerVal: 4.117 ± 0.06	0.646SerTrp: 0.646 ± 0.026	2.064SerTyr: 2.064 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.968ThrAla: 4.968 ± 0.076	0.277ThrCys: 0.277 ± 0.015	2.829ThrAsp: 2.829 ± 0.049	3.984ThrGlu: 3.984 ± 0.064	2.362ThrPhe: 2.362 ± 0.046	4.53ThrGly: 4.53 ± 0.059	1.107ThrHis: 1.107 ± 0.036	4.024ThrIle: 4.024 ± 0.056	2.828ThrLys: 2.828 ± 0.05	5.003ThrLeu: 5.003 ± 0.068	1.324ThrMet: 1.324 ± 0.031	1.875ThrAsn: 1.875 ± 0.045	2.298ThrPro: 2.298 ± 0.049	1.449ThrGln: 1.449 ± 0.032	1.856ThrArg: 1.856 ± 0.041	2.926ThrSer: 2.926 ± 0.053	2.688ThrThr: 2.688 ± 0.052	4.48ThrVal: 4.48 ± 0.068	0.528ThrTrp: 0.528 ± 0.024	1.849ThrTyr: 1.849 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.739ValAla: 5.739 ± 0.074	0.527ValCys: 0.527 ± 0.026	3.71ValAsp: 3.71 ± 0.058	5.142ValGlu: 5.142 ± 0.081	3.395ValPhe: 3.395 ± 0.056	4.689ValGly: 4.689 ± 0.08	1.441ValHis: 1.441 ± 0.037	5.134ValIle: 5.134 ± 0.07	4.189ValLys: 4.189 ± 0.076	7.603ValLeu: 7.603 ± 0.094	2.036ValMet: 2.036 ± 0.044	2.731ValAsn: 2.731 ± 0.052	2.982ValPro: 2.982 ± 0.061	2.509ValGln: 2.509 ± 0.046	2.856ValArg: 2.856 ± 0.051	4.573ValSer: 4.573 ± 0.063	3.988ValThr: 3.988 ± 0.063	5.204ValVal: 5.204 ± 0.077	0.679ValTrp: 0.679 ± 0.029	2.349ValTyr: 2.349 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.719TrpAla: 0.719 ± 0.024	0.059TrpCys: 0.059 ± 0.007	0.508TrpAsp: 0.508 ± 0.025	0.688TrpGlu: 0.688 ± 0.026	0.504TrpPhe: 0.504 ± 0.023	0.708TrpGly: 0.708 ± 0.023	0.238TrpHis: 0.238 ± 0.016	0.773TrpIle: 0.773 ± 0.029	0.689TrpLys: 0.689 ± 0.026	1.219TrpLeu: 1.219 ± 0.033	0.383TrpMet: 0.383 ± 0.018	0.543TrpAsn: 0.543 ± 0.024	0.312TrpPro: 0.312 ± 0.018	0.468TrpGln: 0.468 ± 0.021	0.429TrpArg: 0.429 ± 0.02	0.6TrpSer: 0.6 ± 0.026	0.61TrpThr: 0.61 ± 0.023	0.662TrpVal: 0.662 ± 0.025	0.141TrpTrp: 0.141 ± 0.012	0.315TrpTyr: 0.315 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.048	0.26TyrCys: 0.26 ± 0.017	1.828TyrAsp: 1.828 ± 0.045	2.485TyrGlu: 2.485 ± 0.041	1.766TyrPhe: 1.766 ± 0.042	2.591TyrGly: 2.591 ± 0.051	0.668TyrHis: 0.668 ± 0.029	2.099TyrIle: 2.099 ± 0.043	1.756TyrLys: 1.756 ± 0.042	3.244TyrLeu: 3.244 ± 0.06	0.837TyrMet: 0.837 ± 0.025	1.222TyrAsn: 1.222 ± 0.033	1.389TyrPro: 1.389 ± 0.034	1.258TyrGln: 1.258 ± 0.03	1.653TyrArg: 1.653 ± 0.043	2.006TyrSer: 2.006 ± 0.046	1.811TyrThr: 1.811 ± 0.035	2.047TyrVal: 2.047 ± 0.044	0.392TyrTrp: 0.392 ± 0.018	1.296TyrTyr: 1.296 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3811 proteins (1129360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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