Amino acid dipepetide frequency for Halovirus HRTV-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.494AlaAla: 10.494 ± 1.097
0.794AlaCys: 0.794 ± 0.264
10.406AlaAsp: 10.406 ± 1.058
8.025AlaGlu: 8.025 ± 1.093
2.381AlaPhe: 2.381 ± 0.343
7.407AlaGly: 7.407 ± 0.833
2.028AlaHis: 2.028 ± 0.544
4.497AlaIle: 4.497 ± 0.599
2.998AlaLys: 2.998 ± 0.543
7.055AlaLeu: 7.055 ± 0.825
1.852AlaMet: 1.852 ± 0.391
3.086AlaAsn: 3.086 ± 0.629
3.086AlaPro: 3.086 ± 0.408
2.646AlaGln: 2.646 ± 0.443
6.261AlaArg: 6.261 ± 0.891
5.82AlaSer: 5.82 ± 0.806
8.113AlaThr: 8.113 ± 1.047
6.526AlaVal: 6.526 ± 0.849
1.323AlaTrp: 1.323 ± 0.328
2.469AlaTyr: 2.469 ± 0.453
0.0AlaXaa: 0.0 ± 0.0
Cys
0.705CysAla: 0.705 ± 0.291
0.088CysCys: 0.088 ± 0.104
1.764CysAsp: 1.764 ± 0.651
1.058CysGlu: 1.058 ± 0.399
0.088CysPhe: 0.088 ± 0.077
1.499CysGly: 1.499 ± 0.454
0.176CysHis: 0.176 ± 0.136
0.353CysIle: 0.353 ± 0.165
0.265CysLys: 0.265 ± 0.156
0.176CysLeu: 0.176 ± 0.122
0.0CysMet: 0.0 ± 0.0
0.265CysAsn: 0.265 ± 0.175
0.97CysPro: 0.97 ± 0.421
0.529CysGln: 0.529 ± 0.219
0.529CysArg: 0.529 ± 0.222
0.529CysSer: 0.529 ± 0.36
0.441CysThr: 0.441 ± 0.179
0.97CysVal: 0.97 ± 0.413
0.265CysTrp: 0.265 ± 0.147
0.088CysTyr: 0.088 ± 0.095
0.0CysXaa: 0.0 ± 0.0
Asp
11.552AspAla: 11.552 ± 1.147
0.794AspCys: 0.794 ± 0.273
9.524AspAsp: 9.524 ± 1.264
8.642AspGlu: 8.642 ± 1.107
2.822AspPhe: 2.822 ± 0.511
9.788AspGly: 9.788 ± 1.053
2.293AspHis: 2.293 ± 0.541
3.263AspIle: 3.263 ± 0.587
2.205AspLys: 2.205 ± 0.503
7.407AspLeu: 7.407 ± 1.11
3.086AspMet: 3.086 ± 0.662
2.998AspAsn: 2.998 ± 0.529
4.233AspPro: 4.233 ± 0.786
2.028AspGln: 2.028 ± 0.442
4.409AspArg: 4.409 ± 0.651
4.762AspSer: 4.762 ± 0.551
7.937AspThr: 7.937 ± 0.94
6.437AspVal: 6.437 ± 0.807
1.499AspTrp: 1.499 ± 0.369
3.086AspTyr: 3.086 ± 0.595
0.0AspXaa: 0.0 ± 0.0
Glu
7.937GluAla: 7.937 ± 0.956
1.587GluCys: 1.587 ± 0.471
5.291GluAsp: 5.291 ± 1.15
4.674GluGlu: 4.674 ± 0.911
2.381GluPhe: 2.381 ± 0.402
5.203GluGly: 5.203 ± 0.871
1.94GluHis: 1.94 ± 0.472
3.527GluIle: 3.527 ± 0.591
1.764GluLys: 1.764 ± 0.442
7.231GluLeu: 7.231 ± 0.863
3.616GluMet: 3.616 ± 0.566
2.116GluAsn: 2.116 ± 0.386
2.028GluPro: 2.028 ± 0.418
2.91GluGln: 2.91 ± 0.623
6.878GluArg: 6.878 ± 1.008
4.145GluSer: 4.145 ± 0.534
5.732GluThr: 5.732 ± 0.755
6.966GluVal: 6.966 ± 0.745
2.293GluTrp: 2.293 ± 0.566
3.263GluTyr: 3.263 ± 0.553
0.0GluXaa: 0.0 ± 0.0
Phe
2.469PheAla: 2.469 ± 0.574
0.176PheCys: 0.176 ± 0.121
3.704PheAsp: 3.704 ± 0.573
2.381PheGlu: 2.381 ± 0.536
0.617PhePhe: 0.617 ± 0.199
2.469PheGly: 2.469 ± 0.453
0.265PheHis: 0.265 ± 0.151
0.353PheIle: 0.353 ± 0.162
1.499PheLys: 1.499 ± 0.328
1.411PheLeu: 1.411 ± 0.377
0.265PheMet: 0.265 ± 0.163
1.146PheAsn: 1.146 ± 0.298
1.323PhePro: 1.323 ± 0.373
0.353PheGln: 0.353 ± 0.155
3.086PheArg: 3.086 ± 0.547
1.764PheSer: 1.764 ± 0.396
2.293PheThr: 2.293 ± 0.407
1.411PheVal: 1.411 ± 0.417
0.265PheTrp: 0.265 ± 0.156
0.529PheTyr: 0.529 ± 0.182
0.0PheXaa: 0.0 ± 0.0
Gly
6.79GlyAla: 6.79 ± 0.586
0.441GlyCys: 0.441 ± 0.267
8.554GlyAsp: 8.554 ± 1.082
8.025GlyGlu: 8.025 ± 0.799
1.94GlyPhe: 1.94 ± 0.381
7.76GlyGly: 7.76 ± 1.178
1.235GlyHis: 1.235 ± 0.316
2.028GlyIle: 2.028 ± 0.382
2.293GlyLys: 2.293 ± 0.539
4.938GlyLeu: 4.938 ± 0.609
1.058GlyMet: 1.058 ± 0.286
2.646GlyAsn: 2.646 ± 0.469
2.469GlyPro: 2.469 ± 0.369
2.293GlyGln: 2.293 ± 0.446
4.674GlyArg: 4.674 ± 0.651
4.409GlySer: 4.409 ± 0.701
7.231GlyThr: 7.231 ± 0.992
6.437GlyVal: 6.437 ± 0.835
1.94GlyTrp: 1.94 ± 0.459
2.293GlyTyr: 2.293 ± 0.534
0.0GlyXaa: 0.0 ± 0.0
His
1.852HisAla: 1.852 ± 0.432
0.265HisCys: 0.265 ± 0.171
1.852HisAsp: 1.852 ± 0.498
1.94HisGlu: 1.94 ± 0.459
0.353HisPhe: 0.353 ± 0.162
2.116HisGly: 2.116 ± 0.653
0.617HisHis: 0.617 ± 0.254
0.882HisIle: 0.882 ± 0.276
0.794HisLys: 0.794 ± 0.254
1.764HisLeu: 1.764 ± 0.497
0.353HisMet: 0.353 ± 0.184
0.705HisAsn: 0.705 ± 0.305
0.794HisPro: 0.794 ± 0.267
0.617HisGln: 0.617 ± 0.221
0.97HisArg: 0.97 ± 0.288
0.529HisSer: 0.529 ± 0.188
2.381HisThr: 2.381 ± 0.563
1.94HisVal: 1.94 ± 0.555
0.0HisTrp: 0.0 ± 0.0
0.705HisTyr: 0.705 ± 0.241
0.0HisXaa: 0.0 ± 0.0
Ile
2.998IleAla: 2.998 ± 0.534
0.176IleCys: 0.176 ± 0.117
4.409IleAsp: 4.409 ± 0.603
3.527IleGlu: 3.527 ± 0.682
0.97IlePhe: 0.97 ± 0.275
2.469IleGly: 2.469 ± 0.472
0.794IleHis: 0.794 ± 0.267
0.97IleIle: 0.97 ± 0.272
1.499IleLys: 1.499 ± 0.327
1.94IleLeu: 1.94 ± 0.511
0.617IleMet: 0.617 ± 0.229
1.852IleAsn: 1.852 ± 0.473
1.94IlePro: 1.94 ± 0.375
1.852IleGln: 1.852 ± 0.338
3.086IleArg: 3.086 ± 0.596
1.587IleSer: 1.587 ± 0.336
3.704IleThr: 3.704 ± 0.594
1.675IleVal: 1.675 ± 0.35
0.265IleTrp: 0.265 ± 0.155
0.882IleTyr: 0.882 ± 0.26
0.0IleXaa: 0.0 ± 0.0
Lys
2.998LysAla: 2.998 ± 0.589
0.529LysCys: 0.529 ± 0.266
2.028LysAsp: 2.028 ± 0.418
2.734LysGlu: 2.734 ± 0.47
1.058LysPhe: 1.058 ± 0.359
1.852LysGly: 1.852 ± 0.439
1.323LysHis: 1.323 ± 0.429
1.058LysIle: 1.058 ± 0.25
0.97LysLys: 0.97 ± 0.316
2.822LysLeu: 2.822 ± 0.495
0.353LysMet: 0.353 ± 0.212
0.794LysAsn: 0.794 ± 0.263
1.587LysPro: 1.587 ± 0.452
1.058LysGln: 1.058 ± 0.285
2.028LysArg: 2.028 ± 0.439
2.381LysSer: 2.381 ± 0.395
2.116LysThr: 2.116 ± 0.451
1.675LysVal: 1.675 ± 0.372
0.529LysTrp: 0.529 ± 0.265
1.323LysTyr: 1.323 ± 0.394
0.0LysXaa: 0.0 ± 0.0
Leu
6.702LeuAla: 6.702 ± 0.769
0.353LeuCys: 0.353 ± 0.178
6.085LeuAsp: 6.085 ± 0.817
6.702LeuGlu: 6.702 ± 0.922
1.764LeuPhe: 1.764 ± 0.394
4.321LeuGly: 4.321 ± 0.671
1.235LeuHis: 1.235 ± 0.381
2.734LeuIle: 2.734 ± 0.507
2.028LeuLys: 2.028 ± 0.382
4.145LeuLeu: 4.145 ± 0.553
1.764LeuMet: 1.764 ± 0.486
2.381LeuAsn: 2.381 ± 0.579
2.646LeuPro: 2.646 ± 0.516
2.734LeuGln: 2.734 ± 0.462
5.026LeuArg: 5.026 ± 0.986
5.379LeuSer: 5.379 ± 0.712
6.437LeuThr: 6.437 ± 0.807
3.351LeuVal: 3.351 ± 0.605
0.176LeuTrp: 0.176 ± 0.122
1.499LeuTyr: 1.499 ± 0.395
0.0LeuXaa: 0.0 ± 0.0
Met
2.116MetAla: 2.116 ± 0.402
0.353MetCys: 0.353 ± 0.212
2.028MetAsp: 2.028 ± 0.59
1.587MetGlu: 1.587 ± 0.516
0.882MetPhe: 0.882 ± 0.302
1.323MetGly: 1.323 ± 0.33
0.441MetHis: 0.441 ± 0.177
0.617MetIle: 0.617 ± 0.267
0.882MetLys: 0.882 ± 0.335
1.323MetLeu: 1.323 ± 0.34
0.441MetMet: 0.441 ± 0.189
0.353MetAsn: 0.353 ± 0.184
1.146MetPro: 1.146 ± 0.303
0.441MetGln: 0.441 ± 0.211
0.97MetArg: 0.97 ± 0.272
3.439MetSer: 3.439 ± 0.651
1.764MetThr: 1.764 ± 0.448
0.97MetVal: 0.97 ± 0.272
0.529MetTrp: 0.529 ± 0.238
0.441MetTyr: 0.441 ± 0.195
0.0MetXaa: 0.0 ± 0.0
Asn
3.792AsnAla: 3.792 ± 0.534
0.441AsnCys: 0.441 ± 0.218
4.145AsnAsp: 4.145 ± 0.741
2.91AsnGlu: 2.91 ± 0.475
0.441AsnPhe: 0.441 ± 0.193
3.351AsnGly: 3.351 ± 0.62
1.058AsnHis: 1.058 ± 0.325
1.323AsnIle: 1.323 ± 0.428
0.97AsnLys: 0.97 ± 0.351
2.646AsnLeu: 2.646 ± 0.594
0.529AsnMet: 0.529 ± 0.2
1.058AsnAsn: 1.058 ± 0.35
2.116AsnPro: 2.116 ± 0.386
0.97AsnGln: 0.97 ± 0.247
1.94AsnArg: 1.94 ± 0.433
1.852AsnSer: 1.852 ± 0.407
2.116AsnThr: 2.116 ± 0.562
2.734AsnVal: 2.734 ± 0.442
0.529AsnTrp: 0.529 ± 0.249
0.617AsnTyr: 0.617 ± 0.227
0.0AsnXaa: 0.0 ± 0.0
Pro
3.616ProAla: 3.616 ± 0.731
0.265ProCys: 0.265 ± 0.168
4.586ProAsp: 4.586 ± 0.68
3.616ProGlu: 3.616 ± 0.522
1.235ProPhe: 1.235 ± 0.255
3.263ProGly: 3.263 ± 0.474
0.617ProHis: 0.617 ± 0.214
2.028ProIle: 2.028 ± 0.509
0.882ProLys: 0.882 ± 0.266
2.293ProLeu: 2.293 ± 0.497
1.058ProMet: 1.058 ± 0.292
1.675ProAsn: 1.675 ± 0.383
2.91ProPro: 2.91 ± 0.552
1.852ProGln: 1.852 ± 0.342
2.116ProArg: 2.116 ± 0.437
2.822ProSer: 2.822 ± 0.612
3.527ProThr: 3.527 ± 0.572
3.263ProVal: 3.263 ± 0.5
0.882ProTrp: 0.882 ± 0.247
0.441ProTyr: 0.441 ± 0.177
0.0ProXaa: 0.0 ± 0.0
Gln
3.527GlnAla: 3.527 ± 0.707
0.088GlnCys: 0.088 ± 0.098
2.734GlnAsp: 2.734 ± 0.431
2.469GlnGlu: 2.469 ± 0.433
1.499GlnPhe: 1.499 ± 0.434
2.469GlnGly: 2.469 ± 0.537
0.617GlnHis: 0.617 ± 0.247
1.411GlnIle: 1.411 ± 0.34
0.882GlnLys: 0.882 ± 0.336
2.91GlnLeu: 2.91 ± 0.547
0.441GlnMet: 0.441 ± 0.196
0.794GlnAsn: 0.794 ± 0.257
1.235GlnPro: 1.235 ± 0.348
0.794GlnGln: 0.794 ± 0.233
2.381GlnArg: 2.381 ± 0.492
1.058GlnSer: 1.058 ± 0.377
2.646GlnThr: 2.646 ± 0.449
1.499GlnVal: 1.499 ± 0.384
0.088GlnTrp: 0.088 ± 0.07
1.411GlnTyr: 1.411 ± 0.437
0.0GlnXaa: 0.0 ± 0.0
Arg
5.556ArgAla: 5.556 ± 0.788
1.058ArgCys: 1.058 ± 0.358
5.115ArgAsp: 5.115 ± 0.666
6.085ArgGlu: 6.085 ± 0.643
1.94ArgPhe: 1.94 ± 0.445
3.968ArgGly: 3.968 ± 0.551
1.675ArgHis: 1.675 ± 0.407
2.116ArgIle: 2.116 ± 0.43
2.91ArgLys: 2.91 ± 0.637
3.086ArgLeu: 3.086 ± 0.578
1.94ArgMet: 1.94 ± 0.481
2.557ArgAsn: 2.557 ± 0.49
2.557ArgPro: 2.557 ± 0.537
1.94ArgGln: 1.94 ± 0.445
4.938ArgArg: 4.938 ± 0.624
3.527ArgSer: 3.527 ± 0.657
3.616ArgThr: 3.616 ± 0.57
5.379ArgVal: 5.379 ± 0.657
0.529ArgTrp: 0.529 ± 0.201
1.94ArgTyr: 1.94 ± 0.399
0.0ArgXaa: 0.0 ± 0.0
Ser
5.379SerAla: 5.379 ± 0.598
0.529SerCys: 0.529 ± 0.207
6.79SerAsp: 6.79 ± 0.739
3.527SerGlu: 3.527 ± 0.522
1.411SerPhe: 1.411 ± 0.401
6.261SerGly: 6.261 ± 0.967
0.529SerHis: 0.529 ± 0.236
2.646SerIle: 2.646 ± 0.465
2.469SerLys: 2.469 ± 0.538
3.88SerLeu: 3.88 ± 0.648
0.705SerMet: 0.705 ± 0.258
2.205SerAsn: 2.205 ± 0.387
2.822SerPro: 2.822 ± 0.43
2.469SerGln: 2.469 ± 0.495
2.381SerArg: 2.381 ± 0.596
2.734SerSer: 2.734 ± 0.475
4.233SerThr: 4.233 ± 0.521
4.497SerVal: 4.497 ± 0.56
0.705SerTrp: 0.705 ± 0.245
1.499SerTyr: 1.499 ± 0.411
0.0SerXaa: 0.0 ± 0.0
Thr
8.907ThrAla: 8.907 ± 0.999
0.794ThrCys: 0.794 ± 0.376
8.113ThrAsp: 8.113 ± 0.819
4.497ThrGlu: 4.497 ± 0.568
3.086ThrPhe: 3.086 ± 0.527
5.996ThrGly: 5.996 ± 0.841
2.028ThrHis: 2.028 ± 0.434
4.145ThrIle: 4.145 ± 0.676
1.411ThrLys: 1.411 ± 0.328
5.732ThrLeu: 5.732 ± 0.868
0.882ThrMet: 0.882 ± 0.351
3.175ThrAsn: 3.175 ± 0.66
4.674ThrPro: 4.674 ± 0.689
2.381ThrGln: 2.381 ± 0.601
4.233ThrArg: 4.233 ± 0.708
2.998ThrSer: 2.998 ± 0.496
6.349ThrThr: 6.349 ± 1.413
7.407ThrVal: 7.407 ± 0.784
1.058ThrTrp: 1.058 ± 0.413
2.205ThrTyr: 2.205 ± 0.547
0.0ThrXaa: 0.0 ± 0.0
Val
6.261ValAla: 6.261 ± 0.85
1.235ValCys: 1.235 ± 0.4
7.848ValAsp: 7.848 ± 1.091
6.173ValGlu: 6.173 ± 0.791
1.764ValPhe: 1.764 ± 0.318
4.938ValGly: 4.938 ± 0.688
1.323ValHis: 1.323 ± 0.316
1.852ValIle: 1.852 ± 0.451
2.469ValLys: 2.469 ± 0.518
3.792ValLeu: 3.792 ± 0.55
1.94ValMet: 1.94 ± 0.576
3.792ValAsn: 3.792 ± 0.76
2.822ValPro: 2.822 ± 0.585
1.675ValGln: 1.675 ± 0.36
3.88ValArg: 3.88 ± 0.599
5.379ValSer: 5.379 ± 0.845
6.261ValThr: 6.261 ± 0.774
5.996ValVal: 5.996 ± 0.815
1.411ValTrp: 1.411 ± 0.382
2.028ValTyr: 2.028 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
1.411TrpAla: 1.411 ± 0.406
0.088TrpCys: 0.088 ± 0.093
1.411TrpAsp: 1.411 ± 0.276
0.882TrpGlu: 0.882 ± 0.265
0.617TrpPhe: 0.617 ± 0.231
0.529TrpGly: 0.529 ± 0.161
0.441TrpHis: 0.441 ± 0.226
0.353TrpIle: 0.353 ± 0.206
0.529TrpLys: 0.529 ± 0.203
1.323TrpLeu: 1.323 ± 0.366
0.705TrpMet: 0.705 ± 0.262
0.794TrpAsn: 0.794 ± 0.239
0.617TrpPro: 0.617 ± 0.238
0.265TrpGln: 0.265 ± 0.142
0.617TrpArg: 0.617 ± 0.223
1.146TrpSer: 1.146 ± 0.336
1.146TrpThr: 1.146 ± 0.349
1.323TrpVal: 1.323 ± 0.381
0.088TrpTrp: 0.088 ± 0.094
0.617TrpTyr: 0.617 ± 0.2
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.205TyrAla: 2.205 ± 0.395
0.705TyrCys: 0.705 ± 0.258
2.381TyrAsp: 2.381 ± 0.406
2.116TyrGlu: 2.116 ± 0.44
0.529TyrPhe: 0.529 ± 0.195
2.469TyrGly: 2.469 ± 0.53
0.794TyrHis: 0.794 ± 0.373
1.058TyrIle: 1.058 ± 0.357
1.499TyrLys: 1.499 ± 0.372
1.587TyrLeu: 1.587 ± 0.397
0.353TyrMet: 0.353 ± 0.178
1.146TyrAsn: 1.146 ± 0.299
0.97TyrPro: 0.97 ± 0.268
1.146TyrGln: 1.146 ± 0.308
2.028TyrArg: 2.028 ± 0.368
1.411TyrSer: 1.411 ± 0.357
2.028TyrThr: 2.028 ± 0.449
2.381TyrVal: 2.381 ± 0.458
0.529TyrTrp: 0.529 ± 0.186
0.441TyrTyr: 0.441 ± 0.189
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (11341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski