Amino acid dipepetide frequency for Promicromonospora thailandica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.257AlaAla: 23.257 ± 0.188	0.788AlaCys: 0.788 ± 0.019	9.43AlaAsp: 9.43 ± 0.083	8.441AlaGlu: 8.441 ± 0.092	3.401AlaPhe: 3.401 ± 0.045	15.189AlaGly: 15.189 ± 0.106	2.613AlaHis: 2.613 ± 0.043	3.62AlaIle: 3.62 ± 0.052	1.939AlaLys: 1.939 ± 0.042	14.366AlaLeu: 14.366 ± 0.131	2.485AlaMet: 2.485 ± 0.042	1.949AlaAsn: 1.949 ± 0.036	7.926AlaPro: 7.926 ± 0.106	3.853AlaGln: 3.853 ± 0.049	11.0AlaArg: 11.0 ± 0.114	6.344AlaSer: 6.344 ± 0.065	8.416AlaThr: 8.416 ± 0.083	13.586AlaVal: 13.586 ± 0.109	2.267AlaTrp: 2.267 ± 0.04	2.444AlaTyr: 2.444 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.739CysAla: 0.739 ± 0.022	0.049CysCys: 0.049 ± 0.006	0.342CysAsp: 0.342 ± 0.012	0.278CysGlu: 0.278 ± 0.013	0.141CysPhe: 0.141 ± 0.01	0.638CysGly: 0.638 ± 0.021	0.114CysHis: 0.114 ± 0.008	0.1CysIle: 0.1 ± 0.008	0.05CysLys: 0.05 ± 0.005	0.477CysLeu: 0.477 ± 0.014	0.081CysMet: 0.081 ± 0.007	0.1CysAsn: 0.1 ± 0.008	0.328CysPro: 0.328 ± 0.013	0.105CysGln: 0.105 ± 0.008	0.339CysArg: 0.339 ± 0.014	0.292CysSer: 0.292 ± 0.013	0.371CysThr: 0.371 ± 0.015	0.458CysVal: 0.458 ± 0.017	0.078CysTrp: 0.078 ± 0.008	0.107CysTyr: 0.107 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	9.097AspAla: 9.097 ± 0.082	0.267AspCys: 0.267 ± 0.012	4.605AspAsp: 4.605 ± 0.052	4.087AspGlu: 4.087 ± 0.051	1.402AspPhe: 1.402 ± 0.026	7.733AspGly: 7.733 ± 0.094	1.386AspHis: 1.386 ± 0.033	1.544AspIle: 1.544 ± 0.032	0.812AspLys: 0.812 ± 0.026	7.014AspLeu: 7.014 ± 0.069	0.716AspMet: 0.716 ± 0.021	0.822AspAsn: 0.822 ± 0.024	4.825AspPro: 4.825 ± 0.06	1.693AspGln: 1.693 ± 0.032	4.801AspArg: 4.801 ± 0.055	2.177AspSer: 2.177 ± 0.036	2.98AspThr: 2.98 ± 0.046	6.545AspVal: 6.545 ± 0.069	0.969AspTrp: 0.969 ± 0.024	1.135AspTyr: 1.135 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.381GluAla: 7.381 ± 0.084	0.256GluCys: 0.256 ± 0.013	2.72GluAsp: 2.72 ± 0.044	2.883GluGlu: 2.883 ± 0.048	1.29GluPhe: 1.29 ± 0.026	3.97GluGly: 3.97 ± 0.057	1.661GluHis: 1.661 ± 0.03	2.169GluIle: 2.169 ± 0.03	1.024GluLys: 1.024 ± 0.029	6.125GluLeu: 6.125 ± 0.057	0.791GluMet: 0.791 ± 0.022	1.023GluAsn: 1.023 ± 0.024	3.859GluPro: 3.859 ± 0.06	2.115GluGln: 2.115 ± 0.036	5.207GluArg: 5.207 ± 0.057	2.44GluSer: 2.44 ± 0.037	2.976GluThr: 2.976 ± 0.045	4.988GluVal: 4.988 ± 0.061	0.768GluTrp: 0.768 ± 0.022	1.103GluTyr: 1.103 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.652PheAla: 3.652 ± 0.053	0.153PheCys: 0.153 ± 0.011	1.944PheAsp: 1.944 ± 0.038	1.489PheGlu: 1.489 ± 0.029	0.821PhePhe: 0.821 ± 0.024	2.937PheGly: 2.937 ± 0.044	0.537PheHis: 0.537 ± 0.016	0.594PheIle: 0.594 ± 0.019	0.347PheLys: 0.347 ± 0.015	2.53PheLeu: 2.53 ± 0.042	0.364PheMet: 0.364 ± 0.012	0.481PheAsn: 0.481 ± 0.016	1.316PhePro: 1.316 ± 0.03	0.65PheGln: 0.65 ± 0.017	1.631PheArg: 1.631 ± 0.031	1.336PheSer: 1.336 ± 0.03	1.849PheThr: 1.849 ± 0.034	2.584PheVal: 2.584 ± 0.043	0.491PheTrp: 0.491 ± 0.019	0.603PheTyr: 0.603 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	12.761GlyAla: 12.761 ± 0.108	0.566GlyCys: 0.566 ± 0.019	5.643GlyAsp: 5.643 ± 0.065	5.046GlyGlu: 5.046 ± 0.062	2.818GlyPhe: 2.818 ± 0.045	9.13GlyGly: 9.13 ± 0.099	2.09GlyHis: 2.09 ± 0.036	3.45GlyIle: 3.45 ± 0.047	1.737GlyLys: 1.737 ± 0.036	9.822GlyLeu: 9.822 ± 0.093	1.917GlyMet: 1.917 ± 0.038	1.629GlyAsn: 1.629 ± 0.035	5.684GlyPro: 5.684 ± 0.068	2.687GlyGln: 2.687 ± 0.049	7.428GlyArg: 7.428 ± 0.079	5.585GlySer: 5.585 ± 0.074	7.18GlyThr: 7.18 ± 0.072	8.612GlyVal: 8.612 ± 0.083	1.847GlyTrp: 1.847 ± 0.032	2.354GlyTyr: 2.354 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.537HisAla: 2.537 ± 0.047	0.123HisCys: 0.123 ± 0.007	1.511HisAsp: 1.511 ± 0.033	1.15HisGlu: 1.15 ± 0.023	0.492HisPhe: 0.492 ± 0.016	2.148HisGly: 2.148 ± 0.036	0.552HisHis: 0.552 ± 0.018	0.435HisIle: 0.435 ± 0.018	0.219HisLys: 0.219 ± 0.012	2.334HisLeu: 2.334 ± 0.038	0.286HisMet: 0.286 ± 0.014	0.326HisAsn: 0.326 ± 0.015	1.573HisPro: 1.573 ± 0.034	0.525HisGln: 0.525 ± 0.018	1.711HisArg: 1.711 ± 0.034	0.755HisSer: 0.755 ± 0.02	1.083HisThr: 1.083 ± 0.025	1.959HisVal: 1.959 ± 0.036	0.316HisTrp: 0.316 ± 0.014	0.399HisTyr: 0.399 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.404IleAla: 4.404 ± 0.063	0.172IleCys: 0.172 ± 0.01	2.227IleAsp: 2.227 ± 0.032	2.0IleGlu: 2.0 ± 0.038	0.723IlePhe: 0.723 ± 0.023	3.147IleGly: 3.147 ± 0.048	0.456IleHis: 0.456 ± 0.017	0.829IleIle: 0.829 ± 0.024	0.525IleLys: 0.525 ± 0.019	2.4IleLeu: 2.4 ± 0.047	0.43IleMet: 0.43 ± 0.017	0.61IleAsn: 0.61 ± 0.019	1.61IlePro: 1.61 ± 0.033	0.65IleGln: 0.65 ± 0.02	1.757IleArg: 1.757 ± 0.034	1.489IleSer: 1.489 ± 0.033	2.126IleThr: 2.126 ± 0.042	2.892IleVal: 2.892 ± 0.051	0.359IleTrp: 0.359 ± 0.015	0.515IleTyr: 0.515 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.881LysAla: 1.881 ± 0.039	0.059LysCys: 0.059 ± 0.006	0.976LysAsp: 0.976 ± 0.027	0.792LysGlu: 0.792 ± 0.026	0.36LysPhe: 0.36 ± 0.016	1.192LysGly: 1.192 ± 0.031	0.36LysHis: 0.36 ± 0.015	0.653LysIle: 0.653 ± 0.021	0.47LysLys: 0.47 ± 0.02	1.206LysLeu: 1.206 ± 0.032	0.27LysMet: 0.27 ± 0.014	0.385LysAsn: 0.385 ± 0.016	0.871LysPro: 0.871 ± 0.026	0.472LysGln: 0.472 ± 0.019	0.973LysArg: 0.973 ± 0.025	0.775LysSer: 0.775 ± 0.024	0.884LysThr: 0.884 ± 0.026	1.397LysVal: 1.397 ± 0.034	0.189LysTrp: 0.189 ± 0.01	0.318LysTyr: 0.318 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.956LeuAla: 15.956 ± 0.12	0.538LeuCys: 0.538 ± 0.018	7.305LeuAsp: 7.305 ± 0.069	4.626LeuGlu: 4.626 ± 0.054	2.473LeuPhe: 2.473 ± 0.042	9.65LeuGly: 9.65 ± 0.083	1.891LeuHis: 1.891 ± 0.037	2.533LeuIle: 2.533 ± 0.052	1.21LeuLys: 1.21 ± 0.029	10.422LeuLeu: 10.422 ± 0.127	1.418LeuMet: 1.418 ± 0.035	1.419LeuAsn: 1.419 ± 0.03	6.101LeuPro: 6.101 ± 0.062	2.012LeuGln: 2.012 ± 0.03	8.035LeuArg: 8.035 ± 0.085	4.816LeuSer: 4.816 ± 0.053	6.695LeuThr: 6.695 ± 0.06	10.638LeuVal: 10.638 ± 0.101	1.341LeuTrp: 1.341 ± 0.029	1.585LeuTyr: 1.585 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	1.909MetAla: 1.909 ± 0.033	0.085MetCys: 0.085 ± 0.007	0.76MetAsp: 0.76 ± 0.02	0.602MetGlu: 0.602 ± 0.017	0.47MetPhe: 0.47 ± 0.017	1.143MetGly: 1.143 ± 0.026	0.304MetHis: 0.304 ± 0.014	0.651MetIle: 0.651 ± 0.021	0.26MetLys: 0.26 ± 0.013	1.646MetLeu: 1.646 ± 0.033	0.233MetMet: 0.233 ± 0.011	0.386MetAsn: 0.386 ± 0.015	1.019MetPro: 1.019 ± 0.026	0.399MetGln: 0.399 ± 0.014	1.259MetArg: 1.259 ± 0.028	1.308MetSer: 1.308 ± 0.028	1.674MetThr: 1.674 ± 0.029	1.282MetVal: 1.282 ± 0.028	0.193MetTrp: 0.193 ± 0.01	0.27MetTyr: 0.27 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	1.983AsnAla: 1.983 ± 0.034	0.092AsnCys: 0.092 ± 0.007	0.971AsnAsp: 0.971 ± 0.025	0.786AsnGlu: 0.786 ± 0.021	0.472AsnPhe: 0.472 ± 0.016	1.663AsnGly: 1.663 ± 0.036	0.38AsnHis: 0.38 ± 0.014	0.567AsnIle: 0.567 ± 0.019	0.297AsnLys: 0.297 ± 0.015	1.674AsnLeu: 1.674 ± 0.033	0.251AsnMet: 0.251 ± 0.012	0.383AsnAsn: 0.383 ± 0.019	1.343AsnPro: 1.343 ± 0.027	0.516AsnGln: 0.516 ± 0.019	1.055AsnArg: 1.055 ± 0.022	0.733AsnSer: 0.733 ± 0.022	0.977AsnThr: 0.977 ± 0.025	1.45AsnVal: 1.45 ± 0.029	0.234AsnTrp: 0.234 ± 0.012	0.409AsnTyr: 0.409 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.787ProAla: 9.787 ± 0.1	0.204ProCys: 0.204 ± 0.01	5.053ProAsp: 5.053 ± 0.063	4.248ProGlu: 4.248 ± 0.054	1.578ProPhe: 1.578 ± 0.032	7.393ProGly: 7.393 ± 0.085	1.18ProHis: 1.18 ± 0.024	1.231ProIle: 1.231 ± 0.027	0.705ProLys: 0.705 ± 0.025	4.863ProLeu: 4.863 ± 0.057	0.855ProMet: 0.855 ± 0.022	0.854ProAsn: 0.854 ± 0.024	3.084ProPro: 3.084 ± 0.056	1.536ProGln: 1.536 ± 0.033	3.991ProArg: 3.991 ± 0.052	3.167ProSer: 3.167 ± 0.05	3.511ProThr: 3.511 ± 0.051	6.005ProVal: 6.005 ± 0.065	0.938ProTrp: 0.938 ± 0.026	1.163ProTyr: 1.163 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.715GlnAla: 3.715 ± 0.053	0.115GlnCys: 0.115 ± 0.008	1.517GlnAsp: 1.517 ± 0.031	1.524GlnGlu: 1.524 ± 0.032	0.709GlnPhe: 0.709 ± 0.023	2.216GlnGly: 2.216 ± 0.035	0.558GlnHis: 0.558 ± 0.02	1.029GlnIle: 1.029 ± 0.026	0.433GlnLys: 0.433 ± 0.017	2.464GlnLeu: 2.464 ± 0.036	0.442GlnMet: 0.442 ± 0.015	0.463GlnAsn: 0.463 ± 0.017	1.528GlnPro: 1.528 ± 0.03	1.011GlnGln: 1.011 ± 0.029	2.109GlnArg: 2.109 ± 0.036	1.132GlnSer: 1.132 ± 0.029	1.336GlnThr: 1.336 ± 0.028	2.882GlnVal: 2.882 ± 0.046	0.441GlnTrp: 0.441 ± 0.014	0.565GlnTyr: 0.565 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.302ArgAla: 10.302 ± 0.093	0.347ArgCys: 0.347 ± 0.015	4.412ArgAsp: 4.412 ± 0.058	4.321ArgGlu: 4.321 ± 0.055	2.2ArgPhe: 2.2 ± 0.039	5.789ArgGly: 5.789 ± 0.06	1.731ArgHis: 1.731 ± 0.033	2.625ArgIle: 2.625 ± 0.042	1.148ArgLys: 1.148 ± 0.029	7.962ArgLeu: 7.962 ± 0.077	1.541ArgMet: 1.541 ± 0.032	1.246ArgAsn: 1.246 ± 0.027	4.742ArgPro: 4.742 ± 0.056	1.957ArgGln: 1.957 ± 0.034	7.26ArgArg: 7.26 ± 0.081	4.052ArgSer: 4.052 ± 0.054	5.337ArgThr: 5.337 ± 0.053	6.53ArgVal: 6.53 ± 0.07	1.476ArgTrp: 1.476 ± 0.031	1.733ArgTyr: 1.733 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.935SerAla: 6.935 ± 0.074	0.251SerCys: 0.251 ± 0.012	2.931SerAsp: 2.931 ± 0.047	2.166SerGlu: 2.166 ± 0.037	1.532SerPhe: 1.532 ± 0.029	6.002SerGly: 6.002 ± 0.072	0.842SerHis: 0.842 ± 0.02	1.504SerIle: 1.504 ± 0.03	0.717SerLys: 0.717 ± 0.022	4.552SerLeu: 4.552 ± 0.06	0.956SerMet: 0.956 ± 0.024	0.843SerAsn: 0.843 ± 0.026	3.035SerPro: 3.035 ± 0.042	1.115SerGln: 1.115 ± 0.028	3.427SerArg: 3.427 ± 0.044	2.729SerSer: 2.729 ± 0.048	3.385SerThr: 3.385 ± 0.048	4.34SerVal: 4.34 ± 0.051	0.966SerTrp: 0.966 ± 0.027	1.068SerTyr: 1.068 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.817ThrAla: 8.817 ± 0.082	0.347ThrCys: 0.347 ± 0.015	3.938ThrAsp: 3.938 ± 0.055	3.226ThrGlu: 3.226 ± 0.048	1.918ThrPhe: 1.918 ± 0.031	6.914ThrGly: 6.914 ± 0.071	1.175ThrHis: 1.175 ± 0.024	2.071ThrIle: 2.071 ± 0.036	0.875ThrLys: 0.875 ± 0.025	6.146ThrLeu: 6.146 ± 0.068	0.943ThrMet: 0.943 ± 0.022	1.031ThrAsn: 1.031 ± 0.031	4.448ThrPro: 4.448 ± 0.06	1.505ThrGln: 1.505 ± 0.028	4.113ThrArg: 4.113 ± 0.052	3.487ThrSer: 3.487 ± 0.051	4.615ThrThr: 4.615 ± 0.062	6.567ThrVal: 6.567 ± 0.072	1.166ThrTrp: 1.166 ± 0.023	1.425ThrTyr: 1.425 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	13.866ValAla: 13.866 ± 0.114	0.533ValCys: 0.533 ± 0.018	5.917ValAsp: 5.917 ± 0.06	5.273ValGlu: 5.273 ± 0.055	2.354ValPhe: 2.354 ± 0.043	7.997ValGly: 7.997 ± 0.083	1.881ValHis: 1.881 ± 0.035	2.754ValIle: 2.754 ± 0.048	1.194ValLys: 1.194 ± 0.03	10.758ValLeu: 10.758 ± 0.115	1.338ValMet: 1.338 ± 0.027	1.545ValAsn: 1.545 ± 0.029	6.116ValPro: 6.116 ± 0.067	2.236ValGln: 2.236 ± 0.041	7.663ValArg: 7.663 ± 0.074	4.648ValSer: 4.648 ± 0.062	6.871ValThr: 6.871 ± 0.077	11.104ValVal: 11.104 ± 0.115	1.285ValTrp: 1.285 ± 0.028	1.566ValTyr: 1.566 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.861TrpAla: 1.861 ± 0.038	0.118TrpCys: 0.118 ± 0.008	0.964TrpAsp: 0.964 ± 0.025	0.72TrpGlu: 0.72 ± 0.021	0.584TrpPhe: 0.584 ± 0.02	1.187TrpGly: 1.187 ± 0.027	0.388TrpHis: 0.388 ± 0.014	0.549TrpIle: 0.549 ± 0.019	0.252TrpLys: 0.252 ± 0.013	1.751TrpLeu: 1.751 ± 0.03	0.318TrpMet: 0.318 ± 0.013	0.398TrpAsn: 0.398 ± 0.016	0.837TrpPro: 0.837 ± 0.018	0.549TrpGln: 0.549 ± 0.016	1.306TrpArg: 1.306 ± 0.028	1.082TrpSer: 1.082 ± 0.026	1.206TrpThr: 1.206 ± 0.03	1.276TrpVal: 1.276 ± 0.025	0.396TrpTrp: 0.396 ± 0.016	0.351TrpTyr: 0.351 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.472TyrAla: 2.472 ± 0.036	0.129TyrCys: 0.129 ± 0.009	1.445TyrAsp: 1.445 ± 0.032	1.089TyrGlu: 1.089 ± 0.026	0.571TyrPhe: 0.571 ± 0.019	1.948TyrGly: 1.948 ± 0.04	0.332TyrHis: 0.332 ± 0.014	0.414TyrIle: 0.414 ± 0.016	0.27TyrLys: 0.27 ± 0.013	2.15TyrLeu: 2.15 ± 0.038	0.218TyrMet: 0.218 ± 0.011	0.341TyrAsn: 0.341 ± 0.014	1.102TyrPro: 1.102 ± 0.027	0.601TyrGln: 0.601 ± 0.019	1.647TyrArg: 1.647 ± 0.032	0.949TyrSer: 0.949 ± 0.024	1.255TyrThr: 1.255 ± 0.029	1.802TyrVal: 1.802 ± 0.031	0.376TyrTrp: 0.376 ± 0.015	0.483TyrTyr: 0.483 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5167 proteins (1812030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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