Amino acid dipepetide frequency for Parashewanella spongiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.191AlaAla: 6.191 ± 0.089
1.256AlaCys: 1.256 ± 0.053
4.166AlaAsp: 4.166 ± 0.063
5.36AlaGlu: 5.36 ± 0.096
3.116AlaPhe: 3.116 ± 0.06
4.731AlaGly: 4.731 ± 0.071
1.541AlaHis: 1.541 ± 0.033
5.754AlaIle: 5.754 ± 0.069
5.406AlaLys: 5.406 ± 0.098
7.942AlaLeu: 7.942 ± 0.096
1.989AlaMet: 1.989 ± 0.045
3.492AlaAsn: 3.492 ± 0.057
2.587AlaPro: 2.587 ± 0.062
3.346AlaGln: 3.346 ± 0.057
2.977AlaArg: 2.977 ± 0.048
5.133AlaSer: 5.133 ± 0.072
4.108AlaThr: 4.108 ± 0.062
4.851AlaVal: 4.851 ± 0.063
0.925AlaTrp: 0.925 ± 0.048
2.003AlaTyr: 2.003 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.173CysAla: 1.173 ± 0.081
0.226CysCys: 0.226 ± 0.014
0.673CysAsp: 0.673 ± 0.024
0.656CysGlu: 0.656 ± 0.02
0.582CysPhe: 0.582 ± 0.024
1.068CysGly: 1.068 ± 0.044
0.33CysHis: 0.33 ± 0.015
0.875CysIle: 0.875 ± 0.034
0.646CysLys: 0.646 ± 0.023
1.163CysLeu: 1.163 ± 0.033
0.309CysMet: 0.309 ± 0.026
0.521CysAsn: 0.521 ± 0.02
0.481CysPro: 0.481 ± 0.023
0.548CysGln: 0.548 ± 0.023
0.547CysArg: 0.547 ± 0.021
0.886CysSer: 0.886 ± 0.028
0.604CysThr: 0.604 ± 0.022
0.641CysVal: 0.641 ± 0.02
0.144CysTrp: 0.144 ± 0.013
0.416CysTyr: 0.416 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.846AspAla: 3.846 ± 0.069
0.614AspCys: 0.614 ± 0.02
3.183AspAsp: 3.183 ± 0.061
3.943AspGlu: 3.943 ± 0.069
2.647AspPhe: 2.647 ± 0.051
3.698AspGly: 3.698 ± 0.075
1.02AspHis: 1.02 ± 0.03
4.247AspIle: 4.247 ± 0.064
3.796AspLys: 3.796 ± 0.058
4.966AspLeu: 4.966 ± 0.059
1.141AspMet: 1.141 ± 0.033
2.716AspAsn: 2.716 ± 0.056
1.813AspPro: 1.813 ± 0.036
1.692AspGln: 1.692 ± 0.039
1.935AspArg: 1.935 ± 0.041
3.925AspSer: 3.925 ± 0.076
3.051AspThr: 3.051 ± 0.063
3.674AspVal: 3.674 ± 0.053
0.714AspTrp: 0.714 ± 0.027
1.9AspTyr: 1.9 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.918GluAla: 4.918 ± 0.082
0.623GluCys: 0.623 ± 0.02
2.731GluAsp: 2.731 ± 0.046
3.235GluGlu: 3.235 ± 0.067
2.737GluPhe: 2.737 ± 0.054
3.164GluGly: 3.164 ± 0.057
1.74GluHis: 1.74 ± 0.044
4.006GluIle: 4.006 ± 0.055
4.008GluLys: 4.008 ± 0.066
7.514GluLeu: 7.514 ± 0.105
1.522GluMet: 1.522 ± 0.035
2.896GluAsn: 2.896 ± 0.052
1.979GluPro: 1.979 ± 0.039
3.879GluGln: 3.879 ± 0.058
2.95GluArg: 2.95 ± 0.052
4.196GluSer: 4.196 ± 0.068
3.32GluThr: 3.32 ± 0.047
3.974GluVal: 3.974 ± 0.065
0.646GluTrp: 0.646 ± 0.024
1.865GluTyr: 1.865 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
2.999PheAla: 2.999 ± 0.053
0.597PheCys: 0.597 ± 0.021
3.033PheAsp: 3.033 ± 0.061
2.692PheGlu: 2.692 ± 0.046
1.775PhePhe: 1.775 ± 0.046
2.902PheGly: 2.902 ± 0.057
0.942PheHis: 0.942 ± 0.029
3.349PheIle: 3.349 ± 0.065
2.504PheLys: 2.504 ± 0.049
3.355PheLeu: 3.355 ± 0.057
0.936PheMet: 0.936 ± 0.027
2.5PheAsn: 2.5 ± 0.046
1.414PhePro: 1.414 ± 0.034
1.284PheGln: 1.284 ± 0.033
1.486PheArg: 1.486 ± 0.035
3.755PheSer: 3.755 ± 0.054
2.39PheThr: 2.39 ± 0.049
2.546PheVal: 2.546 ± 0.049
0.459PheTrp: 0.459 ± 0.02
1.403PheTyr: 1.403 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.279GlyAla: 4.279 ± 0.067
0.812GlyCys: 0.812 ± 0.03
3.823GlyAsp: 3.823 ± 0.112
3.648GlyGlu: 3.648 ± 0.066
2.97GlyPhe: 2.97 ± 0.057
3.949GlyGly: 3.949 ± 0.083
1.548GlyHis: 1.548 ± 0.039
4.626GlyIle: 4.626 ± 0.079
3.884GlyLys: 3.884 ± 0.066
6.163GlyLeu: 6.163 ± 0.105
1.654GlyMet: 1.654 ± 0.038
2.774GlyAsn: 2.774 ± 0.062
1.174GlyPro: 1.174 ± 0.035
2.693GlyGln: 2.693 ± 0.052
2.916GlyArg: 2.916 ± 0.06
3.929GlySer: 3.929 ± 0.073
3.02GlyThr: 3.02 ± 0.055
4.362GlyVal: 4.362 ± 0.072
0.72GlyTrp: 0.72 ± 0.024
2.203GlyTyr: 2.203 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.419HisAla: 1.419 ± 0.035
0.408HisCys: 0.408 ± 0.018
1.114HisAsp: 1.114 ± 0.033
1.227HisGlu: 1.227 ± 0.034
1.208HisPhe: 1.208 ± 0.031
1.452HisGly: 1.452 ± 0.035
0.684HisHis: 0.684 ± 0.024
1.524HisIle: 1.524 ± 0.036
1.342HisLys: 1.342 ± 0.04
2.517HisLeu: 2.517 ± 0.05
0.499HisMet: 0.499 ± 0.019
1.021HisAsn: 1.021 ± 0.028
1.05HisPro: 1.05 ± 0.033
1.284HisGln: 1.284 ± 0.041
1.013HisArg: 1.013 ± 0.028
1.779HisSer: 1.779 ± 0.036
1.114HisThr: 1.114 ± 0.028
1.213HisVal: 1.213 ± 0.03
0.367HisTrp: 0.367 ± 0.019
0.922HisTyr: 0.922 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.697IleAla: 5.697 ± 0.072
0.753IleCys: 0.753 ± 0.025
4.364IleAsp: 4.364 ± 0.059
5.087IleGlu: 5.087 ± 0.066
2.495IlePhe: 2.495 ± 0.052
4.342IleGly: 4.342 ± 0.073
1.41IleHis: 1.41 ± 0.034
4.16IleIle: 4.16 ± 0.072
4.7IleLys: 4.7 ± 0.076
5.158IleLeu: 5.158 ± 0.068
1.301IleMet: 1.301 ± 0.036
3.936IleAsn: 3.936 ± 0.062
2.611IlePro: 2.611 ± 0.046
2.599IleGln: 2.599 ± 0.049
2.724IleArg: 2.724 ± 0.047
5.265IleSer: 5.265 ± 0.063
4.349IleThr: 4.349 ± 0.09
3.97IleVal: 3.97 ± 0.061
0.605IleTrp: 0.605 ± 0.023
1.991IleTyr: 1.991 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.123LysAla: 5.123 ± 0.085
0.547LysCys: 0.547 ± 0.024
2.92LysAsp: 2.92 ± 0.051
3.531LysGlu: 3.531 ± 0.069
2.074LysPhe: 2.074 ± 0.046
3.451LysGly: 3.451 ± 0.058
1.522LysHis: 1.522 ± 0.034
3.789LysIle: 3.789 ± 0.057
4.055LysLys: 4.055 ± 0.067
6.949LysLeu: 6.949 ± 0.085
1.522LysMet: 1.522 ± 0.035
3.064LysAsn: 3.064 ± 0.047
2.904LysPro: 2.904 ± 0.082
3.792LysGln: 3.792 ± 0.069
2.863LysArg: 2.863 ± 0.05
4.575LysSer: 4.575 ± 0.064
3.651LysThr: 3.651 ± 0.063
4.358LysVal: 4.358 ± 0.076
0.586LysTrp: 0.586 ± 0.022
1.765LysTyr: 1.765 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
8.29LeuAla: 8.29 ± 0.094
1.17LeuCys: 1.17 ± 0.033
5.351LeuAsp: 5.351 ± 0.066
6.073LeuGlu: 6.073 ± 0.094
4.078LeuPhe: 4.078 ± 0.072
6.151LeuGly: 6.151 ± 0.081
2.096LeuHis: 2.096 ± 0.048
6.584LeuIle: 6.584 ± 0.095
6.87LeuLys: 6.87 ± 0.079
10.771LeuLeu: 10.771 ± 0.152
2.62LeuMet: 2.62 ± 0.06
5.453LeuAsn: 5.453 ± 0.065
5.019LeuPro: 5.019 ± 0.103
3.938LeuGln: 3.938 ± 0.064
3.958LeuArg: 3.958 ± 0.061
8.907LeuSer: 8.907 ± 0.11
6.339LeuThr: 6.339 ± 0.07
6.47LeuVal: 6.47 ± 0.104
0.948LeuTrp: 0.948 ± 0.03
2.632LeuTyr: 2.632 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.308MetAla: 2.308 ± 0.055
0.217MetCys: 0.217 ± 0.014
1.099MetAsp: 1.099 ± 0.03
1.161MetGlu: 1.161 ± 0.027
0.813MetPhe: 0.813 ± 0.024
1.35MetGly: 1.35 ± 0.04
0.469MetHis: 0.469 ± 0.02
1.425MetIle: 1.425 ± 0.037
1.509MetLys: 1.509 ± 0.035
2.567MetLeu: 2.567 ± 0.051
0.681MetMet: 0.681 ± 0.028
1.293MetAsn: 1.293 ± 0.038
1.052MetPro: 1.052 ± 0.03
1.17MetGln: 1.17 ± 0.044
0.958MetArg: 0.958 ± 0.027
1.84MetSer: 1.84 ± 0.032
1.447MetThr: 1.447 ± 0.031
1.412MetVal: 1.412 ± 0.034
0.191MetTrp: 0.191 ± 0.011
0.451MetTyr: 0.451 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.613AsnAla: 3.613 ± 0.057
0.541AsnCys: 0.541 ± 0.021
2.721AsnAsp: 2.721 ± 0.053
3.044AsnGlu: 3.044 ± 0.051
2.036AsnPhe: 2.036 ± 0.042
3.263AsnGly: 3.263 ± 0.056
1.197AsnHis: 1.197 ± 0.03
3.337AsnIle: 3.337 ± 0.052
3.204AsnLys: 3.204 ± 0.05
4.748AsnLeu: 4.748 ± 0.063
0.991AsnMet: 0.991 ± 0.026
2.593AsnAsn: 2.593 ± 0.056
2.043AsnPro: 2.043 ± 0.043
2.492AsnGln: 2.492 ± 0.045
2.149AsnArg: 2.149 ± 0.05
3.332AsnSer: 3.332 ± 0.049
2.738AsnThr: 2.738 ± 0.052
2.886AsnVal: 2.886 ± 0.057
0.67AsnTrp: 0.67 ± 0.023
1.561AsnTyr: 1.561 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.516ProAla: 2.516 ± 0.048
0.33ProCys: 0.33 ± 0.016
2.276ProAsp: 2.276 ± 0.046
2.956ProGlu: 2.956 ± 0.06
1.597ProPhe: 1.597 ± 0.037
1.548ProGly: 1.548 ± 0.041
0.998ProHis: 0.998 ± 0.039
2.59ProIle: 2.59 ± 0.055
2.495ProLys: 2.495 ± 0.048
4.121ProLeu: 4.121 ± 0.067
0.872ProMet: 0.872 ± 0.024
2.038ProAsn: 2.038 ± 0.038
1.112ProPro: 1.112 ± 0.037
1.788ProGln: 1.788 ± 0.046
1.244ProArg: 1.244 ± 0.036
2.707ProSer: 2.707 ± 0.046
2.066ProThr: 2.066 ± 0.044
2.725ProVal: 2.725 ± 0.053
0.413ProTrp: 0.413 ± 0.017
1.14ProTyr: 1.14 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.793GlnAla: 3.793 ± 0.068
0.482GlnCys: 0.482 ± 0.02
1.93GlnAsp: 1.93 ± 0.042
2.344GlnGlu: 2.344 ± 0.051
2.108GlnPhe: 2.108 ± 0.05
2.526GlnGly: 2.526 ± 0.043
1.243GlnHis: 1.243 ± 0.038
2.931GlnIle: 2.931 ± 0.049
2.635GlnLys: 2.635 ± 0.049
6.029GlnLeu: 6.029 ± 0.091
0.974GlnMet: 0.974 ± 0.027
1.929GlnAsn: 1.929 ± 0.041
1.708GlnPro: 1.708 ± 0.036
3.598GlnGln: 3.598 ± 0.082
2.144GlnArg: 2.144 ± 0.044
3.11GlnSer: 3.11 ± 0.057
2.381GlnThr: 2.381 ± 0.048
3.091GlnVal: 3.091 ± 0.049
0.798GlnTrp: 0.798 ± 0.047
1.509GlnTyr: 1.509 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.842ArgAla: 2.842 ± 0.051
0.458ArgCys: 0.458 ± 0.019
2.101ArgAsp: 2.101 ± 0.044
2.53ArgGlu: 2.53 ± 0.054
2.208ArgPhe: 2.208 ± 0.044
2.336ArgGly: 2.336 ± 0.047
1.005ArgHis: 1.005 ± 0.03
2.867ArgIle: 2.867 ± 0.052
2.473ArgLys: 2.473 ± 0.045
4.775ArgLeu: 4.775 ± 0.07
0.964ArgMet: 0.964 ± 0.025
2.009ArgAsn: 2.009 ± 0.037
1.431ArgPro: 1.431 ± 0.037
2.064ArgGln: 2.064 ± 0.04
2.067ArgArg: 2.067 ± 0.045
2.591ArgSer: 2.591 ± 0.046
2.042ArgThr: 2.042 ± 0.049
2.807ArgVal: 2.807 ± 0.049
0.525ArgTrp: 0.525 ± 0.021
1.765ArgTyr: 1.765 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.492SerAla: 5.492 ± 0.076
0.843SerCys: 0.843 ± 0.029
3.969SerAsp: 3.969 ± 0.068
4.61SerGlu: 4.61 ± 0.066
3.194SerPhe: 3.194 ± 0.047
4.832SerGly: 4.832 ± 0.087
1.669SerHis: 1.669 ± 0.038
5.117SerIle: 5.117 ± 0.077
4.342SerLys: 4.342 ± 0.07
8.124SerLeu: 8.124 ± 0.106
1.706SerMet: 1.706 ± 0.038
3.46SerAsn: 3.46 ± 0.056
2.607SerPro: 2.607 ± 0.049
3.356SerGln: 3.356 ± 0.055
2.98SerArg: 2.98 ± 0.051
5.608SerSer: 5.608 ± 0.091
3.872SerThr: 3.872 ± 0.068
4.536SerVal: 4.536 ± 0.07
0.829SerTrp: 0.829 ± 0.026
2.203SerTyr: 2.203 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.489ThrAla: 4.489 ± 0.094
0.799ThrCys: 0.799 ± 0.053
3.08ThrAsp: 3.08 ± 0.05
3.57ThrGlu: 3.57 ± 0.06
2.071ThrPhe: 2.071 ± 0.041
3.752ThrGly: 3.752 ± 0.072
1.35ThrHis: 1.35 ± 0.03
3.469ThrIle: 3.469 ± 0.062
3.044ThrLys: 3.044 ± 0.05
5.859ThrLeu: 5.859 ± 0.081
1.099ThrMet: 1.099 ± 0.03
2.387ThrAsn: 2.387 ± 0.044
2.741ThrPro: 2.741 ± 0.055
2.649ThrGln: 2.649 ± 0.055
2.174ThrArg: 2.174 ± 0.042
3.983ThrSer: 3.983 ± 0.067
3.059ThrThr: 3.059 ± 0.072
3.81ThrVal: 3.81 ± 0.065
0.489ThrTrp: 0.489 ± 0.019
1.436ThrTyr: 1.436 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
5.129ValAla: 5.129 ± 0.075
1.185ValCys: 1.185 ± 0.086
3.84ValAsp: 3.84 ± 0.065
4.192ValGlu: 4.192 ± 0.069
2.569ValPhe: 2.569 ± 0.047
3.902ValGly: 3.902 ± 0.071
1.191ValHis: 1.191 ± 0.037
4.53ValIle: 4.53 ± 0.059
3.855ValLys: 3.855 ± 0.069
6.218ValLeu: 6.218 ± 0.078
1.827ValMet: 1.827 ± 0.055
3.252ValAsn: 3.252 ± 0.053
2.184ValPro: 2.184 ± 0.044
2.138ValGln: 2.138 ± 0.041
2.532ValArg: 2.532 ± 0.046
4.742ValSer: 4.742 ± 0.062
3.872ValThr: 3.872 ± 0.059
4.32ValVal: 4.32 ± 0.079
0.61ValTrp: 0.61 ± 0.024
1.803ValTyr: 1.803 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.656TrpAla: 0.656 ± 0.025
0.168TrpCys: 0.168 ± 0.011
0.59TrpAsp: 0.59 ± 0.024
0.482TrpGlu: 0.482 ± 0.02
0.518TrpPhe: 0.518 ± 0.025
0.824TrpGly: 0.824 ± 0.042
0.313TrpHis: 0.313 ± 0.018
0.608TrpIle: 0.608 ± 0.023
0.629TrpLys: 0.629 ± 0.023
1.502TrpLeu: 1.502 ± 0.042
0.24TrpMet: 0.24 ± 0.014
0.478TrpAsn: 0.478 ± 0.019
0.366TrpPro: 0.366 ± 0.019
0.967TrpGln: 0.967 ± 0.042
0.559TrpArg: 0.559 ± 0.019
0.731TrpSer: 0.731 ± 0.028
0.426TrpThr: 0.426 ± 0.016
0.663TrpVal: 0.663 ± 0.026
0.166TrpTrp: 0.166 ± 0.014
0.334TrpTyr: 0.334 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.101TyrAla: 2.101 ± 0.051
0.459TyrCys: 0.459 ± 0.017
1.56TyrAsp: 1.56 ± 0.036
1.562TyrGlu: 1.562 ± 0.036
1.526TyrPhe: 1.526 ± 0.039
1.908TyrGly: 1.908 ± 0.044
0.89TyrHis: 0.89 ± 0.025
1.726TyrIle: 1.726 ± 0.035
1.646TyrLys: 1.646 ± 0.05
3.276TyrLeu: 3.276 ± 0.052
0.566TyrMet: 0.566 ± 0.021
1.348TyrAsn: 1.348 ± 0.04
1.256TyrPro: 1.256 ± 0.03
1.987TyrGln: 1.987 ± 0.043
1.683TyrArg: 1.683 ± 0.037
2.353TyrSer: 2.353 ± 0.043
1.46TyrThr: 1.46 ± 0.035
1.585TyrVal: 1.585 ± 0.035
0.415TyrTrp: 0.415 ± 0.018
1.016TyrTyr: 1.016 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3857 proteins (1325279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski