Amino acid dipepetide frequency for Prevotella micans F0438

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.488AlaAla: 5.488 ± 0.124
0.886AlaCys: 0.886 ± 0.032
4.382AlaAsp: 4.382 ± 0.084
4.533AlaGlu: 4.533 ± 0.097
3.245AlaPhe: 3.245 ± 0.077
4.78AlaGly: 4.78 ± 0.089
1.361AlaHis: 1.361 ± 0.049
4.965AlaIle: 4.965 ± 0.111
4.13AlaLys: 4.13 ± 0.091
6.607AlaLeu: 6.607 ± 0.111
1.975AlaMet: 1.975 ± 0.051
3.457AlaAsn: 3.457 ± 0.068
2.415AlaPro: 2.415 ± 0.069
3.057AlaGln: 3.057 ± 0.066
3.681AlaArg: 3.681 ± 0.076
4.309AlaSer: 4.309 ± 0.086
4.131AlaThr: 4.131 ± 0.098
4.395AlaVal: 4.395 ± 0.085
0.697AlaTrp: 0.697 ± 0.034
2.888AlaTyr: 2.888 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.758CysAla: 0.758 ± 0.031
0.176CysCys: 0.176 ± 0.018
0.611CysAsp: 0.611 ± 0.032
0.659CysGlu: 0.659 ± 0.033
0.579CysPhe: 0.579 ± 0.027
0.951CysGly: 0.951 ± 0.039
0.303CysHis: 0.303 ± 0.02
0.845CysIle: 0.845 ± 0.039
0.632CysLys: 0.632 ± 0.031
0.965CysLeu: 0.965 ± 0.037
0.271CysMet: 0.271 ± 0.017
0.642CysAsn: 0.642 ± 0.035
0.522CysPro: 0.522 ± 0.03
0.36CysGln: 0.36 ± 0.023
0.675CysArg: 0.675 ± 0.034
0.748CysSer: 0.748 ± 0.038
0.683CysThr: 0.683 ± 0.032
0.668CysVal: 0.668 ± 0.035
0.128CysTrp: 0.128 ± 0.012
0.504CysTyr: 0.504 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.787AspAla: 3.787 ± 0.067
0.611AspCys: 0.611 ± 0.03
2.988AspAsp: 2.988 ± 0.076
3.903AspGlu: 3.903 ± 0.086
2.796AspPhe: 2.796 ± 0.064
4.137AspGly: 4.137 ± 0.088
0.8AspHis: 0.8 ± 0.032
4.186AspIle: 4.186 ± 0.085
3.663AspLys: 3.663 ± 0.083
4.168AspLeu: 4.168 ± 0.084
1.506AspMet: 1.506 ± 0.048
3.122AspAsn: 3.122 ± 0.07
1.958AspPro: 1.958 ± 0.059
1.304AspGln: 1.304 ± 0.05
2.49AspArg: 2.49 ± 0.062
3.438AspSer: 3.438 ± 0.077
2.854AspThr: 2.854 ± 0.065
3.335AspVal: 3.335 ± 0.074
0.733AspTrp: 0.733 ± 0.03
2.733AspTyr: 2.733 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.244GluAla: 4.244 ± 0.091
0.624GluCys: 0.624 ± 0.031
2.759GluAsp: 2.759 ± 0.072
4.312GluGlu: 4.312 ± 0.106
2.477GluPhe: 2.477 ± 0.068
3.386GluGly: 3.386 ± 0.074
1.417GluHis: 1.417 ± 0.045
4.617GluIle: 4.617 ± 0.087
4.478GluLys: 4.478 ± 0.094
5.836GluLeu: 5.836 ± 0.105
1.896GluMet: 1.896 ± 0.053
3.536GluAsn: 3.536 ± 0.073
1.98GluPro: 1.98 ± 0.061
2.888GluGln: 2.888 ± 0.07
3.625GluArg: 3.625 ± 0.082
3.211GluSer: 3.211 ± 0.077
3.565GluThr: 3.565 ± 0.068
3.581GluVal: 3.581 ± 0.084
0.749GluTrp: 0.749 ± 0.039
2.423GluTyr: 2.423 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.279PheAla: 3.279 ± 0.074
0.666PheCys: 0.666 ± 0.028
2.665PheAsp: 2.665 ± 0.062
2.442PheGlu: 2.442 ± 0.067
2.223PhePhe: 2.223 ± 0.063
3.42PheGly: 3.42 ± 0.081
0.948PheHis: 0.948 ± 0.04
3.273PheIle: 3.273 ± 0.065
2.5PheLys: 2.5 ± 0.063
3.647PheLeu: 3.647 ± 0.078
1.147PheMet: 1.147 ± 0.043
2.495PheAsn: 2.495 ± 0.069
1.558PhePro: 1.558 ± 0.054
1.272PheGln: 1.272 ± 0.044
2.361PheArg: 2.361 ± 0.066
3.314PheSer: 3.314 ± 0.067
2.778PheThr: 2.778 ± 0.06
2.992PheVal: 2.992 ± 0.064
0.508PheTrp: 0.508 ± 0.031
1.932PheTyr: 1.932 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.531GlyAla: 4.531 ± 0.088
0.898GlyCys: 0.898 ± 0.041
3.274GlyAsp: 3.274 ± 0.071
3.776GlyGlu: 3.776 ± 0.071
3.109GlyPhe: 3.109 ± 0.079
4.831GlyGly: 4.831 ± 0.108
1.344GlyHis: 1.344 ± 0.044
5.231GlyIle: 5.231 ± 0.097
4.868GlyLys: 4.868 ± 0.092
5.647GlyLeu: 5.647 ± 0.103
1.98GlyMet: 1.98 ± 0.054
3.561GlyAsn: 3.561 ± 0.076
1.379GlyPro: 1.379 ± 0.052
2.313GlyGln: 2.313 ± 0.058
3.499GlyArg: 3.499 ± 0.078
4.08GlySer: 4.08 ± 0.094
4.648GlyThr: 4.648 ± 0.109
4.284GlyVal: 4.284 ± 0.085
0.899GlyTrp: 0.899 ± 0.04
2.989GlyTyr: 2.989 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.32HisAla: 1.32 ± 0.046
0.291HisCys: 0.291 ± 0.018
1.09HisAsp: 1.09 ± 0.041
1.138HisGlu: 1.138 ± 0.047
1.07HisPhe: 1.07 ± 0.041
1.284HisGly: 1.284 ± 0.041
0.49HisHis: 0.49 ± 0.028
1.544HisIle: 1.544 ± 0.049
1.122HisLys: 1.122 ± 0.048
1.886HisLeu: 1.886 ± 0.053
0.37HisMet: 0.37 ± 0.019
1.085HisAsn: 1.085 ± 0.039
1.052HisPro: 1.052 ± 0.041
0.693HisGln: 0.693 ± 0.034
1.188HisArg: 1.188 ± 0.039
1.259HisSer: 1.259 ± 0.05
1.246HisThr: 1.246 ± 0.06
1.112HisVal: 1.112 ± 0.043
0.234HisTrp: 0.234 ± 0.019
0.885HisTyr: 0.885 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.53IleAla: 5.53 ± 0.097
0.881IleCys: 0.881 ± 0.041
4.85IleAsp: 4.85 ± 0.095
4.8IleGlu: 4.8 ± 0.095
2.91IlePhe: 2.91 ± 0.075
4.731IleGly: 4.731 ± 0.092
1.3IleHis: 1.3 ± 0.045
5.449IleIle: 5.449 ± 0.108
4.333IleLys: 4.333 ± 0.083
5.879IleLeu: 5.879 ± 0.097
1.626IleMet: 1.626 ± 0.049
3.743IleAsn: 3.743 ± 0.075
3.194IlePro: 3.194 ± 0.068
2.106IleGln: 2.106 ± 0.057
3.551IleArg: 3.551 ± 0.075
4.823IleSer: 4.823 ± 0.073
4.449IleThr: 4.449 ± 0.096
4.816IleVal: 4.816 ± 0.076
0.58IleTrp: 0.58 ± 0.031
2.766IleTyr: 2.766 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
4.675LysAla: 4.675 ± 0.097
0.511LysCys: 0.511 ± 0.028
3.448LysAsp: 3.448 ± 0.093
4.572LysGlu: 4.572 ± 0.1
2.316LysPhe: 2.316 ± 0.067
4.078LysGly: 4.078 ± 0.078
1.321LysHis: 1.321 ± 0.042
4.507LysIle: 4.507 ± 0.084
4.747LysLys: 4.747 ± 0.116
5.516LysLeu: 5.516 ± 0.09
1.918LysMet: 1.918 ± 0.056
3.514LysAsn: 3.514 ± 0.077
2.443LysPro: 2.443 ± 0.067
2.824LysGln: 2.824 ± 0.068
3.389LysArg: 3.389 ± 0.078
3.507LysSer: 3.507 ± 0.072
3.864LysThr: 3.864 ± 0.081
3.783LysVal: 3.783 ± 0.083
0.755LysTrp: 0.755 ± 0.03
2.536LysTyr: 2.536 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.406LeuAla: 6.406 ± 0.094
1.163LeuCys: 1.163 ± 0.049
4.648LeuAsp: 4.648 ± 0.096
4.728LeuGlu: 4.728 ± 0.082
4.027LeuPhe: 4.027 ± 0.081
5.747LeuGly: 5.747 ± 0.1
1.925LeuHis: 1.925 ± 0.059
5.571LeuIle: 5.571 ± 0.092
5.701LeuLys: 5.701 ± 0.101
8.011LeuLeu: 8.011 ± 0.153
2.323LeuMet: 2.323 ± 0.056
4.68LeuAsn: 4.68 ± 0.098
4.039LeuPro: 4.039 ± 0.082
3.296LeuGln: 3.296 ± 0.074
4.74LeuArg: 4.74 ± 0.095
6.375LeuSer: 6.375 ± 0.108
5.392LeuThr: 5.392 ± 0.093
5.044LeuVal: 5.044 ± 0.093
0.929LeuTrp: 0.929 ± 0.037
3.112LeuTyr: 3.112 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.148MetAla: 2.148 ± 0.057
0.264MetCys: 0.264 ± 0.019
1.145MetAsp: 1.145 ± 0.036
1.589MetGlu: 1.589 ± 0.047
1.087MetPhe: 1.087 ± 0.048
1.778MetGly: 1.778 ± 0.06
0.51MetHis: 0.51 ± 0.026
1.677MetIle: 1.677 ± 0.049
2.428MetLys: 2.428 ± 0.062
2.617MetLeu: 2.617 ± 0.064
0.797MetMet: 0.797 ± 0.035
1.729MetAsn: 1.729 ± 0.048
1.297MetPro: 1.297 ± 0.042
1.205MetGln: 1.205 ± 0.048
1.385MetArg: 1.385 ± 0.044
1.524MetSer: 1.524 ± 0.048
1.471MetThr: 1.471 ± 0.046
1.452MetVal: 1.452 ± 0.041
0.24MetTrp: 0.24 ± 0.017
0.683MetTyr: 0.683 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.481AsnAla: 3.481 ± 0.07
0.597AsnCys: 0.597 ± 0.032
2.909AsnAsp: 2.909 ± 0.072
3.204AsnGlu: 3.204 ± 0.077
2.422AsnPhe: 2.422 ± 0.068
3.905AsnGly: 3.905 ± 0.091
1.05AsnHis: 1.05 ± 0.035
4.563AsnIle: 4.563 ± 0.082
3.33AsnLys: 3.33 ± 0.092
4.682AsnLeu: 4.682 ± 0.073
1.276AsnMet: 1.276 ± 0.046
3.104AsnAsn: 3.104 ± 0.082
2.567AsnPro: 2.567 ± 0.066
1.773AsnGln: 1.773 ± 0.059
2.778AsnArg: 2.778 ± 0.063
3.167AsnSer: 3.167 ± 0.086
2.974AsnThr: 2.974 ± 0.074
3.296AsnVal: 3.296 ± 0.068
0.658AsnTrp: 0.658 ± 0.035
2.291AsnTyr: 2.291 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.792ProAla: 2.792 ± 0.068
0.361ProCys: 0.361 ± 0.027
2.423ProAsp: 2.423 ± 0.061
3.035ProGlu: 3.035 ± 0.064
1.763ProPhe: 1.763 ± 0.043
2.583ProGly: 2.583 ± 0.068
0.817ProHis: 0.817 ± 0.036
2.644ProIle: 2.644 ± 0.061
2.391ProLys: 2.391 ± 0.06
3.06ProLeu: 3.06 ± 0.07
1.085ProMet: 1.085 ± 0.039
2.083ProAsn: 2.083 ± 0.064
0.939ProPro: 0.939 ± 0.04
1.481ProGln: 1.481 ± 0.045
1.572ProArg: 1.572 ± 0.051
2.518ProSer: 2.518 ± 0.061
2.477ProThr: 2.477 ± 0.059
2.645ProVal: 2.645 ± 0.059
0.438ProTrp: 0.438 ± 0.029
1.572ProTyr: 1.572 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.659GlnAla: 2.659 ± 0.074
0.346GlnCys: 0.346 ± 0.026
1.404GlnAsp: 1.404 ± 0.051
2.017GlnGlu: 2.017 ± 0.068
1.625GlnPhe: 1.625 ± 0.05
2.056GlnGly: 2.056 ± 0.058
0.796GlnHis: 0.796 ± 0.034
2.648GlnIle: 2.648 ± 0.076
2.384GlnLys: 2.384 ± 0.059
3.56GlnLeu: 3.56 ± 0.087
1.115GlnMet: 1.115 ± 0.04
2.047GlnAsn: 2.047 ± 0.056
1.447GlnPro: 1.447 ± 0.05
1.793GlnGln: 1.793 ± 0.073
1.97GlnArg: 1.97 ± 0.058
2.144GlnSer: 2.144 ± 0.067
2.478GlnThr: 2.478 ± 0.062
1.973GlnVal: 1.973 ± 0.05
0.476GlnTrp: 0.476 ± 0.025
1.332GlnTyr: 1.332 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.294ArgAla: 3.294 ± 0.075
0.555ArgCys: 0.555 ± 0.032
2.342ArgAsp: 2.342 ± 0.054
3.327ArgGlu: 3.327 ± 0.078
2.517ArgPhe: 2.517 ± 0.06
2.852ArgGly: 2.852 ± 0.074
1.222ArgHis: 1.222 ± 0.042
3.982ArgIle: 3.982 ± 0.091
3.747ArgLys: 3.747 ± 0.086
4.857ArgLeu: 4.857 ± 0.097
1.653ArgMet: 1.653 ± 0.044
2.956ArgAsn: 2.956 ± 0.067
1.927ArgPro: 1.927 ± 0.06
2.151ArgGln: 2.151 ± 0.07
3.081ArgArg: 3.081 ± 0.08
2.704ArgSer: 2.704 ± 0.074
2.941ArgThr: 2.941 ± 0.064
2.78ArgVal: 2.78 ± 0.07
0.682ArgTrp: 0.682 ± 0.03
2.178ArgTyr: 2.178 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.531SerAla: 4.531 ± 0.08
0.745SerCys: 0.745 ± 0.035
3.26SerAsp: 3.26 ± 0.074
3.531SerGlu: 3.531 ± 0.061
3.315SerPhe: 3.315 ± 0.078
4.605SerGly: 4.605 ± 0.104
1.259SerHis: 1.259 ± 0.048
4.514SerIle: 4.514 ± 0.084
3.575SerLys: 3.575 ± 0.08
5.792SerLeu: 5.792 ± 0.113
1.575SerMet: 1.575 ± 0.05
3.177SerAsn: 3.177 ± 0.08
2.498SerPro: 2.498 ± 0.069
2.086SerGln: 2.086 ± 0.057
2.956SerArg: 2.956 ± 0.079
4.144SerSer: 4.144 ± 0.103
3.753SerThr: 3.753 ± 0.065
3.997SerVal: 3.997 ± 0.084
0.759SerTrp: 0.759 ± 0.037
2.426SerTyr: 2.426 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
4.483ThrAla: 4.483 ± 0.094
0.552ThrCys: 0.552 ± 0.032
3.595ThrAsp: 3.595 ± 0.072
3.38ThrGlu: 3.38 ± 0.066
2.809ThrPhe: 2.809 ± 0.066
4.35ThrGly: 4.35 ± 0.084
1.344ThrHis: 1.344 ± 0.066
4.611ThrIle: 4.611 ± 0.092
3.095ThrLys: 3.095 ± 0.07
5.569ThrLeu: 5.569 ± 0.105
1.417ThrMet: 1.417 ± 0.044
2.827ThrAsn: 2.827 ± 0.059
3.078ThrPro: 3.078 ± 0.079
1.887ThrGln: 1.887 ± 0.058
2.596ThrArg: 2.596 ± 0.064
3.64ThrSer: 3.64 ± 0.069
3.675ThrThr: 3.675 ± 0.085
4.095ThrVal: 4.095 ± 0.093
0.661ThrTrp: 0.661 ± 0.032
2.337ThrTyr: 2.337 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.425ValAla: 4.425 ± 0.09
0.924ValCys: 0.924 ± 0.04
3.647ValAsp: 3.647 ± 0.076
3.893ValGlu: 3.893 ± 0.081
2.646ValPhe: 2.646 ± 0.063
4.096ValGly: 4.096 ± 0.103
0.995ValHis: 0.995 ± 0.038
4.038ValIle: 4.038 ± 0.079
3.857ValLys: 3.857 ± 0.076
5.2ValLeu: 5.2 ± 0.093
1.709ValMet: 1.709 ± 0.048
3.159ValAsn: 3.159 ± 0.064
2.521ValPro: 2.521 ± 0.063
1.914ValGln: 1.914 ± 0.053
3.306ValArg: 3.306 ± 0.07
4.288ValSer: 4.288 ± 0.082
3.416ValThr: 3.416 ± 0.07
4.353ValVal: 4.353 ± 0.091
0.683ValTrp: 0.683 ± 0.036
2.436ValTyr: 2.436 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.032
0.137TrpCys: 0.137 ± 0.014
0.59TrpAsp: 0.59 ± 0.03
0.598TrpGlu: 0.598 ± 0.031
0.596TrpPhe: 0.596 ± 0.027
0.823TrpGly: 0.823 ± 0.042
0.309TrpHis: 0.309 ± 0.022
0.728TrpIle: 0.728 ± 0.031
0.795TrpLys: 0.795 ± 0.035
1.126TrpLeu: 1.126 ± 0.047
0.395TrpMet: 0.395 ± 0.026
0.733TrpAsn: 0.733 ± 0.031
0.258TrpPro: 0.258 ± 0.02
0.574TrpGln: 0.574 ± 0.028
0.577TrpArg: 0.577 ± 0.029
0.638TrpSer: 0.638 ± 0.034
0.686TrpThr: 0.686 ± 0.032
0.604TrpVal: 0.604 ± 0.036
0.188TrpTrp: 0.188 ± 0.017
0.384TrpTyr: 0.384 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.792TyrAla: 2.792 ± 0.066
0.494TyrCys: 0.494 ± 0.026
2.48TyrAsp: 2.48 ± 0.058
2.168TyrGlu: 2.168 ± 0.06
1.89TyrPhe: 1.89 ± 0.056
2.745TyrGly: 2.745 ± 0.068
0.847TyrHis: 0.847 ± 0.034
2.724TyrIle: 2.724 ± 0.069
2.449TyrLys: 2.449 ± 0.068
3.235TyrLeu: 3.235 ± 0.063
0.989TyrMet: 0.989 ± 0.042
2.375TyrAsn: 2.375 ± 0.066
1.606TyrPro: 1.606 ± 0.049
1.293TyrGln: 1.293 ± 0.044
2.329TyrArg: 2.329 ± 0.063
2.668TyrSer: 2.668 ± 0.074
2.519TyrThr: 2.519 ± 0.066
2.301TyrVal: 2.301 ± 0.06
0.505TyrTrp: 0.505 ± 0.028
1.839TyrTyr: 1.839 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2058 proteins (708508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski