Amino acid dipepetide frequency for [Haemophilus] felis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.119AlaAla: 6.119 ± 0.135
0.855AlaCys: 0.855 ± 0.046
4.317AlaAsp: 4.317 ± 0.116
6.036AlaGlu: 6.036 ± 0.109
3.283AlaPhe: 3.283 ± 0.074
5.676AlaGly: 5.676 ± 0.141
1.388AlaHis: 1.388 ± 0.046
5.828AlaIle: 5.828 ± 0.152
5.905AlaLys: 5.905 ± 0.129
9.765AlaLeu: 9.765 ± 0.158
2.136AlaMet: 2.136 ± 0.057
4.083AlaAsn: 4.083 ± 0.112
2.527AlaPro: 2.527 ± 0.079
4.305AlaGln: 4.305 ± 0.092
3.318AlaArg: 3.318 ± 0.086
4.42AlaSer: 4.42 ± 0.093
4.696AlaThr: 4.696 ± 0.179
5.784AlaVal: 5.784 ± 0.108
0.758AlaTrp: 0.758 ± 0.039
2.334AlaTyr: 2.334 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.801CysAla: 0.801 ± 0.039
0.194CysCys: 0.194 ± 0.02
0.552CysAsp: 0.552 ± 0.031
0.727CysGlu: 0.727 ± 0.041
0.479CysPhe: 0.479 ± 0.029
0.904CysGly: 0.904 ± 0.046
0.288CysHis: 0.288 ± 0.025
0.553CysIle: 0.553 ± 0.033
0.453CysLys: 0.453 ± 0.027
1.012CysLeu: 1.012 ± 0.044
0.147CysMet: 0.147 ± 0.014
0.384CysAsn: 0.384 ± 0.027
0.403CysPro: 0.403 ± 0.029
0.511CysGln: 0.511 ± 0.031
0.412CysArg: 0.412 ± 0.027
0.604CysSer: 0.604 ± 0.033
0.372CysThr: 0.372 ± 0.027
0.66CysVal: 0.66 ± 0.035
0.114CysTrp: 0.114 ± 0.014
0.358CysTyr: 0.358 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.661AspAla: 3.661 ± 0.117
0.511AspCys: 0.511 ± 0.032
2.422AspAsp: 2.422 ± 0.083
3.568AspGlu: 3.568 ± 0.081
2.585AspPhe: 2.585 ± 0.067
3.293AspGly: 3.293 ± 0.161
0.907AspHis: 0.907 ± 0.042
3.717AspIle: 3.717 ± 0.076
3.473AspLys: 3.473 ± 0.101
5.165AspLeu: 5.165 ± 0.093
1.054AspMet: 1.054 ± 0.045
2.572AspAsn: 2.572 ± 0.097
2.108AspPro: 2.108 ± 0.066
1.679AspGln: 1.679 ± 0.059
2.05AspArg: 2.05 ± 0.056
2.755AspSer: 2.755 ± 0.076
2.346AspThr: 2.346 ± 0.086
3.523AspVal: 3.523 ± 0.077
0.705AspTrp: 0.705 ± 0.037
2.067AspTyr: 2.067 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.591GluAla: 4.591 ± 0.087
0.502GluCys: 0.502 ± 0.034
2.67GluAsp: 2.67 ± 0.079
3.794GluGlu: 3.794 ± 0.107
2.511GluPhe: 2.511 ± 0.064
3.512GluGly: 3.512 ± 0.101
1.315GluHis: 1.315 ± 0.039
4.733GluIle: 4.733 ± 0.087
5.156GluLys: 5.156 ± 0.11
6.502GluLeu: 6.502 ± 0.124
1.737GluMet: 1.737 ± 0.064
4.022GluAsn: 4.022 ± 0.078
1.772GluPro: 1.772 ± 0.066
4.612GluGln: 4.612 ± 0.119
3.165GluArg: 3.165 ± 0.088
2.99GluSer: 2.99 ± 0.06
3.105GluThr: 3.105 ± 0.079
4.131GluVal: 4.131 ± 0.093
0.695GluTrp: 0.695 ± 0.031
1.739GluTyr: 1.739 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.66PheAla: 3.66 ± 0.068
0.582PheCys: 0.582 ± 0.034
2.709PheAsp: 2.709 ± 0.076
2.642PheGlu: 2.642 ± 0.061
1.988PhePhe: 1.988 ± 0.074
3.206PheGly: 3.206 ± 0.085
0.832PheHis: 0.832 ± 0.036
2.974PheIle: 2.974 ± 0.093
2.229PheLys: 2.229 ± 0.054
3.911PheLeu: 3.911 ± 0.108
0.947PheMet: 0.947 ± 0.041
2.362PheAsn: 2.362 ± 0.065
1.445PhePro: 1.445 ± 0.053
1.49PheGln: 1.49 ± 0.052
1.549PheArg: 1.549 ± 0.056
3.33PheSer: 3.33 ± 0.093
2.337PheThr: 2.337 ± 0.068
2.809PheVal: 2.809 ± 0.073
0.512PheTrp: 0.512 ± 0.033
1.546PheTyr: 1.546 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.257GlyAla: 5.257 ± 0.154
0.744GlyCys: 0.744 ± 0.042
3.305GlyAsp: 3.305 ± 0.106
4.41GlyGlu: 4.41 ± 0.103
3.035GlyPhe: 3.035 ± 0.078
4.76GlyGly: 4.76 ± 0.137
1.228GlyHis: 1.228 ± 0.039
5.009GlyIle: 5.009 ± 0.117
5.258GlyLys: 5.258 ± 0.137
6.686GlyLeu: 6.686 ± 0.117
1.607GlyMet: 1.607 ± 0.054
3.356GlyAsn: 3.356 ± 0.178
1.089GlyPro: 1.089 ± 0.046
2.584GlyGln: 2.584 ± 0.075
2.816GlyArg: 2.816 ± 0.079
3.833GlySer: 3.833 ± 0.137
3.584GlyThr: 3.584 ± 0.185
5.152GlyVal: 5.152 ± 0.104
0.8GlyTrp: 0.8 ± 0.032
2.492GlyTyr: 2.492 ± 0.064
0.001GlyXaa: 0.001 ± 0.001
His
1.121HisAla: 1.121 ± 0.047
0.371HisCys: 0.371 ± 0.022
0.736HisAsp: 0.736 ± 0.039
0.75HisGlu: 0.75 ± 0.034
1.26HisPhe: 1.26 ± 0.049
1.169HisGly: 1.169 ± 0.044
0.673HisHis: 0.673 ± 0.034
1.749HisIle: 1.749 ± 0.054
1.241HisLys: 1.241 ± 0.042
2.544HisLeu: 2.544 ± 0.068
0.307HisMet: 0.307 ± 0.021
1.088HisAsn: 1.088 ± 0.045
0.926HisPro: 0.926 ± 0.046
1.372HisGln: 1.372 ± 0.053
0.997HisArg: 0.997 ± 0.04
1.512HisSer: 1.512 ± 0.057
1.01HisThr: 1.01 ± 0.039
0.721HisVal: 0.721 ± 0.036
0.328HisTrp: 0.328 ± 0.022
0.848HisTyr: 0.848 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.499IleAla: 6.499 ± 0.102
0.785IleCys: 0.785 ± 0.046
3.892IleAsp: 3.892 ± 0.077
4.606IleGlu: 4.606 ± 0.096
2.715IlePhe: 2.715 ± 0.083
4.833IleGly: 4.833 ± 0.129
1.342IleHis: 1.342 ± 0.047
4.127IleIle: 4.127 ± 0.109
3.927IleLys: 3.927 ± 0.08
6.384IleLeu: 6.384 ± 0.137
1.213IleMet: 1.213 ± 0.05
3.448IleAsn: 3.448 ± 0.076
2.778IlePro: 2.778 ± 0.076
2.923IleGln: 2.923 ± 0.071
2.971IleArg: 2.971 ± 0.069
4.676IleSer: 4.676 ± 0.093
3.781IleThr: 3.781 ± 0.103
4.124IleVal: 4.124 ± 0.095
0.67IleTrp: 0.67 ± 0.032
2.067IleTyr: 2.067 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.432LysAla: 5.432 ± 0.128
0.41LysCys: 0.41 ± 0.031
3.13LysAsp: 3.13 ± 0.108
4.102LysGlu: 4.102 ± 0.096
2.077LysPhe: 2.077 ± 0.058
4.22LysGly: 4.22 ± 0.103
1.184LysHis: 1.184 ± 0.047
4.401LysIle: 4.401 ± 0.088
4.039LysLys: 4.039 ± 0.09
6.232LysLeu: 6.232 ± 0.102
1.842LysMet: 1.842 ± 0.058
3.451LysAsn: 3.451 ± 0.09
2.438LysPro: 2.438 ± 0.079
3.744LysGln: 3.744 ± 0.101
2.92LysArg: 2.92 ± 0.068
3.429LysSer: 3.429 ± 0.08
3.566LysThr: 3.566 ± 0.085
4.366LysVal: 4.366 ± 0.094
0.648LysTrp: 0.648 ± 0.036
1.809LysTyr: 1.809 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
9.611LeuAla: 9.611 ± 0.157
1.086LeuCys: 1.086 ± 0.045
5.629LeuAsp: 5.629 ± 0.112
6.061LeuGlu: 6.061 ± 0.111
4.552LeuPhe: 4.552 ± 0.131
6.925LeuGly: 6.925 ± 0.098
2.042LeuHis: 2.042 ± 0.052
6.502LeuIle: 6.502 ± 0.128
6.216LeuLys: 6.216 ± 0.113
10.655LeuLeu: 10.655 ± 0.245
2.325LeuMet: 2.325 ± 0.072
5.362LeuAsn: 5.362 ± 0.112
4.625LeuPro: 4.625 ± 0.109
4.87LeuGln: 4.87 ± 0.112
4.628LeuArg: 4.628 ± 0.103
7.66LeuSer: 7.66 ± 0.131
6.102LeuThr: 6.102 ± 0.114
6.471LeuVal: 6.471 ± 0.131
1.001LeuTrp: 1.001 ± 0.048
2.693LeuTyr: 2.693 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.131MetAla: 2.131 ± 0.063
0.187MetCys: 0.187 ± 0.015
0.94MetAsp: 0.94 ± 0.038
1.088MetGlu: 1.088 ± 0.042
0.816MetPhe: 0.816 ± 0.037
1.416MetGly: 1.416 ± 0.051
0.399MetHis: 0.399 ± 0.025
1.346MetIle: 1.346 ± 0.046
1.549MetLys: 1.549 ± 0.048
2.477MetLeu: 2.477 ± 0.075
0.588MetMet: 0.588 ± 0.032
1.134MetAsn: 1.134 ± 0.04
0.956MetPro: 0.956 ± 0.043
1.253MetGln: 1.253 ± 0.05
0.966MetArg: 0.966 ± 0.04
1.502MetSer: 1.502 ± 0.055
1.305MetThr: 1.305 ± 0.047
1.254MetVal: 1.254 ± 0.046
0.216MetTrp: 0.216 ± 0.017
0.467MetTyr: 0.467 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.339AsnAla: 4.339 ± 0.122
0.444AsnCys: 0.444 ± 0.03
2.35AsnAsp: 2.35 ± 0.086
2.912AsnGlu: 2.912 ± 0.07
1.994AsnPhe: 1.994 ± 0.058
3.692AsnGly: 3.692 ± 0.149
1.127AsnHis: 1.127 ± 0.045
3.591AsnIle: 3.591 ± 0.091
3.172AsnLys: 3.172 ± 0.107
5.136AsnLeu: 5.136 ± 0.097
0.965AsnMet: 0.965 ± 0.038
2.816AsnAsn: 2.816 ± 0.133
2.485AsnPro: 2.485 ± 0.069
2.86AsnGln: 2.86 ± 0.091
2.098AsnArg: 2.098 ± 0.06
2.924AsnSer: 2.924 ± 0.109
2.563AsnThr: 2.563 ± 0.11
3.233AsnVal: 3.233 ± 0.087
0.634AsnTrp: 0.634 ± 0.035
1.67AsnTyr: 1.67 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.854ProAla: 2.854 ± 0.102
0.33ProCys: 0.33 ± 0.026
1.806ProAsp: 1.806 ± 0.067
2.909ProGlu: 2.909 ± 0.094
1.744ProPhe: 1.744 ± 0.056
1.307ProGly: 1.307 ± 0.053
0.883ProHis: 0.883 ± 0.036
2.528ProIle: 2.528 ± 0.063
2.384ProLys: 2.384 ± 0.065
3.739ProLeu: 3.739 ± 0.092
0.864ProMet: 0.864 ± 0.038
2.301ProAsn: 2.301 ± 0.079
1.115ProPro: 1.115 ± 0.053
1.798ProGln: 1.798 ± 0.059
1.301ProArg: 1.301 ± 0.049
2.127ProSer: 2.127 ± 0.066
2.362ProThr: 2.362 ± 0.078
2.661ProVal: 2.661 ± 0.068
0.305ProTrp: 0.305 ± 0.024
1.295ProTyr: 1.295 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
4.749GlnAla: 4.749 ± 0.116
0.363GlnCys: 0.363 ± 0.023
2.283GlnAsp: 2.283 ± 0.054
2.867GlnGlu: 2.867 ± 0.086
2.152GlnPhe: 2.152 ± 0.063
3.582GlnGly: 3.582 ± 0.105
1.342GlnHis: 1.342 ± 0.054
3.466GlnIle: 3.466 ± 0.085
3.232GlnLys: 3.232 ± 0.087
5.609GlnLeu: 5.609 ± 0.131
1.083GlnMet: 1.083 ± 0.038
2.461GlnAsn: 2.461 ± 0.074
1.87GlnPro: 1.87 ± 0.075
4.512GlnGln: 4.512 ± 0.143
2.53GlnArg: 2.53 ± 0.085
2.591GlnSer: 2.591 ± 0.063
2.409GlnThr: 2.409 ± 0.057
3.114GlnVal: 3.114 ± 0.082
0.658GlnTrp: 0.658 ± 0.034
1.539GlnTyr: 1.539 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.185ArgAla: 3.185 ± 0.083
0.428ArgCys: 0.428 ± 0.028
2.125ArgAsp: 2.125 ± 0.057
2.987ArgGlu: 2.987 ± 0.084
2.169ArgPhe: 2.169 ± 0.068
2.56ArgGly: 2.56 ± 0.073
1.031ArgHis: 1.031 ± 0.046
3.086ArgIle: 3.086 ± 0.076
2.628ArgLys: 2.628 ± 0.069
5.03ArgLeu: 5.03 ± 0.107
0.923ArgMet: 0.923 ± 0.036
2.022ArgAsn: 2.022 ± 0.058
1.502ArgPro: 1.502 ± 0.051
2.398ArgGln: 2.398 ± 0.069
2.067ArgArg: 2.067 ± 0.067
2.344ArgSer: 2.344 ± 0.07
2.023ArgThr: 2.023 ± 0.065
2.679ArgVal: 2.679 ± 0.088
0.507ArgTrp: 0.507 ± 0.03
1.727ArgTyr: 1.727 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.382SerAla: 5.382 ± 0.093
0.526SerCys: 0.526 ± 0.03
2.949SerAsp: 2.949 ± 0.068
3.574SerGlu: 3.574 ± 0.071
2.65SerPhe: 2.65 ± 0.067
4.466SerGly: 4.466 ± 0.112
1.327SerHis: 1.327 ± 0.055
3.949SerIle: 3.949 ± 0.083
3.232SerLys: 3.232 ± 0.085
6.395SerLeu: 6.395 ± 0.107
1.182SerMet: 1.182 ± 0.041
2.731SerAsn: 2.731 ± 0.081
2.219SerPro: 2.219 ± 0.062
3.061SerGln: 3.061 ± 0.083
2.56SerArg: 2.56 ± 0.069
3.73SerSer: 3.73 ± 0.097
3.102SerThr: 3.102 ± 0.097
4.064SerVal: 4.064 ± 0.095
0.686SerTrp: 0.686 ± 0.034
2.025SerTyr: 2.025 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.685ThrAla: 4.685 ± 0.174
0.436ThrCys: 0.436 ± 0.027
2.724ThrAsp: 2.724 ± 0.11
3.46ThrGlu: 3.46 ± 0.088
2.13ThrPhe: 2.13 ± 0.067
4.039ThrGly: 4.039 ± 0.154
1.185ThrHis: 1.185 ± 0.039
3.201ThrIle: 3.201 ± 0.096
2.798ThrLys: 2.798 ± 0.078
6.376ThrLeu: 6.376 ± 0.119
0.901ThrMet: 0.901 ± 0.044
2.366ThrAsn: 2.366 ± 0.113
2.578ThrPro: 2.578 ± 0.077
2.723ThrGln: 2.723 ± 0.074
1.911ThrArg: 1.911 ± 0.054
2.899ThrSer: 2.899 ± 0.084
3.029ThrThr: 3.029 ± 0.167
3.442ThrVal: 3.442 ± 0.121
0.472ThrTrp: 0.472 ± 0.027
1.566ThrTyr: 1.566 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
6.146ValAla: 6.146 ± 0.123
0.634ValCys: 0.634 ± 0.035
3.525ValAsp: 3.525 ± 0.095
4.61ValGlu: 4.61 ± 0.103
2.661ValPhe: 2.661 ± 0.073
4.677ValGly: 4.677 ± 0.113
1.098ValHis: 1.098 ± 0.042
4.601ValIle: 4.601 ± 0.095
4.381ValLys: 4.381 ± 0.096
6.353ValLeu: 6.353 ± 0.122
1.471ValMet: 1.471 ± 0.056
3.276ValAsn: 3.276 ± 0.088
2.219ValPro: 2.219 ± 0.064
2.654ValGln: 2.654 ± 0.065
2.806ValArg: 2.806 ± 0.076
4.042ValSer: 4.042 ± 0.089
3.336ValThr: 3.336 ± 0.114
4.841ValVal: 4.841 ± 0.112
0.571ValTrp: 0.571 ± 0.034
1.782ValTyr: 1.782 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.761TrpAla: 0.761 ± 0.038
0.166TrpCys: 0.166 ± 0.016
0.492TrpAsp: 0.492 ± 0.029
0.542TrpGlu: 0.542 ± 0.03
0.575TrpPhe: 0.575 ± 0.037
0.638TrpGly: 0.638 ± 0.035
0.28TrpHis: 0.28 ± 0.02
0.685TrpIle: 0.685 ± 0.033
0.62TrpLys: 0.62 ± 0.034
1.597TrpLeu: 1.597 ± 0.058
0.159TrpMet: 0.159 ± 0.016
0.499TrpAsn: 0.499 ± 0.029
0.149TrpPro: 0.149 ± 0.015
1.035TrpGln: 1.035 ± 0.045
0.607TrpArg: 0.607 ± 0.035
0.53TrpSer: 0.53 ± 0.03
0.436TrpThr: 0.436 ± 0.03
0.66TrpVal: 0.66 ± 0.029
0.161TrpTrp: 0.161 ± 0.014
0.307TrpTyr: 0.307 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.549TyrAla: 2.549 ± 0.074
0.371TyrCys: 0.371 ± 0.027
1.603TyrAsp: 1.603 ± 0.045
1.609TyrGlu: 1.609 ± 0.052
1.685TyrPhe: 1.685 ± 0.059
2.13TyrGly: 2.13 ± 0.063
0.854TyrHis: 0.854 ± 0.041
1.715TyrIle: 1.715 ± 0.055
1.55TyrLys: 1.55 ± 0.052
3.45TyrLeu: 3.45 ± 0.1
0.536TyrMet: 0.536 ± 0.03
1.269TyrAsn: 1.269 ± 0.05
1.41TyrPro: 1.41 ± 0.049
2.028TyrGln: 2.028 ± 0.072
1.752TyrArg: 1.752 ± 0.056
1.911TyrSer: 1.911 ± 0.062
1.457TyrThr: 1.457 ± 0.047
1.996TyrVal: 1.996 ± 0.049
0.458TyrTrp: 0.458 ± 0.026
1.032TyrTyr: 1.032 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2132 proteins (685025 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski