Amino acid dipepetide frequency for Paracoccus suum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.341AlaAla: 22.341 ± 0.313	1.057AlaCys: 1.057 ± 0.032	7.817AlaAsp: 7.817 ± 0.117	9.186AlaGlu: 9.186 ± 0.128	4.242AlaPhe: 4.242 ± 0.063	12.515AlaGly: 12.515 ± 0.144	2.332AlaHis: 2.332 ± 0.055	6.397AlaIle: 6.397 ± 0.075	3.309AlaLys: 3.309 ± 0.08	14.909AlaLeu: 14.909 ± 0.163	4.229AlaMet: 4.229 ± 0.064	2.784AlaAsn: 2.784 ± 0.057	7.704AlaPro: 7.704 ± 0.135	4.634AlaGln: 4.634 ± 0.082	11.02AlaArg: 11.02 ± 0.142	6.315AlaSer: 6.315 ± 0.088	6.71AlaThr: 6.71 ± 0.092	9.378AlaVal: 9.378 ± 0.112	1.671AlaTrp: 1.671 ± 0.043	2.259AlaTyr: 2.259 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.053CysAla: 1.053 ± 0.035	0.103CysCys: 0.103 ± 0.009	0.539CysAsp: 0.539 ± 0.025	0.395CysGlu: 0.395 ± 0.022	0.247CysPhe: 0.247 ± 0.017	0.864CysGly: 0.864 ± 0.035	0.266CysHis: 0.266 ± 0.018	0.377CysIle: 0.377 ± 0.022	0.149CysLys: 0.149 ± 0.012	0.71CysLeu: 0.71 ± 0.031	0.139CysMet: 0.139 ± 0.011	0.192CysAsn: 0.192 ± 0.013	0.487CysPro: 0.487 ± 0.023	0.217CysGln: 0.217 ± 0.015	0.566CysArg: 0.566 ± 0.029	0.346CysSer: 0.346 ± 0.018	0.386CysThr: 0.386 ± 0.023	0.51CysVal: 0.51 ± 0.024	0.115CysTrp: 0.115 ± 0.012	0.161CysTyr: 0.161 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.854AspAla: 7.854 ± 0.095	0.467AspCys: 0.467 ± 0.024	3.173AspAsp: 3.173 ± 0.077	3.286AspGlu: 3.286 ± 0.064	2.088AspPhe: 2.088 ± 0.046	5.683AspGly: 5.683 ± 0.087	1.269AspHis: 1.269 ± 0.039	2.485AspIle: 2.485 ± 0.059	1.421AspLys: 1.421 ± 0.05	6.433AspLeu: 6.433 ± 0.081	1.371AspMet: 1.371 ± 0.035	1.147AspAsn: 1.147 ± 0.037	4.169AspPro: 4.169 ± 0.075	1.794AspGln: 1.794 ± 0.045	4.718AspArg: 4.718 ± 0.081	2.252AspSer: 2.252 ± 0.048	2.59AspThr: 2.59 ± 0.059	3.821AspVal: 3.821 ± 0.065	1.209AspTrp: 1.209 ± 0.035	1.4AspTyr: 1.4 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.98GluAla: 8.98 ± 0.131	0.312GluCys: 0.312 ± 0.021	2.757GluAsp: 2.757 ± 0.059	2.386GluGlu: 2.386 ± 0.055	1.554GluPhe: 1.554 ± 0.04	5.12GluGly: 5.12 ± 0.078	0.975GluHis: 0.975 ± 0.032	3.011GluIle: 3.011 ± 0.059	1.45GluLys: 1.45 ± 0.047	4.534GluLeu: 4.534 ± 0.072	1.6GluMet: 1.6 ± 0.042	1.263GluAsn: 1.263 ± 0.035	2.644GluPro: 2.644 ± 0.057	1.573GluGln: 1.573 ± 0.039	4.27GluArg: 4.27 ± 0.073	1.974GluSer: 1.974 ± 0.048	2.975GluThr: 2.975 ± 0.057	4.587GluVal: 4.587 ± 0.076	0.698GluTrp: 0.698 ± 0.032	0.91GluTyr: 0.91 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.483PheAla: 4.483 ± 0.069	0.358PheCys: 0.358 ± 0.02	2.512PheAsp: 2.512 ± 0.049	1.716PheGlu: 1.716 ± 0.051	1.139PhePhe: 1.139 ± 0.039	3.394PheGly: 3.394 ± 0.06	0.678PheHis: 0.678 ± 0.026	1.447PheIle: 1.447 ± 0.041	0.721PheLys: 0.721 ± 0.029	3.033PheLeu: 3.033 ± 0.05	0.733PheMet: 0.733 ± 0.026	0.89PheAsn: 0.89 ± 0.03	1.497PhePro: 1.497 ± 0.04	0.959PheGln: 0.959 ± 0.036	2.132PheArg: 2.132 ± 0.052	1.787PheSer: 1.787 ± 0.048	1.88PheThr: 1.88 ± 0.051	2.476PheVal: 2.476 ± 0.06	0.567PheTrp: 0.567 ± 0.025	0.793PheTyr: 0.793 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.3GlyAla: 11.3 ± 0.146	0.83GlyCys: 0.83 ± 0.028	4.786GlyAsp: 4.786 ± 0.09	4.73GlyGlu: 4.73 ± 0.07	3.544GlyPhe: 3.544 ± 0.063	8.322GlyGly: 8.322 ± 0.131	1.886GlyHis: 1.886 ± 0.047	4.518GlyIle: 4.518 ± 0.087	2.914GlyLys: 2.914 ± 0.067	9.771GlyLeu: 9.771 ± 0.109	2.6GlyMet: 2.6 ± 0.056	2.134GlyAsn: 2.134 ± 0.074	4.486GlyPro: 4.486 ± 0.071	3.2GlyGln: 3.2 ± 0.064	6.986GlyArg: 6.986 ± 0.101	4.337GlySer: 4.337 ± 0.069	5.088GlyThr: 5.088 ± 0.086	6.486GlyVal: 6.486 ± 0.089	1.62GlyTrp: 1.62 ± 0.046	2.055GlyTyr: 2.055 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.418HisAla: 2.418 ± 0.056	0.196HisCys: 0.196 ± 0.017	1.297HisAsp: 1.297 ± 0.038	0.946HisGlu: 0.946 ± 0.033	0.71HisPhe: 0.71 ± 0.026	1.922HisGly: 1.922 ± 0.049	0.497HisHis: 0.497 ± 0.025	0.822HisIle: 0.822 ± 0.033	0.393HisLys: 0.393 ± 0.021	2.047HisLeu: 2.047 ± 0.049	0.464HisMet: 0.464 ± 0.025	0.394HisAsn: 0.394 ± 0.023	1.439HisPro: 1.439 ± 0.042	0.546HisGln: 0.546 ± 0.027	1.408HisArg: 1.408 ± 0.038	0.779HisSer: 0.779 ± 0.027	0.698HisThr: 0.698 ± 0.032	1.407HisVal: 1.407 ± 0.038	0.339HisTrp: 0.339 ± 0.017	0.498HisTyr: 0.498 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.734IleAla: 7.734 ± 0.091	0.484IleCys: 0.484 ± 0.024	3.427IleAsp: 3.427 ± 0.059	3.217IleGlu: 3.217 ± 0.058	1.499IlePhe: 1.499 ± 0.044	4.759IleGly: 4.759 ± 0.073	0.852IleHis: 0.852 ± 0.033	2.048IleIle: 2.048 ± 0.055	1.099IleLys: 1.099 ± 0.033	4.397IleLeu: 4.397 ± 0.087	1.04IleMet: 1.04 ± 0.031	1.183IleAsn: 1.183 ± 0.037	2.243IlePro: 2.243 ± 0.053	1.028IleGln: 1.028 ± 0.035	3.133IleArg: 3.133 ± 0.056	2.463IleSer: 2.463 ± 0.05	2.803IleThr: 2.803 ± 0.055	3.565IleVal: 3.565 ± 0.072	0.653IleTrp: 0.653 ± 0.027	1.043IleTyr: 1.043 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.446LysAla: 3.446 ± 0.084	0.126LysCys: 0.126 ± 0.01	1.422LysAsp: 1.422 ± 0.046	1.011LysGlu: 1.011 ± 0.035	0.703LysPhe: 0.703 ± 0.029	2.324LysGly: 2.324 ± 0.059	0.438LysHis: 0.438 ± 0.02	1.225LysIle: 1.225 ± 0.041	0.782LysLys: 0.782 ± 0.036	2.43LysLeu: 2.43 ± 0.06	0.65LysMet: 0.65 ± 0.025	0.581LysAsn: 0.581 ± 0.029	1.547LysPro: 1.547 ± 0.042	0.678LysGln: 0.678 ± 0.028	1.734LysArg: 1.734 ± 0.048	1.411LysSer: 1.411 ± 0.043	1.541LysThr: 1.541 ± 0.041	1.985LysVal: 1.985 ± 0.048	0.288LysTrp: 0.288 ± 0.02	0.496LysTyr: 0.496 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.145LeuAla: 15.145 ± 0.157	0.795LeuCys: 0.795 ± 0.032	6.09LeuAsp: 6.09 ± 0.078	4.433LeuGlu: 4.433 ± 0.076	3.074LeuPhe: 3.074 ± 0.072	9.055LeuGly: 9.055 ± 0.128	1.854LeuHis: 1.854 ± 0.045	5.225LeuIle: 5.225 ± 0.093	2.56LeuLys: 2.56 ± 0.053	8.929LeuLeu: 8.929 ± 0.137	2.66LeuMet: 2.66 ± 0.059	2.314LeuAsn: 2.314 ± 0.046	6.254LeuPro: 6.254 ± 0.087	2.618LeuGln: 2.618 ± 0.053	7.778LeuArg: 7.778 ± 0.119	6.108LeuSer: 6.108 ± 0.088	6.386LeuThr: 6.386 ± 0.09	7.069LeuVal: 7.069 ± 0.099	1.331LeuTrp: 1.331 ± 0.038	1.73LeuTyr: 1.73 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.736MetAla: 3.736 ± 0.067	0.138MetCys: 0.138 ± 0.012	1.355MetAsp: 1.355 ± 0.037	1.112MetGlu: 1.112 ± 0.031	0.745MetPhe: 0.745 ± 0.03	2.145MetGly: 2.145 ± 0.055	0.411MetHis: 0.411 ± 0.024	1.452MetIle: 1.452 ± 0.037	0.742MetLys: 0.742 ± 0.031	2.744MetLeu: 2.744 ± 0.059	0.711MetMet: 0.711 ± 0.029	0.736MetAsn: 0.736 ± 0.026	1.602MetPro: 1.602 ± 0.037	0.911MetGln: 0.911 ± 0.027	1.997MetArg: 1.997 ± 0.048	1.632MetSer: 1.632 ± 0.042	2.01MetThr: 2.01 ± 0.051	1.805MetVal: 1.805 ± 0.046	0.213MetTrp: 0.213 ± 0.015	0.299MetTyr: 0.299 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.917AsnAla: 2.917 ± 0.053	0.218AsnCys: 0.218 ± 0.015	1.246AsnAsp: 1.246 ± 0.058	0.965AsnGlu: 0.965 ± 0.032	0.807AsnPhe: 0.807 ± 0.032	2.083AsnGly: 2.083 ± 0.054	0.408AsnHis: 0.408 ± 0.018	1.167AsnIle: 1.167 ± 0.038	0.498AsnLys: 0.498 ± 0.023	2.382AsnLeu: 2.382 ± 0.052	0.575AsnMet: 0.575 ± 0.024	0.528AsnAsn: 0.528 ± 0.027	1.824AsnPro: 1.824 ± 0.041	0.619AsnGln: 0.619 ± 0.025	1.669AsnArg: 1.669 ± 0.041	0.998AsnSer: 0.998 ± 0.037	1.057AsnThr: 1.057 ± 0.039	1.583AsnVal: 1.583 ± 0.043	0.419AsnTrp: 0.419 ± 0.021	0.559AsnTyr: 0.559 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	8.388ProAla: 8.388 ± 0.143	0.33ProCys: 0.33 ± 0.02	4.209ProAsp: 4.209 ± 0.069	4.041ProGlu: 4.041 ± 0.067	1.802ProPhe: 1.802 ± 0.049	5.603ProGly: 5.603 ± 0.092	1.105ProHis: 1.105 ± 0.037	2.258ProIle: 2.258 ± 0.05	1.325ProLys: 1.325 ± 0.042	5.336ProLeu: 5.336 ± 0.083	1.354ProMet: 1.354 ± 0.04	1.19ProAsn: 1.19 ± 0.032	3.271ProPro: 3.271 ± 0.078	2.075ProGln: 2.075 ± 0.053	3.68ProArg: 3.68 ± 0.078	2.647ProSer: 2.647 ± 0.061	2.73ProThr: 2.73 ± 0.054	4.624ProVal: 4.624 ± 0.074	0.775ProTrp: 0.775 ± 0.031	1.122ProTyr: 1.122 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.2GlnAla: 4.2 ± 0.073	0.179GlnCys: 0.179 ± 0.015	1.508GlnAsp: 1.508 ± 0.039	1.095GlnGlu: 1.095 ± 0.035	1.003GlnPhe: 1.003 ± 0.03	2.661GlnGly: 2.661 ± 0.053	0.58GlnHis: 0.58 ± 0.025	1.929GlnIle: 1.929 ± 0.043	0.791GlnLys: 0.791 ± 0.031	2.911GlnLeu: 2.911 ± 0.062	1.008GlnMet: 1.008 ± 0.032	0.73GlnAsn: 0.73 ± 0.031	2.005GlnPro: 2.005 ± 0.048	1.117GlnGln: 1.117 ± 0.036	2.388GlnArg: 2.388 ± 0.057	1.589GlnSer: 1.589 ± 0.039	1.727GlnThr: 1.727 ± 0.037	2.446GlnVal: 2.446 ± 0.046	0.371GlnTrp: 0.371 ± 0.02	0.551GlnTyr: 0.551 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.886ArgAla: 9.886 ± 0.102	0.485ArgCys: 0.485 ± 0.026	4.5ArgAsp: 4.5 ± 0.068	4.085ArgGlu: 4.085 ± 0.064	2.658ArgPhe: 2.658 ± 0.052	5.611ArgGly: 5.611 ± 0.077	1.643ArgHis: 1.643 ± 0.042	4.052ArgIle: 4.052 ± 0.063	1.85ArgLys: 1.85 ± 0.04	8.596ArgLeu: 8.596 ± 0.137	2.144ArgMet: 2.144 ± 0.048	1.626ArgAsn: 1.626 ± 0.036	4.356ArgPro: 4.356 ± 0.078	2.499ArgGln: 2.499 ± 0.056	6.116ArgArg: 6.116 ± 0.09	3.221ArgSer: 3.221 ± 0.062	3.327ArgThr: 3.327 ± 0.059	5.19ArgVal: 5.19 ± 0.082	1.08ArgTrp: 1.08 ± 0.035	1.472ArgTyr: 1.472 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.207SerAla: 6.207 ± 0.1	0.377SerCys: 0.377 ± 0.023	2.81SerAsp: 2.81 ± 0.061	2.356SerGlu: 2.356 ± 0.048	1.921SerPhe: 1.921 ± 0.048	5.467SerGly: 5.467 ± 0.082	0.977SerHis: 0.977 ± 0.034	2.284SerIle: 2.284 ± 0.054	1.028SerLys: 1.028 ± 0.041	4.857SerLeu: 4.857 ± 0.081	1.156SerMet: 1.156 ± 0.038	1.131SerAsn: 1.131 ± 0.036	2.657SerPro: 2.657 ± 0.064	1.503SerGln: 1.503 ± 0.042	3.454SerArg: 3.454 ± 0.069	2.15SerSer: 2.15 ± 0.049	2.32SerThr: 2.32 ± 0.049	3.545SerVal: 3.545 ± 0.062	0.695SerTrp: 0.695 ± 0.029	1.134SerTyr: 1.134 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.13ThrAla: 7.13 ± 0.093	0.458ThrCys: 0.458 ± 0.025	3.051ThrAsp: 3.051 ± 0.06	2.876ThrGlu: 2.876 ± 0.058	1.737ThrPhe: 1.737 ± 0.044	5.522ThrGly: 5.522 ± 0.081	1.037ThrHis: 1.037 ± 0.034	2.5ThrIle: 2.5 ± 0.053	1.114ThrLys: 1.114 ± 0.035	5.894ThrLeu: 5.894 ± 0.082	1.158ThrMet: 1.158 ± 0.036	1.13ThrAsn: 1.13 ± 0.036	3.692ThrPro: 3.692 ± 0.064	1.423ThrGln: 1.423 ± 0.038	3.794ThrArg: 3.794 ± 0.059	2.435ThrSer: 2.435 ± 0.049	2.898ThrThr: 2.898 ± 0.07	4.224ThrVal: 4.224 ± 0.067	0.646ThrTrp: 0.646 ± 0.029	1.043ThrTyr: 1.043 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.671ValAla: 9.671 ± 0.108	0.557ValCys: 0.557 ± 0.025	3.954ValAsp: 3.954 ± 0.07	4.214ValGlu: 4.214 ± 0.066	2.454ValPhe: 2.454 ± 0.057	5.57ValGly: 5.57 ± 0.083	1.25ValHis: 1.25 ± 0.043	4.097ValIle: 4.097 ± 0.072	1.839ValLys: 1.839 ± 0.054	7.605ValLeu: 7.605 ± 0.106	2.138ValMet: 2.138 ± 0.053	1.699ValAsn: 1.699 ± 0.043	4.18ValPro: 4.18 ± 0.066	2.097ValGln: 2.097 ± 0.047	4.737ValArg: 4.737 ± 0.06	3.813ValSer: 3.813 ± 0.062	4.838ValThr: 4.838 ± 0.083	5.596ValVal: 5.596 ± 0.105	1.011ValTrp: 1.011 ± 0.035	1.289ValTyr: 1.289 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.471TrpAla: 1.471 ± 0.044	0.141TrpCys: 0.141 ± 0.012	0.813TrpAsp: 0.813 ± 0.033	0.525TrpGlu: 0.525 ± 0.026	0.516TrpPhe: 0.516 ± 0.024	1.078TrpGly: 1.078 ± 0.039	0.341TrpHis: 0.341 ± 0.019	0.632TrpIle: 0.632 ± 0.026	0.366TrpLys: 0.366 ± 0.021	1.866TrpLeu: 1.866 ± 0.05	0.364TrpMet: 0.364 ± 0.02	0.391TrpAsn: 0.391 ± 0.022	0.769TrpPro: 0.769 ± 0.031	0.652TrpGln: 0.652 ± 0.025	1.327TrpArg: 1.327 ± 0.039	0.783TrpSer: 0.783 ± 0.028	0.822TrpThr: 0.822 ± 0.031	0.89TrpVal: 0.89 ± 0.036	0.261TrpTrp: 0.261 ± 0.018	0.25TrpTyr: 0.25 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.451TyrAla: 2.451 ± 0.05	0.21TyrCys: 0.21 ± 0.014	1.362TyrAsp: 1.362 ± 0.04	0.996TyrGlu: 0.996 ± 0.038	0.752TyrPhe: 0.752 ± 0.027	1.894TyrGly: 1.894 ± 0.049	0.421TyrHis: 0.421 ± 0.022	0.744TyrIle: 0.744 ± 0.029	0.467TyrLys: 0.467 ± 0.025	2.023TyrLeu: 2.023 ± 0.044	0.402TyrMet: 0.402 ± 0.022	0.483TyrAsn: 0.483 ± 0.024	1.039TyrPro: 1.039 ± 0.035	0.645TyrGln: 0.645 ± 0.027	1.489TyrArg: 1.489 ± 0.049	0.989TyrSer: 0.989 ± 0.034	0.975TyrThr: 0.975 ± 0.035	1.424TyrVal: 1.424 ± 0.038	0.295TyrTrp: 0.295 ± 0.017	0.476TyrTyr: 0.476 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3039 proteins (964569 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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