Amino acid dipepetide frequency for Sphingomonas edaphi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.033AlaAla: 18.033 ± 0.245
0.987AlaCys: 0.987 ± 0.041
7.254AlaAsp: 7.254 ± 0.114
7.686AlaGlu: 7.686 ± 0.134
4.182AlaPhe: 4.182 ± 0.083
10.778AlaGly: 10.778 ± 0.142
2.16AlaHis: 2.16 ± 0.055
7.057AlaIle: 7.057 ± 0.104
4.544AlaLys: 4.544 ± 0.096
13.294AlaLeu: 13.294 ± 0.163
3.867AlaMet: 3.867 ± 0.08
3.453AlaAsn: 3.453 ± 0.079
5.757AlaPro: 5.757 ± 0.117
4.007AlaGln: 4.007 ± 0.078
9.126AlaArg: 9.126 ± 0.143
6.774AlaSer: 6.774 ± 0.121
6.276AlaThr: 6.276 ± 0.089
8.551AlaVal: 8.551 ± 0.118
1.437AlaTrp: 1.437 ± 0.05
2.448AlaTyr: 2.448 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.038
0.074CysCys: 0.074 ± 0.01
0.517CysAsp: 0.517 ± 0.025
0.373CysGlu: 0.373 ± 0.022
0.269CysPhe: 0.269 ± 0.02
0.815CysGly: 0.815 ± 0.036
0.214CysHis: 0.214 ± 0.019
0.354CysIle: 0.354 ± 0.023
0.199CysLys: 0.199 ± 0.017
0.633CysLeu: 0.633 ± 0.029
0.137CysMet: 0.137 ± 0.013
0.221CysAsn: 0.221 ± 0.02
0.475CysPro: 0.475 ± 0.026
0.196CysGln: 0.196 ± 0.017
0.524CysArg: 0.524 ± 0.032
0.479CysSer: 0.479 ± 0.026
0.346CysThr: 0.346 ± 0.02
0.512CysVal: 0.512 ± 0.028
0.085CysTrp: 0.085 ± 0.011
0.147CysTyr: 0.147 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.315AspAla: 7.315 ± 0.112
0.505AspCys: 0.505 ± 0.027
3.438AspAsp: 3.438 ± 0.077
4.105AspGlu: 4.105 ± 0.082
2.142AspPhe: 2.142 ± 0.062
5.82AspGly: 5.82 ± 0.127
1.265AspHis: 1.265 ± 0.041
2.87AspIle: 2.87 ± 0.071
1.897AspLys: 1.897 ± 0.048
5.802AspLeu: 5.802 ± 0.088
1.278AspMet: 1.278 ± 0.038
1.371AspAsn: 1.371 ± 0.049
3.738AspPro: 3.738 ± 0.078
1.865AspGln: 1.865 ± 0.046
5.072AspArg: 5.072 ± 0.088
2.533AspSer: 2.533 ± 0.058
2.448AspThr: 2.448 ± 0.084
4.146AspVal: 4.146 ± 0.082
1.029AspTrp: 1.029 ± 0.046
1.53AspTyr: 1.53 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
8.143GluAla: 8.143 ± 0.123
0.358GluCys: 0.358 ± 0.022
2.843GluAsp: 2.843 ± 0.071
3.519GluGlu: 3.519 ± 0.079
1.736GluPhe: 1.736 ± 0.049
4.984GluGly: 4.984 ± 0.084
1.14GluHis: 1.14 ± 0.042
3.069GluIle: 3.069 ± 0.069
2.212GluLys: 2.212 ± 0.052
5.661GluLeu: 5.661 ± 0.089
1.455GluMet: 1.455 ± 0.043
1.434GluAsn: 1.434 ± 0.044
2.79GluPro: 2.79 ± 0.064
2.262GluGln: 2.262 ± 0.059
5.245GluArg: 5.245 ± 0.1
2.491GluSer: 2.491 ± 0.06
2.997GluThr: 2.997 ± 0.064
3.955GluVal: 3.955 ± 0.076
0.858GluTrp: 0.858 ± 0.037
0.996GluTyr: 0.996 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.651PheAla: 4.651 ± 0.101
0.305PheCys: 0.305 ± 0.018
2.735PheAsp: 2.735 ± 0.06
2.138PheGlu: 2.138 ± 0.057
1.304PhePhe: 1.304 ± 0.048
3.568PheGly: 3.568 ± 0.077
0.685PheHis: 0.685 ± 0.031
1.573PheIle: 1.573 ± 0.048
0.969PheLys: 0.969 ± 0.038
2.977PheLeu: 2.977 ± 0.066
0.653PheMet: 0.653 ± 0.034
1.033PheAsn: 1.033 ± 0.034
1.434PhePro: 1.434 ± 0.038
0.876PheGln: 0.876 ± 0.036
2.13PheArg: 2.13 ± 0.059
1.947PheSer: 1.947 ± 0.056
1.962PheThr: 1.962 ± 0.055
2.627PheVal: 2.627 ± 0.068
0.502PheTrp: 0.502 ± 0.03
0.888PheTyr: 0.888 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
9.417GlyAla: 9.417 ± 0.131
0.788GlyCys: 0.788 ± 0.037
5.117GlyAsp: 5.117 ± 0.097
5.345GlyGlu: 5.345 ± 0.095
3.41GlyPhe: 3.41 ± 0.083
8.253GlyGly: 8.253 ± 0.169
1.84GlyHis: 1.84 ± 0.052
4.597GlyIle: 4.597 ± 0.096
3.679GlyLys: 3.679 ± 0.078
8.478GlyLeu: 8.478 ± 0.112
2.204GlyMet: 2.204 ± 0.052
2.455GlyAsn: 2.455 ± 0.095
3.689GlyPro: 3.689 ± 0.073
3.051GlyGln: 3.051 ± 0.056
6.565GlyArg: 6.565 ± 0.105
5.219GlySer: 5.219 ± 0.107
4.622GlyThr: 4.622 ± 0.1
6.042GlyVal: 6.042 ± 0.084
1.645GlyTrp: 1.645 ± 0.055
2.236GlyTyr: 2.236 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.183HisAla: 2.183 ± 0.052
0.224HisCys: 0.224 ± 0.018
1.124HisAsp: 1.124 ± 0.033
1.039HisGlu: 1.039 ± 0.041
0.812HisPhe: 0.812 ± 0.034
1.925HisGly: 1.925 ± 0.057
0.556HisHis: 0.556 ± 0.029
0.859HisIle: 0.859 ± 0.037
0.487HisLys: 0.487 ± 0.025
1.864HisLeu: 1.864 ± 0.048
0.41HisMet: 0.41 ± 0.027
0.423HisAsn: 0.423 ± 0.024
1.274HisPro: 1.274 ± 0.042
0.534HisGln: 0.534 ± 0.025
1.482HisArg: 1.482 ± 0.046
1.061HisSer: 1.061 ± 0.042
0.58HisThr: 0.58 ± 0.027
1.337HisVal: 1.337 ± 0.044
0.339HisTrp: 0.339 ± 0.021
0.52HisTyr: 0.52 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
7.544IleAla: 7.544 ± 0.096
0.38IleCys: 0.38 ± 0.026
4.063IleAsp: 4.063 ± 0.073
3.704IleGlu: 3.704 ± 0.065
1.623IlePhe: 1.623 ± 0.054
5.05IleGly: 5.05 ± 0.096
0.865IleHis: 0.865 ± 0.032
2.188IleIle: 2.188 ± 0.056
1.35IleLys: 1.35 ± 0.048
4.332IleLeu: 4.332 ± 0.082
0.881IleMet: 0.881 ± 0.034
1.419IleAsn: 1.419 ± 0.049
2.266IlePro: 2.266 ± 0.061
1.205IleGln: 1.205 ± 0.042
3.248IleArg: 3.248 ± 0.066
2.749IleSer: 2.749 ± 0.064
2.275IleThr: 2.275 ± 0.063
4.278IleVal: 4.278 ± 0.072
0.535IleTrp: 0.535 ± 0.027
1.005IleTyr: 1.005 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.433LysAla: 4.433 ± 0.085
0.174LysCys: 0.174 ± 0.015
1.864LysAsp: 1.864 ± 0.057
1.588LysGlu: 1.588 ± 0.05
0.926LysPhe: 0.926 ± 0.037
2.868LysGly: 2.868 ± 0.065
0.565LysHis: 0.565 ± 0.03
1.65LysIle: 1.65 ± 0.052
1.367LysLys: 1.367 ± 0.059
3.801LysLeu: 3.801 ± 0.079
0.878LysMet: 0.878 ± 0.037
0.734LysAsn: 0.734 ± 0.033
2.1LysPro: 2.1 ± 0.061
1.061LysGln: 1.061 ± 0.041
2.609LysArg: 2.609 ± 0.071
1.993LysSer: 1.993 ± 0.053
1.754LysThr: 1.754 ± 0.043
2.583LysVal: 2.583 ± 0.059
0.421LysTrp: 0.421 ± 0.026
0.627LysTyr: 0.627 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
13.888LeuAla: 13.888 ± 0.175
0.685LeuCys: 0.685 ± 0.033
6.329LeuAsp: 6.329 ± 0.096
5.231LeuGlu: 5.231 ± 0.086
3.671LeuPhe: 3.671 ± 0.083
8.574LeuGly: 8.574 ± 0.123
1.79LeuHis: 1.79 ± 0.054
4.85LeuIle: 4.85 ± 0.084
3.663LeuLys: 3.663 ± 0.081
9.705LeuLeu: 9.705 ± 0.167
2.094LeuMet: 2.094 ± 0.05
2.543LeuAsn: 2.543 ± 0.067
5.168LeuPro: 5.168 ± 0.089
2.662LeuGln: 2.662 ± 0.062
6.509LeuArg: 6.509 ± 0.096
6.097LeuSer: 6.097 ± 0.09
5.454LeuThr: 5.454 ± 0.1
7.527LeuVal: 7.527 ± 0.119
1.153LeuTrp: 1.153 ± 0.044
1.908LeuTyr: 1.908 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
3.071MetAla: 3.071 ± 0.066
0.154MetCys: 0.154 ± 0.014
1.15MetAsp: 1.15 ± 0.038
1.05MetGlu: 1.05 ± 0.039
0.689MetPhe: 0.689 ± 0.033
1.839MetGly: 1.839 ± 0.048
0.408MetHis: 0.408 ± 0.024
1.348MetIle: 1.348 ± 0.045
1.037MetLys: 1.037 ± 0.039
2.595MetLeu: 2.595 ± 0.06
0.663MetMet: 0.663 ± 0.028
0.689MetAsn: 0.689 ± 0.032
1.424MetPro: 1.424 ± 0.045
0.693MetGln: 0.693 ± 0.031
1.785MetArg: 1.785 ± 0.048
1.493MetSer: 1.493 ± 0.049
1.726MetThr: 1.726 ± 0.047
1.667MetVal: 1.667 ± 0.051
0.251MetTrp: 0.251 ± 0.019
0.255MetTyr: 0.255 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.184AsnAla: 3.184 ± 0.073
0.247AsnCys: 0.247 ± 0.021
1.569AsnAsp: 1.569 ± 0.067
1.315AsnGlu: 1.315 ± 0.047
0.951AsnPhe: 0.951 ± 0.044
2.432AsnGly: 2.432 ± 0.076
0.504AsnHis: 0.504 ± 0.026
1.365AsnIle: 1.365 ± 0.046
0.719AsnLys: 0.719 ± 0.031
2.585AsnLeu: 2.585 ± 0.06
0.563AsnMet: 0.563 ± 0.026
0.709AsnAsn: 0.709 ± 0.036
1.806AsnPro: 1.806 ± 0.055
0.854AsnGln: 0.854 ± 0.035
2.037AsnArg: 2.037 ± 0.054
1.475AsnSer: 1.475 ± 0.047
0.98AsnThr: 0.98 ± 0.048
1.925AsnVal: 1.925 ± 0.054
0.421AsnTrp: 0.421 ± 0.024
0.681AsnTyr: 0.681 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
6.487ProAla: 6.487 ± 0.118
0.318ProCys: 0.318 ± 0.023
3.591ProAsp: 3.591 ± 0.071
3.424ProGlu: 3.424 ± 0.067
1.835ProPhe: 1.835 ± 0.052
4.519ProGly: 4.519 ± 0.081
0.944ProHis: 0.944 ± 0.036
2.555ProIle: 2.555 ± 0.058
1.795ProLys: 1.795 ± 0.053
4.761ProLeu: 4.761 ± 0.075
1.234ProMet: 1.234 ± 0.046
1.359ProAsn: 1.359 ± 0.047
2.893ProPro: 2.893 ± 0.116
1.65ProGln: 1.65 ± 0.048
3.019ProArg: 3.019 ± 0.062
2.959ProSer: 2.959 ± 0.071
2.639ProThr: 2.639 ± 0.063
4.29ProVal: 4.29 ± 0.079
0.616ProTrp: 0.616 ± 0.028
1.123ProTyr: 1.123 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.869GlnAla: 3.869 ± 0.077
0.203GlnCys: 0.203 ± 0.016
1.357GlnAsp: 1.357 ± 0.045
1.328GlnGlu: 1.328 ± 0.045
1.142GlnPhe: 1.142 ± 0.038
2.404GlnGly: 2.404 ± 0.061
0.598GlnHis: 0.598 ± 0.03
1.549GlnIle: 1.549 ± 0.047
1.01GlnLys: 1.01 ± 0.039
3.478GlnLeu: 3.478 ± 0.073
0.836GlnMet: 0.836 ± 0.037
0.719GlnAsn: 0.719 ± 0.038
1.927GlnPro: 1.927 ± 0.051
1.224GlnGln: 1.224 ± 0.052
2.649GlnArg: 2.649 ± 0.065
1.88GlnSer: 1.88 ± 0.056
1.392GlnThr: 1.392 ± 0.044
2.384GlnVal: 2.384 ± 0.057
0.409GlnTrp: 0.409 ± 0.026
0.608GlnTyr: 0.608 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
8.318ArgAla: 8.318 ± 0.123
0.484ArgCys: 0.484 ± 0.024
4.337ArgAsp: 4.337 ± 0.072
4.28ArgGlu: 4.28 ± 0.098
3.148ArgPhe: 3.148 ± 0.065
5.127ArgGly: 5.127 ± 0.084
1.61ArgHis: 1.61 ± 0.049
3.995ArgIle: 3.995 ± 0.066
2.392ArgLys: 2.392 ± 0.053
8.404ArgLeu: 8.404 ± 0.125
1.984ArgMet: 1.984 ± 0.053
1.924ArgAsn: 1.924 ± 0.051
3.733ArgPro: 3.733 ± 0.069
2.623ArgGln: 2.623 ± 0.06
5.913ArgArg: 5.913 ± 0.104
4.0ArgSer: 4.0 ± 0.085
3.506ArgThr: 3.506 ± 0.067
4.75ArgVal: 4.75 ± 0.088
1.208ArgTrp: 1.208 ± 0.044
1.801ArgTyr: 1.801 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
6.708SerAla: 6.708 ± 0.12
0.413SerCys: 0.413 ± 0.025
3.279SerAsp: 3.279 ± 0.068
2.901SerGlu: 2.901 ± 0.073
2.183SerPhe: 2.183 ± 0.053
5.576SerGly: 5.576 ± 0.11
0.981SerHis: 0.981 ± 0.034
2.953SerIle: 2.953 ± 0.059
1.783SerLys: 1.783 ± 0.049
5.617SerLeu: 5.617 ± 0.085
1.339SerMet: 1.339 ± 0.04
1.523SerAsn: 1.523 ± 0.043
2.827SerPro: 2.827 ± 0.059
1.619SerGln: 1.619 ± 0.047
3.83SerArg: 3.83 ± 0.074
3.268SerSer: 3.268 ± 0.077
2.697SerThr: 2.697 ± 0.066
3.745SerVal: 3.745 ± 0.071
0.803SerTrp: 0.803 ± 0.034
1.254SerTyr: 1.254 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.948ThrAla: 5.948 ± 0.085
0.365ThrCys: 0.365 ± 0.025
2.812ThrAsp: 2.812 ± 0.065
2.503ThrGlu: 2.503 ± 0.059
1.672ThrPhe: 1.672 ± 0.051
5.026ThrGly: 5.026 ± 0.103
0.876ThrHis: 0.876 ± 0.037
2.89ThrIle: 2.89 ± 0.067
1.504ThrLys: 1.504 ± 0.05
5.363ThrLeu: 5.363 ± 0.088
1.134ThrMet: 1.134 ± 0.04
1.309ThrAsn: 1.309 ± 0.049
3.174ThrPro: 3.174 ± 0.064
1.376ThrGln: 1.376 ± 0.044
3.233ThrArg: 3.233 ± 0.068
2.688ThrSer: 2.688 ± 0.062
2.54ThrThr: 2.54 ± 0.066
4.262ThrVal: 4.262 ± 0.089
0.494ThrTrp: 0.494 ± 0.03
1.086ThrTyr: 1.086 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
9.793ValAla: 9.793 ± 0.142
0.494ValCys: 0.494 ± 0.025
4.61ValAsp: 4.61 ± 0.088
4.876ValGlu: 4.876 ± 0.087
1.951ValPhe: 1.951 ± 0.061
6.101ValGly: 6.101 ± 0.102
1.319ValHis: 1.319 ± 0.05
3.793ValIle: 3.793 ± 0.076
2.249ValLys: 2.249 ± 0.069
6.252ValLeu: 6.252 ± 0.094
1.658ValMet: 1.658 ± 0.046
2.004ValAsn: 2.004 ± 0.054
3.858ValPro: 3.858 ± 0.075
1.983ValGln: 1.983 ± 0.058
5.377ValArg: 5.377 ± 0.09
4.105ValSer: 4.105 ± 0.084
4.431ValThr: 4.431 ± 0.093
5.33ValVal: 5.33 ± 0.097
0.807ValTrp: 0.807 ± 0.037
1.25ValTyr: 1.25 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.405TrpAla: 1.405 ± 0.051
0.102TrpCys: 0.102 ± 0.011
0.696TrpAsp: 0.696 ± 0.026
0.576TrpGlu: 0.576 ± 0.028
0.465TrpPhe: 0.465 ± 0.027
0.882TrpGly: 0.882 ± 0.034
0.284TrpHis: 0.284 ± 0.024
0.661TrpIle: 0.661 ± 0.033
0.493TrpLys: 0.493 ± 0.027
1.74TrpLeu: 1.74 ± 0.064
0.354TrpMet: 0.354 ± 0.023
0.435TrpAsn: 0.435 ± 0.025
0.701TrpPro: 0.701 ± 0.03
0.537TrpGln: 0.537 ± 0.028
1.243TrpArg: 1.243 ± 0.046
0.887TrpSer: 0.887 ± 0.035
0.799TrpThr: 0.799 ± 0.033
0.878TrpVal: 0.878 ± 0.038
0.258TrpTrp: 0.258 ± 0.021
0.254TrpTyr: 0.254 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.055
0.206TyrCys: 0.206 ± 0.017
1.485TyrAsp: 1.485 ± 0.047
1.166TyrGlu: 1.166 ± 0.039
0.844TyrPhe: 0.844 ± 0.035
2.111TyrGly: 2.111 ± 0.061
0.43TyrHis: 0.43 ± 0.027
0.785TyrIle: 0.785 ± 0.034
0.646TyrLys: 0.646 ± 0.031
2.159TyrLeu: 2.159 ± 0.054
0.365TyrMet: 0.365 ± 0.02
0.564TyrAsn: 0.564 ± 0.031
0.977TyrPro: 0.977 ± 0.041
0.689TyrGln: 0.689 ± 0.035
1.939TyrArg: 1.939 ± 0.061
1.202TyrSer: 1.202 ± 0.042
0.83TyrThr: 0.83 ± 0.038
1.452TyrVal: 1.452 ± 0.046
0.379TyrTrp: 0.379 ± 0.022
0.561TyrTyr: 0.561 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2311 proteins (728684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski