Amino acid dipepetide frequency for Xanthomarina gelatinilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.891AlaAla: 3.891 ± 0.085
0.606AlaCys: 0.606 ± 0.029
3.121AlaAsp: 3.121 ± 0.06
3.831AlaGlu: 3.831 ± 0.081
3.61AlaPhe: 3.61 ± 0.077
3.825AlaGly: 3.825 ± 0.085
1.226AlaHis: 1.226 ± 0.039
5.572AlaIle: 5.572 ± 0.088
4.651AlaLys: 4.651 ± 0.091
6.58AlaLeu: 6.58 ± 0.088
1.504AlaMet: 1.504 ± 0.049
3.679AlaAsn: 3.679 ± 0.075
1.792AlaPro: 1.792 ± 0.045
2.429AlaGln: 2.429 ± 0.054
1.79AlaArg: 1.79 ± 0.048
4.198AlaSer: 4.198 ± 0.074
3.851AlaThr: 3.851 ± 0.089
3.892AlaVal: 3.892 ± 0.067
0.594AlaTrp: 0.594 ± 0.028
2.725AlaTyr: 2.725 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.479CysAla: 0.479 ± 0.025
0.122CysCys: 0.122 ± 0.017
0.429CysAsp: 0.429 ± 0.026
0.443CysGlu: 0.443 ± 0.025
0.438CysPhe: 0.438 ± 0.024
0.625CysGly: 0.625 ± 0.031
0.217CysHis: 0.217 ± 0.016
0.54CysIle: 0.54 ± 0.03
0.511CysLys: 0.511 ± 0.027
0.678CysLeu: 0.678 ± 0.031
0.184CysMet: 0.184 ± 0.014
0.428CysAsn: 0.428 ± 0.023
0.325CysPro: 0.325 ± 0.023
0.236CysGln: 0.236 ± 0.02
0.173CysArg: 0.173 ± 0.016
0.546CysSer: 0.546 ± 0.029
0.39CysThr: 0.39 ± 0.032
0.448CysVal: 0.448 ± 0.021
0.081CysTrp: 0.081 ± 0.01
0.32CysTyr: 0.32 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.848AspAla: 3.848 ± 0.078
0.451AspCys: 0.451 ± 0.026
2.839AspAsp: 2.839 ± 0.072
3.492AspGlu: 3.492 ± 0.07
3.483AspPhe: 3.483 ± 0.061
3.398AspGly: 3.398 ± 0.082
0.903AspHis: 0.903 ± 0.037
4.621AspIle: 4.621 ± 0.069
3.999AspLys: 3.999 ± 0.077
5.332AspLeu: 5.332 ± 0.078
1.249AspMet: 1.249 ± 0.035
3.139AspAsn: 3.139 ± 0.071
1.516AspPro: 1.516 ± 0.045
1.446AspGln: 1.446 ± 0.043
1.627AspArg: 1.627 ± 0.044
3.119AspSer: 3.119 ± 0.067
3.032AspThr: 3.032 ± 0.059
3.876AspVal: 3.876 ± 0.069
0.679AspTrp: 0.679 ± 0.026
2.924AspTyr: 2.924 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.966GluAla: 4.966 ± 0.091
0.328GluCys: 0.328 ± 0.022
3.644GluAsp: 3.644 ± 0.081
4.583GluGlu: 4.583 ± 0.094
2.971GluPhe: 2.971 ± 0.062
3.529GluGly: 3.529 ± 0.077
1.332GluHis: 1.332 ± 0.041
5.124GluIle: 5.124 ± 0.086
5.363GluLys: 5.363 ± 0.096
6.168GluLeu: 6.168 ± 0.085
1.445GluMet: 1.445 ± 0.045
4.444GluAsn: 4.444 ± 0.076
1.666GluPro: 1.666 ± 0.044
2.461GluGln: 2.461 ± 0.058
2.326GluArg: 2.326 ± 0.065
3.296GluSer: 3.296 ± 0.056
4.487GluThr: 4.487 ± 0.07
4.183GluVal: 4.183 ± 0.075
0.553GluTrp: 0.553 ± 0.027
2.327GluTyr: 2.327 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.972PheAla: 2.972 ± 0.064
0.421PheCys: 0.421 ± 0.024
3.04PheAsp: 3.04 ± 0.056
3.5PheGlu: 3.5 ± 0.068
2.73PhePhe: 2.73 ± 0.071
3.584PheGly: 3.584 ± 0.079
0.907PheHis: 0.907 ± 0.032
4.066PheIle: 4.066 ± 0.083
4.209PheLys: 4.209 ± 0.069
4.718PheLeu: 4.718 ± 0.093
1.216PheMet: 1.216 ± 0.039
3.582PheAsn: 3.582 ± 0.077
1.664PhePro: 1.664 ± 0.042
1.748PheGln: 1.748 ± 0.047
1.42PheArg: 1.42 ± 0.038
3.906PheSer: 3.906 ± 0.075
3.05PheThr: 3.05 ± 0.062
3.126PheVal: 3.126 ± 0.061
0.567PheTrp: 0.567 ± 0.026
2.238PheTyr: 2.238 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
3.751GlyAla: 3.751 ± 0.069
0.615GlyCys: 0.615 ± 0.042
3.268GlyAsp: 3.268 ± 0.063
3.415GlyGlu: 3.415 ± 0.067
3.83GlyPhe: 3.83 ± 0.071
4.138GlyGly: 4.138 ± 0.091
1.174GlyHis: 1.174 ± 0.039
5.13GlyIle: 5.13 ± 0.088
4.497GlyLys: 4.497 ± 0.089
5.775GlyLeu: 5.775 ± 0.083
1.613GlyMet: 1.613 ± 0.049
3.643GlyAsn: 3.643 ± 0.084
1.301GlyPro: 1.301 ± 0.044
1.831GlyGln: 1.831 ± 0.046
1.88GlyArg: 1.88 ± 0.054
3.869GlySer: 3.869 ± 0.082
4.004GlyThr: 4.004 ± 0.111
4.156GlyVal: 4.156 ± 0.063
0.665GlyTrp: 0.665 ± 0.028
2.745GlyTyr: 2.745 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.188HisAla: 1.188 ± 0.042
0.18HisCys: 0.18 ± 0.017
0.886HisAsp: 0.886 ± 0.031
1.108HisGlu: 1.108 ± 0.033
1.246HisPhe: 1.246 ± 0.039
1.13HisGly: 1.13 ± 0.033
0.535HisHis: 0.535 ± 0.027
1.742HisIle: 1.742 ± 0.045
1.352HisLys: 1.352 ± 0.043
2.01HisLeu: 2.01 ± 0.049
0.382HisMet: 0.382 ± 0.021
1.052HisAsn: 1.052 ± 0.03
0.945HisPro: 0.945 ± 0.038
0.74HisGln: 0.74 ± 0.028
0.62HisArg: 0.62 ± 0.027
1.065HisSer: 1.065 ± 0.04
1.064HisThr: 1.064 ± 0.036
1.271HisVal: 1.271 ± 0.044
0.222HisTrp: 0.222 ± 0.015
0.93HisTyr: 0.93 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.392IleAla: 5.392 ± 0.09
0.607IleCys: 0.607 ± 0.029
5.013IleAsp: 5.013 ± 0.089
5.466IleGlu: 5.466 ± 0.084
3.486IlePhe: 3.486 ± 0.068
5.076IleGly: 5.076 ± 0.088
1.475IleHis: 1.475 ± 0.049
5.848IleIle: 5.848 ± 0.108
6.033IleLys: 6.033 ± 0.096
7.03IleLeu: 7.03 ± 0.117
1.467IleMet: 1.467 ± 0.047
4.767IleAsn: 4.767 ± 0.083
3.252IlePro: 3.252 ± 0.064
2.669IleGln: 2.669 ± 0.05
2.24IleArg: 2.24 ± 0.049
5.648IleSer: 5.648 ± 0.083
4.894IleThr: 4.894 ± 0.084
4.855IleVal: 4.855 ± 0.084
0.672IleTrp: 0.672 ± 0.029
2.88IleTyr: 2.88 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
5.271LysAla: 5.271 ± 0.097
0.318LysCys: 0.318 ± 0.019
4.613LysAsp: 4.613 ± 0.09
6.009LysGlu: 6.009 ± 0.108
2.809LysPhe: 2.809 ± 0.053
4.279LysGly: 4.279 ± 0.086
1.928LysHis: 1.928 ± 0.052
5.668LysIle: 5.668 ± 0.095
6.671LysLys: 6.671 ± 0.112
6.819LysLeu: 6.819 ± 0.105
1.969LysMet: 1.969 ± 0.056
5.261LysAsn: 5.261 ± 0.09
2.727LysPro: 2.727 ± 0.067
3.525LysGln: 3.525 ± 0.069
2.863LysArg: 2.863 ± 0.06
4.363LysSer: 4.363 ± 0.072
5.169LysThr: 5.169 ± 0.099
4.36LysVal: 4.36 ± 0.079
0.71LysTrp: 0.71 ± 0.029
2.821LysTyr: 2.821 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
5.865LeuAla: 5.865 ± 0.086
0.702LeuCys: 0.702 ± 0.032
5.258LeuAsp: 5.258 ± 0.082
6.391LeuGlu: 6.391 ± 0.098
4.938LeuPhe: 4.938 ± 0.096
5.711LeuGly: 5.711 ± 0.092
1.66LeuHis: 1.66 ± 0.044
7.132LeuIle: 7.132 ± 0.128
8.357LeuLys: 8.357 ± 0.144
8.763LeuLeu: 8.763 ± 0.136
2.154LeuMet: 2.154 ± 0.056
6.088LeuAsn: 6.088 ± 0.088
3.398LeuPro: 3.398 ± 0.066
3.483LeuGln: 3.483 ± 0.079
2.919LeuArg: 2.919 ± 0.059
6.649LeuSer: 6.649 ± 0.089
5.22LeuThr: 5.22 ± 0.077
5.601LeuVal: 5.601 ± 0.095
0.815LeuTrp: 0.815 ± 0.03
3.316LeuTyr: 3.316 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.746MetAla: 1.746 ± 0.044
0.155MetCys: 0.155 ± 0.014
1.312MetAsp: 1.312 ± 0.04
1.474MetGlu: 1.474 ± 0.045
1.074MetPhe: 1.074 ± 0.036
1.227MetGly: 1.227 ± 0.042
0.392MetHis: 0.392 ± 0.019
1.506MetIle: 1.506 ± 0.045
2.078MetLys: 2.078 ± 0.053
2.193MetLeu: 2.193 ± 0.059
0.556MetMet: 0.556 ± 0.027
1.257MetAsn: 1.257 ± 0.038
0.86MetPro: 0.86 ± 0.035
0.894MetGln: 0.894 ± 0.033
0.727MetArg: 0.727 ± 0.031
1.539MetSer: 1.539 ± 0.037
1.189MetThr: 1.189 ± 0.04
1.516MetVal: 1.516 ± 0.047
0.149MetTrp: 0.149 ± 0.011
0.771MetTyr: 0.771 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.662AsnAla: 3.662 ± 0.073
0.457AsnCys: 0.457 ± 0.025
3.237AsnAsp: 3.237 ± 0.065
3.703AsnGlu: 3.703 ± 0.068
2.929AsnPhe: 2.929 ± 0.061
3.868AsnGly: 3.868 ± 0.098
1.272AsnHis: 1.272 ± 0.04
5.047AsnIle: 5.047 ± 0.079
4.842AsnLys: 4.842 ± 0.087
5.652AsnLeu: 5.652 ± 0.094
1.486AsnMet: 1.486 ± 0.037
4.606AsnAsn: 4.606 ± 0.099
3.04AsnPro: 3.04 ± 0.064
2.531AsnGln: 2.531 ± 0.059
2.085AsnArg: 2.085 ± 0.053
3.889AsnSer: 3.889 ± 0.08
4.04AsnThr: 4.04 ± 0.086
3.476AsnVal: 3.476 ± 0.072
0.716AsnTrp: 0.716 ± 0.03
2.926AsnTyr: 2.926 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.714ProAla: 1.714 ± 0.044
0.237ProCys: 0.237 ± 0.017
1.98ProAsp: 1.98 ± 0.045
2.976ProGlu: 2.976 ± 0.052
1.921ProPhe: 1.921 ± 0.048
1.82ProGly: 1.82 ± 0.049
0.628ProHis: 0.628 ± 0.029
2.791ProIle: 2.791 ± 0.063
2.693ProLys: 2.693 ± 0.066
2.972ProLeu: 2.972 ± 0.055
0.695ProMet: 0.695 ± 0.027
2.45ProAsn: 2.45 ± 0.069
0.841ProPro: 0.841 ± 0.043
1.058ProGln: 1.058 ± 0.034
0.864ProArg: 0.864 ± 0.034
2.05ProSer: 2.05 ± 0.058
2.05ProThr: 2.05 ± 0.062
2.313ProVal: 2.313 ± 0.053
0.293ProTrp: 0.293 ± 0.019
1.426ProTyr: 1.426 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.45GlnAla: 2.45 ± 0.06
0.185GlnCys: 0.185 ± 0.016
1.942GlnAsp: 1.942 ± 0.047
2.625GlnGlu: 2.625 ± 0.058
1.758GlnPhe: 1.758 ± 0.041
1.922GlnGly: 1.922 ± 0.055
0.71GlnHis: 0.71 ± 0.028
2.775GlnIle: 2.775 ± 0.053
2.711GlnLys: 2.711 ± 0.058
3.73GlnLeu: 3.73 ± 0.069
0.877GlnMet: 0.877 ± 0.028
2.203GlnAsn: 2.203 ± 0.054
1.17GlnPro: 1.17 ± 0.036
1.458GlnGln: 1.458 ± 0.045
1.122GlnArg: 1.122 ± 0.032
1.885GlnSer: 1.885 ± 0.046
2.091GlnThr: 2.091 ± 0.061
2.443GlnVal: 2.443 ± 0.057
0.339GlnTrp: 0.339 ± 0.023
1.38GlnTyr: 1.38 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
1.913ArgAla: 1.913 ± 0.045
0.177ArgCys: 0.177 ± 0.015
1.714ArgAsp: 1.714 ± 0.043
2.048ArgGlu: 2.048 ± 0.063
1.753ArgPhe: 1.753 ± 0.046
1.686ArgGly: 1.686 ± 0.044
0.624ArgHis: 0.624 ± 0.027
2.608ArgIle: 2.608 ± 0.061
2.41ArgLys: 2.41 ± 0.067
3.049ArgLeu: 3.049 ± 0.063
0.853ArgMet: 0.853 ± 0.03
1.77ArgAsn: 1.77 ± 0.04
0.986ArgPro: 0.986 ± 0.037
1.081ArgGln: 1.081 ± 0.04
1.12ArgArg: 1.12 ± 0.039
1.611ArgSer: 1.611 ± 0.037
1.63ArgThr: 1.63 ± 0.043
2.028ArgVal: 2.028 ± 0.046
0.347ArgTrp: 0.347 ± 0.022
1.461ArgTyr: 1.461 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.429SerAla: 3.429 ± 0.056
0.628SerCys: 0.628 ± 0.03
3.187SerAsp: 3.187 ± 0.067
3.855SerGlu: 3.855 ± 0.067
3.561SerPhe: 3.561 ± 0.063
4.582SerGly: 4.582 ± 0.105
1.218SerHis: 1.218 ± 0.038
5.003SerIle: 5.003 ± 0.077
5.263SerLys: 5.263 ± 0.097
6.032SerLeu: 6.032 ± 0.091
1.37SerMet: 1.37 ± 0.04
4.203SerAsn: 4.203 ± 0.093
2.005SerPro: 2.005 ± 0.055
2.324SerGln: 2.324 ± 0.048
1.901SerArg: 1.901 ± 0.045
3.969SerSer: 3.969 ± 0.075
3.348SerThr: 3.348 ± 0.073
3.925SerVal: 3.925 ± 0.076
0.723SerTrp: 0.723 ± 0.028
2.783SerTyr: 2.783 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.657ThrAla: 3.657 ± 0.082
0.474ThrCys: 0.474 ± 0.028
3.319ThrAsp: 3.319 ± 0.063
3.652ThrGlu: 3.652 ± 0.073
3.285ThrPhe: 3.285 ± 0.072
3.975ThrGly: 3.975 ± 0.099
1.217ThrHis: 1.217 ± 0.036
5.078ThrIle: 5.078 ± 0.096
4.107ThrLys: 4.107 ± 0.076
5.698ThrLeu: 5.698 ± 0.08
1.095ThrMet: 1.095 ± 0.034
3.767ThrAsn: 3.767 ± 0.098
2.344ThrPro: 2.344 ± 0.061
1.968ThrGln: 1.968 ± 0.052
1.506ThrArg: 1.506 ± 0.045
3.954ThrSer: 3.954 ± 0.088
3.658ThrThr: 3.658 ± 0.087
3.906ThrVal: 3.906 ± 0.092
0.59ThrTrp: 0.59 ± 0.028
2.609ThrTyr: 2.609 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
4.146ValAla: 4.146 ± 0.076
0.533ValCys: 0.533 ± 0.025
3.459ValAsp: 3.459 ± 0.061
3.953ValGlu: 3.953 ± 0.079
3.763ValPhe: 3.763 ± 0.064
3.757ValGly: 3.757 ± 0.072
1.033ValHis: 1.033 ± 0.038
4.891ValIle: 4.891 ± 0.088
4.377ValLys: 4.377 ± 0.078
6.199ValLeu: 6.199 ± 0.084
1.42ValMet: 1.42 ± 0.046
3.518ValAsn: 3.518 ± 0.073
2.235ValPro: 2.235 ± 0.053
1.733ValGln: 1.733 ± 0.05
1.836ValArg: 1.836 ± 0.046
4.598ValSer: 4.598 ± 0.081
3.825ValThr: 3.825 ± 0.09
4.397ValVal: 4.397 ± 0.071
0.587ValTrp: 0.587 ± 0.027
2.543ValTyr: 2.543 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.522TrpAla: 0.522 ± 0.026
0.095TrpCys: 0.095 ± 0.01
0.538TrpAsp: 0.538 ± 0.024
0.583TrpGlu: 0.583 ± 0.028
0.59TrpPhe: 0.59 ± 0.029
0.516TrpGly: 0.516 ± 0.027
0.224TrpHis: 0.224 ± 0.013
0.762TrpIle: 0.762 ± 0.031
0.744TrpLys: 0.744 ± 0.032
1.015TrpLeu: 1.015 ± 0.039
0.315TrpMet: 0.315 ± 0.018
0.746TrpAsn: 0.746 ± 0.032
0.205TrpPro: 0.205 ± 0.017
0.393TrpGln: 0.393 ± 0.02
0.345TrpArg: 0.345 ± 0.021
0.577TrpSer: 0.577 ± 0.029
0.564TrpThr: 0.564 ± 0.03
0.6TrpVal: 0.6 ± 0.027
0.135TrpTrp: 0.135 ± 0.013
0.423TrpTyr: 0.423 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.506TyrAla: 2.506 ± 0.054
0.32TyrCys: 0.32 ± 0.02
2.174TyrAsp: 2.174 ± 0.053
2.089TyrGlu: 2.089 ± 0.048
2.489TyrPhe: 2.489 ± 0.055
2.653TyrGly: 2.653 ± 0.061
0.992TyrHis: 0.992 ± 0.038
2.865TyrIle: 2.865 ± 0.06
3.285TyrLys: 3.285 ± 0.069
4.008TyrLeu: 4.008 ± 0.074
0.765TyrMet: 0.765 ± 0.028
2.862TyrAsn: 2.862 ± 0.065
1.502TyrPro: 1.502 ± 0.042
1.765TyrGln: 1.765 ± 0.048
1.508TyrArg: 1.508 ± 0.045
2.576TyrSer: 2.576 ± 0.063
2.302TyrThr: 2.302 ± 0.064
2.432TyrVal: 2.432 ± 0.059
0.457TyrTrp: 0.457 ± 0.025
1.959TyrTyr: 1.959 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2841 proteins (902307 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski