Amino acid dipepetide frequency for Halostagnicola larsenii XH-48

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.844AlaAla: 10.844 ± 0.12	0.723AlaCys: 0.723 ± 0.03	8.825AlaAsp: 8.825 ± 0.109	8.019AlaGlu: 8.019 ± 0.105	3.701AlaPhe: 3.701 ± 0.062	8.515AlaGly: 8.515 ± 0.097	1.731AlaHis: 1.731 ± 0.042	5.62AlaIle: 5.62 ± 0.094	1.855AlaLys: 1.855 ± 0.046	9.296AlaLeu: 9.296 ± 0.115	2.062AlaMet: 2.062 ± 0.042	2.496AlaAsn: 2.496 ± 0.053	3.313AlaPro: 3.313 ± 0.056	2.274AlaGln: 2.274 ± 0.052	5.413AlaArg: 5.413 ± 0.077	5.4AlaSer: 5.4 ± 0.075	6.639AlaThr: 6.639 ± 0.086	9.079AlaVal: 9.079 ± 0.099	0.962AlaTrp: 0.962 ± 0.029	2.541AlaTyr: 2.541 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.562CysAla: 0.562 ± 0.021	0.106CysCys: 0.106 ± 0.01	0.587CysAsp: 0.587 ± 0.024	0.637CysGlu: 0.637 ± 0.029	0.221CysPhe: 0.221 ± 0.015	0.817CysGly: 0.817 ± 0.032	0.197CysHis: 0.197 ± 0.013	0.299CysIle: 0.299 ± 0.016	0.144CysLys: 0.144 ± 0.012	0.614CysLeu: 0.614 ± 0.023	0.118CysMet: 0.118 ± 0.011	0.172CysAsn: 0.172 ± 0.011	0.51CysPro: 0.51 ± 0.021	0.198CysGln: 0.198 ± 0.014	0.496CysArg: 0.496 ± 0.021	0.501CysSer: 0.501 ± 0.025	0.427CysThr: 0.427 ± 0.022	0.48CysVal: 0.48 ± 0.024	0.107CysTrp: 0.107 ± 0.01	0.235CysTyr: 0.235 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.662AspAla: 8.662 ± 0.094	0.634AspCys: 0.634 ± 0.026	7.881AspAsp: 7.881 ± 0.12	8.644AspGlu: 8.644 ± 0.118	1.996AspPhe: 1.996 ± 0.042	8.177AspGly: 8.177 ± 0.125	1.758AspHis: 1.758 ± 0.042	3.7AspIle: 3.7 ± 0.064	0.96AspLys: 0.96 ± 0.033	6.886AspLeu: 6.886 ± 0.089	1.194AspMet: 1.194 ± 0.037	1.432AspAsn: 1.432 ± 0.039	4.496AspPro: 4.496 ± 0.075	1.916AspGln: 1.916 ± 0.041	6.162AspArg: 6.162 ± 0.087	4.445AspSer: 4.445 ± 0.08	3.946AspThr: 3.946 ± 0.075	7.038AspVal: 7.038 ± 0.08	0.947AspTrp: 0.947 ± 0.033	1.759AspTyr: 1.759 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.396GluAla: 8.396 ± 0.088	0.561GluCys: 0.561 ± 0.026	6.419GluAsp: 6.419 ± 0.1	7.226GluGlu: 7.226 ± 0.114	3.256GluPhe: 3.256 ± 0.058	5.521GluGly: 5.521 ± 0.076	2.091GluHis: 2.091 ± 0.044	4.749GluIle: 4.749 ± 0.072	2.079GluLys: 2.079 ± 0.052	7.866GluLeu: 7.866 ± 0.089	2.074GluMet: 2.074 ± 0.044	2.928GluAsn: 2.928 ± 0.054	4.398GluPro: 4.398 ± 0.063	3.135GluGln: 3.135 ± 0.063	7.563GluArg: 7.563 ± 0.106	6.459GluSer: 6.459 ± 0.083	7.726GluThr: 7.726 ± 0.095	5.486GluVal: 5.486 ± 0.08	1.22GluTrp: 1.22 ± 0.037	3.137GluTyr: 3.137 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.44PheAla: 3.44 ± 0.06	0.308PheCys: 0.308 ± 0.015	3.369PheAsp: 3.369 ± 0.058	3.441PheGlu: 3.441 ± 0.06	1.14PhePhe: 1.14 ± 0.038	3.258PheGly: 3.258 ± 0.066	0.671PheHis: 0.671 ± 0.025	1.269PheIle: 1.269 ± 0.04	0.476PheLys: 0.476 ± 0.021	2.812PheLeu: 2.812 ± 0.058	0.535PheMet: 0.535 ± 0.027	0.758PheAsn: 0.758 ± 0.03	1.336PhePro: 1.336 ± 0.035	0.856PheGln: 0.856 ± 0.028	1.723PheArg: 1.723 ± 0.036	1.894PheSer: 1.894 ± 0.044	1.925PheThr: 1.925 ± 0.047	3.305PheVal: 3.305 ± 0.064	0.421PheTrp: 0.421 ± 0.02	0.878PheTyr: 0.878 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.367GlyAla: 7.367 ± 0.099	0.732GlyCys: 0.732 ± 0.029	6.49GlyAsp: 6.49 ± 0.097	7.14GlyGlu: 7.14 ± 0.087	3.149GlyPhe: 3.149 ± 0.061	7.0GlyGly: 7.0 ± 0.119	1.629GlyHis: 1.629 ± 0.046	4.817GlyIle: 4.817 ± 0.075	1.892GlyLys: 1.892 ± 0.045	7.133GlyLeu: 7.133 ± 0.092	1.653GlyMet: 1.653 ± 0.047	2.129GlyAsn: 2.129 ± 0.043	3.297GlyPro: 3.297 ± 0.063	2.078GlyGln: 2.078 ± 0.044	4.442GlyArg: 4.442 ± 0.067	5.433GlySer: 5.433 ± 0.077	5.908GlyThr: 5.908 ± 0.082	7.093GlyVal: 7.093 ± 0.09	1.064GlyTrp: 1.064 ± 0.033	2.684GlyTyr: 2.684 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.9HisAla: 1.9 ± 0.041	0.225HisCys: 0.225 ± 0.012	1.82HisAsp: 1.82 ± 0.043	1.79HisGlu: 1.79 ± 0.042	0.599HisPhe: 0.599 ± 0.027	1.95HisGly: 1.95 ± 0.05	0.522HisHis: 0.522 ± 0.025	0.773HisIle: 0.773 ± 0.029	0.29HisLys: 0.29 ± 0.018	1.704HisLeu: 1.704 ± 0.043	0.321HisMet: 0.321 ± 0.016	0.478HisAsn: 0.478 ± 0.022	1.183HisPro: 1.183 ± 0.032	0.511HisGln: 0.511 ± 0.021	1.284HisArg: 1.284 ± 0.033	0.947HisSer: 0.947 ± 0.031	1.091HisThr: 1.091 ± 0.034	1.821HisVal: 1.821 ± 0.042	0.243HisTrp: 0.243 ± 0.014	0.542HisTyr: 0.542 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.537IleAla: 5.537 ± 0.085	0.353IleCys: 0.353 ± 0.017	4.858IleAsp: 4.858 ± 0.063	4.972IleGlu: 4.972 ± 0.07	1.244IlePhe: 1.244 ± 0.04	4.71IleGly: 4.71 ± 0.068	0.917IleHis: 0.917 ± 0.03	1.861IleIle: 1.861 ± 0.051	0.77IleLys: 0.77 ± 0.024	3.489IleLeu: 3.489 ± 0.07	0.589IleMet: 0.589 ± 0.023	1.213IleAsn: 1.213 ± 0.033	2.392IlePro: 2.392 ± 0.043	1.292IleGln: 1.292 ± 0.035	2.702IleArg: 2.702 ± 0.047	2.72IleSer: 2.72 ± 0.06	2.845IleThr: 2.845 ± 0.047	4.478IleVal: 4.478 ± 0.076	0.412IleTrp: 0.412 ± 0.02	1.081IleTyr: 1.081 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	1.764LysAla: 1.764 ± 0.044	0.11LysCys: 0.11 ± 0.012	1.088LysAsp: 1.088 ± 0.035	1.297LysGlu: 1.297 ± 0.044	0.52LysPhe: 0.52 ± 0.022	1.279LysGly: 1.279 ± 0.033	0.5LysHis: 0.5 ± 0.023	0.92LysIle: 0.92 ± 0.032	0.519LysLys: 0.519 ± 0.028	1.733LysLeu: 1.733 ± 0.041	0.452LysMet: 0.452 ± 0.021	0.604LysAsn: 0.604 ± 0.024	0.989LysPro: 0.989 ± 0.033	0.758LysGln: 0.758 ± 0.03	1.673LysArg: 1.673 ± 0.046	1.249LysSer: 1.249 ± 0.038	1.402LysThr: 1.402 ± 0.04	1.091LysVal: 1.091 ± 0.034	0.218LysTrp: 0.218 ± 0.015	0.57LysTyr: 0.57 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	9.578LeuAla: 9.578 ± 0.116	0.625LeuCys: 0.625 ± 0.024	5.513LeuAsp: 5.513 ± 0.066	12.19LeuGlu: 12.19 ± 0.123	3.185LeuPhe: 3.185 ± 0.067	7.035LeuGly: 7.035 ± 0.097	1.411LeuHis: 1.411 ± 0.034	3.448LeuIle: 3.448 ± 0.065	1.453LeuLys: 1.453 ± 0.034	8.071LeuLeu: 8.071 ± 0.128	1.318LeuMet: 1.318 ± 0.038	1.774LeuAsn: 1.774 ± 0.047	3.874LeuPro: 3.874 ± 0.052	2.051LeuGln: 2.051 ± 0.04	4.582LeuArg: 4.582 ± 0.069	5.65LeuSer: 5.65 ± 0.079	5.018LeuThr: 5.018 ± 0.079	7.682LeuVal: 7.682 ± 0.112	0.804LeuTrp: 0.804 ± 0.026	2.166LeuTyr: 2.166 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.91MetAla: 1.91 ± 0.047	0.108MetCys: 0.108 ± 0.01	1.27MetAsp: 1.27 ± 0.033	1.182MetGlu: 1.182 ± 0.032	0.567MetPhe: 0.567 ± 0.024	1.539MetGly: 1.539 ± 0.041	0.376MetHis: 0.376 ± 0.018	0.858MetIle: 0.858 ± 0.029	0.485MetLys: 0.485 ± 0.02	1.582MetLeu: 1.582 ± 0.038	0.365MetMet: 0.365 ± 0.018	0.692MetAsn: 0.692 ± 0.026	0.782MetPro: 0.782 ± 0.03	0.498MetGln: 0.498 ± 0.026	1.03MetArg: 1.03 ± 0.03	1.536MetSer: 1.536 ± 0.037	1.601MetThr: 1.601 ± 0.035	1.395MetVal: 1.395 ± 0.041	0.186MetTrp: 0.186 ± 0.014	0.445MetTyr: 0.445 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.767AsnAla: 2.767 ± 0.053	0.249AsnCys: 0.249 ± 0.015	1.964AsnAsp: 1.964 ± 0.049	2.233AsnGlu: 2.233 ± 0.056	0.713AsnPhe: 0.713 ± 0.025	2.326AsnGly: 2.326 ± 0.052	0.593AsnHis: 0.593 ± 0.024	1.068AsnIle: 1.068 ± 0.037	0.43AsnLys: 0.43 ± 0.021	2.089AsnLeu: 2.089 ± 0.046	0.481AsnMet: 0.481 ± 0.02	0.588AsnAsn: 0.588 ± 0.025	1.549AsnPro: 1.549 ± 0.037	0.72AsnGln: 0.72 ± 0.025	1.755AsnArg: 1.755 ± 0.04	1.253AsnSer: 1.253 ± 0.037	1.415AsnThr: 1.415 ± 0.041	2.379AsnVal: 2.379 ± 0.043	0.355AsnTrp: 0.355 ± 0.016	0.734AsnTyr: 0.734 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.248ProAla: 4.248 ± 0.067	0.234ProCys: 0.234 ± 0.015	4.619ProAsp: 4.619 ± 0.071	4.543ProGlu: 4.543 ± 0.066	1.615ProPhe: 1.615 ± 0.036	3.463ProGly: 3.463 ± 0.059	0.919ProHis: 0.919 ± 0.032	2.352ProIle: 2.352 ± 0.051	0.904ProLys: 0.904 ± 0.031	3.607ProLeu: 3.607 ± 0.064	0.885ProMet: 0.885 ± 0.029	1.282ProAsn: 1.282 ± 0.034	2.032ProPro: 2.032 ± 0.047	0.998ProGln: 0.998 ± 0.029	2.138ProArg: 2.138 ± 0.048	2.765ProSer: 2.765 ± 0.053	3.134ProThr: 3.134 ± 0.053	3.869ProVal: 3.869 ± 0.056	0.505ProTrp: 0.505 ± 0.022	1.171ProTyr: 1.171 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.425GlnAla: 2.425 ± 0.051	0.173GlnCys: 0.173 ± 0.013	1.46GlnAsp: 1.46 ± 0.038	1.874GlnGlu: 1.874 ± 0.048	1.096GlnPhe: 1.096 ± 0.031	1.677GlnGly: 1.677 ± 0.04	0.614GlnHis: 0.614 ± 0.023	1.379GlnIle: 1.379 ± 0.042	0.641GlnLys: 0.641 ± 0.03	2.54GlnLeu: 2.54 ± 0.05	0.583GlnMet: 0.583 ± 0.023	0.839GlnAsn: 0.839 ± 0.032	1.194GlnPro: 1.194 ± 0.028	1.119GlnGln: 1.119 ± 0.043	1.944GlnArg: 1.944 ± 0.046	1.791GlnSer: 1.791 ± 0.039	1.857GlnThr: 1.857 ± 0.047	1.763GlnVal: 1.763 ± 0.042	0.382GlnTrp: 0.382 ± 0.02	0.954GlnTyr: 0.954 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.627ArgAla: 5.627 ± 0.081	0.489ArgCys: 0.489 ± 0.025	4.67ArgAsp: 4.67 ± 0.059	6.13ArgGlu: 6.13 ± 0.09	2.172ArgPhe: 2.172 ± 0.049	4.122ArgGly: 4.122 ± 0.071	1.091ArgHis: 1.091 ± 0.031	3.17ArgIle: 3.17 ± 0.053	1.373ArgLys: 1.373 ± 0.039	5.544ArgLeu: 5.544 ± 0.077	1.309ArgMet: 1.309 ± 0.033	1.703ArgAsn: 1.703 ± 0.038	2.409ArgPro: 2.409 ± 0.048	1.718ArgGln: 1.718 ± 0.044	4.287ArgArg: 4.287 ± 0.082	3.992ArgSer: 3.992 ± 0.059	4.199ArgThr: 4.199 ± 0.071	4.769ArgVal: 4.769 ± 0.078	0.774ArgTrp: 0.774 ± 0.031	1.921ArgTyr: 1.921 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.472SerAla: 5.472 ± 0.086	0.339SerCys: 0.339 ± 0.018	4.835SerAsp: 4.835 ± 0.076	4.932SerGlu: 4.932 ± 0.078	2.083SerPhe: 2.083 ± 0.041	5.612SerGly: 5.612 ± 0.079	1.162SerHis: 1.162 ± 0.034	3.299SerIle: 3.299 ± 0.061	1.305SerLys: 1.305 ± 0.034	5.19SerLeu: 5.19 ± 0.077	1.328SerMet: 1.328 ± 0.038	1.705SerAsn: 1.705 ± 0.037	2.619SerPro: 2.619 ± 0.052	1.564SerGln: 1.564 ± 0.038	3.499SerArg: 3.499 ± 0.05	4.04SerSer: 4.04 ± 0.08	4.04SerThr: 4.04 ± 0.066	5.295SerVal: 5.295 ± 0.07	0.678SerTrp: 0.678 ± 0.024	1.545SerTyr: 1.545 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.889ThrAla: 6.889 ± 0.084	0.415ThrCys: 0.415 ± 0.022	6.029ThrAsp: 6.029 ± 0.084	5.11ThrGlu: 5.11 ± 0.062	2.17ThrPhe: 2.17 ± 0.048	5.803ThrGly: 5.803 ± 0.064	1.255ThrHis: 1.255 ± 0.042	3.717ThrIle: 3.717 ± 0.065	1.144ThrLys: 1.144 ± 0.033	5.711ThrLeu: 5.711 ± 0.06	1.151ThrMet: 1.151 ± 0.032	1.827ThrAsn: 1.827 ± 0.044	3.079ThrPro: 3.079 ± 0.052	1.55ThrGln: 1.55 ± 0.04	3.214ThrArg: 3.214 ± 0.049	3.177ThrSer: 3.177 ± 0.064	4.4ThrThr: 4.4 ± 0.071	6.668ThrVal: 6.668 ± 0.097	0.64ThrTrp: 0.64 ± 0.023	1.807ThrTyr: 1.807 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	8.401ValAla: 8.401 ± 0.087	0.691ValCys: 0.691 ± 0.027	7.363ValAsp: 7.363 ± 0.095	7.329ValGlu: 7.329 ± 0.099	3.054ValPhe: 3.054 ± 0.064	7.036ValGly: 7.036 ± 0.104	1.642ValHis: 1.642 ± 0.035	3.689ValIle: 3.689 ± 0.069	1.3ValLys: 1.3 ± 0.033	7.899ValLeu: 7.899 ± 0.107	1.295ValMet: 1.295 ± 0.039	1.943ValAsn: 1.943 ± 0.047	4.064ValPro: 4.064 ± 0.065	1.9ValGln: 1.9 ± 0.043	4.952ValArg: 4.952 ± 0.082	5.326ValSer: 5.326 ± 0.08	5.868ValThr: 5.868 ± 0.083	7.902ValVal: 7.902 ± 0.107	0.812ValTrp: 0.812 ± 0.028	2.106ValTyr: 2.106 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.882TrpAla: 0.882 ± 0.032	0.104TrpCys: 0.104 ± 0.009	0.816TrpAsp: 0.816 ± 0.032	0.871TrpGlu: 0.871 ± 0.028	0.428TrpPhe: 0.428 ± 0.019	0.884TrpGly: 0.884 ± 0.027	0.266TrpHis: 0.266 ± 0.017	0.583TrpIle: 0.583 ± 0.026	0.317TrpLys: 0.317 ± 0.018	1.162TrpLeu: 1.162 ± 0.038	0.258TrpMet: 0.258 ± 0.015	0.429TrpAsn: 0.429 ± 0.021	0.479TrpPro: 0.479 ± 0.021	0.348TrpGln: 0.348 ± 0.021	0.751TrpArg: 0.751 ± 0.023	0.64TrpSer: 0.64 ± 0.023	0.749TrpThr: 0.749 ± 0.027	0.775TrpVal: 0.775 ± 0.028	0.196TrpTrp: 0.196 ± 0.016	0.361TrpTyr: 0.361 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.639TyrAla: 2.639 ± 0.055	0.249TyrCys: 0.249 ± 0.014	2.758TyrAsp: 2.758 ± 0.048	2.728TyrGlu: 2.728 ± 0.057	0.903TyrPhe: 0.903 ± 0.027	2.408TyrGly: 2.408 ± 0.047	0.648TyrHis: 0.648 ± 0.024	0.866TyrIle: 0.866 ± 0.025	0.398TyrLys: 0.398 ± 0.019	2.5TyrLeu: 2.5 ± 0.049	0.435TyrMet: 0.435 ± 0.017	0.668TyrAsn: 0.668 ± 0.022	1.291TyrPro: 1.291 ± 0.034	0.821TyrGln: 0.821 ± 0.03	1.86TyrArg: 1.86 ± 0.042	1.325TyrSer: 1.325 ± 0.036	1.565TyrThr: 1.565 ± 0.038	2.204TyrVal: 2.204 ± 0.044	0.372TyrTrp: 0.372 ± 0.02	0.878TyrTyr: 0.878 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4086 proteins (1126012 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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