Amino acid dipepetide frequency for Streptomyces bungoensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.469AlaAla: 22.469 ± 0.159	1.15AlaCys: 1.15 ± 0.021	8.396AlaAsp: 8.396 ± 0.064	8.9AlaGlu: 8.9 ± 0.085	3.514AlaPhe: 3.514 ± 0.043	14.004AlaGly: 14.004 ± 0.101	3.147AlaHis: 3.147 ± 0.04	3.089AlaIle: 3.089 ± 0.038	2.714AlaLys: 2.714 ± 0.05	15.064AlaLeu: 15.064 ± 0.114	2.339AlaMet: 2.339 ± 0.038	1.812AlaAsn: 1.812 ± 0.033	7.437AlaPro: 7.437 ± 0.092	3.811AlaGln: 3.811 ± 0.041	11.251AlaArg: 11.251 ± 0.105	5.727AlaSer: 5.727 ± 0.055	7.004AlaThr: 7.004 ± 0.068	12.78AlaVal: 12.78 ± 0.085	1.881AlaTrp: 1.881 ± 0.03	2.806AlaTyr: 2.806 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.123CysAla: 1.123 ± 0.02	0.092CysCys: 0.092 ± 0.007	0.487CysAsp: 0.487 ± 0.013	0.397CysGlu: 0.397 ± 0.013	0.214CysPhe: 0.214 ± 0.009	0.947CysGly: 0.947 ± 0.019	0.201CysHis: 0.201 ± 0.01	0.147CysIle: 0.147 ± 0.008	0.106CysLys: 0.106 ± 0.007	0.771CysLeu: 0.771 ± 0.018	0.115CysMet: 0.115 ± 0.007	0.132CysAsn: 0.132 ± 0.008	0.522CysPro: 0.522 ± 0.015	0.157CysGln: 0.157 ± 0.008	0.652CysArg: 0.652 ± 0.019	0.424CysSer: 0.424 ± 0.013	0.514CysThr: 0.514 ± 0.016	0.685CysVal: 0.685 ± 0.019	0.121CysTrp: 0.121 ± 0.006	0.143CysTyr: 0.143 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.773AspAla: 7.773 ± 0.071	0.418AspCys: 0.418 ± 0.015	3.53AspAsp: 3.53 ± 0.044	3.671AspGlu: 3.671 ± 0.044	1.635AspPhe: 1.635 ± 0.027	6.458AspGly: 6.458 ± 0.063	1.47AspHis: 1.47 ± 0.024	1.705AspIle: 1.705 ± 0.029	1.093AspLys: 1.093 ± 0.03	6.351AspLeu: 6.351 ± 0.066	0.78AspMet: 0.78 ± 0.019	0.894AspAsn: 0.894 ± 0.023	4.546AspPro: 4.546 ± 0.045	1.478AspGln: 1.478 ± 0.025	5.108AspArg: 5.108 ± 0.054	2.42AspSer: 2.42 ± 0.032	3.275AspThr: 3.275 ± 0.038	4.779AspVal: 4.779 ± 0.05	1.069AspTrp: 1.069 ± 0.021	1.099AspTyr: 1.099 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.477GluAla: 7.477 ± 0.08	0.345GluCys: 0.345 ± 0.013	2.836GluAsp: 2.836 ± 0.035	3.715GluGlu: 3.715 ± 0.058	1.39GluPhe: 1.39 ± 0.028	4.165GluGly: 4.165 ± 0.044	1.539GluHis: 1.539 ± 0.026	2.092GluIle: 2.092 ± 0.031	1.334GluLys: 1.334 ± 0.026	6.637GluLeu: 6.637 ± 0.071	0.849GluMet: 0.849 ± 0.021	0.959GluAsn: 0.959 ± 0.02	3.372GluPro: 3.372 ± 0.042	2.189GluGln: 2.189 ± 0.028	5.61GluArg: 5.61 ± 0.059	2.333GluSer: 2.333 ± 0.035	2.808GluThr: 2.808 ± 0.037	4.402GluVal: 4.402 ± 0.05	0.72GluTrp: 0.72 ± 0.019	1.044GluTyr: 1.044 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.677PheAla: 3.677 ± 0.042	0.271PheCys: 0.271 ± 0.011	1.924PheAsp: 1.924 ± 0.028	1.383PheGlu: 1.383 ± 0.025	0.872PhePhe: 0.872 ± 0.02	2.943PheGly: 2.943 ± 0.042	0.636PheHis: 0.636 ± 0.017	0.615PheIle: 0.615 ± 0.018	0.486PheLys: 0.486 ± 0.016	2.614PheLeu: 2.614 ± 0.041	0.387PheMet: 0.387 ± 0.014	0.511PheAsn: 0.511 ± 0.018	1.375PhePro: 1.375 ± 0.024	0.633PheGln: 0.633 ± 0.018	1.861PheArg: 1.861 ± 0.03	1.409PheSer: 1.409 ± 0.026	2.009PheThr: 2.009 ± 0.033	2.184PheVal: 2.184 ± 0.031	0.4PheTrp: 0.4 ± 0.014	0.572PheTyr: 0.572 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.432GlyAla: 11.432 ± 0.082	0.835GlyCys: 0.835 ± 0.022	5.358GlyAsp: 5.358 ± 0.047	4.992GlyGlu: 4.992 ± 0.042	2.832GlyPhe: 2.832 ± 0.037	9.001GlyGly: 9.001 ± 0.084	2.572GlyHis: 2.572 ± 0.035	3.222GlyIle: 3.222 ± 0.04	2.254GlyLys: 2.254 ± 0.04	9.605GlyLeu: 9.605 ± 0.069	1.937GlyMet: 1.937 ± 0.031	1.702GlyAsn: 1.702 ± 0.034	5.366GlyPro: 5.366 ± 0.066	2.661GlyGln: 2.661 ± 0.04	8.369GlyArg: 8.369 ± 0.071	5.304GlySer: 5.304 ± 0.053	6.617GlyThr: 6.617 ± 0.065	7.609GlyVal: 7.609 ± 0.063	1.746GlyTrp: 1.746 ± 0.032	2.331GlyTyr: 2.331 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.968HisAla: 2.968 ± 0.038	0.215HisCys: 0.215 ± 0.01	1.421HisAsp: 1.421 ± 0.028	1.234HisGlu: 1.234 ± 0.026	0.664HisPhe: 0.664 ± 0.015	2.636HisGly: 2.636 ± 0.036	0.734HisHis: 0.734 ± 0.019	0.615HisIle: 0.615 ± 0.015	0.351HisLys: 0.351 ± 0.012	2.574HisLeu: 2.574 ± 0.041	0.341HisMet: 0.341 ± 0.011	0.36HisAsn: 0.36 ± 0.013	1.954HisPro: 1.954 ± 0.03	0.642HisGln: 0.642 ± 0.017	2.291HisArg: 2.291 ± 0.035	1.014HisSer: 1.014 ± 0.022	1.407HisThr: 1.407 ± 0.024	1.843HisVal: 1.843 ± 0.033	0.407HisTrp: 0.407 ± 0.013	0.504HisTyr: 0.504 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.445IleAla: 4.445 ± 0.054	0.26IleCys: 0.26 ± 0.011	2.039IleAsp: 2.039 ± 0.035	1.787IleGlu: 1.787 ± 0.028	0.608IlePhe: 0.608 ± 0.017	3.271IleGly: 3.271 ± 0.04	0.573IleHis: 0.573 ± 0.016	0.723IleIle: 0.723 ± 0.021	0.642IleLys: 0.642 ± 0.019	2.253IleLeu: 2.253 ± 0.037	0.391IleMet: 0.391 ± 0.013	0.594IleAsn: 0.594 ± 0.017	1.621IlePro: 1.621 ± 0.027	0.692IleGln: 0.692 ± 0.017	2.136IleArg: 2.136 ± 0.028	1.422IleSer: 1.422 ± 0.022	2.113IleThr: 2.113 ± 0.029	2.517IleVal: 2.517 ± 0.033	0.332IleTrp: 0.332 ± 0.012	0.481IleTyr: 0.481 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.832LysAla: 2.832 ± 0.044	0.111LysCys: 0.111 ± 0.007	1.289LysAsp: 1.289 ± 0.034	1.088LysGlu: 1.088 ± 0.026	0.417LysPhe: 0.417 ± 0.016	1.764LysGly: 1.764 ± 0.035	0.397LysHis: 0.397 ± 0.013	0.784LysIle: 0.784 ± 0.02	0.8LysLys: 0.8 ± 0.028	1.898LysLeu: 1.898 ± 0.03	0.349LysMet: 0.349 ± 0.013	0.487LysAsn: 0.487 ± 0.018	1.23LysPro: 1.23 ± 0.029	0.672LysGln: 0.672 ± 0.02	1.351LysArg: 1.351 ± 0.027	1.063LysSer: 1.063 ± 0.026	1.205LysThr: 1.205 ± 0.028	1.826LysVal: 1.826 ± 0.038	0.254LysTrp: 0.254 ± 0.01	0.441LysTyr: 0.441 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.664LeuAla: 15.664 ± 0.118	0.879LeuCys: 0.879 ± 0.021	6.788LeuAsp: 6.788 ± 0.065	4.874LeuGlu: 4.874 ± 0.054	2.584LeuPhe: 2.584 ± 0.035	9.414LeuGly: 9.414 ± 0.07	2.42LeuHis: 2.42 ± 0.032	3.04LeuIle: 3.04 ± 0.038	1.946LeuLys: 1.946 ± 0.038	11.769LeuLeu: 11.769 ± 0.094	1.614LeuMet: 1.614 ± 0.031	1.609LeuAsn: 1.609 ± 0.028	6.654LeuPro: 6.654 ± 0.062	2.235LeuGln: 2.235 ± 0.033	9.127LeuArg: 9.127 ± 0.076	5.196LeuSer: 5.196 ± 0.052	7.045LeuThr: 7.045 ± 0.07	9.031LeuVal: 9.031 ± 0.076	1.297LeuTrp: 1.297 ± 0.025	1.903LeuTyr: 1.903 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.151MetAla: 2.151 ± 0.032	0.133MetCys: 0.133 ± 0.008	0.849MetAsp: 0.849 ± 0.02	0.688MetGlu: 0.688 ± 0.018	0.428MetPhe: 0.428 ± 0.014	1.255MetGly: 1.255 ± 0.026	0.369MetHis: 0.369 ± 0.012	0.594MetIle: 0.594 ± 0.018	0.406MetLys: 0.406 ± 0.015	1.584MetLeu: 1.584 ± 0.023	0.273MetMet: 0.273 ± 0.011	0.397MetAsn: 0.397 ± 0.013	1.065MetPro: 1.065 ± 0.025	0.425MetGln: 0.425 ± 0.015	1.375MetArg: 1.375 ± 0.026	1.242MetSer: 1.242 ± 0.025	1.523MetThr: 1.523 ± 0.026	1.189MetVal: 1.189 ± 0.025	0.206MetTrp: 0.206 ± 0.01	0.309MetTyr: 0.309 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.1AsnAla: 2.1 ± 0.033	0.156AsnCys: 0.156 ± 0.01	0.875AsnAsp: 0.875 ± 0.021	0.733AsnGlu: 0.733 ± 0.024	0.446AsnPhe: 0.446 ± 0.014	1.775AsnGly: 1.775 ± 0.04	0.385AsnHis: 0.385 ± 0.012	0.569AsnIle: 0.569 ± 0.018	0.373AsnLys: 0.373 ± 0.016	1.571AsnLeu: 1.571 ± 0.031	0.271AsnMet: 0.271 ± 0.011	0.407AsnAsn: 0.407 ± 0.015	1.272AsnPro: 1.272 ± 0.027	0.475AsnGln: 0.475 ± 0.016	1.206AsnArg: 1.206 ± 0.021	0.856AsnSer: 0.856 ± 0.024	1.027AsnThr: 1.027 ± 0.025	1.327AsnVal: 1.327 ± 0.026	0.266AsnTrp: 0.266 ± 0.01	0.385AsnTyr: 0.385 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.51ProAla: 9.51 ± 0.092	0.358ProCys: 0.358 ± 0.014	4.461ProAsp: 4.461 ± 0.051	4.282ProGlu: 4.282 ± 0.051	1.494ProPhe: 1.494 ± 0.026	7.078ProGly: 7.078 ± 0.075	1.496ProHis: 1.496 ± 0.029	1.072ProIle: 1.072 ± 0.021	1.092ProLys: 1.092 ± 0.022	5.49ProLeu: 5.49 ± 0.061	0.915ProMet: 0.915 ± 0.021	0.823ProAsn: 0.823 ± 0.019	3.676ProPro: 3.676 ± 0.066	1.778ProGln: 1.778 ± 0.038	4.193ProArg: 4.193 ± 0.046	3.089ProSer: 3.089 ± 0.051	2.937ProThr: 2.937 ± 0.04	5.625ProVal: 5.625 ± 0.051	0.891ProTrp: 0.891 ± 0.024	1.439ProTyr: 1.439 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.842GlnAla: 3.842 ± 0.045	0.17GlnCys: 0.17 ± 0.008	1.412GlnAsp: 1.412 ± 0.025	1.441GlnGlu: 1.441 ± 0.031	0.641GlnPhe: 0.641 ± 0.017	2.275GlnGly: 2.275 ± 0.037	0.677GlnHis: 0.677 ± 0.019	1.001GlnIle: 1.001 ± 0.019	0.632GlnLys: 0.632 ± 0.017	2.919GlnLeu: 2.919 ± 0.036	0.474GlnMet: 0.474 ± 0.014	0.456GlnAsn: 0.456 ± 0.015	1.717GlnPro: 1.717 ± 0.037	1.223GlnGln: 1.223 ± 0.033	2.367GlnArg: 2.367 ± 0.039	1.213GlnSer: 1.213 ± 0.022	1.334GlnThr: 1.334 ± 0.021	2.355GlnVal: 2.355 ± 0.038	0.456GlnTrp: 0.456 ± 0.015	0.605GlnTyr: 0.605 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.573ArgAla: 10.573 ± 0.088	0.609ArgCys: 0.609 ± 0.017	4.431ArgAsp: 4.431 ± 0.049	4.865ArgGlu: 4.865 ± 0.054	2.422ArgPhe: 2.422 ± 0.035	6.091ArgGly: 6.091 ± 0.058	2.335ArgHis: 2.335 ± 0.036	3.192ArgIle: 3.192 ± 0.045	1.592ArgLys: 1.592 ± 0.033	9.668ArgLeu: 9.668 ± 0.089	1.733ArgMet: 1.733 ± 0.031	1.278ArgAsn: 1.278 ± 0.022	5.346ArgPro: 5.346 ± 0.062	2.396ArgGln: 2.396 ± 0.029	8.384ArgArg: 8.384 ± 0.091	3.944ArgSer: 3.944 ± 0.043	5.629ArgThr: 5.629 ± 0.055	6.11ArgVal: 6.11 ± 0.057	1.408ArgTrp: 1.408 ± 0.029	1.841ArgTyr: 1.841 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.637SerAla: 6.637 ± 0.06	0.406SerCys: 0.406 ± 0.014	2.497SerAsp: 2.497 ± 0.033	2.119SerGlu: 2.119 ± 0.036	1.484SerPhe: 1.484 ± 0.025	5.873SerGly: 5.873 ± 0.059	1.015SerHis: 1.015 ± 0.02	1.269SerIle: 1.269 ± 0.025	0.93SerLys: 0.93 ± 0.023	4.803SerLeu: 4.803 ± 0.05	0.965SerMet: 0.965 ± 0.02	0.787SerAsn: 0.787 ± 0.019	3.099SerPro: 3.099 ± 0.042	1.162SerGln: 1.162 ± 0.027	3.65SerArg: 3.65 ± 0.041	2.7SerSer: 2.7 ± 0.047	2.872SerThr: 2.872 ± 0.042	4.146SerVal: 4.146 ± 0.047	0.853SerTrp: 0.853 ± 0.022	1.188SerTyr: 1.188 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.3ThrAla: 9.3 ± 0.077	0.45ThrCys: 0.45 ± 0.016	3.59ThrAsp: 3.59 ± 0.044	3.121ThrGlu: 3.121 ± 0.036	1.546ThrPhe: 1.546 ± 0.031	7.057ThrGly: 7.057 ± 0.069	1.28ThrHis: 1.28 ± 0.026	1.511ThrIle: 1.511 ± 0.031	1.071ThrLys: 1.071 ± 0.025	5.793ThrLeu: 5.793 ± 0.06	0.878ThrMet: 0.878 ± 0.021	0.936ThrAsn: 0.936 ± 0.024	4.1ThrPro: 4.1 ± 0.04	1.275ThrGln: 1.275 ± 0.025	4.121ThrArg: 4.121 ± 0.045	2.999ThrSer: 2.999 ± 0.046	3.675ThrThr: 3.675 ± 0.05	6.139ThrVal: 6.139 ± 0.058	0.891ThrTrp: 0.891 ± 0.02	1.34ThrTyr: 1.34 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.787ValAla: 10.787 ± 0.074	0.771ValCys: 0.771 ± 0.022	4.907ValAsp: 4.907 ± 0.045	4.588ValGlu: 4.588 ± 0.055	2.429ValPhe: 2.429 ± 0.039	6.349ValGly: 6.349 ± 0.059	2.134ValHis: 2.134 ± 0.031	2.657ValIle: 2.657 ± 0.039	1.684ValLys: 1.684 ± 0.032	9.875ValLeu: 9.875 ± 0.074	1.351ValMet: 1.351 ± 0.029	1.565ValAsn: 1.565 ± 0.028	5.495ValPro: 5.495 ± 0.057	2.088ValGln: 2.088 ± 0.028	7.571ValArg: 7.571 ± 0.072	4.267ValSer: 4.267 ± 0.049	5.828ValThr: 5.828 ± 0.059	8.108ValVal: 8.108 ± 0.076	1.197ValTrp: 1.197 ± 0.026	1.619ValTyr: 1.619 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.727TrpAla: 1.727 ± 0.028	0.15TrpCys: 0.15 ± 0.008	0.832TrpAsp: 0.832 ± 0.02	0.706TrpGlu: 0.706 ± 0.017	0.5TrpPhe: 0.5 ± 0.016	1.062TrpGly: 1.062 ± 0.022	0.389TrpHis: 0.389 ± 0.014	0.538TrpIle: 0.538 ± 0.015	0.359TrpLys: 0.359 ± 0.015	1.747TrpLeu: 1.747 ± 0.031	0.253TrpMet: 0.253 ± 0.011	0.388TrpAsn: 0.388 ± 0.016	0.785TrpPro: 0.785 ± 0.02	0.63TrpGln: 0.63 ± 0.017	1.371TrpArg: 1.371 ± 0.027	0.911TrpSer: 0.911 ± 0.021	1.068TrpThr: 1.068 ± 0.021	0.963TrpVal: 0.963 ± 0.023	0.35TrpTrp: 0.35 ± 0.014	0.382TrpTyr: 0.382 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.807TyrAla: 2.807 ± 0.034	0.174TyrCys: 0.174 ± 0.009	1.629TyrAsp: 1.629 ± 0.033	1.233TyrGlu: 1.233 ± 0.025	0.645TyrPhe: 0.645 ± 0.018	2.329TyrGly: 2.329 ± 0.04	0.405TyrHis: 0.405 ± 0.014	0.464TyrIle: 0.464 ± 0.013	0.393TyrLys: 0.393 ± 0.013	2.103TyrLeu: 2.103 ± 0.033	0.247TyrMet: 0.247 ± 0.01	0.377TyrAsn: 0.377 ± 0.015	1.066TyrPro: 1.066 ± 0.022	0.59TyrGln: 0.59 ± 0.016	1.853TyrArg: 1.853 ± 0.028	0.92TyrSer: 0.92 ± 0.023	1.182TyrThr: 1.182 ± 0.026	1.649TyrVal: 1.649 ± 0.027	0.367TyrTrp: 0.367 ± 0.012	0.438TyrTyr: 0.438 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6972 proteins (2307537 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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