Amino acid dipepetide frequency for Streptomyces curacoi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.649AlaAla: 20.649 ± 0.136	1.071AlaCys: 1.071 ± 0.023	8.279AlaAsp: 8.279 ± 0.069	8.976AlaGlu: 8.976 ± 0.098	3.44AlaPhe: 3.44 ± 0.038	12.49AlaGly: 12.49 ± 0.086	2.873AlaHis: 2.873 ± 0.039	3.519AlaIle: 3.519 ± 0.045	3.062AlaLys: 3.062 ± 0.061	14.418AlaLeu: 14.418 ± 0.103	2.436AlaMet: 2.436 ± 0.034	1.975AlaAsn: 1.975 ± 0.029	6.887AlaPro: 6.887 ± 0.077	3.83AlaGln: 3.83 ± 0.045	10.109AlaArg: 10.109 ± 0.082	5.8AlaSer: 5.8 ± 0.048	6.908AlaThr: 6.908 ± 0.059	12.191AlaVal: 12.191 ± 0.092	1.899AlaTrp: 1.899 ± 0.031	2.893AlaTyr: 2.893 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.095CysAla: 1.095 ± 0.025	0.095CysCys: 0.095 ± 0.006	0.455CysAsp: 0.455 ± 0.014	0.42CysGlu: 0.42 ± 0.014	0.228CysPhe: 0.228 ± 0.009	0.952CysGly: 0.952 ± 0.021	0.191CysHis: 0.191 ± 0.01	0.162CysIle: 0.162 ± 0.008	0.116CysLys: 0.116 ± 0.007	0.797CysLeu: 0.797 ± 0.019	0.129CysMet: 0.129 ± 0.007	0.13CysAsn: 0.13 ± 0.008	0.482CysPro: 0.482 ± 0.016	0.165CysGln: 0.165 ± 0.008	0.6CysArg: 0.6 ± 0.018	0.408CysSer: 0.408 ± 0.016	0.52CysThr: 0.52 ± 0.016	0.695CysVal: 0.695 ± 0.015	0.131CysTrp: 0.131 ± 0.008	0.156CysTyr: 0.156 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.443AspAla: 7.443 ± 0.06	0.444AspCys: 0.444 ± 0.016	3.678AspAsp: 3.678 ± 0.047	3.999AspGlu: 3.999 ± 0.041	1.709AspPhe: 1.709 ± 0.029	6.398AspGly: 6.398 ± 0.064	1.437AspHis: 1.437 ± 0.027	2.011AspIle: 2.011 ± 0.034	1.331AspLys: 1.331 ± 0.028	6.164AspLeu: 6.164 ± 0.06	0.826AspMet: 0.826 ± 0.016	1.0AspAsn: 1.0 ± 0.019	4.504AspPro: 4.504 ± 0.045	1.538AspGln: 1.538 ± 0.028	4.841AspArg: 4.841 ± 0.052	2.586AspSer: 2.586 ± 0.032	3.183AspThr: 3.183 ± 0.039	4.763AspVal: 4.763 ± 0.053	1.073AspTrp: 1.073 ± 0.021	1.158AspTyr: 1.158 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.592GluAla: 7.592 ± 0.077	0.389GluCys: 0.389 ± 0.012	2.865GluAsp: 2.865 ± 0.031	3.78GluGlu: 3.78 ± 0.051	1.544GluPhe: 1.544 ± 0.024	4.451GluGly: 4.451 ± 0.052	1.557GluHis: 1.557 ± 0.029	2.254GluIle: 2.254 ± 0.036	1.638GluLys: 1.638 ± 0.032	6.981GluLeu: 6.981 ± 0.064	0.903GluMet: 0.903 ± 0.021	1.102GluAsn: 1.102 ± 0.024	3.47GluPro: 3.47 ± 0.046	2.299GluGln: 2.299 ± 0.031	5.567GluArg: 5.567 ± 0.062	2.571GluSer: 2.571 ± 0.032	2.944GluThr: 2.944 ± 0.04	4.559GluVal: 4.559 ± 0.051	0.805GluTrp: 0.805 ± 0.022	1.184GluTyr: 1.184 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.623PheAla: 3.623 ± 0.04	0.253PheCys: 0.253 ± 0.01	1.914PheAsp: 1.914 ± 0.028	1.492PheGlu: 1.492 ± 0.028	0.911PhePhe: 0.911 ± 0.022	3.029PheGly: 3.029 ± 0.037	0.609PheHis: 0.609 ± 0.015	0.734PheIle: 0.734 ± 0.018	0.556PheLys: 0.556 ± 0.017	2.652PheLeu: 2.652 ± 0.038	0.436PheMet: 0.436 ± 0.015	0.568PheAsn: 0.568 ± 0.017	1.382PhePro: 1.382 ± 0.021	0.719PheGln: 0.719 ± 0.018	1.862PheArg: 1.862 ± 0.028	1.452PheSer: 1.452 ± 0.027	2.008PheThr: 2.008 ± 0.033	2.262PheVal: 2.262 ± 0.031	0.438PheTrp: 0.438 ± 0.016	0.584PheTyr: 0.584 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.819GlyAla: 10.819 ± 0.088	0.838GlyCys: 0.838 ± 0.019	5.24GlyAsp: 5.24 ± 0.053	5.243GlyGlu: 5.243 ± 0.05	2.885GlyPhe: 2.885 ± 0.042	8.669GlyGly: 8.669 ± 0.095	2.288GlyHis: 2.288 ± 0.033	3.47GlyIle: 3.47 ± 0.042	2.495GlyLys: 2.495 ± 0.042	9.342GlyLeu: 9.342 ± 0.081	1.976GlyMet: 1.976 ± 0.03	1.781GlyAsn: 1.781 ± 0.036	4.971GlyPro: 4.971 ± 0.053	2.678GlyGln: 2.678 ± 0.035	7.557GlyArg: 7.557 ± 0.065	5.279GlySer: 5.279 ± 0.051	6.365GlyThr: 6.365 ± 0.056	7.49GlyVal: 7.49 ± 0.065	1.744GlyTrp: 1.744 ± 0.029	2.312GlyTyr: 2.312 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.642HisAla: 2.642 ± 0.035	0.225HisCys: 0.225 ± 0.009	1.371HisAsp: 1.371 ± 0.025	1.234HisGlu: 1.234 ± 0.022	0.648HisPhe: 0.648 ± 0.018	2.408HisGly: 2.408 ± 0.036	0.676HisHis: 0.676 ± 0.018	0.721HisIle: 0.721 ± 0.018	0.381HisLys: 0.381 ± 0.013	2.393HisLeu: 2.393 ± 0.036	0.341HisMet: 0.341 ± 0.013	0.409HisAsn: 0.409 ± 0.013	1.832HisPro: 1.832 ± 0.032	0.647HisGln: 0.647 ± 0.016	2.088HisArg: 2.088 ± 0.031	0.997HisSer: 0.997 ± 0.022	1.361HisThr: 1.361 ± 0.027	1.732HisVal: 1.732 ± 0.025	0.378HisTrp: 0.378 ± 0.012	0.498HisTyr: 0.498 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.801IleAla: 4.801 ± 0.048	0.282IleCys: 0.282 ± 0.011	2.271IleAsp: 2.271 ± 0.033	2.074IleGlu: 2.074 ± 0.032	0.713IlePhe: 0.713 ± 0.018	3.538IleGly: 3.538 ± 0.044	0.63IleHis: 0.63 ± 0.015	0.892IleIle: 0.892 ± 0.022	0.805IleLys: 0.805 ± 0.021	2.436IleLeu: 2.436 ± 0.039	0.467IleMet: 0.467 ± 0.015	0.699IleAsn: 0.699 ± 0.018	1.862IlePro: 1.862 ± 0.031	0.771IleGln: 0.771 ± 0.019	2.296IleArg: 2.296 ± 0.033	1.665IleSer: 1.665 ± 0.031	2.228IleThr: 2.228 ± 0.035	2.739IleVal: 2.739 ± 0.039	0.401IleTrp: 0.401 ± 0.014	0.541IleTyr: 0.541 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.132LysAla: 3.132 ± 0.049	0.127LysCys: 0.127 ± 0.007	1.446LysAsp: 1.446 ± 0.031	1.367LysGlu: 1.367 ± 0.031	0.496LysPhe: 0.496 ± 0.016	2.018LysGly: 2.018 ± 0.037	0.447LysHis: 0.447 ± 0.017	0.928LysIle: 0.928 ± 0.025	0.962LysLys: 0.962 ± 0.03	2.153LysLeu: 2.153 ± 0.035	0.417LysMet: 0.417 ± 0.015	0.559LysAsn: 0.559 ± 0.018	1.455LysPro: 1.455 ± 0.034	0.754LysGln: 0.754 ± 0.019	1.484LysArg: 1.484 ± 0.029	1.246LysSer: 1.246 ± 0.027	1.333LysThr: 1.333 ± 0.029	2.076LysVal: 2.076 ± 0.041	0.289LysTrp: 0.289 ± 0.011	0.511LysTyr: 0.511 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.924LeuAla: 14.924 ± 0.116	0.871LeuCys: 0.871 ± 0.019	6.658LeuAsp: 6.658 ± 0.063	4.666LeuGlu: 4.666 ± 0.045	2.629LeuPhe: 2.629 ± 0.035	9.18LeuGly: 9.18 ± 0.07	2.26LeuHis: 2.26 ± 0.032	3.294LeuIle: 3.294 ± 0.045	2.23LeuLys: 2.23 ± 0.035	11.228LeuLeu: 11.228 ± 0.113	1.659LeuMet: 1.659 ± 0.026	1.764LeuAsn: 1.764 ± 0.031	6.431LeuPro: 6.431 ± 0.056	2.277LeuGln: 2.277 ± 0.033	8.604LeuArg: 8.604 ± 0.079	5.258LeuSer: 5.258 ± 0.055	6.9LeuThr: 6.9 ± 0.058	8.828LeuVal: 8.828 ± 0.078	1.339LeuTrp: 1.339 ± 0.027	1.965LeuTyr: 1.965 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.246MetAla: 2.246 ± 0.034	0.135MetCys: 0.135 ± 0.008	0.884MetAsp: 0.884 ± 0.018	0.755MetGlu: 0.755 ± 0.018	0.445MetPhe: 0.445 ± 0.014	1.312MetGly: 1.312 ± 0.026	0.353MetHis: 0.353 ± 0.012	0.661MetIle: 0.661 ± 0.018	0.44MetLys: 0.44 ± 0.013	1.622MetLeu: 1.622 ± 0.024	0.302MetMet: 0.302 ± 0.01	0.441MetAsn: 0.441 ± 0.013	1.113MetPro: 1.113 ± 0.026	0.438MetGln: 0.438 ± 0.014	1.46MetArg: 1.46 ± 0.023	1.303MetSer: 1.303 ± 0.023	1.554MetThr: 1.554 ± 0.028	1.301MetVal: 1.301 ± 0.024	0.225MetTrp: 0.225 ± 0.01	0.334MetTyr: 0.334 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.226AsnAla: 2.226 ± 0.034	0.166AsnCys: 0.166 ± 0.008	0.999AsnAsp: 0.999 ± 0.023	0.857AsnGlu: 0.857 ± 0.021	0.504AsnPhe: 0.504 ± 0.017	1.954AsnGly: 1.954 ± 0.038	0.409AsnHis: 0.409 ± 0.014	0.67AsnIle: 0.67 ± 0.017	0.457AsnLys: 0.457 ± 0.016	1.713AsnLeu: 1.713 ± 0.029	0.298AsnMet: 0.298 ± 0.011	0.485AsnAsn: 0.485 ± 0.018	1.398AsnPro: 1.398 ± 0.029	0.562AsnGln: 0.562 ± 0.014	1.269AsnArg: 1.269 ± 0.023	0.986AsnSer: 0.986 ± 0.022	1.166AsnThr: 1.166 ± 0.027	1.407AsnVal: 1.407 ± 0.028	0.323AsnTrp: 0.323 ± 0.012	0.431AsnTyr: 0.431 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.282ProAla: 8.282 ± 0.098	0.33ProCys: 0.33 ± 0.013	4.514ProAsp: 4.514 ± 0.051	4.48ProGlu: 4.48 ± 0.046	1.532ProPhe: 1.532 ± 0.028	6.394ProGly: 6.394 ± 0.068	1.455ProHis: 1.455 ± 0.028	1.298ProIle: 1.298 ± 0.023	1.303ProLys: 1.303 ± 0.027	5.334ProLeu: 5.334 ± 0.058	0.981ProMet: 0.981 ± 0.02	0.939ProAsn: 0.939 ± 0.025	3.503ProPro: 3.503 ± 0.057	1.81ProGln: 1.81 ± 0.038	3.876ProArg: 3.876 ± 0.049	3.258ProSer: 3.258 ± 0.045	3.26ProThr: 3.26 ± 0.043	5.41ProVal: 5.41 ± 0.054	0.898ProTrp: 0.898 ± 0.02	1.539ProTyr: 1.539 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.776GlnAla: 3.776 ± 0.047	0.163GlnCys: 0.163 ± 0.01	1.445GlnAsp: 1.445 ± 0.024	1.544GlnGlu: 1.544 ± 0.027	0.676GlnPhe: 0.676 ± 0.016	2.38GlnGly: 2.38 ± 0.033	0.7GlnHis: 0.7 ± 0.018	1.088GlnIle: 1.088 ± 0.021	0.65GlnLys: 0.65 ± 0.02	3.103GlnLeu: 3.103 ± 0.039	0.513GlnMet: 0.513 ± 0.016	0.525GlnAsn: 0.525 ± 0.017	1.789GlnPro: 1.789 ± 0.034	1.284GlnGln: 1.284 ± 0.031	2.36GlnArg: 2.36 ± 0.034	1.313GlnSer: 1.313 ± 0.023	1.365GlnThr: 1.365 ± 0.024	2.367GlnVal: 2.367 ± 0.036	0.486GlnTrp: 0.486 ± 0.015	0.644GlnTyr: 0.644 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.717ArgAla: 9.717 ± 0.08	0.572ArgCys: 0.572 ± 0.018	4.227ArgAsp: 4.227 ± 0.046	4.853ArgGlu: 4.853 ± 0.049	2.319ArgPhe: 2.319 ± 0.03	5.785ArgGly: 5.785 ± 0.053	2.125ArgHis: 2.125 ± 0.035	3.21ArgIle: 3.21 ± 0.038	1.756ArgLys: 1.756 ± 0.029	8.836ArgLeu: 8.836 ± 0.08	1.702ArgMet: 1.702 ± 0.03	1.352ArgAsn: 1.352 ± 0.027	4.857ArgPro: 4.857 ± 0.053	2.342ArgGln: 2.342 ± 0.036	7.668ArgArg: 7.668 ± 0.076	3.889ArgSer: 3.889 ± 0.044	5.402ArgThr: 5.402 ± 0.052	5.831ArgVal: 5.831 ± 0.057	1.4ArgTrp: 1.4 ± 0.026	1.843ArgTyr: 1.843 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.718SerAla: 6.718 ± 0.061	0.407SerCys: 0.407 ± 0.014	2.719SerAsp: 2.719 ± 0.035	2.45SerGlu: 2.45 ± 0.028	1.506SerPhe: 1.506 ± 0.024	5.857SerGly: 5.857 ± 0.06	1.005SerHis: 1.005 ± 0.02	1.407SerIle: 1.407 ± 0.024	1.092SerLys: 1.092 ± 0.024	4.788SerLeu: 4.788 ± 0.052	1.068SerMet: 1.068 ± 0.022	0.92SerAsn: 0.92 ± 0.022	3.18SerPro: 3.18 ± 0.042	1.254SerGln: 1.254 ± 0.022	3.585SerArg: 3.585 ± 0.037	2.787SerSer: 2.787 ± 0.047	3.021SerThr: 3.021 ± 0.039	4.247SerVal: 4.247 ± 0.044	0.902SerTrp: 0.902 ± 0.019	1.295SerTyr: 1.295 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.908ThrAla: 8.908 ± 0.069	0.444ThrCys: 0.444 ± 0.016	3.655ThrAsp: 3.655 ± 0.04	3.302ThrGlu: 3.302 ± 0.043	1.622ThrPhe: 1.622 ± 0.027	6.584ThrGly: 6.584 ± 0.056	1.207ThrHis: 1.207 ± 0.023	1.757ThrIle: 1.757 ± 0.032	1.26ThrLys: 1.26 ± 0.026	5.662ThrLeu: 5.662 ± 0.057	0.914ThrMet: 0.914 ± 0.02	1.048ThrAsn: 1.048 ± 0.021	4.239ThrPro: 4.239 ± 0.052	1.39ThrGln: 1.39 ± 0.024	3.875ThrArg: 3.875 ± 0.042	3.164ThrSer: 3.164 ± 0.043	3.805ThrThr: 3.805 ± 0.051	6.059ThrVal: 6.059 ± 0.053	0.933ThrTrp: 0.933 ± 0.021	1.454ThrTyr: 1.454 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.512ValAla: 10.512 ± 0.074	0.774ValCys: 0.774 ± 0.018	4.926ValAsp: 4.926 ± 0.042	4.832ValGlu: 4.832 ± 0.052	2.47ValPhe: 2.47 ± 0.038	6.467ValGly: 6.467 ± 0.064	1.976ValHis: 1.976 ± 0.029	2.959ValIle: 2.959 ± 0.038	1.832ValLys: 1.832 ± 0.035	9.431ValLeu: 9.431 ± 0.084	1.402ValMet: 1.402 ± 0.027	1.696ValAsn: 1.696 ± 0.03	5.212ValPro: 5.212 ± 0.052	2.125ValGln: 2.125 ± 0.033	7.328ValArg: 7.328 ± 0.055	4.302ValSer: 4.302 ± 0.048	5.672ValThr: 5.672 ± 0.052	8.073ValVal: 8.073 ± 0.071	1.19ValTrp: 1.19 ± 0.026	1.649ValTyr: 1.649 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.712TrpAla: 1.712 ± 0.027	0.15TrpCys: 0.15 ± 0.008	0.86TrpAsp: 0.86 ± 0.021	0.765TrpGlu: 0.765 ± 0.018	0.517TrpPhe: 0.517 ± 0.015	1.124TrpGly: 1.124 ± 0.022	0.379TrpHis: 0.379 ± 0.013	0.557TrpIle: 0.557 ± 0.016	0.402TrpLys: 0.402 ± 0.015	1.816TrpLeu: 1.816 ± 0.032	0.292TrpMet: 0.292 ± 0.013	0.451TrpAsn: 0.451 ± 0.016	0.755TrpPro: 0.755 ± 0.02	0.672TrpGln: 0.672 ± 0.017	1.349TrpArg: 1.349 ± 0.027	0.937TrpSer: 0.937 ± 0.017	1.085TrpThr: 1.085 ± 0.02	1.018TrpVal: 1.018 ± 0.021	0.36TrpTrp: 0.36 ± 0.013	0.392TrpTyr: 0.392 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.89TyrAla: 2.89 ± 0.036	0.191TyrCys: 0.191 ± 0.009	1.678TyrAsp: 1.678 ± 0.035	1.367TyrGlu: 1.367 ± 0.026	0.69TyrPhe: 0.69 ± 0.017	2.453TyrGly: 2.453 ± 0.038	0.403TyrHis: 0.403 ± 0.013	0.52TyrIle: 0.52 ± 0.016	0.432TyrLys: 0.432 ± 0.013	2.096TyrLeu: 2.096 ± 0.036	0.261TyrMet: 0.261 ± 0.011	0.436TyrAsn: 0.436 ± 0.015	1.074TyrPro: 1.074 ± 0.029	0.615TyrGln: 0.615 ± 0.017	1.907TyrArg: 1.907 ± 0.031	1.008TyrSer: 1.008 ± 0.02	1.202TyrThr: 1.202 ± 0.025	1.779TyrVal: 1.779 ± 0.026	0.381TyrTrp: 0.381 ± 0.011	0.486TyrTyr: 0.486 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7114 proteins (2369746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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