Amino acid dipepetide frequency for Lachancea mirantina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.938AlaAla: 5.938 ± 0.075
0.944AlaCys: 0.944 ± 0.02
3.367AlaAsp: 3.367 ± 0.039
4.121AlaGlu: 4.121 ± 0.046
2.93AlaPhe: 2.93 ± 0.037
4.157AlaGly: 4.157 ± 0.055
1.45AlaHis: 1.45 ± 0.026
3.783AlaIle: 3.783 ± 0.043
4.291AlaLys: 4.291 ± 0.048
7.026AlaLeu: 7.026 ± 0.059
1.516AlaMet: 1.516 ± 0.023
2.948AlaAsn: 2.948 ± 0.04
3.038AlaPro: 3.038 ± 0.053
2.921AlaGln: 2.921 ± 0.041
3.579AlaArg: 3.579 ± 0.042
6.198AlaSer: 6.198 ± 0.069
4.084AlaThr: 4.084 ± 0.048
4.365AlaVal: 4.365 ± 0.05
0.668AlaTrp: 0.668 ± 0.017
1.852AlaTyr: 1.852 ± 0.028
0.0AlaXaa: 0.0 ± 0.0
Cys
0.817CysAla: 0.817 ± 0.02
0.294CysCys: 0.294 ± 0.01
0.789CysAsp: 0.789 ± 0.016
0.708CysGlu: 0.708 ± 0.017
0.693CysPhe: 0.693 ± 0.017
0.98CysGly: 0.98 ± 0.022
0.355CysHis: 0.355 ± 0.012
0.853CysIle: 0.853 ± 0.023
0.687CysLys: 0.687 ± 0.018
1.401CysLeu: 1.401 ± 0.022
0.284CysMet: 0.284 ± 0.01
0.523CysAsn: 0.523 ± 0.016
0.541CysPro: 0.541 ± 0.018
0.503CysGln: 0.503 ± 0.015
0.673CysArg: 0.673 ± 0.016
1.142CysSer: 1.142 ± 0.02
0.614CysThr: 0.614 ± 0.017
0.934CysVal: 0.934 ± 0.022
0.178CysTrp: 0.178 ± 0.009
0.491CysTyr: 0.491 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.11AspAla: 4.11 ± 0.044
0.679AspCys: 0.679 ± 0.017
4.16AspAsp: 4.16 ± 0.059
4.924AspGlu: 4.924 ± 0.063
2.87AspPhe: 2.87 ± 0.035
3.175AspGly: 3.175 ± 0.045
1.146AspHis: 1.146 ± 0.021
3.311AspIle: 3.311 ± 0.034
3.203AspLys: 3.203 ± 0.035
5.846AspLeu: 5.846 ± 0.057
1.153AspMet: 1.153 ± 0.022
2.339AspAsn: 2.339 ± 0.031
2.47AspPro: 2.47 ± 0.035
2.0AspGln: 2.0 ± 0.031
2.54AspArg: 2.54 ± 0.029
4.52AspSer: 4.52 ± 0.048
2.746AspThr: 2.746 ± 0.035
4.052AspVal: 4.052 ± 0.04
0.65AspTrp: 0.65 ± 0.016
1.938AspTyr: 1.938 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
4.243GluAla: 4.243 ± 0.049
0.698GluCys: 0.698 ± 0.016
4.203GluAsp: 4.203 ± 0.06
5.465GluGlu: 5.465 ± 0.074
2.873GluPhe: 2.873 ± 0.039
3.083GluGly: 3.083 ± 0.04
1.354GluHis: 1.354 ± 0.025
4.017GluIle: 4.017 ± 0.043
4.679GluLys: 4.679 ± 0.059
6.813GluLeu: 6.813 ± 0.066
1.425GluMet: 1.425 ± 0.023
3.668GluAsn: 3.668 ± 0.039
2.323GluPro: 2.323 ± 0.036
2.802GluGln: 2.802 ± 0.043
3.517GluArg: 3.517 ± 0.04
4.99GluSer: 4.99 ± 0.06
3.794GluThr: 3.794 ± 0.043
3.759GluVal: 3.759 ± 0.044
0.684GluTrp: 0.684 ± 0.017
1.928GluTyr: 1.928 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
2.875PheAla: 2.875 ± 0.037
0.645PheCys: 0.645 ± 0.016
2.885PheAsp: 2.885 ± 0.038
3.078PheGlu: 3.078 ± 0.036
2.052PhePhe: 2.052 ± 0.036
2.856PheGly: 2.856 ± 0.047
0.976PheHis: 0.976 ± 0.021
2.349PheIle: 2.349 ± 0.033
2.799PheLys: 2.799 ± 0.033
4.415PheLeu: 4.415 ± 0.051
0.938PheMet: 0.938 ± 0.019
2.1PheAsn: 2.1 ± 0.03
1.825PhePro: 1.825 ± 0.024
1.931PheGln: 1.931 ± 0.029
2.021PheArg: 2.021 ± 0.028
3.785PheSer: 3.785 ± 0.042
2.394PheThr: 2.394 ± 0.039
2.914PheVal: 2.914 ± 0.036
0.558PheTrp: 0.558 ± 0.017
1.623PheTyr: 1.623 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
3.935GlyAla: 3.935 ± 0.052
0.797GlyCys: 0.797 ± 0.02
3.107GlyAsp: 3.107 ± 0.041
3.21GlyGlu: 3.21 ± 0.038
2.758GlyPhe: 2.758 ± 0.034
3.828GlyGly: 3.828 ± 0.076
1.31GlyHis: 1.31 ± 0.024
3.394GlyIle: 3.394 ± 0.038
3.652GlyLys: 3.652 ± 0.041
5.301GlyLeu: 5.301 ± 0.061
1.076GlyMet: 1.076 ± 0.02
2.662GlyAsn: 2.662 ± 0.034
2.074GlyPro: 2.074 ± 0.036
2.058GlyGln: 2.058 ± 0.034
2.777GlyArg: 2.777 ± 0.035
5.411GlySer: 5.411 ± 0.061
3.131GlyThr: 3.131 ± 0.044
3.783GlyVal: 3.783 ± 0.041
0.676GlyTrp: 0.676 ± 0.019
1.818GlyTyr: 1.818 ± 0.027
0.0GlyXaa: 0.0 ± 0.0
His
1.333HisAla: 1.333 ± 0.024
0.336HisCys: 0.336 ± 0.012
1.257HisAsp: 1.257 ± 0.024
1.44HisGlu: 1.44 ± 0.028
1.068HisPhe: 1.068 ± 0.021
1.323HisGly: 1.323 ± 0.028
0.661HisHis: 0.661 ± 0.025
1.214HisIle: 1.214 ± 0.022
1.189HisLys: 1.189 ± 0.021
2.196HisLeu: 2.196 ± 0.033
0.458HisMet: 0.458 ± 0.013
0.911HisAsn: 0.911 ± 0.021
1.078HisPro: 1.078 ± 0.023
0.904HisGln: 0.904 ± 0.022
1.195HisArg: 1.195 ± 0.02
1.818HisSer: 1.818 ± 0.031
1.03HisThr: 1.03 ± 0.021
1.4HisVal: 1.4 ± 0.027
0.258HisTrp: 0.258 ± 0.011
0.743HisTyr: 0.743 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
3.765IleAla: 3.765 ± 0.041
0.862IleCys: 0.862 ± 0.019
3.475IleAsp: 3.475 ± 0.043
3.566IleGlu: 3.566 ± 0.04
2.505IlePhe: 2.505 ± 0.035
2.983IleGly: 2.983 ± 0.043
1.115IleHis: 1.115 ± 0.022
2.916IleIle: 2.916 ± 0.039
3.449IleLys: 3.449 ± 0.042
5.451IleLeu: 5.451 ± 0.054
1.164IleMet: 1.164 ± 0.023
2.569IleAsn: 2.569 ± 0.032
2.782IlePro: 2.782 ± 0.029
2.025IleGln: 2.025 ± 0.029
2.592IleArg: 2.592 ± 0.034
4.892IleSer: 4.892 ± 0.046
2.942IleThr: 2.942 ± 0.039
3.601IleVal: 3.601 ± 0.046
0.627IleTrp: 0.627 ± 0.016
1.767IleTyr: 1.767 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.96LysAla: 3.96 ± 0.042
0.779LysCys: 0.779 ± 0.021
3.447LysAsp: 3.447 ± 0.041
4.193LysGlu: 4.193 ± 0.05
2.814LysPhe: 2.814 ± 0.037
2.85LysGly: 2.85 ± 0.04
1.369LysHis: 1.369 ± 0.026
3.868LysIle: 3.868 ± 0.042
4.954LysLys: 4.954 ± 0.076
6.588LysLeu: 6.588 ± 0.059
1.337LysMet: 1.337 ± 0.024
3.249LysAsn: 3.249 ± 0.038
2.767LysPro: 2.767 ± 0.04
2.538LysGln: 2.538 ± 0.039
3.997LysArg: 3.997 ± 0.049
5.138LysSer: 5.138 ± 0.055
3.664LysThr: 3.664 ± 0.047
3.756LysVal: 3.756 ± 0.04
0.743LysTrp: 0.743 ± 0.017
2.065LysTyr: 2.065 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
6.921LeuAla: 6.921 ± 0.058
1.4LeuCys: 1.4 ± 0.027
5.59LeuAsp: 5.59 ± 0.051
6.601LeuGlu: 6.601 ± 0.06
4.165LeuPhe: 4.165 ± 0.053
5.166LeuGly: 5.166 ± 0.048
2.182LeuHis: 2.182 ± 0.035
5.108LeuIle: 5.108 ± 0.055
6.938LeuLys: 6.938 ± 0.068
9.735LeuLeu: 9.735 ± 0.092
2.064LeuMet: 2.064 ± 0.032
4.744LeuAsn: 4.744 ± 0.047
4.694LeuPro: 4.694 ± 0.05
4.581LeuGln: 4.581 ± 0.05
5.492LeuArg: 5.492 ± 0.051
8.473LeuSer: 8.473 ± 0.082
5.229LeuThr: 5.229 ± 0.046
5.886LeuVal: 5.886 ± 0.057
1.022LeuTrp: 1.022 ± 0.022
2.883LeuTyr: 2.883 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
1.605MetAla: 1.605 ± 0.027
0.315MetCys: 0.315 ± 0.012
1.185MetAsp: 1.185 ± 0.022
1.192MetGlu: 1.192 ± 0.022
0.797MetPhe: 0.797 ± 0.019
1.288MetGly: 1.288 ± 0.025
0.402MetHis: 0.402 ± 0.013
1.144MetIle: 1.144 ± 0.023
1.269MetLys: 1.269 ± 0.022
1.898MetLeu: 1.898 ± 0.028
0.447MetMet: 0.447 ± 0.015
1.024MetAsn: 1.024 ± 0.019
0.902MetPro: 0.902 ± 0.021
0.752MetGln: 0.752 ± 0.019
1.097MetArg: 1.097 ± 0.018
2.049MetSer: 2.049 ± 0.026
1.139MetThr: 1.139 ± 0.021
1.245MetVal: 1.245 ± 0.026
0.206MetTrp: 0.206 ± 0.009
0.518MetTyr: 0.518 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.302AsnAla: 3.302 ± 0.035
0.664AsnCys: 0.664 ± 0.017
2.868AsnAsp: 2.868 ± 0.034
3.243AsnGlu: 3.243 ± 0.038
2.205AsnPhe: 2.205 ± 0.036
3.029AsnGly: 3.029 ± 0.035
0.925AsnHis: 0.925 ± 0.019
2.503AsnIle: 2.503 ± 0.034
2.768AsnLys: 2.768 ± 0.035
4.524AsnLeu: 4.524 ± 0.045
0.956AsnMet: 0.956 ± 0.019
2.123AsnAsn: 2.123 ± 0.038
2.1AsnPro: 2.1 ± 0.028
1.634AsnGln: 1.634 ± 0.026
2.154AsnArg: 2.154 ± 0.029
4.167AsnSer: 4.167 ± 0.05
2.344AsnThr: 2.344 ± 0.034
3.179AsnVal: 3.179 ± 0.034
0.576AsnTrp: 0.576 ± 0.018
1.643AsnTyr: 1.643 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
3.192ProAla: 3.192 ± 0.047
0.417ProCys: 0.417 ± 0.015
2.337ProAsp: 2.337 ± 0.037
3.199ProGlu: 3.199 ± 0.039
1.985ProPhe: 1.985 ± 0.03
2.389ProGly: 2.389 ± 0.034
1.044ProHis: 1.044 ± 0.022
2.31ProIle: 2.31 ± 0.032
2.551ProLys: 2.551 ± 0.037
4.219ProLeu: 4.219 ± 0.041
0.784ProMet: 0.784 ± 0.02
1.946ProAsn: 1.946 ± 0.032
2.452ProPro: 2.452 ± 0.063
2.101ProGln: 2.101 ± 0.035
2.161ProArg: 2.161 ± 0.033
4.038ProSer: 4.038 ± 0.051
2.587ProThr: 2.587 ± 0.041
2.943ProVal: 2.943 ± 0.041
0.467ProTrp: 0.467 ± 0.014
1.252ProTyr: 1.252 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
2.685GlnAla: 2.685 ± 0.04
0.456GlnCys: 0.456 ± 0.013
2.304GlnAsp: 2.304 ± 0.03
2.979GlnGlu: 2.979 ± 0.041
1.762GlnPhe: 1.762 ± 0.029
2.073GlnGly: 2.073 ± 0.03
0.95GlnHis: 0.95 ± 0.024
2.316GlnIle: 2.316 ± 0.034
2.641GlnLys: 2.641 ± 0.031
4.203GlnLeu: 4.203 ± 0.044
0.878GlnMet: 0.878 ± 0.02
2.146GlnAsn: 2.146 ± 0.035
1.726GlnPro: 1.726 ± 0.032
2.688GlnGln: 2.688 ± 0.107
2.37GlnArg: 2.37 ± 0.036
3.0GlnSer: 3.0 ± 0.037
2.141GlnThr: 2.141 ± 0.035
2.38GlnVal: 2.38 ± 0.033
0.453GlnTrp: 0.453 ± 0.014
1.198GlnTyr: 1.198 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
3.472ArgAla: 3.472 ± 0.041
0.742ArgCys: 0.742 ± 0.021
3.094ArgAsp: 3.094 ± 0.036
3.484ArgGlu: 3.484 ± 0.046
2.349ArgPhe: 2.349 ± 0.03
2.774ArgGly: 2.774 ± 0.037
1.236ArgHis: 1.236 ± 0.026
2.94ArgIle: 2.94 ± 0.034
3.774ArgLys: 3.774 ± 0.044
5.002ArgLeu: 5.002 ± 0.045
1.009ArgMet: 1.009 ± 0.019
2.643ArgAsn: 2.643 ± 0.033
2.143ArgPro: 2.143 ± 0.033
2.248ArgGln: 2.248 ± 0.03
3.706ArgArg: 3.706 ± 0.05
4.122ArgSer: 4.122 ± 0.047
2.623ArgThr: 2.623 ± 0.032
2.961ArgVal: 2.961 ± 0.036
0.551ArgTrp: 0.551 ± 0.016
1.655ArgTyr: 1.655 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
5.909SerAla: 5.909 ± 0.066
1.055SerCys: 1.055 ± 0.023
4.764SerAsp: 4.764 ± 0.05
5.237SerGlu: 5.237 ± 0.065
3.781SerPhe: 3.781 ± 0.041
5.249SerGly: 5.249 ± 0.05
1.91SerHis: 1.91 ± 0.028
4.53SerIle: 4.53 ± 0.045
5.528SerLys: 5.528 ± 0.05
8.336SerLeu: 8.336 ± 0.071
1.754SerMet: 1.754 ± 0.03
4.033SerAsn: 4.033 ± 0.047
3.914SerPro: 3.914 ± 0.057
3.672SerGln: 3.672 ± 0.045
4.589SerArg: 4.589 ± 0.049
9.526SerSer: 9.526 ± 0.145
5.057SerThr: 5.057 ± 0.067
5.097SerVal: 5.097 ± 0.044
0.894SerTrp: 0.894 ± 0.02
2.321SerTyr: 2.321 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
3.893ThrAla: 3.893 ± 0.046
0.709ThrCys: 0.709 ± 0.016
2.718ThrAsp: 2.718 ± 0.032
3.127ThrGlu: 3.127 ± 0.043
2.44ThrPhe: 2.44 ± 0.033
3.464ThrGly: 3.464 ± 0.049
1.142ThrHis: 1.142 ± 0.023
3.0ThrIle: 3.0 ± 0.036
3.281ThrLys: 3.281 ± 0.039
5.452ThrLeu: 5.452 ± 0.052
1.048ThrMet: 1.048 ± 0.022
2.412ThrAsn: 2.412 ± 0.029
2.894ThrPro: 2.894 ± 0.041
2.006ThrGln: 2.006 ± 0.027
2.688ThrArg: 2.688 ± 0.033
5.167ThrSer: 5.167 ± 0.074
3.439ThrThr: 3.439 ± 0.062
3.532ThrVal: 3.532 ± 0.035
0.579ThrTrp: 0.579 ± 0.019
1.504ThrTyr: 1.504 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
4.52ValAla: 4.52 ± 0.046
0.899ValCys: 0.899 ± 0.022
3.705ValAsp: 3.705 ± 0.042
3.981ValGlu: 3.981 ± 0.044
2.95ValPhe: 2.95 ± 0.041
3.535ValGly: 3.535 ± 0.047
1.299ValHis: 1.299 ± 0.025
3.344ValIle: 3.344 ± 0.036
3.894ValLys: 3.894 ± 0.049
6.188ValLeu: 6.188 ± 0.05
1.289ValMet: 1.289 ± 0.022
2.837ValAsn: 2.837 ± 0.037
3.041ValPro: 3.041 ± 0.033
2.271ValGln: 2.271 ± 0.03
3.123ValArg: 3.123 ± 0.038
5.428ValSer: 5.428 ± 0.052
3.51ValThr: 3.51 ± 0.042
4.411ValVal: 4.411 ± 0.059
0.666ValTrp: 0.666 ± 0.017
1.881ValTyr: 1.881 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
0.647TrpAla: 0.647 ± 0.019
0.27TrpCys: 0.27 ± 0.012
0.686TrpAsp: 0.686 ± 0.02
0.617TrpGlu: 0.617 ± 0.017
0.54TrpPhe: 0.54 ± 0.017
0.6TrpGly: 0.6 ± 0.017
0.254TrpHis: 0.254 ± 0.011
0.618TrpIle: 0.618 ± 0.016
0.777TrpLys: 0.777 ± 0.02
1.067TrpLeu: 1.067 ± 0.023
0.235TrpMet: 0.235 ± 0.01
0.611TrpAsn: 0.611 ± 0.016
0.367TrpPro: 0.367 ± 0.012
0.459TrpGln: 0.459 ± 0.015
0.664TrpArg: 0.664 ± 0.016
0.908TrpSer: 0.908 ± 0.019
0.569TrpThr: 0.569 ± 0.016
0.584TrpVal: 0.584 ± 0.018
0.169TrpTrp: 0.169 ± 0.009
0.365TrpTyr: 0.365 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.053TyrAla: 2.053 ± 0.029
0.5TyrCys: 0.5 ± 0.013
1.889TyrAsp: 1.889 ± 0.026
1.954TyrGlu: 1.954 ± 0.025
1.479TyrPhe: 1.479 ± 0.027
1.956TyrGly: 1.956 ± 0.04
0.733TyrHis: 0.733 ± 0.018
1.531TyrIle: 1.531 ± 0.026
1.75TyrLys: 1.75 ± 0.029
3.212TyrLeu: 3.212 ± 0.039
0.662TyrMet: 0.662 ± 0.018
1.418TyrAsn: 1.418 ± 0.025
1.245TyrPro: 1.245 ± 0.027
1.255TyrGln: 1.255 ± 0.025
1.592TyrArg: 1.592 ± 0.025
2.383TyrSer: 2.383 ± 0.035
1.458TyrThr: 1.458 ± 0.026
1.992TyrVal: 1.992 ± 0.031
0.383TyrTrp: 0.383 ± 0.015
1.127TyrTyr: 1.127 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5053 proteins (2449895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski