Amino acid dipepetide frequency for Granulicella pectinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.021AlaAla: 14.021 ± 0.142
0.993AlaCys: 0.993 ± 0.026
5.115AlaAsp: 5.115 ± 0.064
5.959AlaGlu: 5.959 ± 0.086
3.983AlaPhe: 3.983 ± 0.043
9.32AlaGly: 9.32 ± 0.107
2.301AlaHis: 2.301 ± 0.04
5.756AlaIle: 5.756 ± 0.063
4.299AlaLys: 4.299 ± 0.077
11.286AlaLeu: 11.286 ± 0.112
2.988AlaMet: 2.988 ± 0.048
3.524AlaAsn: 3.524 ± 0.059
5.622AlaPro: 5.622 ± 0.082
4.391AlaGln: 4.391 ± 0.063
5.957AlaArg: 5.957 ± 0.073
6.954AlaSer: 6.954 ± 0.085
7.102AlaThr: 7.102 ± 0.123
8.146AlaVal: 8.146 ± 0.09
1.37AlaTrp: 1.37 ± 0.03
2.735AlaTyr: 2.735 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.022
0.179CysCys: 0.179 ± 0.04
0.404CysAsp: 0.404 ± 0.018
0.371CysGlu: 0.371 ± 0.016
0.348CysPhe: 0.348 ± 0.014
0.916CysGly: 0.916 ± 0.029
0.245CysHis: 0.245 ± 0.015
0.386CysIle: 0.386 ± 0.017
0.206CysLys: 0.206 ± 0.011
0.822CysLeu: 0.822 ± 0.026
0.193CysMet: 0.193 ± 0.011
0.252CysAsn: 0.252 ± 0.013
0.419CysPro: 0.419 ± 0.017
0.213CysGln: 0.213 ± 0.012
0.466CysArg: 0.466 ± 0.016
0.531CysSer: 0.531 ± 0.022
0.522CysThr: 0.522 ± 0.022
0.661CysVal: 0.661 ± 0.021
0.103CysTrp: 0.103 ± 0.008
0.228CysTyr: 0.228 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
5.704AspAla: 5.704 ± 0.073
0.386AspCys: 0.386 ± 0.015
2.43AspAsp: 2.43 ± 0.055
2.801AspGlu: 2.801 ± 0.062
2.056AspPhe: 2.056 ± 0.042
4.442AspGly: 4.442 ± 0.077
1.205AspHis: 1.205 ± 0.03
2.274AspIle: 2.274 ± 0.041
1.804AspLys: 1.804 ± 0.038
5.082AspLeu: 5.082 ± 0.058
1.008AspMet: 1.008 ± 0.023
1.286AspAsn: 1.286 ± 0.034
3.308AspPro: 3.308 ± 0.05
1.715AspGln: 1.715 ± 0.032
3.14AspArg: 3.14 ± 0.048
2.445AspSer: 2.445 ± 0.041
2.77AspThr: 2.77 ± 0.039
3.742AspVal: 3.742 ± 0.055
0.806AspTrp: 0.806 ± 0.02
1.518AspTyr: 1.518 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.017GluAla: 6.017 ± 0.081
0.361GluCys: 0.361 ± 0.015
2.508GluAsp: 2.508 ± 0.045
2.992GluGlu: 2.992 ± 0.054
1.841GluPhe: 1.841 ± 0.034
3.748GluGly: 3.748 ± 0.051
1.231GluHis: 1.231 ± 0.034
2.944GluIle: 2.944 ± 0.05
2.288GluLys: 2.288 ± 0.044
5.022GluLeu: 5.022 ± 0.08
1.496GluMet: 1.496 ± 0.032
1.551GluAsn: 1.551 ± 0.033
2.239GluPro: 2.239 ± 0.046
2.269GluGln: 2.269 ± 0.043
3.635GluArg: 3.635 ± 0.064
2.734GluSer: 2.734 ± 0.049
3.126GluThr: 3.126 ± 0.046
3.566GluVal: 3.566 ± 0.058
0.672GluTrp: 0.672 ± 0.023
1.307GluTyr: 1.307 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.341PheAla: 4.341 ± 0.054
0.42PheCys: 0.42 ± 0.019
2.333PheAsp: 2.333 ± 0.039
1.919PheGlu: 1.919 ± 0.036
1.77PhePhe: 1.77 ± 0.045
3.657PheGly: 3.657 ± 0.056
1.027PheHis: 1.027 ± 0.024
1.468PheIle: 1.468 ± 0.038
1.116PheLys: 1.116 ± 0.027
3.964PheLeu: 3.964 ± 0.061
0.738PheMet: 0.738 ± 0.019
1.374PheAsn: 1.374 ± 0.039
1.882PhePro: 1.882 ± 0.033
1.273PheGln: 1.273 ± 0.03
2.183PheArg: 2.183 ± 0.035
2.679PheSer: 2.679 ± 0.045
2.567PheThr: 2.567 ± 0.05
2.698PheVal: 2.698 ± 0.04
0.541PheTrp: 0.541 ± 0.019
1.226PheTyr: 1.226 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.053GlyAla: 8.053 ± 0.11
0.794GlyCys: 0.794 ± 0.025
3.866GlyAsp: 3.866 ± 0.066
3.795GlyGlu: 3.795 ± 0.056
3.528GlyPhe: 3.528 ± 0.052
6.975GlyGly: 6.975 ± 0.099
1.853GlyHis: 1.853 ± 0.035
4.616GlyIle: 4.616 ± 0.061
3.608GlyLys: 3.608 ± 0.062
7.999GlyLeu: 7.999 ± 0.084
2.176GlyMet: 2.176 ± 0.044
2.718GlyAsn: 2.718 ± 0.059
3.437GlyPro: 3.437 ± 0.054
2.828GlyGln: 2.828 ± 0.048
4.697GlyArg: 4.697 ± 0.063
5.386GlySer: 5.386 ± 0.084
5.965GlyThr: 5.965 ± 0.119
6.193GlyVal: 6.193 ± 0.075
1.324GlyTrp: 1.324 ± 0.033
2.665GlyTyr: 2.665 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.426HisAla: 2.426 ± 0.043
0.214HisCys: 0.214 ± 0.012
1.184HisAsp: 1.184 ± 0.029
1.12HisGlu: 1.12 ± 0.029
1.014HisPhe: 1.014 ± 0.024
2.026HisGly: 2.026 ± 0.035
0.626HisHis: 0.626 ± 0.024
1.08HisIle: 1.08 ± 0.027
0.585HisLys: 0.585 ± 0.019
2.422HisLeu: 2.422 ± 0.048
0.502HisMet: 0.502 ± 0.018
0.671HisAsn: 0.671 ± 0.021
1.546HisPro: 1.546 ± 0.032
0.741HisGln: 0.741 ± 0.022
1.369HisArg: 1.369 ± 0.031
1.106HisSer: 1.106 ± 0.027
1.356HisThr: 1.356 ± 0.031
1.651HisVal: 1.651 ± 0.036
0.361HisTrp: 0.361 ± 0.017
0.672HisTyr: 0.672 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.567IleAla: 6.567 ± 0.081
0.424IleCys: 0.424 ± 0.018
2.964IleAsp: 2.964 ± 0.041
2.89IleGlu: 2.89 ± 0.049
1.838IlePhe: 1.838 ± 0.037
4.315IleGly: 4.315 ± 0.063
1.134IleHis: 1.134 ± 0.029
1.716IleIle: 1.716 ± 0.041
1.412IleLys: 1.412 ± 0.037
4.754IleLeu: 4.754 ± 0.069
0.736IleMet: 0.736 ± 0.023
1.527IleAsn: 1.527 ± 0.035
2.934IlePro: 2.934 ± 0.047
1.639IleGln: 1.639 ± 0.034
2.915IleArg: 2.915 ± 0.044
3.002IleSer: 3.002 ± 0.051
3.176IleThr: 3.176 ± 0.059
3.928IleVal: 3.928 ± 0.054
0.507IleTrp: 0.507 ± 0.02
1.284IleTyr: 1.284 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.148LysAla: 4.148 ± 0.064
0.165LysCys: 0.165 ± 0.012
1.942LysAsp: 1.942 ± 0.045
1.765LysGlu: 1.765 ± 0.038
1.199LysPhe: 1.199 ± 0.026
2.696LysGly: 2.696 ± 0.046
0.794LysHis: 0.794 ± 0.024
1.899LysIle: 1.899 ± 0.039
1.853LysLys: 1.853 ± 0.058
3.675LysLeu: 3.675 ± 0.051
1.013LysMet: 1.013 ± 0.03
1.226LysAsn: 1.226 ± 0.031
2.331LysPro: 2.331 ± 0.043
1.46LysGln: 1.46 ± 0.037
2.156LysArg: 2.156 ± 0.04
1.995LysSer: 1.995 ± 0.038
2.566LysThr: 2.566 ± 0.041
2.665LysVal: 2.665 ± 0.046
0.383LysTrp: 0.383 ± 0.016
0.975LysTyr: 0.975 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
11.712LeuAla: 11.712 ± 0.111
0.953LeuCys: 0.953 ± 0.024
5.148LeuAsp: 5.148 ± 0.055
5.114LeuGlu: 5.114 ± 0.076
3.76LeuPhe: 3.76 ± 0.061
7.668LeuGly: 7.668 ± 0.082
2.388LeuHis: 2.388 ± 0.045
4.609LeuIle: 4.609 ± 0.066
3.814LeuLys: 3.814 ± 0.059
10.373LeuLeu: 10.373 ± 0.133
2.149LeuMet: 2.149 ± 0.043
3.179LeuAsn: 3.179 ± 0.053
5.871LeuPro: 5.871 ± 0.063
3.248LeuGln: 3.248 ± 0.049
6.444LeuArg: 6.444 ± 0.083
6.395LeuSer: 6.395 ± 0.067
6.542LeuThr: 6.542 ± 0.09
6.682LeuVal: 6.682 ± 0.077
1.274LeuTrp: 1.274 ± 0.031
2.568LeuTyr: 2.568 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.628MetAla: 2.628 ± 0.042
0.147MetCys: 0.147 ± 0.01
1.082MetAsp: 1.082 ± 0.025
1.18MetGlu: 1.18 ± 0.03
0.684MetPhe: 0.684 ± 0.022
1.787MetGly: 1.787 ± 0.039
0.6MetHis: 0.6 ± 0.021
1.081MetIle: 1.081 ± 0.033
1.159MetLys: 1.159 ± 0.027
2.424MetLeu: 2.424 ± 0.043
0.638MetMet: 0.638 ± 0.026
0.829MetAsn: 0.829 ± 0.023
1.472MetPro: 1.472 ± 0.032
1.009MetGln: 1.009 ± 0.027
1.642MetArg: 1.642 ± 0.033
1.467MetSer: 1.467 ± 0.034
1.632MetThr: 1.632 ± 0.034
1.644MetVal: 1.644 ± 0.034
0.222MetTrp: 0.222 ± 0.013
0.467MetTyr: 0.467 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.539AsnAla: 3.539 ± 0.057
0.285AsnCys: 0.285 ± 0.014
1.587AsnAsp: 1.587 ± 0.033
1.438AsnGlu: 1.438 ± 0.032
1.405AsnPhe: 1.405 ± 0.041
2.999AsnGly: 2.999 ± 0.061
0.717AsnHis: 0.717 ± 0.019
1.66AsnIle: 1.66 ± 0.038
0.903AsnLys: 0.903 ± 0.026
3.219AsnLeu: 3.219 ± 0.051
0.596AsnMet: 0.596 ± 0.017
1.177AsnAsn: 1.177 ± 0.039
2.4AsnPro: 2.4 ± 0.049
1.295AsnGln: 1.295 ± 0.038
1.806AsnArg: 1.806 ± 0.039
1.825AsnSer: 1.825 ± 0.048
2.014AsnThr: 2.014 ± 0.047
2.266AsnVal: 2.266 ± 0.044
0.44AsnTrp: 0.44 ± 0.016
1.17AsnTyr: 1.17 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.501ProAla: 6.501 ± 0.088
0.344ProCys: 0.344 ± 0.016
3.0ProAsp: 3.0 ± 0.053
3.501ProGlu: 3.501 ± 0.052
2.033ProPhe: 2.033 ± 0.036
4.764ProGly: 4.764 ± 0.067
1.211ProHis: 1.211 ± 0.032
2.574ProIle: 2.574 ± 0.038
1.966ProLys: 1.966 ± 0.04
4.738ProLeu: 4.738 ± 0.067
1.219ProMet: 1.219 ± 0.03
1.96ProAsn: 1.96 ± 0.046
2.605ProPro: 2.605 ± 0.065
1.959ProGln: 1.959 ± 0.043
2.61ProArg: 2.61 ± 0.047
3.393ProSer: 3.393 ± 0.052
3.593ProThr: 3.593 ± 0.066
4.437ProVal: 4.437 ± 0.055
0.697ProTrp: 0.697 ± 0.021
1.458ProTyr: 1.458 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.946GlnAla: 3.946 ± 0.068
0.2GlnCys: 0.2 ± 0.011
1.633GlnAsp: 1.633 ± 0.033
1.57GlnGlu: 1.57 ± 0.03
1.42GlnPhe: 1.42 ± 0.038
2.605GlnGly: 2.605 ± 0.051
0.87GlnHis: 0.87 ± 0.021
1.987GlnIle: 1.987 ± 0.035
1.371GlnLys: 1.371 ± 0.032
3.232GlnLeu: 3.232 ± 0.051
1.084GlnMet: 1.084 ± 0.026
1.266GlnAsn: 1.266 ± 0.032
2.09GlnPro: 2.09 ± 0.049
1.928GlnGln: 1.928 ± 0.059
2.349GlnArg: 2.349 ± 0.042
2.286GlnSer: 2.286 ± 0.046
2.528GlnThr: 2.528 ± 0.041
2.596GlnVal: 2.596 ± 0.047
0.455GlnTrp: 0.455 ± 0.018
1.03GlnTyr: 1.03 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
5.658ArgAla: 5.658 ± 0.072
0.412ArgCys: 0.412 ± 0.017
2.937ArgAsp: 2.937 ± 0.049
3.48ArgGlu: 3.48 ± 0.061
2.533ArgPhe: 2.533 ± 0.037
3.914ArgGly: 3.914 ± 0.057
1.264ArgHis: 1.264 ± 0.028
3.464ArgIle: 3.464 ± 0.049
2.278ArgLys: 2.278 ± 0.039
5.933ArgLeu: 5.933 ± 0.073
1.845ArgMet: 1.845 ± 0.038
2.038ArgAsn: 2.038 ± 0.039
2.78ArgPro: 2.78 ± 0.053
2.13ArgGln: 2.13 ± 0.043
3.931ArgArg: 3.931 ± 0.06
3.457ArgSer: 3.457 ± 0.051
3.524ArgThr: 3.524 ± 0.049
4.339ArgVal: 4.339 ± 0.066
0.942ArgTrp: 0.942 ± 0.029
1.808ArgTyr: 1.808 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
6.425SerAla: 6.425 ± 0.07
0.505SerCys: 0.505 ± 0.022
2.754SerAsp: 2.754 ± 0.044
2.779SerGlu: 2.779 ± 0.05
2.644SerPhe: 2.644 ± 0.044
5.873SerGly: 5.873 ± 0.091
1.284SerHis: 1.284 ± 0.03
3.301SerIle: 3.301 ± 0.055
1.978SerLys: 1.978 ± 0.04
6.341SerLeu: 6.341 ± 0.063
1.437SerMet: 1.437 ± 0.035
2.025SerAsn: 2.025 ± 0.049
3.293SerPro: 3.293 ± 0.053
1.996SerGln: 1.996 ± 0.046
3.168SerArg: 3.168 ± 0.058
4.249SerSer: 4.249 ± 0.08
4.226SerThr: 4.226 ± 0.087
4.465SerVal: 4.465 ± 0.067
0.737SerTrp: 0.737 ± 0.021
1.729SerTyr: 1.729 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.081ThrAla: 7.081 ± 0.115
0.503ThrCys: 0.503 ± 0.016
2.938ThrAsp: 2.938 ± 0.048
2.897ThrGlu: 2.897 ± 0.045
2.594ThrPhe: 2.594 ± 0.056
5.993ThrGly: 5.993 ± 0.133
1.435ThrHis: 1.435 ± 0.034
3.54ThrIle: 3.54 ± 0.058
2.071ThrLys: 2.071 ± 0.04
6.854ThrLeu: 6.854 ± 0.088
1.381ThrMet: 1.381 ± 0.032
2.162ThrAsn: 2.162 ± 0.062
4.392ThrPro: 4.392 ± 0.069
2.212ThrGln: 2.212 ± 0.054
3.221ThrArg: 3.221 ± 0.044
3.889ThrSer: 3.889 ± 0.077
4.518ThrThr: 4.518 ± 0.104
5.237ThrVal: 5.237 ± 0.086
0.86ThrTrp: 0.86 ± 0.025
1.844ThrTyr: 1.844 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
8.245ValAla: 8.245 ± 0.082
0.694ValCys: 0.694 ± 0.023
3.854ValAsp: 3.854 ± 0.053
4.035ValGlu: 4.035 ± 0.059
2.759ValPhe: 2.759 ± 0.045
5.324ValGly: 5.324 ± 0.066
1.514ValHis: 1.514 ± 0.029
3.428ValIle: 3.428 ± 0.052
2.663ValLys: 2.663 ± 0.052
7.559ValLeu: 7.559 ± 0.079
1.667ValMet: 1.667 ± 0.037
2.379ValAsn: 2.379 ± 0.044
3.954ValPro: 3.954 ± 0.051
2.481ValGln: 2.481 ± 0.044
4.324ValArg: 4.324 ± 0.066
4.843ValSer: 4.843 ± 0.071
5.175ValThr: 5.175 ± 0.087
5.938ValVal: 5.938 ± 0.068
0.934ValTrp: 0.934 ± 0.028
1.86ValTyr: 1.86 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.03
0.115TrpCys: 0.115 ± 0.009
0.65TrpAsp: 0.65 ± 0.02
0.566TrpGlu: 0.566 ± 0.019
0.571TrpPhe: 0.571 ± 0.021
0.92TrpGly: 0.92 ± 0.026
0.37TrpHis: 0.37 ± 0.016
0.758TrpIle: 0.758 ± 0.025
0.626TrpLys: 0.626 ± 0.021
1.364TrpLeu: 1.364 ± 0.036
0.469TrpMet: 0.469 ± 0.017
0.55TrpAsn: 0.55 ± 0.021
0.548TrpPro: 0.548 ± 0.02
0.604TrpGln: 0.604 ± 0.022
0.804TrpArg: 0.804 ± 0.021
0.891TrpSer: 0.891 ± 0.027
0.848TrpThr: 0.848 ± 0.024
0.906TrpVal: 0.906 ± 0.029
0.246TrpTrp: 0.246 ± 0.013
0.357TrpTyr: 0.357 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.879TyrAla: 2.879 ± 0.044
0.215TyrCys: 0.215 ± 0.011
1.59TyrAsp: 1.59 ± 0.038
1.374TyrGlu: 1.374 ± 0.028
1.194TyrPhe: 1.194 ± 0.028
2.534TyrGly: 2.534 ± 0.047
0.604TyrHis: 0.604 ± 0.019
1.123TyrIle: 1.123 ± 0.028
0.908TyrLys: 0.908 ± 0.026
2.826TyrLeu: 2.826 ± 0.043
0.461TyrMet: 0.461 ± 0.016
1.05TyrAsn: 1.05 ± 0.038
1.441TyrPro: 1.441 ± 0.037
1.054TyrGln: 1.054 ± 0.033
1.851TyrArg: 1.851 ± 0.034
1.684TyrSer: 1.684 ± 0.043
1.871TyrThr: 1.871 ± 0.042
1.869TyrVal: 1.869 ± 0.035
0.373TyrTrp: 0.373 ± 0.018
0.783TyrTyr: 0.783 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4259 proteins (1581086 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski