Amino acid dipepetide frequency for Anaeromicrobium sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.603AlaAla: 3.603 ± 0.075	0.718AlaCys: 0.718 ± 0.027	2.423AlaAsp: 2.423 ± 0.051	3.095AlaGlu: 3.095 ± 0.06	2.509AlaPhe: 2.509 ± 0.048	3.882AlaGly: 3.882 ± 0.074	1.03AlaHis: 1.03 ± 0.03	5.629AlaIle: 5.629 ± 0.077	4.615AlaLys: 4.615 ± 0.064	5.605AlaLeu: 5.605 ± 0.075	1.773AlaMet: 1.773 ± 0.046	2.543AlaAsn: 2.543 ± 0.046	1.477AlaPro: 1.477 ± 0.041	1.549AlaGln: 1.549 ± 0.038	1.849AlaArg: 1.849 ± 0.041	3.226AlaSer: 3.226 ± 0.061	2.886AlaThr: 2.886 ± 0.055	3.75AlaVal: 3.75 ± 0.074	0.361AlaTrp: 0.361 ± 0.018	2.169AlaTyr: 2.169 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.606CysAla: 0.606 ± 0.024	0.194CysCys: 0.194 ± 0.015	0.661CysAsp: 0.661 ± 0.026	0.813CysGlu: 0.813 ± 0.027	0.41CysPhe: 0.41 ± 0.019	1.084CysGly: 1.084 ± 0.033	0.235CysHis: 0.235 ± 0.014	1.057CysIle: 1.057 ± 0.031	0.856CysLys: 0.856 ± 0.028	0.821CysLeu: 0.821 ± 0.028	0.31CysMet: 0.31 ± 0.016	0.624CysAsn: 0.624 ± 0.024	0.495CysPro: 0.495 ± 0.022	0.207CysGln: 0.207 ± 0.013	0.411CysArg: 0.411 ± 0.018	0.711CysSer: 0.711 ± 0.018	0.606CysThr: 0.606 ± 0.022	0.685CysVal: 0.685 ± 0.026	0.08CysTrp: 0.08 ± 0.008	0.34CysTyr: 0.34 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.468AspAla: 2.468 ± 0.045	0.564AspCys: 0.564 ± 0.024	2.724AspAsp: 2.724 ± 0.059	5.07AspGlu: 5.07 ± 0.078	2.692AspPhe: 2.692 ± 0.052	3.467AspGly: 3.467 ± 0.051	0.933AspHis: 0.933 ± 0.032	5.448AspIle: 5.448 ± 0.072	5.314AspLys: 5.314 ± 0.073	5.086AspLeu: 5.086 ± 0.073	1.728AspMet: 1.728 ± 0.04	3.046AspAsn: 3.046 ± 0.056	1.499AspPro: 1.499 ± 0.037	0.89AspGln: 0.89 ± 0.03	2.027AspArg: 2.027 ± 0.04	2.957AspSer: 2.957 ± 0.041	2.733AspThr: 2.733 ± 0.049	3.505AspVal: 3.505 ± 0.055	0.405AspTrp: 0.405 ± 0.019	2.656AspTyr: 2.656 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.062GluAla: 4.062 ± 0.058	0.707GluCys: 0.707 ± 0.025	4.695GluAsp: 4.695 ± 0.084	7.659GluGlu: 7.659 ± 0.127	3.039GluPhe: 3.039 ± 0.048	4.371GluGly: 4.371 ± 0.067	1.146GluHis: 1.146 ± 0.035	7.471GluIle: 7.471 ± 0.081	8.257GluLys: 8.257 ± 0.109	6.667GluLeu: 6.667 ± 0.08	2.175GluMet: 2.175 ± 0.047	5.227GluAsn: 5.227 ± 0.075	1.53GluPro: 1.53 ± 0.039	1.652GluGln: 1.652 ± 0.039	2.78GluArg: 2.78 ± 0.049	3.756GluSer: 3.756 ± 0.059	2.988GluThr: 2.988 ± 0.052	5.237GluVal: 5.237 ± 0.069	0.463GluTrp: 0.463 ± 0.021	3.267GluTyr: 3.267 ± 0.059	0.001GluXaa: 0.001 ± 0.001
Phe	2.229PheAla: 2.229 ± 0.042	0.492PheCys: 0.492 ± 0.022	2.121PheAsp: 2.121 ± 0.046	2.636PheGlu: 2.636 ± 0.041	1.965PhePhe: 1.965 ± 0.047	2.882PheGly: 2.882 ± 0.052	0.737PheHis: 0.737 ± 0.026	4.441PheIle: 4.441 ± 0.073	3.572PheLys: 3.572 ± 0.049	3.874PheLeu: 3.874 ± 0.067	1.323PheMet: 1.323 ± 0.038	2.651PheAsn: 2.651 ± 0.047	1.224PhePro: 1.224 ± 0.037	1.015PheGln: 1.015 ± 0.028	1.28PheArg: 1.28 ± 0.034	3.067PheSer: 3.067 ± 0.051	2.289PheThr: 2.289 ± 0.038	2.751PheVal: 2.751 ± 0.055	0.311PheTrp: 0.311 ± 0.017	1.72PheTyr: 1.72 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.346GlyAla: 4.346 ± 0.082	0.911GlyCys: 0.911 ± 0.029	3.258GlyAsp: 3.258 ± 0.052	4.478GlyGlu: 4.478 ± 0.064	3.075GlyPhe: 3.075 ± 0.056	4.536GlyGly: 4.536 ± 0.076	1.238GlyHis: 1.238 ± 0.035	7.092GlyIle: 7.092 ± 0.081	5.667GlyLys: 5.667 ± 0.068	6.01GlyLeu: 6.01 ± 0.081	2.046GlyMet: 2.046 ± 0.044	3.248GlyAsn: 3.248 ± 0.052	1.431GlyPro: 1.431 ± 0.035	1.718GlyGln: 1.718 ± 0.041	2.303GlyArg: 2.303 ± 0.051	3.696GlySer: 3.696 ± 0.06	3.758GlyThr: 3.758 ± 0.056	4.965GlyVal: 4.965 ± 0.073	0.531GlyTrp: 0.531 ± 0.02	2.936GlyTyr: 2.936 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.784HisAla: 0.784 ± 0.025	0.214HisCys: 0.214 ± 0.014	0.785HisAsp: 0.785 ± 0.023	1.132HisGlu: 1.132 ± 0.038	0.688HisPhe: 0.688 ± 0.023	1.143HisGly: 1.143 ± 0.03	0.331HisHis: 0.331 ± 0.018	1.976HisIle: 1.976 ± 0.04	1.345HisLys: 1.345 ± 0.034	1.313HisLeu: 1.313 ± 0.035	0.642HisMet: 0.642 ± 0.023	0.93HisAsn: 0.93 ± 0.028	0.7HisPro: 0.7 ± 0.025	0.304HisGln: 0.304 ± 0.016	0.636HisArg: 0.636 ± 0.02	0.889HisSer: 0.889 ± 0.029	0.807HisThr: 0.807 ± 0.025	1.143HisVal: 1.143 ± 0.028	0.138HisTrp: 0.138 ± 0.01	0.636HisTyr: 0.636 ± 0.022	0.002HisXaa: 0.002 ± 0.001
Ile	5.207IleAla: 5.207 ± 0.079	1.269IleCys: 1.269 ± 0.029	6.047IleAsp: 6.047 ± 0.074	7.542IleGlu: 7.542 ± 0.086	4.017IlePhe: 4.017 ± 0.074	7.087IleGly: 7.087 ± 0.08	1.635IleHis: 1.635 ± 0.039	9.418IleIle: 9.418 ± 0.113	8.648IleLys: 8.648 ± 0.1	9.19IleLeu: 9.19 ± 0.091	2.591IleMet: 2.591 ± 0.049	5.546IleAsn: 5.546 ± 0.079	3.487IlePro: 3.487 ± 0.05	2.246IleGln: 2.246 ± 0.043	3.315IleArg: 3.315 ± 0.057	6.54IleSer: 6.54 ± 0.082	4.777IleThr: 4.777 ± 0.066	6.335IleVal: 6.335 ± 0.076	0.635IleTrp: 0.635 ± 0.026	3.605IleTyr: 3.605 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.547LysAla: 4.547 ± 0.064	0.75LysCys: 0.75 ± 0.026	6.014LysAsp: 6.014 ± 0.075	9.245LysGlu: 9.245 ± 0.108	3.046LysPhe: 3.046 ± 0.05	5.451LysGly: 5.451 ± 0.063	1.255LysHis: 1.255 ± 0.029	8.499LysIle: 8.499 ± 0.091	8.584LysLys: 8.584 ± 0.11	7.202LysLeu: 7.202 ± 0.079	2.558LysMet: 2.558 ± 0.042	5.956LysAsn: 5.956 ± 0.075	2.03LysPro: 2.03 ± 0.05	1.656LysGln: 1.656 ± 0.036	3.376LysArg: 3.376 ± 0.059	4.901LysSer: 4.901 ± 0.07	3.825LysThr: 3.825 ± 0.052	6.039LysVal: 6.039 ± 0.071	0.661LysTrp: 0.661 ± 0.024	4.122LysTyr: 4.122 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	5.031LeuAla: 5.031 ± 0.08	1.03LeuCys: 1.03 ± 0.028	5.129LeuAsp: 5.129 ± 0.068	6.551LeuGlu: 6.551 ± 0.079	3.808LeuPhe: 3.808 ± 0.061	6.612LeuGly: 6.612 ± 0.081	1.288LeuHis: 1.288 ± 0.031	8.162LeuIle: 8.162 ± 0.101	8.227LeuLys: 8.227 ± 0.088	7.937LeuLeu: 7.937 ± 0.087	2.456LeuMet: 2.456 ± 0.044	5.454LeuAsn: 5.454 ± 0.074	2.718LeuPro: 2.718 ± 0.045	1.887LeuGln: 1.887 ± 0.032	3.13LeuArg: 3.13 ± 0.055	6.226LeuSer: 6.226 ± 0.072	4.271LeuThr: 4.271 ± 0.052	5.88LeuVal: 5.88 ± 0.073	0.584LeuTrp: 0.584 ± 0.022	3.227LeuTyr: 3.227 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.191MetAla: 2.191 ± 0.049	0.281MetCys: 0.281 ± 0.014	1.962MetAsp: 1.962 ± 0.037	2.348MetGlu: 2.348 ± 0.048	1.088MetPhe: 1.088 ± 0.031	2.174MetGly: 2.174 ± 0.04	0.411MetHis: 0.411 ± 0.023	2.469MetIle: 2.469 ± 0.04	2.925MetLys: 2.925 ± 0.05	2.195MetLeu: 2.195 ± 0.044	0.797MetMet: 0.797 ± 0.026	1.833MetAsn: 1.833 ± 0.034	0.954MetPro: 0.954 ± 0.029	0.473MetGln: 0.473 ± 0.019	1.028MetArg: 1.028 ± 0.027	1.746MetSer: 1.746 ± 0.04	1.38MetThr: 1.38 ± 0.034	1.906MetVal: 1.906 ± 0.036	0.171MetTrp: 0.171 ± 0.012	0.93MetTyr: 0.93 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.472AsnAla: 2.472 ± 0.044	0.618AsnCys: 0.618 ± 0.023	2.698AsnAsp: 2.698 ± 0.054	4.4AsnGlu: 4.4 ± 0.062	2.263AsnPhe: 2.263 ± 0.054	3.325AsnGly: 3.325 ± 0.05	1.037AsnHis: 1.037 ± 0.028	6.815AsnIle: 6.815 ± 0.088	5.625AsnLys: 5.625 ± 0.07	5.448AsnLeu: 5.448 ± 0.075	2.083AsnMet: 2.083 ± 0.039	3.844AsnAsn: 3.844 ± 0.077	2.172AsnPro: 2.172 ± 0.04	1.157AsnGln: 1.157 ± 0.033	2.156AsnArg: 2.156 ± 0.042	3.179AsnSer: 3.179 ± 0.054	2.788AsnThr: 2.788 ± 0.048	3.694AsnVal: 3.694 ± 0.053	0.434AsnTrp: 0.434 ± 0.019	2.378AsnTyr: 2.378 ± 0.046	0.001AsnXaa: 0.001 ± 0.001
Pro	1.533ProAla: 1.533 ± 0.039	0.333ProCys: 0.333 ± 0.02	1.414ProAsp: 1.414 ± 0.031	2.138ProGlu: 2.138 ± 0.047	1.482ProPhe: 1.482 ± 0.036	1.768ProGly: 1.768 ± 0.04	0.6ProHis: 0.6 ± 0.025	2.97ProIle: 2.97 ± 0.048	2.369ProLys: 2.369 ± 0.042	2.684ProLeu: 2.684 ± 0.04	0.815ProMet: 0.815 ± 0.027	1.661ProAsn: 1.661 ± 0.037	0.747ProPro: 0.747 ± 0.029	0.775ProGln: 0.775 ± 0.024	0.869ProArg: 0.869 ± 0.026	1.679ProSer: 1.679 ± 0.038	1.637ProThr: 1.637 ± 0.032	2.243ProVal: 2.243 ± 0.042	0.242ProTrp: 0.242 ± 0.017	1.356ProTyr: 1.356 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.265GlnAla: 1.265 ± 0.034	0.231GlnCys: 0.231 ± 0.015	1.025GlnAsp: 1.025 ± 0.027	1.641GlnGlu: 1.641 ± 0.04	0.99GlnPhe: 0.99 ± 0.03	1.403GlnGly: 1.403 ± 0.03	0.304GlnHis: 0.304 ± 0.015	2.177GlnIle: 2.177 ± 0.04	1.72GlnLys: 1.72 ± 0.042	2.142GlnLeu: 2.142 ± 0.041	0.71GlnMet: 0.71 ± 0.024	1.308GlnAsn: 1.308 ± 0.039	0.61GlnPro: 0.61 ± 0.024	0.597GlnGln: 0.597 ± 0.023	0.931GlnArg: 0.931 ± 0.029	1.275GlnSer: 1.275 ± 0.03	0.969GlnThr: 0.969 ± 0.03	1.705GlnVal: 1.705 ± 0.037	0.194GlnTrp: 0.194 ± 0.013	0.854GlnTyr: 0.854 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	1.972ArgAla: 1.972 ± 0.041	0.366ArgCys: 0.366 ± 0.017	1.946ArgAsp: 1.946 ± 0.045	3.1ArgGlu: 3.1 ± 0.056	1.407ArgPhe: 1.407 ± 0.035	2.139ArgGly: 2.139 ± 0.039	0.569ArgHis: 0.569 ± 0.021	3.328ArgIle: 3.328 ± 0.053	3.242ArgLys: 3.242 ± 0.054	3.068ArgLeu: 3.068 ± 0.055	0.978ArgMet: 0.978 ± 0.028	2.069ArgAsn: 2.069 ± 0.04	1.002ArgPro: 1.002 ± 0.027	0.996ArgGln: 0.996 ± 0.029	1.489ArgArg: 1.489 ± 0.039	1.698ArgSer: 1.698 ± 0.038	1.557ArgThr: 1.557 ± 0.037	2.442ArgVal: 2.442 ± 0.05	0.255ArgTrp: 0.255 ± 0.015	1.36ArgTyr: 1.36 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	2.98SerAla: 2.98 ± 0.047	0.643SerCys: 0.643 ± 0.025	2.828SerAsp: 2.828 ± 0.047	3.548SerGlu: 3.548 ± 0.054	2.836SerPhe: 2.836 ± 0.045	4.028SerGly: 4.028 ± 0.055	1.106SerHis: 1.106 ± 0.027	6.534SerIle: 6.534 ± 0.084	5.28SerLys: 5.28 ± 0.07	5.618SerLeu: 5.618 ± 0.068	1.844SerMet: 1.844 ± 0.04	3.393SerAsn: 3.393 ± 0.061	1.767SerPro: 1.767 ± 0.034	1.55SerGln: 1.55 ± 0.037	1.968SerArg: 1.968 ± 0.034	3.783SerSer: 3.783 ± 0.069	3.085SerThr: 3.085 ± 0.052	3.722SerVal: 3.722 ± 0.052	0.44SerTrp: 0.44 ± 0.018	2.359SerTyr: 2.359 ± 0.047	0.002SerXaa: 0.002 ± 0.001
Thr	2.733ThrAla: 2.733 ± 0.063	0.547ThrCys: 0.547 ± 0.021	2.346ThrAsp: 2.346 ± 0.047	2.792ThrGlu: 2.792 ± 0.045	2.193ThrPhe: 2.193 ± 0.046	3.747ThrGly: 3.747 ± 0.055	0.868ThrHis: 0.868 ± 0.028	5.041ThrIle: 5.041 ± 0.062	3.759ThrLys: 3.759 ± 0.044	4.805ThrLeu: 4.805 ± 0.064	1.275ThrMet: 1.275 ± 0.033	2.731ThrAsn: 2.731 ± 0.056	1.916ThrPro: 1.916 ± 0.049	1.108ThrGln: 1.108 ± 0.03	1.608ThrArg: 1.608 ± 0.034	2.979ThrSer: 2.979 ± 0.045	2.64ThrThr: 2.64 ± 0.052	3.23ThrVal: 3.23 ± 0.057	0.386ThrTrp: 0.386 ± 0.016	2.012ThrTyr: 2.012 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.247ValAla: 4.247 ± 0.068	0.81ValCys: 0.81 ± 0.024	4.119ValAsp: 4.119 ± 0.058	5.076ValGlu: 5.076 ± 0.064	2.822ValPhe: 2.822 ± 0.05	4.838ValGly: 4.838 ± 0.077	1.071ValHis: 1.071 ± 0.033	6.06ValIle: 6.06 ± 0.075	5.618ValLys: 5.618 ± 0.068	5.98ValLeu: 5.98 ± 0.077	1.757ValMet: 1.757 ± 0.035	3.608ValAsn: 3.608 ± 0.057	2.103ValPro: 2.103 ± 0.043	1.426ValGln: 1.426 ± 0.029	2.11ValArg: 2.11 ± 0.041	4.262ValSer: 4.262 ± 0.071	3.332ValThr: 3.332 ± 0.054	4.907ValVal: 4.907 ± 0.075	0.449ValTrp: 0.449 ± 0.02	2.486ValTyr: 2.486 ± 0.045	0.002ValXaa: 0.002 ± 0.001
Trp	0.466TrpAla: 0.466 ± 0.021	0.074TrpCys: 0.074 ± 0.007	0.438TrpAsp: 0.438 ± 0.026	0.441TrpGlu: 0.441 ± 0.018	0.35TrpPhe: 0.35 ± 0.016	0.552TrpGly: 0.552 ± 0.024	0.127TrpHis: 0.127 ± 0.011	0.691TrpIle: 0.691 ± 0.022	0.57TrpLys: 0.57 ± 0.02	0.567TrpLeu: 0.567 ± 0.023	0.191TrpMet: 0.191 ± 0.013	0.452TrpAsn: 0.452 ± 0.018	0.19TrpPro: 0.19 ± 0.012	0.209TrpGln: 0.209 ± 0.013	0.25TrpArg: 0.25 ± 0.014	0.405TrpSer: 0.405 ± 0.018	0.382TrpThr: 0.382 ± 0.018	0.421TrpVal: 0.421 ± 0.019	0.08TrpTrp: 0.08 ± 0.009	0.273TrpTyr: 0.273 ± 0.015	0.001TrpXaa: 0.001 ± 0.001
Tyr	1.948TyrAla: 1.948 ± 0.039	0.454TyrCys: 0.454 ± 0.02	2.58TyrAsp: 2.58 ± 0.048	3.445TyrGlu: 3.445 ± 0.065	1.897TyrPhe: 1.897 ± 0.039	2.752TyrGly: 2.752 ± 0.048	0.617TyrHis: 0.617 ± 0.021	3.86TyrIle: 3.86 ± 0.061	3.524TyrLys: 3.524 ± 0.058	3.396TyrLeu: 3.396 ± 0.055	1.212TyrMet: 1.212 ± 0.032	2.462TyrAsn: 2.462 ± 0.044	1.259TyrPro: 1.259 ± 0.031	0.634TyrGln: 0.634 ± 0.023	1.469TyrArg: 1.469 ± 0.038	2.339TyrSer: 2.339 ± 0.044	2.008TyrThr: 2.008 ± 0.038	2.522TyrVal: 2.522 ± 0.048	0.311TyrTrp: 0.311 ± 0.018	1.776TyrTyr: 1.776 ± 0.044	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4258 proteins (1330799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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