Amino acid dipepetide frequency for Hydrogenibacillus schlegelii (Bacillus schlegelii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.112AlaAla: 19.112 ± 0.32	0.523AlaCys: 0.523 ± 0.033	5.824AlaAsp: 5.824 ± 0.095	9.691AlaGlu: 9.691 ± 0.172	5.59AlaPhe: 5.59 ± 0.098	12.015AlaGly: 12.015 ± 0.189	2.08AlaHis: 2.08 ± 0.061	5.667AlaIle: 5.667 ± 0.103	3.234AlaLys: 3.234 ± 0.086	16.895AlaLeu: 16.895 ± 0.214	2.651AlaMet: 2.651 ± 0.068	1.743AlaAsn: 1.743 ± 0.056	6.507AlaPro: 6.507 ± 0.127	2.418AlaGln: 2.418 ± 0.05	10.548AlaArg: 10.548 ± 0.151	4.709AlaSer: 4.709 ± 0.088	4.51AlaThr: 4.51 ± 0.078	12.018AlaVal: 12.018 ± 0.158	1.732AlaTrp: 1.732 ± 0.055	3.536AlaTyr: 3.536 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.389CysAla: 0.389 ± 0.027	0.044CysCys: 0.044 ± 0.01	0.18CysAsp: 0.18 ± 0.017	0.158CysGlu: 0.158 ± 0.015	0.128CysPhe: 0.128 ± 0.014	0.608CysGly: 0.608 ± 0.037	0.116CysHis: 0.116 ± 0.014	0.153CysIle: 0.153 ± 0.017	0.073CysLys: 0.073 ± 0.011	0.343CysLeu: 0.343 ± 0.022	0.064CysMet: 0.064 ± 0.009	0.071CysAsn: 0.071 ± 0.011	0.416CysPro: 0.416 ± 0.029	0.099CysGln: 0.099 ± 0.014	0.375CysArg: 0.375 ± 0.023	0.186CysSer: 0.186 ± 0.019	0.205CysThr: 0.205 ± 0.018	0.221CysVal: 0.221 ± 0.021	0.052CysTrp: 0.052 ± 0.009	0.112CysTyr: 0.112 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.023AspAla: 6.023 ± 0.096	0.126AspCys: 0.126 ± 0.014	2.942AspAsp: 2.942 ± 0.074	3.468AspGlu: 3.468 ± 0.078	1.657AspPhe: 1.657 ± 0.056	5.515AspGly: 5.515 ± 0.112	0.964AspHis: 0.964 ± 0.041	1.796AspIle: 1.796 ± 0.058	1.051AspLys: 1.051 ± 0.04	5.079AspLeu: 5.079 ± 0.09	0.578AspMet: 0.578 ± 0.03	0.632AspAsn: 0.632 ± 0.033	3.856AspPro: 3.856 ± 0.081	0.878AspGln: 0.878 ± 0.037	5.348AspArg: 5.348 ± 0.092	1.019AspSer: 1.019 ± 0.036	1.343AspThr: 1.343 ± 0.051	5.511AspVal: 5.511 ± 0.101	0.689AspTrp: 0.689 ± 0.03	1.107AspTyr: 1.107 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	13.519GluAla: 13.519 ± 0.212	0.125GluCys: 0.125 ± 0.014	2.881GluAsp: 2.881 ± 0.07	4.87GluGlu: 4.87 ± 0.099	1.382GluPhe: 1.382 ± 0.051	5.77GluGly: 5.77 ± 0.105	1.177GluHis: 1.177 ± 0.043	3.362GluIle: 3.362 ± 0.076	2.867GluLys: 2.867 ± 0.078	5.815GluLeu: 5.815 ± 0.102	1.357GluMet: 1.357 ± 0.051	1.429GluAsn: 1.429 ± 0.048	2.934GluPro: 2.934 ± 0.073	1.58GluGln: 1.58 ± 0.047	8.02GluArg: 8.02 ± 0.129	2.151GluSer: 2.151 ± 0.062	3.758GluThr: 3.758 ± 0.068	4.72GluVal: 4.72 ± 0.095	0.708GluTrp: 0.708 ± 0.038	1.016GluTyr: 1.016 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.065PheAla: 4.065 ± 0.08	0.199PheCys: 0.199 ± 0.018	2.144PheAsp: 2.144 ± 0.055	2.009PheGlu: 2.009 ± 0.059	2.009PhePhe: 2.009 ± 0.067	3.93PheGly: 3.93 ± 0.083	0.753PheHis: 0.753 ± 0.032	1.602PheIle: 1.602 ± 0.053	0.741PheLys: 0.741 ± 0.03	4.101PheLeu: 4.101 ± 0.088	0.594PheMet: 0.594 ± 0.031	0.664PheAsn: 0.664 ± 0.033	1.981PhePro: 1.981 ± 0.054	0.939PheGln: 0.939 ± 0.036	3.34PheArg: 3.34 ± 0.075	1.974PheSer: 1.974 ± 0.055	1.564PheThr: 1.564 ± 0.053	3.421PheVal: 3.421 ± 0.072	0.685PheTrp: 0.685 ± 0.036	1.235PheTyr: 1.235 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	10.711GlyAla: 10.711 ± 0.164	0.427GlyCys: 0.427 ± 0.026	4.164GlyAsp: 4.164 ± 0.084	6.091GlyGlu: 6.091 ± 0.101	3.174GlyPhe: 3.174 ± 0.079	8.517GlyGly: 8.517 ± 0.147	1.548GlyHis: 1.548 ± 0.049	4.175GlyIle: 4.175 ± 0.086	3.196GlyLys: 3.196 ± 0.07	9.537GlyLeu: 9.537 ± 0.135	2.084GlyMet: 2.084 ± 0.068	1.315GlyAsn: 1.315 ± 0.044	4.402GlyPro: 4.402 ± 0.096	1.886GlyGln: 1.886 ± 0.057	9.067GlyArg: 9.067 ± 0.151	3.71GlySer: 3.71 ± 0.09	4.741GlyThr: 4.741 ± 0.096	6.898GlyVal: 6.898 ± 0.099	1.324GlyTrp: 1.324 ± 0.05	2.296GlyTyr: 2.296 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.856HisAla: 1.856 ± 0.049	0.1HisCys: 0.1 ± 0.012	0.859HisAsp: 0.859 ± 0.039	0.927HisGlu: 0.927 ± 0.036	0.753HisPhe: 0.753 ± 0.032	1.629HisGly: 1.629 ± 0.054	0.535HisHis: 0.535 ± 0.036	0.753HisIle: 0.753 ± 0.03	0.36HisLys: 0.36 ± 0.022	2.28HisLeu: 2.28 ± 0.056	0.33HisMet: 0.33 ± 0.02	0.349HisAsn: 0.349 ± 0.024	1.791HisPro: 1.791 ± 0.055	0.411HisGln: 0.411 ± 0.021	1.809HisArg: 1.809 ± 0.05	0.616HisSer: 0.616 ± 0.032	0.757HisThr: 0.757 ± 0.032	1.413HisVal: 1.413 ± 0.045	0.225HisTrp: 0.225 ± 0.018	0.526HisTyr: 0.526 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.078IleAla: 6.078 ± 0.108	0.192IleCys: 0.192 ± 0.017	2.955IleAsp: 2.955 ± 0.082	3.452IleGlu: 3.452 ± 0.075	1.397IlePhe: 1.397 ± 0.055	4.505IleGly: 4.505 ± 0.093	0.871IleHis: 0.871 ± 0.036	1.773IleIle: 1.773 ± 0.064	1.131IleLys: 1.131 ± 0.044	4.103IleLeu: 4.103 ± 0.09	0.637IleMet: 0.637 ± 0.033	0.808IleAsn: 0.808 ± 0.036	2.392IlePro: 2.392 ± 0.065	1.132IleGln: 1.132 ± 0.045	4.157IleArg: 4.157 ± 0.081	1.538IleSer: 1.538 ± 0.055	1.914IleThr: 1.914 ± 0.059	4.952IleVal: 4.952 ± 0.089	0.391IleTrp: 0.391 ± 0.028	0.977IleTyr: 0.977 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.139LysAla: 4.139 ± 0.075	0.116LysCys: 0.116 ± 0.013	1.532LysAsp: 1.532 ± 0.055	2.458LysGlu: 2.458 ± 0.071	0.555LysPhe: 0.555 ± 0.029	2.431LysGly: 2.431 ± 0.068	0.451LysHis: 0.451 ± 0.029	1.69LysIle: 1.69 ± 0.051	1.729LysLys: 1.729 ± 0.064	2.674LysLeu: 2.674 ± 0.069	0.648LysMet: 0.648 ± 0.03	0.984LysAsn: 0.984 ± 0.043	1.647LysPro: 1.647 ± 0.048	0.757LysGln: 0.757 ± 0.038	2.607LysArg: 2.607 ± 0.062	1.282LysSer: 1.282 ± 0.047	2.039LysThr: 2.039 ± 0.067	2.173LysVal: 2.173 ± 0.072	0.323LysTrp: 0.323 ± 0.024	0.661LysTyr: 0.661 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.662LeuAla: 13.662 ± 0.169	0.279LeuCys: 0.279 ± 0.023	5.327LeuAsp: 5.327 ± 0.099	7.236LeuGlu: 7.236 ± 0.128	4.899LeuPhe: 4.899 ± 0.099	9.022LeuGly: 9.022 ± 0.13	1.745LeuHis: 1.745 ± 0.049	5.264LeuIle: 5.264 ± 0.099	3.94LeuLys: 3.94 ± 0.094	11.663LeuLeu: 11.663 ± 0.175	1.963LeuMet: 1.963 ± 0.058	1.978LeuAsn: 1.978 ± 0.057	6.193LeuPro: 6.193 ± 0.096	2.5LeuGln: 2.5 ± 0.068	9.085LeuArg: 9.085 ± 0.134	6.007LeuSer: 6.007 ± 0.093	4.93LeuThr: 4.93 ± 0.101	8.334LeuVal: 8.334 ± 0.142	1.514LeuTrp: 1.514 ± 0.059	2.818LeuTyr: 2.818 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.394MetAla: 2.394 ± 0.065	0.092MetCys: 0.092 ± 0.012	0.872MetAsp: 0.872 ± 0.036	1.212MetGlu: 1.212 ± 0.042	0.631MetPhe: 0.631 ± 0.029	1.493MetGly: 1.493 ± 0.046	0.378MetHis: 0.378 ± 0.022	1.115MetIle: 1.115 ± 0.042	0.843MetLys: 0.843 ± 0.034	2.074MetLeu: 2.074 ± 0.059	0.471MetMet: 0.471 ± 0.029	0.586MetAsn: 0.586 ± 0.031	1.039MetPro: 1.039 ± 0.039	0.58MetGln: 0.58 ± 0.031	1.661MetArg: 1.661 ± 0.052	0.964MetSer: 0.964 ± 0.039	1.259MetThr: 1.259 ± 0.046	1.257MetVal: 1.257 ± 0.049	0.167MetTrp: 0.167 ± 0.018	0.305MetTyr: 0.305 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.163AsnAla: 2.163 ± 0.056	0.1AsnCys: 0.1 ± 0.013	0.849AsnAsp: 0.849 ± 0.039	1.009AsnGlu: 1.009 ± 0.039	0.644AsnPhe: 0.644 ± 0.033	1.612AsnGly: 1.612 ± 0.054	0.358AsnHis: 0.358 ± 0.024	0.871AsnIle: 0.871 ± 0.038	0.512AsnLys: 0.512 ± 0.028	1.852AsnLeu: 1.852 ± 0.055	0.376AsnMet: 0.376 ± 0.021	0.326AsnAsn: 0.326 ± 0.022	1.356AsnPro: 1.356 ± 0.051	0.405AsnGln: 0.405 ± 0.026	1.622AsnArg: 1.622 ± 0.052	0.539AsnSer: 0.539 ± 0.03	0.85AsnThr: 0.85 ± 0.036	1.804AsnVal: 1.804 ± 0.057	0.205AsnTrp: 0.205 ± 0.016	0.414AsnTyr: 0.414 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.717ProAla: 7.717 ± 0.148	0.215ProCys: 0.215 ± 0.019	3.895ProAsp: 3.895 ± 0.077	6.055ProGlu: 6.055 ± 0.1	2.266ProPhe: 2.266 ± 0.061	5.245ProGly: 5.245 ± 0.106	1.08ProHis: 1.08 ± 0.041	2.365ProIle: 2.365 ± 0.051	1.946ProLys: 1.946 ± 0.054	5.555ProLeu: 5.555 ± 0.095	1.121ProMet: 1.121 ± 0.042	1.216ProAsn: 1.216 ± 0.039	4.248ProPro: 4.248 ± 0.1	0.936ProGln: 0.936 ± 0.038	3.16ProArg: 3.16 ± 0.07	2.809ProSer: 2.809 ± 0.067	2.53ProThr: 2.53 ± 0.058	4.565ProVal: 4.565 ± 0.084	0.753ProTrp: 0.753 ± 0.035	1.564ProTyr: 1.564 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	3.767GlnAla: 3.767 ± 0.084	0.07GlnCys: 0.07 ± 0.01	0.948GlnAsp: 0.948 ± 0.037	1.462GlnGlu: 1.462 ± 0.044	0.69GlnPhe: 0.69 ± 0.031	1.764GlnGly: 1.764 ± 0.054	0.366GlnHis: 0.366 ± 0.024	1.033GlnIle: 1.033 ± 0.047	1.232GlnLys: 1.232 ± 0.046	1.696GlnLeu: 1.696 ± 0.057	0.557GlnMet: 0.557 ± 0.03	0.631GlnAsn: 0.631 ± 0.029	1.023GlnPro: 1.023 ± 0.04	0.48GlnGln: 0.48 ± 0.026	1.385GlnArg: 1.385 ± 0.044	0.946GlnSer: 0.946 ± 0.038	1.208GlnThr: 1.208 ± 0.05	1.533GlnVal: 1.533 ± 0.051	0.23GlnTrp: 0.23 ± 0.019	0.516GlnTyr: 0.516 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	10.524ArgAla: 10.524 ± 0.153	0.376ArgCys: 0.376 ± 0.028	3.52ArgAsp: 3.52 ± 0.079	6.302ArgGlu: 6.302 ± 0.112	3.712ArgPhe: 3.712 ± 0.074	5.715ArgGly: 5.715 ± 0.094	1.759ArgHis: 1.759 ± 0.054	4.103ArgIle: 4.103 ± 0.073	2.52ArgLys: 2.52 ± 0.067	11.5ArgLeu: 11.5 ± 0.169	2.202ArgMet: 2.202 ± 0.054	1.138ArgAsn: 1.138 ± 0.048	6.495ArgPro: 6.495 ± 0.103	2.15ArgGln: 2.15 ± 0.056	10.108ArgArg: 10.108 ± 0.178	4.061ArgSer: 4.061 ± 0.083	4.322ArgThr: 4.322 ± 0.085	5.617ArgVal: 5.617 ± 0.083	1.45ArgTrp: 1.45 ± 0.053	2.462ArgTyr: 2.462 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.109SerAla: 5.109 ± 0.107	0.233SerCys: 0.233 ± 0.02	1.963SerAsp: 1.963 ± 0.05	2.306SerGlu: 2.306 ± 0.056	1.776SerPhe: 1.776 ± 0.056	4.976SerGly: 4.976 ± 0.096	0.732SerHis: 0.732 ± 0.034	1.927SerIle: 1.927 ± 0.059	0.961SerLys: 0.961 ± 0.042	4.33SerLeu: 4.33 ± 0.085	0.801SerMet: 0.801 ± 0.032	0.666SerAsn: 0.666 ± 0.031	2.782SerPro: 2.782 ± 0.065	0.725SerGln: 0.725 ± 0.037	3.107SerArg: 3.107 ± 0.073	1.815SerSer: 1.815 ± 0.057	1.876SerThr: 1.876 ± 0.058	3.285SerVal: 3.285 ± 0.067	0.451SerTrp: 0.451 ± 0.026	0.93SerTyr: 0.93 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.638ThrAla: 5.638 ± 0.086	0.222ThrCys: 0.222 ± 0.019	2.08ThrAsp: 2.08 ± 0.062	2.718ThrGlu: 2.718 ± 0.06	1.914ThrPhe: 1.914 ± 0.051	4.516ThrGly: 4.516 ± 0.084	0.839ThrHis: 0.839 ± 0.031	2.392ThrIle: 2.392 ± 0.061	1.308ThrLys: 1.308 ± 0.049	5.453ThrLeu: 5.453 ± 0.091	0.908ThrMet: 0.908 ± 0.035	0.975ThrAsn: 0.975 ± 0.036	3.126ThrPro: 3.126 ± 0.065	0.78ThrGln: 0.78 ± 0.033	2.674ThrArg: 2.674 ± 0.061	1.808ThrSer: 1.808 ± 0.051	2.237ThrThr: 2.237 ± 0.06	4.77ThrVal: 4.77 ± 0.09	0.557ThrTrp: 0.557 ± 0.032	1.139ThrTyr: 1.139 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	9.56ValAla: 9.56 ± 0.136	0.378ValCys: 0.378 ± 0.024	4.561ValAsp: 4.561 ± 0.083	5.869ValGlu: 5.869 ± 0.097	3.314ValPhe: 3.314 ± 0.079	6.643ValGly: 6.643 ± 0.106	1.744ValHis: 1.744 ± 0.051	3.681ValIle: 3.681 ± 0.068	2.305ValLys: 2.305 ± 0.07	9.108ValLeu: 9.108 ± 0.118	1.36ValMet: 1.36 ± 0.052	1.511ValAsn: 1.511 ± 0.045	4.95ValPro: 4.95 ± 0.076	1.885ValGln: 1.885 ± 0.051	8.258ValArg: 8.258 ± 0.116	3.26ValSer: 3.26 ± 0.074	3.973ValThr: 3.973 ± 0.085	7.844ValVal: 7.844 ± 0.119	0.942ValTrp: 0.942 ± 0.04	2.202ValTyr: 2.202 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	1.542TrpAla: 1.542 ± 0.053	0.052TrpCys: 0.052 ± 0.008	0.541TrpAsp: 0.541 ± 0.029	0.703TrpGlu: 0.703 ± 0.039	0.469TrpPhe: 0.469 ± 0.029	0.821TrpGly: 0.821 ± 0.038	0.235TrpHis: 0.235 ± 0.02	0.756TrpIle: 0.756 ± 0.032	0.397TrpLys: 0.397 ± 0.026	1.683TrpLeu: 1.683 ± 0.06	0.346TrpMet: 0.346 ± 0.023	0.328TrpAsn: 0.328 ± 0.024	0.703TrpPro: 0.703 ± 0.034	0.394TrpGln: 0.394 ± 0.02	1.039TrpArg: 1.039 ± 0.042	0.59TrpSer: 0.59 ± 0.03	0.836TrpThr: 0.836 ± 0.035	0.978TrpVal: 0.978 ± 0.046	0.196TrpTrp: 0.196 ± 0.018	0.282TrpTyr: 0.282 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.035TyrAla: 3.035 ± 0.066	0.122TyrCys: 0.122 ± 0.015	1.549TyrAsp: 1.549 ± 0.045	1.446TyrGlu: 1.446 ± 0.043	0.99TyrPhe: 0.99 ± 0.038	2.538TyrGly: 2.538 ± 0.06	0.551TyrHis: 0.551 ± 0.03	0.875TyrIle: 0.875 ± 0.036	0.551TyrLys: 0.551 ± 0.028	2.617TyrLeu: 2.617 ± 0.064	0.34TyrMet: 0.34 ± 0.023	0.514TyrAsn: 0.514 ± 0.031	1.4TyrPro: 1.4 ± 0.051	0.602TyrGln: 0.602 ± 0.029	2.665TyrArg: 2.665 ± 0.06	0.767TyrSer: 0.767 ± 0.035	1.202TyrThr: 1.202 ± 0.043	2.036TyrVal: 2.036 ± 0.063	0.299TyrTrp: 0.299 ± 0.019	0.669TyrTyr: 0.669 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2254 proteins (688065 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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