Amino acid dipepetide frequency for Bacillus taxi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.343AlaAla: 6.343 ± 0.079	0.624AlaCys: 0.624 ± 0.018	3.754AlaAsp: 3.754 ± 0.063	4.936AlaGlu: 4.936 ± 0.056	3.249AlaPhe: 3.249 ± 0.045	5.315AlaGly: 5.315 ± 0.102	1.109AlaHis: 1.109 ± 0.026	6.157AlaIle: 6.157 ± 0.062	4.843AlaLys: 4.843 ± 0.055	6.961AlaLeu: 6.961 ± 0.072	1.912AlaMet: 1.912 ± 0.038	3.087AlaAsn: 3.087 ± 0.046	1.972AlaPro: 1.972 ± 0.042	2.087AlaGln: 2.087 ± 0.035	2.341AlaArg: 2.341 ± 0.042	4.335AlaSer: 4.335 ± 0.053	3.431AlaThr: 3.431 ± 0.058	5.471AlaVal: 5.471 ± 0.063	0.658AlaTrp: 0.658 ± 0.021	2.387AlaTyr: 2.387 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.442CysAla: 0.442 ± 0.018	0.107CysCys: 0.107 ± 0.01	0.336CysAsp: 0.336 ± 0.014	0.436CysGlu: 0.436 ± 0.015	0.37CysPhe: 0.37 ± 0.015	0.606CysGly: 0.606 ± 0.021	0.178CysHis: 0.178 ± 0.012	0.589CysIle: 0.589 ± 0.02	0.398CysLys: 0.398 ± 0.016	0.716CysLeu: 0.716 ± 0.023	0.204CysMet: 0.204 ± 0.013	0.284CysAsn: 0.284 ± 0.014	0.285CysPro: 0.285 ± 0.013	0.212CysGln: 0.212 ± 0.013	0.27CysArg: 0.27 ± 0.013	0.528CysSer: 0.528 ± 0.018	0.392CysThr: 0.392 ± 0.016	0.401CysVal: 0.401 ± 0.016	0.072CysTrp: 0.072 ± 0.007	0.266CysTyr: 0.266 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.183AspAla: 3.183 ± 0.048	0.375AspCys: 0.375 ± 0.015	2.44AspAsp: 2.44 ± 0.047	4.001AspGlu: 4.001 ± 0.059	2.508AspPhe: 2.508 ± 0.039	3.407AspGly: 3.407 ± 0.059	0.9AspHis: 0.9 ± 0.025	4.515AspIle: 4.515 ± 0.061	3.791AspLys: 3.791 ± 0.053	4.791AspLeu: 4.791 ± 0.052	1.366AspMet: 1.366 ± 0.028	2.285AspAsn: 2.285 ± 0.048	1.694AspPro: 1.694 ± 0.038	1.529AspGln: 1.529 ± 0.032	2.005AspArg: 2.005 ± 0.039	3.038AspSer: 3.038 ± 0.048	2.564AspThr: 2.564 ± 0.042	3.45AspVal: 3.45 ± 0.048	0.684AspTrp: 0.684 ± 0.024	2.321AspTyr: 2.321 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.181GluAla: 5.181 ± 0.063	0.362GluCys: 0.362 ± 0.016	3.821GluAsp: 3.821 ± 0.06	6.923GluGlu: 6.923 ± 0.087	2.604GluPhe: 2.604 ± 0.042	3.968GluGly: 3.968 ± 0.058	1.402GluHis: 1.402 ± 0.029	5.596GluIle: 5.596 ± 0.058	6.635GluLys: 6.635 ± 0.073	7.344GluLeu: 7.344 ± 0.081	2.21GluMet: 2.21 ± 0.042	4.006GluAsn: 4.006 ± 0.058	1.754GluPro: 1.754 ± 0.039	3.267GluGln: 3.267 ± 0.047	2.92GluArg: 2.92 ± 0.052	3.587GluSer: 3.587 ± 0.054	3.742GluThr: 3.742 ± 0.053	4.825GluVal: 4.825 ± 0.055	0.808GluTrp: 0.808 ± 0.026	2.465GluTyr: 2.465 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.233PheAla: 3.233 ± 0.045	0.37PheCys: 0.37 ± 0.015	2.288PheAsp: 2.288 ± 0.044	2.624PheGlu: 2.624 ± 0.043	2.381PhePhe: 2.381 ± 0.049	3.306PheGly: 3.306 ± 0.053	1.034PheHis: 1.034 ± 0.023	4.069PheIle: 4.069 ± 0.056	2.563PheLys: 2.563 ± 0.048	4.683PheLeu: 4.683 ± 0.059	1.178PheMet: 1.178 ± 0.028	1.986PheAsn: 1.986 ± 0.041	1.677PhePro: 1.677 ± 0.035	1.656PheGln: 1.656 ± 0.035	1.439PheArg: 1.439 ± 0.032	3.361PheSer: 3.361 ± 0.052	2.659PheThr: 2.659 ± 0.049	2.987PheVal: 2.987 ± 0.05	0.45PheTrp: 0.45 ± 0.017	1.847PheTyr: 1.847 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.681GlyAla: 4.681 ± 0.082	0.583GlyCys: 0.583 ± 0.018	3.032GlyAsp: 3.032 ± 0.048	4.334GlyGlu: 4.334 ± 0.064	3.424GlyPhe: 3.424 ± 0.053	4.531GlyGly: 4.531 ± 0.074	1.222GlyHis: 1.222 ± 0.027	6.186GlyIle: 6.186 ± 0.069	5.081GlyLys: 5.081 ± 0.06	6.486GlyLeu: 6.486 ± 0.072	2.015GlyMet: 2.015 ± 0.049	2.976GlyAsn: 2.976 ± 0.048	1.673GlyPro: 1.673 ± 0.091	2.033GlyGln: 2.033 ± 0.036	2.303GlyArg: 2.303 ± 0.04	4.042GlySer: 4.042 ± 0.054	3.887GlyThr: 3.887 ± 0.053	4.804GlyVal: 4.804 ± 0.068	0.802GlyTrp: 0.802 ± 0.025	2.812GlyTyr: 2.812 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.241HisAla: 1.241 ± 0.032	0.191HisCys: 0.191 ± 0.014	0.912HisAsp: 0.912 ± 0.029	1.263HisGlu: 1.263 ± 0.031	1.084HisPhe: 1.084 ± 0.03	1.234HisGly: 1.234 ± 0.028	0.61HisHis: 0.61 ± 0.02	1.588HisIle: 1.588 ± 0.034	1.079HisLys: 1.079 ± 0.025	1.984HisLeu: 1.984 ± 0.033	0.466HisMet: 0.466 ± 0.018	0.797HisAsn: 0.797 ± 0.028	0.932HisPro: 0.932 ± 0.022	0.714HisGln: 0.714 ± 0.021	0.716HisArg: 0.716 ± 0.025	1.177HisSer: 1.177 ± 0.031	1.045HisThr: 1.045 ± 0.027	1.253HisVal: 1.253 ± 0.027	0.233HisTrp: 0.233 ± 0.012	0.925HisTyr: 0.925 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.339IleAla: 6.339 ± 0.071	0.693IleCys: 0.693 ± 0.023	4.262IleAsp: 4.262 ± 0.059	5.35IleGlu: 5.35 ± 0.067	3.456IlePhe: 3.456 ± 0.047	6.213IleGly: 6.213 ± 0.076	1.681IleHis: 1.681 ± 0.034	6.682IleIle: 6.682 ± 0.08	5.226IleLys: 5.226 ± 0.064	7.611IleLeu: 7.611 ± 0.086	2.015IleMet: 2.015 ± 0.039	3.821IleAsn: 3.821 ± 0.058	3.377IlePro: 3.377 ± 0.041	2.82IleGln: 2.82 ± 0.045	2.936IleArg: 2.936 ± 0.046	5.727IleSer: 5.727 ± 0.065	4.728IleThr: 4.728 ± 0.059	5.621IleVal: 5.621 ± 0.066	0.71IleTrp: 0.71 ± 0.022	2.658IleTyr: 2.658 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.027LysAla: 5.027 ± 0.06	0.319LysCys: 0.319 ± 0.015	4.254LysAsp: 4.254 ± 0.063	7.217LysGlu: 7.217 ± 0.072	2.02LysPhe: 2.02 ± 0.039	4.638LysGly: 4.638 ± 0.058	1.373LysHis: 1.373 ± 0.032	4.899LysIle: 4.899 ± 0.055	6.156LysLys: 6.156 ± 0.067	6.419LysLeu: 6.419 ± 0.059	2.161LysMet: 2.161 ± 0.041	3.621LysAsn: 3.621 ± 0.044	2.098LysPro: 2.098 ± 0.042	3.326LysGln: 3.326 ± 0.043	3.14LysArg: 3.14 ± 0.048	3.831LysSer: 3.831 ± 0.044	3.936LysThr: 3.936 ± 0.061	4.633LysVal: 4.633 ± 0.05	0.84LysTrp: 0.84 ± 0.024	2.46LysTyr: 2.46 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	7.528LeuAla: 7.528 ± 0.084	0.691LeuCys: 0.691 ± 0.02	4.84LeuAsp: 4.84 ± 0.062	6.882LeuGlu: 6.882 ± 0.082	4.861LeuPhe: 4.861 ± 0.068	6.331LeuGly: 6.331 ± 0.076	1.948LeuHis: 1.948 ± 0.033	7.367LeuIle: 7.367 ± 0.096	6.693LeuLys: 6.693 ± 0.064	10.76LeuLeu: 10.76 ± 0.111	2.481LeuMet: 2.481 ± 0.044	4.515LeuAsn: 4.515 ± 0.058	3.797LeuPro: 3.797 ± 0.051	3.693LeuGln: 3.693 ± 0.053	3.296LeuArg: 3.296 ± 0.053	7.003LeuSer: 7.003 ± 0.063	5.667LeuThr: 5.667 ± 0.055	6.192LeuVal: 6.192 ± 0.064	0.835LeuTrp: 0.835 ± 0.024	3.286LeuTyr: 3.286 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.89MetAla: 1.89 ± 0.036	0.124MetCys: 0.124 ± 0.009	1.499MetAsp: 1.499 ± 0.03	2.207MetGlu: 2.207 ± 0.037	1.052MetPhe: 1.052 ± 0.029	1.641MetGly: 1.641 ± 0.029	0.423MetHis: 0.423 ± 0.017	2.033MetIle: 2.033 ± 0.036	2.468MetLys: 2.468 ± 0.041	2.67MetLeu: 2.67 ± 0.043	0.834MetMet: 0.834 ± 0.026	1.499MetAsn: 1.499 ± 0.032	1.034MetPro: 1.034 ± 0.027	0.94MetGln: 0.94 ± 0.026	0.96MetArg: 0.96 ± 0.029	1.72MetSer: 1.72 ± 0.038	1.499MetThr: 1.499 ± 0.033	1.671MetVal: 1.671 ± 0.031	0.181MetTrp: 0.181 ± 0.012	0.789MetTyr: 0.789 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.934AsnAla: 2.934 ± 0.043	0.315AsnCys: 0.315 ± 0.015	2.421AsnAsp: 2.421 ± 0.046	3.48AsnGlu: 3.48 ± 0.052	1.769AsnPhe: 1.769 ± 0.036	3.632AsnGly: 3.632 ± 0.053	1.011AsnHis: 1.011 ± 0.029	4.072AsnIle: 4.072 ± 0.059	3.581AsnLys: 3.581 ± 0.054	4.032AsnLeu: 4.032 ± 0.053	1.288AsnMet: 1.288 ± 0.029	2.484AsnAsn: 2.484 ± 0.04	2.135AsnPro: 2.135 ± 0.041	1.756AsnGln: 1.756 ± 0.038	1.991AsnArg: 1.991 ± 0.039	2.887AsnSer: 2.887 ± 0.051	2.539AsnThr: 2.539 ± 0.038	2.99AsnVal: 2.99 ± 0.041	0.591AsnTrp: 0.591 ± 0.021	1.741AsnTyr: 1.741 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.439ProAla: 2.439 ± 0.057	0.182ProCys: 0.182 ± 0.011	1.799ProAsp: 1.799 ± 0.031	2.572ProGlu: 2.572 ± 0.045	1.972ProPhe: 1.972 ± 0.038	1.988ProGly: 1.988 ± 0.047	0.712ProHis: 0.712 ± 0.022	2.903ProIle: 2.903 ± 0.048	2.022ProLys: 2.022 ± 0.04	3.282ProLeu: 3.282 ± 0.051	0.775ProMet: 0.775 ± 0.022	1.661ProAsn: 1.661 ± 0.032	0.819ProPro: 0.819 ± 0.027	0.997ProGln: 0.997 ± 0.022	0.909ProArg: 0.909 ± 0.026	2.157ProSer: 2.157 ± 0.044	1.891ProThr: 1.891 ± 0.055	2.65ProVal: 2.65 ± 0.044	0.34ProTrp: 0.34 ± 0.015	1.438ProTyr: 1.438 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.608GlnAla: 2.608 ± 0.046	0.187GlnCys: 0.187 ± 0.011	1.682GlnAsp: 1.682 ± 0.033	2.868GlnGlu: 2.868 ± 0.046	1.567GlnPhe: 1.567 ± 0.036	1.984GlnGly: 1.984 ± 0.035	0.749GlnHis: 0.749 ± 0.021	2.521GlnIle: 2.521 ± 0.043	2.844GlnLys: 2.844 ± 0.044	3.791GlnLeu: 3.791 ± 0.055	1.07GlnMet: 1.07 ± 0.029	1.65GlnAsn: 1.65 ± 0.036	0.981GlnPro: 0.981 ± 0.026	1.663GlnGln: 1.663 ± 0.039	1.272GlnArg: 1.272 ± 0.031	2.119GlnSer: 2.119 ± 0.04	1.984GlnThr: 1.984 ± 0.034	2.255GlnVal: 2.255 ± 0.038	0.348GlnTrp: 0.348 ± 0.014	1.383GlnTyr: 1.383 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.105ArgAla: 2.105 ± 0.044	0.222ArgCys: 0.222 ± 0.014	1.775ArgAsp: 1.775 ± 0.038	2.702ArgGlu: 2.702 ± 0.045	1.77ArgPhe: 1.77 ± 0.038	2.011ArgGly: 2.011 ± 0.042	0.675ArgHis: 0.675 ± 0.021	3.004ArgIle: 3.004 ± 0.05	3.099ArgLys: 3.099 ± 0.046	3.708ArgLeu: 3.708 ± 0.055	1.099ArgMet: 1.099 ± 0.026	1.923ArgAsn: 1.923 ± 0.034	1.106ArgPro: 1.106 ± 0.026	1.313ArgGln: 1.313 ± 0.033	1.622ArgArg: 1.622 ± 0.04	2.083ArgSer: 2.083 ± 0.039	1.882ArgThr: 1.882 ± 0.033	2.198ArgVal: 2.198 ± 0.046	0.386ArgTrp: 0.386 ± 0.016	1.418ArgTyr: 1.418 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.044SerAla: 4.044 ± 0.057	0.438SerCys: 0.438 ± 0.016	2.95SerAsp: 2.95 ± 0.048	3.965SerGlu: 3.965 ± 0.051	3.563SerPhe: 3.563 ± 0.047	4.362SerGly: 4.362 ± 0.058	1.183SerHis: 1.183 ± 0.035	5.785SerIle: 5.785 ± 0.07	4.255SerLys: 4.255 ± 0.056	6.641SerLeu: 6.641 ± 0.068	1.761SerMet: 1.761 ± 0.032	2.933SerAsn: 2.933 ± 0.045	1.987SerPro: 1.987 ± 0.04	1.971SerGln: 1.971 ± 0.034	2.1SerArg: 2.1 ± 0.041	4.547SerSer: 4.547 ± 0.068	3.426SerThr: 3.426 ± 0.051	4.303SerVal: 4.303 ± 0.054	0.654SerTrp: 0.654 ± 0.02	2.506SerTyr: 2.506 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.229ThrAla: 4.229 ± 0.061	0.35ThrCys: 0.35 ± 0.014	2.868ThrAsp: 2.868 ± 0.052	3.79ThrGlu: 3.79 ± 0.055	2.511ThrPhe: 2.511 ± 0.045	4.249ThrGly: 4.249 ± 0.093	0.93ThrHis: 0.93 ± 0.023	4.771ThrIle: 4.771 ± 0.063	3.582ThrLys: 3.582 ± 0.046	5.123ThrLeu: 5.123 ± 0.05	1.26ThrMet: 1.26 ± 0.028	2.69ThrAsn: 2.69 ± 0.041	2.124ThrPro: 2.124 ± 0.043	1.403ThrGln: 1.403 ± 0.03	1.691ThrArg: 1.691 ± 0.028	3.494ThrSer: 3.494 ± 0.052	2.957ThrThr: 2.957 ± 0.051	4.19ThrVal: 4.19 ± 0.058	0.565ThrTrp: 0.565 ± 0.021	1.945ThrTyr: 1.945 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.711ValAla: 4.711 ± 0.063	0.565ValCys: 0.565 ± 0.02	3.449ValAsp: 3.449 ± 0.053	4.643ValGlu: 4.643 ± 0.059	3.239ValPhe: 3.239 ± 0.05	4.301ValGly: 4.301 ± 0.057	1.257ValHis: 1.257 ± 0.031	5.602ValIle: 5.602 ± 0.061	4.737ValLys: 4.737 ± 0.056	6.801ValLeu: 6.801 ± 0.071	1.737ValMet: 1.737 ± 0.038	3.179ValAsn: 3.179 ± 0.043	2.442ValPro: 2.442 ± 0.039	2.286ValGln: 2.286 ± 0.045	2.314ValArg: 2.314 ± 0.045	4.708ValSer: 4.708 ± 0.056	3.87ValThr: 3.87 ± 0.061	4.484ValVal: 4.484 ± 0.069	0.644ValTrp: 0.644 ± 0.021	2.282ValTyr: 2.282 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.61TrpAla: 0.61 ± 0.022	0.078TrpCys: 0.078 ± 0.008	0.538TrpAsp: 0.538 ± 0.016	0.7TrpGlu: 0.7 ± 0.026	0.479TrpPhe: 0.479 ± 0.019	0.701TrpGly: 0.701 ± 0.023	0.216TrpHis: 0.216 ± 0.014	0.869TrpIle: 0.869 ± 0.024	0.821TrpLys: 0.821 ± 0.023	1.128TrpLeu: 1.128 ± 0.031	0.319TrpMet: 0.319 ± 0.014	0.589TrpAsn: 0.589 ± 0.019	0.224TrpPro: 0.224 ± 0.013	0.401TrpGln: 0.401 ± 0.018	0.38TrpArg: 0.38 ± 0.017	0.638TrpSer: 0.638 ± 0.023	0.562TrpThr: 0.562 ± 0.019	0.621TrpVal: 0.621 ± 0.018	0.145TrpTrp: 0.145 ± 0.009	0.359TrpTyr: 0.359 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.203TyrAla: 2.203 ± 0.042	0.315TyrCys: 0.315 ± 0.014	1.928TyrAsp: 1.928 ± 0.042	2.526TyrGlu: 2.526 ± 0.043	1.91TyrPhe: 1.91 ± 0.038	2.49TyrGly: 2.49 ± 0.042	0.83TyrHis: 0.83 ± 0.026	2.716TyrIle: 2.716 ± 0.038	2.496TyrLys: 2.496 ± 0.044	3.736TyrLeu: 3.736 ± 0.048	0.983TyrMet: 0.983 ± 0.025	1.664TyrAsn: 1.664 ± 0.033	1.392TyrPro: 1.392 ± 0.032	1.46TyrGln: 1.46 ± 0.03	1.5TyrArg: 1.5 ± 0.033	2.393TyrSer: 2.393 ± 0.042	2.062TyrThr: 2.062 ± 0.037	2.252TyrVal: 2.252 ± 0.045	0.432TyrTrp: 0.432 ± 0.017	1.637TyrTyr: 1.637 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5402 proteins (1569371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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