Amino acid dipepetide frequency for Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.983AlaAla: 9.983 ± 0.096	1.171AlaCys: 1.171 ± 0.028	5.914AlaAsp: 5.914 ± 0.058	6.034AlaGlu: 6.034 ± 0.069	3.278AlaPhe: 3.278 ± 0.041	7.282AlaGly: 7.282 ± 0.074	1.507AlaHis: 1.507 ± 0.025	5.638AlaIle: 5.638 ± 0.052	3.964AlaLys: 3.964 ± 0.063	7.269AlaLeu: 7.269 ± 0.063	2.893AlaMet: 2.893 ± 0.045	3.422AlaAsn: 3.422 ± 0.049	3.811AlaPro: 3.811 ± 0.057	2.765AlaGln: 2.765 ± 0.038	5.021AlaArg: 5.021 ± 0.062	7.205AlaSer: 7.205 ± 0.064	6.032AlaThr: 6.032 ± 0.068	6.387AlaVal: 6.387 ± 0.059	1.295AlaTrp: 1.295 ± 0.027	1.835AlaTyr: 1.835 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.709CysAla: 0.709 ± 0.019	0.311CysCys: 0.311 ± 0.015	0.848CysAsp: 0.848 ± 0.022	0.734CysGlu: 0.734 ± 0.02	0.568CysPhe: 0.568 ± 0.019	1.153CysGly: 1.153 ± 0.031	0.48CysHis: 0.48 ± 0.02	0.493CysIle: 0.493 ± 0.017	0.358CysLys: 0.358 ± 0.013	1.255CysLeu: 1.255 ± 0.028	0.261CysMet: 0.261 ± 0.013	0.368CysAsn: 0.368 ± 0.013	0.693CysPro: 0.693 ± 0.019	0.521CysGln: 0.521 ± 0.016	0.993CysArg: 0.993 ± 0.026	0.885CysSer: 0.885 ± 0.019	0.535CysThr: 0.535 ± 0.017	0.996CysVal: 0.996 ± 0.026	0.213CysTrp: 0.213 ± 0.009	0.293CysTyr: 0.293 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.374AspAla: 6.374 ± 0.067	0.726AspCys: 0.726 ± 0.02	4.256AspAsp: 4.256 ± 0.069	4.475AspGlu: 4.475 ± 0.049	2.294AspPhe: 2.294 ± 0.037	5.43AspGly: 5.43 ± 0.084	1.511AspHis: 1.511 ± 0.031	2.382AspIle: 2.382 ± 0.045	1.518AspLys: 1.518 ± 0.032	5.676AspLeu: 5.676 ± 0.059	1.069AspMet: 1.069 ± 0.024	1.714AspAsn: 1.714 ± 0.043	3.625AspPro: 3.625 ± 0.046	2.801AspGln: 2.801 ± 0.038	4.449AspArg: 4.449 ± 0.044	4.532AspSer: 4.532 ± 0.065	2.675AspThr: 2.675 ± 0.052	4.298AspVal: 4.298 ± 0.051	1.143AspTrp: 1.143 ± 0.024	1.421AspTyr: 1.421 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.427GluAla: 5.427 ± 0.063	0.567GluCys: 0.567 ± 0.018	3.026GluAsp: 3.026 ± 0.044	3.46GluGlu: 3.46 ± 0.06	2.209GluPhe: 2.209 ± 0.032	3.579GluGly: 3.579 ± 0.054	1.35GluHis: 1.35 ± 0.028	3.261GluIle: 3.261 ± 0.039	2.341GluLys: 2.341 ± 0.045	6.483GluLeu: 6.483 ± 0.059	1.668GluMet: 1.668 ± 0.032	2.118GluAsn: 2.118 ± 0.034	2.871GluPro: 2.871 ± 0.041	2.783GluGln: 2.783 ± 0.04	3.987GluArg: 3.987 ± 0.051	5.025GluSer: 5.025 ± 0.056	4.026GluThr: 4.026 ± 0.045	4.018GluVal: 4.018 ± 0.045	0.774GluTrp: 0.774 ± 0.022	1.172GluTyr: 1.172 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.976PheAla: 3.976 ± 0.047	0.53PheCys: 0.53 ± 0.018	2.876PheAsp: 2.876 ± 0.044	2.304PheGlu: 2.304 ± 0.036	1.45PhePhe: 1.45 ± 0.03	3.258PheGly: 3.258 ± 0.04	0.876PheHis: 0.876 ± 0.023	1.404PheIle: 1.404 ± 0.026	0.862PheLys: 0.862 ± 0.021	3.277PheLeu: 3.277 ± 0.046	0.649PheMet: 0.649 ± 0.017	1.158PheAsn: 1.158 ± 0.029	1.669PhePro: 1.669 ± 0.028	1.409PheGln: 1.409 ± 0.027	2.557PheArg: 2.557 ± 0.037	2.452PheSer: 2.452 ± 0.035	2.01PheThr: 2.01 ± 0.047	2.876PheVal: 2.876 ± 0.038	0.548PheTrp: 0.548 ± 0.016	0.851PheTyr: 0.851 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.216GlyAla: 5.216 ± 0.065	1.169GlyCys: 1.169 ± 0.03	4.761GlyAsp: 4.761 ± 0.075	4.614GlyGlu: 4.614 ± 0.043	2.968GlyPhe: 2.968 ± 0.043	6.535GlyGly: 6.535 ± 0.148	1.699GlyHis: 1.699 ± 0.031	3.726GlyIle: 3.726 ± 0.048	3.216GlyLys: 3.216 ± 0.057	6.712GlyLeu: 6.712 ± 0.057	2.103GlyMet: 2.103 ± 0.039	2.706GlyAsn: 2.706 ± 0.061	3.057GlyPro: 3.057 ± 0.043	2.936GlyGln: 2.936 ± 0.037	5.053GlyArg: 5.053 ± 0.065	5.342GlySer: 5.342 ± 0.087	4.567GlyThr: 4.567 ± 0.106	5.207GlyVal: 5.207 ± 0.057	1.399GlyTrp: 1.399 ± 0.029	1.898GlyTyr: 1.898 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.096HisAla: 2.096 ± 0.033	0.416HisCys: 0.416 ± 0.014	1.357HisAsp: 1.357 ± 0.03	1.234HisGlu: 1.234 ± 0.025	0.999HisPhe: 0.999 ± 0.024	1.789HisGly: 1.789 ± 0.027	0.778HisHis: 0.778 ± 0.022	0.81HisIle: 0.81 ± 0.022	0.503HisLys: 0.503 ± 0.014	2.242HisLeu: 2.242 ± 0.04	0.382HisMet: 0.382 ± 0.013	0.641HisAsn: 0.641 ± 0.017	1.544HisPro: 1.544 ± 0.028	1.008HisGln: 1.008 ± 0.023	2.006HisArg: 2.006 ± 0.036	1.619HisSer: 1.619 ± 0.032	0.998HisThr: 0.998 ± 0.021	1.561HisVal: 1.561 ± 0.031	0.487HisTrp: 0.487 ± 0.018	0.582HisTyr: 0.582 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.933IleAla: 5.933 ± 0.058	0.611IleCys: 0.611 ± 0.015	4.084IleAsp: 4.084 ± 0.047	3.837IleGlu: 3.837 ± 0.047	1.305IlePhe: 1.305 ± 0.027	4.268IleGly: 4.268 ± 0.048	1.184IleHis: 1.184 ± 0.027	1.714IleIle: 1.714 ± 0.034	1.271IleLys: 1.271 ± 0.026	3.745IleLeu: 3.745 ± 0.04	0.696IleMet: 0.696 ± 0.019	1.569IleAsn: 1.569 ± 0.033	2.413IlePro: 2.413 ± 0.034	2.001IleGln: 2.001 ± 0.034	3.661IleArg: 3.661 ± 0.04	3.168IleSer: 3.168 ± 0.043	2.655IleThr: 2.655 ± 0.063	3.785IleVal: 3.785 ± 0.041	0.634IleTrp: 0.634 ± 0.016	0.964IleTyr: 0.964 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.87LysAla: 2.87 ± 0.051	0.338LysCys: 0.338 ± 0.013	1.686LysAsp: 1.686 ± 0.036	1.809LysGlu: 1.809 ± 0.035	1.131LysPhe: 1.131 ± 0.025	1.812LysGly: 1.812 ± 0.036	0.834LysHis: 0.834 ± 0.021	1.717LysIle: 1.717 ± 0.033	1.567LysLys: 1.567 ± 0.04	3.499LysLeu: 3.499 ± 0.054	0.914LysMet: 0.914 ± 0.02	1.111LysAsn: 1.111 ± 0.026	2.148LysPro: 2.148 ± 0.036	1.668LysGln: 1.668 ± 0.031	2.752LysArg: 2.752 ± 0.044	2.495LysSer: 2.495 ± 0.037	2.288LysThr: 2.288 ± 0.04	2.206LysVal: 2.206 ± 0.037	0.527LysTrp: 0.527 ± 0.015	0.708LysTyr: 0.708 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	9.766LeuAla: 9.766 ± 0.073	1.146LeuCys: 1.146 ± 0.027	5.747LeuAsp: 5.747 ± 0.06	4.921LeuGlu: 4.921 ± 0.055	3.31LeuPhe: 3.31 ± 0.042	6.527LeuGly: 6.527 ± 0.06	2.125LeuHis: 2.125 ± 0.034	4.791LeuIle: 4.791 ± 0.048	3.252LeuLys: 3.252 ± 0.048	8.968LeuLeu: 8.968 ± 0.079	2.128LeuMet: 2.128 ± 0.038	3.075LeuAsn: 3.075 ± 0.047	5.491LeuPro: 5.491 ± 0.058	3.753LeuGln: 3.753 ± 0.039	6.555LeuArg: 6.555 ± 0.071	6.682LeuSer: 6.682 ± 0.058	5.449LeuThr: 5.449 ± 0.061	6.777LeuVal: 6.777 ± 0.066	1.163LeuTrp: 1.163 ± 0.025	1.727LeuTyr: 1.727 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.251MetAla: 2.251 ± 0.04	0.251MetCys: 0.251 ± 0.011	1.203MetAsp: 1.203 ± 0.021	1.165MetGlu: 1.165 ± 0.027	0.802MetPhe: 0.802 ± 0.018	1.565MetGly: 1.565 ± 0.031	0.556MetHis: 0.556 ± 0.015	1.309MetIle: 1.309 ± 0.028	1.02MetLys: 1.02 ± 0.022	2.464MetLeu: 2.464 ± 0.039	0.696MetMet: 0.696 ± 0.019	0.994MetAsn: 0.994 ± 0.022	1.542MetPro: 1.542 ± 0.027	1.058MetGln: 1.058 ± 0.026	1.675MetArg: 1.675 ± 0.029	1.842MetSer: 1.842 ± 0.034	1.68MetThr: 1.68 ± 0.031	1.667MetVal: 1.667 ± 0.031	0.254MetTrp: 0.254 ± 0.011	0.314MetTyr: 0.314 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.245AsnAla: 3.245 ± 0.054	0.407AsnCys: 0.407 ± 0.013	2.217AsnAsp: 2.217 ± 0.054	2.22AsnGlu: 2.22 ± 0.033	1.127AsnPhe: 1.127 ± 0.026	2.871AsnGly: 2.871 ± 0.069	0.855AsnHis: 0.855 ± 0.02	1.22AsnIle: 1.22 ± 0.026	0.796AsnLys: 0.796 ± 0.022	2.99AsnLeu: 2.99 ± 0.035	0.615AsnMet: 0.615 ± 0.016	1.11AsnAsn: 1.11 ± 0.041	2.13AsnPro: 2.13 ± 0.033	1.664AsnGln: 1.664 ± 0.03	2.612AsnArg: 2.612 ± 0.036	2.28AsnSer: 2.28 ± 0.044	1.631AsnThr: 1.631 ± 0.044	2.421AsnVal: 2.421 ± 0.048	0.559AsnTrp: 0.559 ± 0.018	0.756AsnTyr: 0.756 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.048ProAla: 5.048 ± 0.06	0.489ProCys: 0.489 ± 0.015	3.408ProAsp: 3.408 ± 0.043	3.722ProGlu: 3.722 ± 0.038	1.889ProPhe: 1.889 ± 0.033	3.775ProGly: 3.775 ± 0.05	1.162ProHis: 1.162 ± 0.032	2.849ProIle: 2.849 ± 0.041	2.003ProLys: 2.003 ± 0.036	4.382ProLeu: 4.382 ± 0.044	1.39ProMet: 1.39 ± 0.028	2.171ProAsn: 2.171 ± 0.034	3.028ProPro: 3.028 ± 0.058	1.754ProGln: 1.754 ± 0.033	2.946ProArg: 2.946 ± 0.041	4.236ProSer: 4.236 ± 0.045	3.565ProThr: 3.565 ± 0.044	3.744ProVal: 3.744 ± 0.056	0.744ProTrp: 0.744 ± 0.019	1.018ProTyr: 1.018 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.442GlnAla: 3.442 ± 0.047	0.487GlnCys: 0.487 ± 0.018	1.669GlnAsp: 1.669 ± 0.029	1.677GlnGlu: 1.677 ± 0.029	1.638GlnPhe: 1.638 ± 0.03	2.029GlnGly: 2.029 ± 0.032	1.023GlnHis: 1.023 ± 0.024	2.265GlnIle: 2.265 ± 0.032	1.309GlnLys: 1.309 ± 0.026	4.184GlnLeu: 4.184 ± 0.047	1.014GlnMet: 1.014 ± 0.023	1.342GlnAsn: 1.342 ± 0.028	2.487GlnPro: 2.487 ± 0.035	1.99GlnGln: 1.99 ± 0.042	3.202GlnArg: 3.202 ± 0.045	3.527GlnSer: 3.527 ± 0.047	2.893GlnThr: 2.893 ± 0.038	2.508GlnVal: 2.508 ± 0.036	0.748GlnTrp: 0.748 ± 0.021	0.869GlnTyr: 0.869 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	4.622ArgAla: 4.622 ± 0.047	1.092ArgCys: 1.092 ± 0.027	4.018ArgAsp: 4.018 ± 0.047	4.081ArgGlu: 4.081 ± 0.053	3.092ArgPhe: 3.092 ± 0.033	4.512ArgGly: 4.512 ± 0.054	1.658ArgHis: 1.658 ± 0.029	3.561ArgIle: 3.561 ± 0.041	2.388ArgLys: 2.388 ± 0.041	7.209ArgLeu: 7.209 ± 0.07	2.035ArgMet: 2.035 ± 0.034	2.274ArgAsn: 2.274 ± 0.036	3.453ArgPro: 3.453 ± 0.046	2.832ArgGln: 2.832 ± 0.036	5.86ArgArg: 5.86 ± 0.082	5.146ArgSer: 5.146 ± 0.058	3.627ArgThr: 3.627 ± 0.045	4.749ArgVal: 4.749 ± 0.046	1.425ArgTrp: 1.425 ± 0.03	1.717ArgTyr: 1.717 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.145SerAla: 6.145 ± 0.058	0.828SerCys: 0.828 ± 0.024	4.804SerAsp: 4.804 ± 0.062	4.382SerGlu: 4.382 ± 0.051	2.657SerPhe: 2.657 ± 0.037	6.092SerGly: 6.092 ± 0.097	1.655SerHis: 1.655 ± 0.029	3.862SerIle: 3.862 ± 0.043	2.529SerLys: 2.529 ± 0.037	6.963SerLeu: 6.963 ± 0.054	1.867SerMet: 1.867 ± 0.03	2.612SerAsn: 2.612 ± 0.046	4.258SerPro: 4.258 ± 0.042	2.809SerGln: 2.809 ± 0.038	4.919SerArg: 4.919 ± 0.049	5.668SerSer: 5.668 ± 0.094	4.154SerThr: 4.154 ± 0.053	5.245SerVal: 5.245 ± 0.057	0.965SerTrp: 0.965 ± 0.022	1.335SerTyr: 1.335 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.435ThrAla: 5.435 ± 0.082	0.618ThrCys: 0.618 ± 0.019	3.608ThrAsp: 3.608 ± 0.061	3.26ThrGlu: 3.26 ± 0.04	2.24ThrPhe: 2.24 ± 0.054	4.611ThrGly: 4.611 ± 0.077	1.248ThrHis: 1.248 ± 0.022	3.296ThrIle: 3.296 ± 0.07	1.914ThrLys: 1.914 ± 0.037	5.715ThrLeu: 5.715 ± 0.064	1.351ThrMet: 1.351 ± 0.024	1.971ThrAsn: 1.971 ± 0.039	3.653ThrPro: 3.653 ± 0.046	2.154ThrGln: 2.154 ± 0.034	3.465ThrArg: 3.465 ± 0.042	4.214ThrSer: 4.214 ± 0.057	3.616ThrThr: 3.616 ± 0.066	4.136ThrVal: 4.136 ± 0.092	0.837ThrTrp: 0.837 ± 0.023	1.212ThrTyr: 1.212 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.276ValAla: 7.276 ± 0.064	1.0ValCys: 1.0 ± 0.025	4.739ValAsp: 4.739 ± 0.062	4.169ValGlu: 4.169 ± 0.051	2.486ValPhe: 2.486 ± 0.041	5.178ValGly: 5.178 ± 0.056	1.561ValHis: 1.561 ± 0.031	3.577ValIle: 3.577 ± 0.043	2.003ValLys: 2.003 ± 0.035	6.547ValLeu: 6.547 ± 0.068	1.67ValMet: 1.67 ± 0.028	2.114ValAsn: 2.114 ± 0.041	3.6ValPro: 3.6 ± 0.041	2.552ValGln: 2.552 ± 0.035	4.764ValArg: 4.764 ± 0.053	5.017ValSer: 5.017 ± 0.054	4.233ValThr: 4.233 ± 0.095	5.594ValVal: 5.594 ± 0.061	1.064ValTrp: 1.064 ± 0.028	1.387ValTyr: 1.387 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.081TrpAla: 1.081 ± 0.026	0.226TrpCys: 0.226 ± 0.009	0.754TrpAsp: 0.754 ± 0.02	0.689TrpGlu: 0.689 ± 0.02	0.651TrpPhe: 0.651 ± 0.018	0.898TrpGly: 0.898 ± 0.023	0.433TrpHis: 0.433 ± 0.013	0.937TrpIle: 0.937 ± 0.024	0.72TrpLys: 0.72 ± 0.02	1.718TrpLeu: 1.718 ± 0.033	0.562TrpMet: 0.562 ± 0.018	0.614TrpAsn: 0.614 ± 0.021	0.763TrpPro: 0.763 ± 0.021	0.792TrpGln: 0.792 ± 0.023	1.048TrpArg: 1.048 ± 0.025	1.08TrpSer: 1.08 ± 0.027	0.914TrpThr: 0.914 ± 0.021	0.951TrpVal: 0.951 ± 0.02	0.304TrpTrp: 0.304 ± 0.014	0.308TrpTyr: 0.308 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.814TyrAla: 1.814 ± 0.03	0.284TyrCys: 0.284 ± 0.013	1.395TyrAsp: 1.395 ± 0.027	1.357TyrGlu: 1.357 ± 0.027	0.897TyrPhe: 0.897 ± 0.022	1.721TyrGly: 1.721 ± 0.029	0.558TyrHis: 0.558 ± 0.016	0.687TyrIle: 0.687 ± 0.017	0.547TyrLys: 0.547 ± 0.018	2.054TyrLeu: 2.054 ± 0.035	0.344TyrMet: 0.344 ± 0.013	0.637TyrAsn: 0.637 ± 0.017	1.087TyrPro: 1.087 ± 0.025	1.053TyrGln: 1.053 ± 0.022	1.828TyrArg: 1.828 ± 0.025	1.334TyrSer: 1.334 ± 0.027	1.006TyrThr: 1.006 ± 0.033	1.404TyrVal: 1.404 ± 0.025	0.361TyrTrp: 0.361 ± 0.013	0.591TyrTyr: 0.591 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7271 proteins (2290149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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