Amino acid dipepetide frequency for Sodiomyces alkalinus F11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.92AlaAla: 10.92 ± 0.08
1.066AlaCys: 1.066 ± 0.016
4.67AlaAsp: 4.67 ± 0.036
5.517AlaGlu: 5.517 ± 0.04
3.043AlaPhe: 3.043 ± 0.031
6.353AlaGly: 6.353 ± 0.039
1.982AlaHis: 1.982 ± 0.021
3.796AlaIle: 3.796 ± 0.032
3.877AlaLys: 3.877 ± 0.037
7.843AlaLeu: 7.843 ± 0.056
1.988AlaMet: 1.988 ± 0.025
2.85AlaAsn: 2.85 ± 0.023
5.434AlaPro: 5.434 ± 0.049
3.528AlaGln: 3.528 ± 0.037
5.875AlaArg: 5.875 ± 0.039
7.777AlaSer: 7.777 ± 0.044
5.559AlaThr: 5.559 ± 0.04
5.716AlaVal: 5.716 ± 0.045
1.236AlaTrp: 1.236 ± 0.019
2.054AlaTyr: 2.054 ± 0.023
0.0AlaXaa: 0.0 ± 0.0
Cys
0.935CysAla: 0.935 ± 0.017
0.268CysCys: 0.268 ± 0.009
0.654CysAsp: 0.654 ± 0.015
0.584CysGlu: 0.584 ± 0.012
0.537CysPhe: 0.537 ± 0.012
0.95CysGly: 0.95 ± 0.02
0.379CysHis: 0.379 ± 0.009
0.654CysIle: 0.654 ± 0.014
0.445CysLys: 0.445 ± 0.011
1.306CysLeu: 1.306 ± 0.018
0.263CysMet: 0.263 ± 0.007
0.39CysAsn: 0.39 ± 0.01
0.75CysPro: 0.75 ± 0.015
0.438CysGln: 0.438 ± 0.01
0.887CysArg: 0.887 ± 0.017
0.919CysSer: 0.919 ± 0.018
0.666CysThr: 0.666 ± 0.014
0.768CysVal: 0.768 ± 0.014
0.197CysTrp: 0.197 ± 0.007
0.326CysTyr: 0.326 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
5.281AspAla: 5.281 ± 0.036
0.612AspCys: 0.612 ± 0.012
5.051AspAsp: 5.051 ± 0.062
4.62AspGlu: 4.62 ± 0.044
2.093AspPhe: 2.093 ± 0.021
4.497AspGly: 4.497 ± 0.038
1.368AspHis: 1.368 ± 0.018
2.659AspIle: 2.659 ± 0.021
2.22AspLys: 2.22 ± 0.023
5.002AspLeu: 5.002 ± 0.038
1.332AspMet: 1.332 ± 0.019
1.775AspAsn: 1.775 ± 0.023
3.573AspPro: 3.573 ± 0.025
1.846AspGln: 1.846 ± 0.022
3.534AspArg: 3.534 ± 0.038
3.889AspSer: 3.889 ± 0.037
2.819AspThr: 2.819 ± 0.024
3.925AspVal: 3.925 ± 0.027
0.868AspTrp: 0.868 ± 0.015
1.412AspTyr: 1.412 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
5.829GluAla: 5.829 ± 0.049
0.595GluCys: 0.595 ± 0.012
4.324GluAsp: 4.324 ± 0.038
5.761GluGlu: 5.761 ± 0.066
1.781GluPhe: 1.781 ± 0.021
4.027GluGly: 4.027 ± 0.032
1.327GluHis: 1.327 ± 0.018
2.494GluIle: 2.494 ± 0.025
3.424GluLys: 3.424 ± 0.035
4.961GluLeu: 4.961 ± 0.039
1.431GluMet: 1.431 ± 0.02
2.006GluAsn: 2.006 ± 0.022
3.075GluPro: 3.075 ± 0.038
2.345GluGln: 2.345 ± 0.025
4.229GluArg: 4.229 ± 0.04
4.026GluSer: 4.026 ± 0.037
3.462GluThr: 3.462 ± 0.031
3.531GluVal: 3.531 ± 0.029
0.808GluTrp: 0.808 ± 0.014
1.524GluTyr: 1.524 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
2.981PheAla: 2.981 ± 0.027
0.549PheCys: 0.549 ± 0.012
2.192PheAsp: 2.192 ± 0.024
1.959PheGlu: 1.959 ± 0.021
1.659PhePhe: 1.659 ± 0.026
2.666PheGly: 2.666 ± 0.031
0.932PheHis: 0.932 ± 0.015
1.553PheIle: 1.553 ± 0.021
1.241PheLys: 1.241 ± 0.018
3.457PheLeu: 3.457 ± 0.035
0.702PheMet: 0.702 ± 0.012
1.205PheAsn: 1.205 ± 0.017
2.078PhePro: 2.078 ± 0.023
1.262PheGln: 1.262 ± 0.018
2.154PheArg: 2.154 ± 0.023
2.846PheSer: 2.846 ± 0.028
1.92PheThr: 1.92 ± 0.022
2.398PheVal: 2.398 ± 0.027
0.586PheTrp: 0.586 ± 0.012
0.985PheTyr: 0.985 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
5.714GlyAla: 5.714 ± 0.043
0.867GlyCys: 0.867 ± 0.017
4.017GlyAsp: 4.017 ± 0.035
3.948GlyGlu: 3.948 ± 0.034
2.663GlyPhe: 2.663 ± 0.026
6.865GlyGly: 6.865 ± 0.058
1.934GlyHis: 1.934 ± 0.025
3.139GlyIle: 3.139 ± 0.028
3.176GlyLys: 3.176 ± 0.032
6.033GlyLeu: 6.033 ± 0.039
1.545GlyMet: 1.545 ± 0.023
2.455GlyAsn: 2.455 ± 0.028
4.072GlyPro: 4.072 ± 0.043
2.697GlyGln: 2.697 ± 0.028
5.015GlyArg: 5.015 ± 0.045
5.886GlySer: 5.886 ± 0.046
4.091GlyThr: 4.091 ± 0.036
4.409GlyVal: 4.409 ± 0.036
1.118GlyTrp: 1.118 ± 0.018
1.944GlyTyr: 1.944 ± 0.023
0.0GlyXaa: 0.0 ± 0.0
His
2.128HisAla: 2.128 ± 0.023
0.353HisCys: 0.353 ± 0.009
1.469HisAsp: 1.469 ± 0.02
1.325HisGlu: 1.325 ± 0.019
0.959HisPhe: 0.959 ± 0.016
1.955HisGly: 1.955 ± 0.025
1.142HisHis: 1.142 ± 0.027
1.159HisIle: 1.159 ± 0.016
0.873HisLys: 0.873 ± 0.014
2.399HisLeu: 2.399 ± 0.023
0.519HisMet: 0.519 ± 0.012
0.82HisAsn: 0.82 ± 0.015
1.974HisPro: 1.974 ± 0.025
1.129HisGln: 1.129 ± 0.022
1.823HisArg: 1.823 ± 0.023
1.868HisSer: 1.868 ± 0.024
1.273HisThr: 1.273 ± 0.017
1.6HisVal: 1.6 ± 0.02
0.338HisTrp: 0.338 ± 0.009
0.689HisTyr: 0.689 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
3.561IleAla: 3.561 ± 0.03
0.668IleCys: 0.668 ± 0.012
2.494IleAsp: 2.494 ± 0.026
2.409IleGlu: 2.409 ± 0.022
1.69IlePhe: 1.69 ± 0.02
2.657IleGly: 2.657 ± 0.03
1.128IleHis: 1.128 ± 0.015
2.041IleIle: 2.041 ± 0.023
1.736IleLys: 1.736 ± 0.023
3.991IleLeu: 3.991 ± 0.037
0.894IleMet: 0.894 ± 0.016
1.471IleAsn: 1.471 ± 0.021
2.844IlePro: 2.844 ± 0.027
1.634IleGln: 1.634 ± 0.019
2.886IleArg: 2.886 ± 0.024
3.249IleSer: 3.249 ± 0.028
2.396IleThr: 2.396 ± 0.024
2.788IleVal: 2.788 ± 0.025
0.629IleTrp: 0.629 ± 0.011
1.166IleTyr: 1.166 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.997LysAla: 3.997 ± 0.039
0.423LysCys: 0.423 ± 0.011
2.398LysAsp: 2.398 ± 0.025
3.003LysGlu: 3.003 ± 0.036
1.21LysPhe: 1.21 ± 0.018
2.769LysGly: 2.769 ± 0.029
1.022LysHis: 1.022 ± 0.017
1.76LysIle: 1.76 ± 0.022
3.146LysLys: 3.146 ± 0.04
3.641LysLeu: 3.641 ± 0.038
0.959LysMet: 0.959 ± 0.016
1.459LysAsn: 1.459 ± 0.019
2.624LysPro: 2.624 ± 0.03
1.677LysGln: 1.677 ± 0.023
3.363LysArg: 3.363 ± 0.032
2.973LysSer: 2.973 ± 0.029
2.66LysThr: 2.66 ± 0.025
2.497LysVal: 2.497 ± 0.027
0.575LysTrp: 0.575 ± 0.011
1.124LysTyr: 1.124 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
8.276LeuAla: 8.276 ± 0.054
1.201LeuCys: 1.201 ± 0.017
5.207LeuAsp: 5.207 ± 0.041
5.215LeuGlu: 5.215 ± 0.048
3.293LeuPhe: 3.293 ± 0.034
5.987LeuGly: 5.987 ± 0.045
2.289LeuHis: 2.289 ± 0.028
3.364LeuIle: 3.364 ± 0.032
3.539LeuLys: 3.539 ± 0.034
8.293LeuLeu: 8.293 ± 0.063
1.642LeuMet: 1.642 ± 0.018
2.768LeuAsn: 2.768 ± 0.025
5.871LeuPro: 5.871 ± 0.039
3.543LeuGln: 3.543 ± 0.037
6.463LeuArg: 6.463 ± 0.044
7.111LeuSer: 7.111 ± 0.051
4.601LeuThr: 4.601 ± 0.035
5.616LeuVal: 5.616 ± 0.043
1.165LeuTrp: 1.165 ± 0.019
2.197LeuTyr: 2.197 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
2.315MetAla: 2.315 ± 0.025
0.224MetCys: 0.224 ± 0.007
1.234MetAsp: 1.234 ± 0.017
1.225MetGlu: 1.225 ± 0.017
0.66MetPhe: 0.66 ± 0.013
1.506MetGly: 1.506 ± 0.021
0.478MetHis: 0.478 ± 0.01
0.79MetIle: 0.79 ± 0.015
0.863MetLys: 0.863 ± 0.015
1.739MetLeu: 1.739 ± 0.023
0.53MetMet: 0.53 ± 0.012
0.703MetAsn: 0.703 ± 0.012
1.334MetPro: 1.334 ± 0.02
0.804MetGln: 0.804 ± 0.015
1.355MetArg: 1.355 ± 0.016
1.785MetSer: 1.785 ± 0.022
1.294MetThr: 1.294 ± 0.017
1.3MetVal: 1.3 ± 0.02
0.245MetTrp: 0.245 ± 0.008
0.504MetTyr: 0.504 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.925AsnAla: 2.925 ± 0.027
0.412AsnCys: 0.412 ± 0.01
1.846AsnAsp: 1.846 ± 0.025
1.749AsnGlu: 1.749 ± 0.022
1.13AsnPhe: 1.13 ± 0.02
2.768AsnGly: 2.768 ± 0.033
0.872AsnHis: 0.872 ± 0.014
1.622AsnIle: 1.622 ± 0.022
1.355AsnLys: 1.355 ± 0.02
2.934AsnLeu: 2.934 ± 0.027
0.758AsnMet: 0.758 ± 0.013
1.519AsnAsn: 1.519 ± 0.035
2.426AsnPro: 2.426 ± 0.023
1.16AsnGln: 1.16 ± 0.017
2.019AsnArg: 2.019 ± 0.022
2.334AsnSer: 2.334 ± 0.023
1.929AsnThr: 1.929 ± 0.023
2.113AsnVal: 2.113 ± 0.023
0.492AsnTrp: 0.492 ± 0.01
0.862AsnTyr: 0.862 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
6.105ProAla: 6.105 ± 0.043
0.661ProCys: 0.661 ± 0.015
3.578ProAsp: 3.578 ± 0.032
3.981ProGlu: 3.981 ± 0.037
2.174ProPhe: 2.174 ± 0.025
4.64ProGly: 4.64 ± 0.041
1.62ProHis: 1.62 ± 0.023
2.354ProIle: 2.354 ± 0.024
2.452ProLys: 2.452 ± 0.029
5.133ProLeu: 5.133 ± 0.041
1.139ProMet: 1.139 ± 0.02
2.133ProAsn: 2.133 ± 0.026
6.729ProPro: 6.729 ± 0.08
2.677ProGln: 2.677 ± 0.04
4.314ProArg: 4.314 ± 0.039
6.791ProSer: 6.791 ± 0.055
4.352ProThr: 4.352 ± 0.037
3.905ProVal: 3.905 ± 0.036
0.795ProTrp: 0.795 ± 0.016
1.501ProTyr: 1.501 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
3.522GlnAla: 3.522 ± 0.032
0.447GlnCys: 0.447 ± 0.011
2.063GlnAsp: 2.063 ± 0.021
2.275GlnGlu: 2.275 ± 0.027
1.165GlnPhe: 1.165 ± 0.017
2.572GlnGly: 2.572 ± 0.027
1.17GlnHis: 1.17 ± 0.022
1.558GlnIle: 1.558 ± 0.017
1.759GlnLys: 1.759 ± 0.022
3.332GlnLeu: 3.332 ± 0.03
0.81GlnMet: 0.81 ± 0.014
1.366GlnAsn: 1.366 ± 0.017
2.942GlnPro: 2.942 ± 0.043
3.131GlnGln: 3.131 ± 0.076
2.803GlnArg: 2.803 ± 0.025
2.922GlnSer: 2.922 ± 0.029
2.227GlnThr: 2.227 ± 0.026
2.191GlnVal: 2.191 ± 0.024
0.535GlnTrp: 0.535 ± 0.012
1.018GlnTyr: 1.018 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
5.453ArgAla: 5.453 ± 0.041
0.857ArgCys: 0.857 ± 0.016
4.003ArgAsp: 4.003 ± 0.044
4.381ArgGlu: 4.381 ± 0.043
2.296ArgPhe: 2.296 ± 0.024
4.514ArgGly: 4.514 ± 0.04
2.021ArgHis: 2.021 ± 0.023
2.938ArgIle: 2.938 ± 0.025
3.472ArgLys: 3.472 ± 0.035
6.09ArgLeu: 6.09 ± 0.039
1.432ArgMet: 1.432 ± 0.019
2.367ArgAsn: 2.367 ± 0.023
4.488ArgPro: 4.488 ± 0.037
2.931ArgGln: 2.931 ± 0.028
6.498ArgArg: 6.498 ± 0.054
5.297ArgSer: 5.297 ± 0.049
3.746ArgThr: 3.746 ± 0.03
3.778ArgVal: 3.778 ± 0.028
1.012ArgTrp: 1.012 ± 0.016
1.707ArgTyr: 1.707 ± 0.02
0.0ArgXaa: 0.0 ± 0.0
Ser
6.928SerAla: 6.928 ± 0.044
0.932SerCys: 0.932 ± 0.015
4.145SerAsp: 4.145 ± 0.033
3.89SerGlu: 3.89 ± 0.036
2.925SerPhe: 2.925 ± 0.026
5.666SerGly: 5.666 ± 0.048
2.141SerHis: 2.141 ± 0.027
3.369SerIle: 3.369 ± 0.03
3.152SerLys: 3.152 ± 0.031
7.072SerLeu: 7.072 ± 0.053
1.609SerMet: 1.609 ± 0.021
2.59SerAsn: 2.59 ± 0.025
6.183SerPro: 6.183 ± 0.052
3.208SerGln: 3.208 ± 0.031
5.746SerArg: 5.746 ± 0.048
9.354SerSer: 9.354 ± 0.081
5.264SerThr: 5.264 ± 0.043
4.557SerVal: 4.557 ± 0.033
1.074SerTrp: 1.074 ± 0.017
1.878SerTyr: 1.878 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
5.433ThrAla: 5.433 ± 0.039
0.766ThrCys: 0.766 ± 0.014
2.774ThrAsp: 2.774 ± 0.029
2.993ThrGlu: 2.993 ± 0.032
2.045ThrPhe: 2.045 ± 0.02
4.194ThrGly: 4.194 ± 0.035
1.347ThrHis: 1.347 ± 0.02
2.675ThrIle: 2.675 ± 0.024
2.379ThrLys: 2.379 ± 0.027
4.952ThrLeu: 4.952 ± 0.04
1.164ThrMet: 1.164 ± 0.016
1.917ThrAsn: 1.917 ± 0.026
4.544ThrPro: 4.544 ± 0.044
2.011ThrGln: 2.011 ± 0.021
3.624ThrArg: 3.624 ± 0.027
5.261ThrSer: 5.261 ± 0.04
4.574ThrThr: 4.574 ± 0.054
3.576ThrVal: 3.576 ± 0.032
0.824ThrTrp: 0.824 ± 0.014
1.461ThrTyr: 1.461 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.621ValAla: 5.621 ± 0.038
0.833ValCys: 0.833 ± 0.014
3.77ValAsp: 3.77 ± 0.031
3.873ValGlu: 3.873 ± 0.033
2.408ValPhe: 2.408 ± 0.027
4.14ValGly: 4.14 ± 0.036
1.505ValHis: 1.505 ± 0.019
2.616ValIle: 2.616 ± 0.027
2.576ValLys: 2.576 ± 0.027
5.721ValLeu: 5.721 ± 0.044
1.266ValMet: 1.266 ± 0.015
1.986ValAsn: 1.986 ± 0.023
3.956ValPro: 3.956 ± 0.033
2.288ValGln: 2.288 ± 0.022
3.992ValArg: 3.992 ± 0.032
4.637ValSer: 4.637 ± 0.032
3.424ValThr: 3.424 ± 0.029
4.609ValVal: 4.609 ± 0.041
0.874ValTrp: 0.874 ± 0.015
1.604ValTyr: 1.604 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
1.151TrpAla: 1.151 ± 0.016
0.198TrpCys: 0.198 ± 0.007
0.924TrpAsp: 0.924 ± 0.017
0.839TrpGlu: 0.839 ± 0.014
0.528TrpPhe: 0.528 ± 0.011
0.909TrpGly: 0.909 ± 0.016
0.371TrpHis: 0.371 ± 0.01
0.617TrpIle: 0.617 ± 0.012
0.687TrpLys: 0.687 ± 0.012
1.298TrpLeu: 1.298 ± 0.018
0.36TrpMet: 0.36 ± 0.009
0.535TrpAsn: 0.535 ± 0.012
0.656TrpPro: 0.656 ± 0.013
0.52TrpGln: 0.52 ± 0.012
1.024TrpArg: 1.024 ± 0.016
1.004TrpSer: 1.004 ± 0.016
0.883TrpThr: 0.883 ± 0.015
0.873TrpVal: 0.873 ± 0.014
0.262TrpTrp: 0.262 ± 0.008
0.386TrpTyr: 0.386 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.01TyrAla: 2.01 ± 0.021
0.382TyrCys: 0.382 ± 0.009
1.561TyrAsp: 1.561 ± 0.02
1.414TyrGlu: 1.414 ± 0.019
1.066TyrPhe: 1.066 ± 0.018
1.952TyrGly: 1.952 ± 0.023
0.763TyrHis: 0.763 ± 0.013
1.175TyrIle: 1.175 ± 0.02
0.91TyrLys: 0.91 ± 0.015
2.444TyrLeu: 2.444 ± 0.023
0.544TyrMet: 0.544 ± 0.011
0.91TyrAsn: 0.91 ± 0.015
1.481TyrPro: 1.481 ± 0.022
0.98TyrGln: 0.98 ± 0.019
1.677TyrArg: 1.677 ± 0.021
1.757TyrSer: 1.757 ± 0.024
1.375TyrThr: 1.375 ± 0.018
1.549TyrVal: 1.549 ± 0.02
0.391TyrTrp: 0.391 ± 0.011
0.81TyrTyr: 0.81 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9397 proteins (4378554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski