Amino acid dipepetide frequency for Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1) (Peptococcus heliotrinreducens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.588AlaAla: 13.588 ± 0.205
2.032AlaCys: 2.032 ± 0.052
7.148AlaAsp: 7.148 ± 0.107
7.657AlaGlu: 7.657 ± 0.143
4.272AlaPhe: 4.272 ± 0.1
8.186AlaGly: 8.186 ± 0.109
1.847AlaHis: 1.847 ± 0.043
5.569AlaIle: 5.569 ± 0.091
4.395AlaLys: 4.395 ± 0.091
9.811AlaLeu: 9.811 ± 0.106
3.399AlaMet: 3.399 ± 0.063
3.197AlaAsn: 3.197 ± 0.059
3.856AlaPro: 3.856 ± 0.083
3.699AlaGln: 3.699 ± 0.076
5.433AlaArg: 5.433 ± 0.106
6.09AlaSer: 6.09 ± 0.091
5.371AlaThr: 5.371 ± 0.111
8.072AlaVal: 8.072 ± 0.112
1.186AlaTrp: 1.186 ± 0.045
3.173AlaTyr: 3.173 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.61CysAla: 1.61 ± 0.051
0.296CysCys: 0.296 ± 0.02
1.006CysAsp: 1.006 ± 0.035
1.024CysGlu: 1.024 ± 0.035
0.537CysPhe: 0.537 ± 0.028
1.823CysGly: 1.823 ± 0.051
0.36CysHis: 0.36 ± 0.024
0.985CysIle: 0.985 ± 0.036
0.572CysLys: 0.572 ± 0.026
1.317CysLeu: 1.317 ± 0.039
0.473CysMet: 0.473 ± 0.026
0.508CysAsn: 0.508 ± 0.027
0.917CysPro: 0.917 ± 0.044
0.418CysGln: 0.418 ± 0.023
0.841CysArg: 0.841 ± 0.031
0.938CysSer: 0.938 ± 0.035
0.952CysThr: 0.952 ± 0.033
1.296CysVal: 1.296 ± 0.045
0.174CysTrp: 0.174 ± 0.012
0.455CysTyr: 0.455 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
7.515AspAla: 7.515 ± 0.109
0.84AspCys: 0.84 ± 0.034
4.391AspAsp: 4.391 ± 0.081
5.67AspGlu: 5.67 ± 0.097
2.546AspPhe: 2.546 ± 0.054
5.83AspGly: 5.83 ± 0.094
1.05AspHis: 1.05 ± 0.038
3.486AspIle: 3.486 ± 0.061
2.285AspLys: 2.285 ± 0.06
5.384AspLeu: 5.384 ± 0.084
1.987AspMet: 1.987 ± 0.052
1.778AspAsn: 1.778 ± 0.053
2.985AspPro: 2.985 ± 0.066
1.625AspGln: 1.625 ± 0.045
3.261AspArg: 3.261 ± 0.074
3.104AspSer: 3.104 ± 0.068
3.154AspThr: 3.154 ± 0.064
5.253AspVal: 5.253 ± 0.072
0.859AspTrp: 0.859 ± 0.031
2.221AspTyr: 2.221 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
7.554GluAla: 7.554 ± 0.116
0.89GluCys: 0.89 ± 0.03
4.228GluAsp: 4.228 ± 0.074
4.914GluGlu: 4.914 ± 0.102
2.362GluPhe: 2.362 ± 0.049
5.446GluGly: 5.446 ± 0.084
1.49GluHis: 1.49 ± 0.048
3.361GluIle: 3.361 ± 0.073
2.927GluLys: 2.927 ± 0.057
6.267GluLeu: 6.267 ± 0.099
1.939GluMet: 1.939 ± 0.044
2.551GluAsn: 2.551 ± 0.062
3.013GluPro: 3.013 ± 0.094
2.51GluGln: 2.51 ± 0.064
4.287GluArg: 4.287 ± 0.088
3.725GluSer: 3.725 ± 0.069
3.74GluThr: 3.74 ± 0.066
4.531GluVal: 4.531 ± 0.081
0.792GluTrp: 0.792 ± 0.033
2.289GluTyr: 2.289 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
4.111PheAla: 4.111 ± 0.075
0.767PheCys: 0.767 ± 0.025
3.135PheAsp: 3.135 ± 0.066
2.718PheGlu: 2.718 ± 0.05
1.443PhePhe: 1.443 ± 0.048
3.519PheGly: 3.519 ± 0.061
0.61PheHis: 0.61 ± 0.026
1.887PheIle: 1.887 ± 0.054
1.35PheLys: 1.35 ± 0.041
3.04PheLeu: 3.04 ± 0.068
1.179PheMet: 1.179 ± 0.039
1.327PheAsn: 1.327 ± 0.039
1.296PhePro: 1.296 ± 0.042
0.85PheGln: 0.85 ± 0.031
1.568PheArg: 1.568 ± 0.046
2.334PheSer: 2.334 ± 0.056
2.161PheThr: 2.161 ± 0.058
3.18PheVal: 3.18 ± 0.061
0.458PheTrp: 0.458 ± 0.023
1.287PheTyr: 1.287 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
7.415GlyAla: 7.415 ± 0.114
1.583GlyCys: 1.583 ± 0.041
4.511GlyAsp: 4.511 ± 0.079
5.021GlyGlu: 5.021 ± 0.075
3.467GlyPhe: 3.467 ± 0.064
6.08GlyGly: 6.08 ± 0.128
1.552GlyHis: 1.552 ± 0.045
5.063GlyIle: 5.063 ± 0.077
3.786GlyLys: 3.786 ± 0.057
6.859GlyLeu: 6.859 ± 0.097
2.611GlyMet: 2.611 ± 0.058
2.729GlyAsn: 2.729 ± 0.066
2.245GlyPro: 2.245 ± 0.054
2.224GlyGln: 2.224 ± 0.047
4.198GlyArg: 4.198 ± 0.076
4.89GlySer: 4.89 ± 0.097
5.01GlyThr: 5.01 ± 0.137
6.274GlyVal: 6.274 ± 0.105
1.234GlyTrp: 1.234 ± 0.058
3.101GlyTyr: 3.101 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.997HisAla: 1.997 ± 0.05
0.346HisCys: 0.346 ± 0.019
1.273HisAsp: 1.273 ± 0.041
1.176HisGlu: 1.176 ± 0.036
0.742HisPhe: 0.742 ± 0.032
1.584HisGly: 1.584 ± 0.042
0.407HisHis: 0.407 ± 0.03
1.085HisIle: 1.085 ± 0.036
0.576HisLys: 0.576 ± 0.026
1.528HisLeu: 1.528 ± 0.047
0.557HisMet: 0.557 ± 0.023
0.58HisAsn: 0.58 ± 0.024
1.03HisPro: 1.03 ± 0.032
0.448HisGln: 0.448 ± 0.023
1.017HisArg: 1.017 ± 0.035
0.921HisSer: 0.921 ± 0.037
0.955HisThr: 0.955 ± 0.032
1.573HisVal: 1.573 ± 0.042
0.2HisTrp: 0.2 ± 0.015
0.627HisTyr: 0.627 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.185IleAla: 6.185 ± 0.095
0.968IleCys: 0.968 ± 0.032
4.047IleAsp: 4.047 ± 0.07
3.872IleGlu: 3.872 ± 0.069
1.498IlePhe: 1.498 ± 0.047
4.412IleGly: 4.412 ± 0.085
0.876IleHis: 0.876 ± 0.032
2.781IleIle: 2.781 ± 0.062
1.904IleLys: 1.904 ± 0.05
4.237IleLeu: 4.237 ± 0.087
1.467IleMet: 1.467 ± 0.045
1.682IleAsn: 1.682 ± 0.05
2.527IlePro: 2.527 ± 0.055
1.368IleGln: 1.368 ± 0.043
2.712IleArg: 2.712 ± 0.061
2.992IleSer: 2.992 ± 0.054
3.005IleThr: 3.005 ± 0.079
4.685IleVal: 4.685 ± 0.084
0.482IleTrp: 0.482 ± 0.026
1.382IleTyr: 1.382 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.436LysAla: 4.436 ± 0.079
0.498LysCys: 0.498 ± 0.024
2.434LysAsp: 2.434 ± 0.053
2.498LysGlu: 2.498 ± 0.061
1.135LysPhe: 1.135 ± 0.036
2.926LysGly: 2.926 ± 0.066
0.834LysHis: 0.834 ± 0.032
1.791LysIle: 1.791 ± 0.051
2.215LysLys: 2.215 ± 0.056
3.51LysLeu: 3.51 ± 0.061
1.127LysMet: 1.127 ± 0.041
1.551LysAsn: 1.551 ± 0.045
1.895LysPro: 1.895 ± 0.044
1.334LysGln: 1.334 ± 0.041
2.803LysArg: 2.803 ± 0.051
2.257LysSer: 2.257 ± 0.051
2.519LysThr: 2.519 ± 0.059
3.035LysVal: 3.035 ± 0.07
0.483LysTrp: 0.483 ± 0.029
1.182LysTyr: 1.182 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
9.854LeuAla: 9.854 ± 0.128
1.416LeuCys: 1.416 ± 0.04
5.674LeuAsp: 5.674 ± 0.085
5.814LeuGlu: 5.814 ± 0.089
3.389LeuPhe: 3.389 ± 0.075
6.753LeuGly: 6.753 ± 0.106
1.607LeuHis: 1.607 ± 0.049
4.294LeuIle: 4.294 ± 0.085
3.558LeuLys: 3.558 ± 0.076
7.538LeuLeu: 7.538 ± 0.122
2.469LeuMet: 2.469 ± 0.054
2.627LeuAsn: 2.627 ± 0.055
4.056LeuPro: 4.056 ± 0.069
2.375LeuGln: 2.375 ± 0.049
4.698LeuArg: 4.698 ± 0.087
5.571LeuSer: 5.571 ± 0.091
4.836LeuThr: 4.836 ± 0.105
7.02LeuVal: 7.02 ± 0.091
0.854LeuTrp: 0.854 ± 0.032
2.485LeuTyr: 2.485 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
3.253MetAla: 3.253 ± 0.066
0.468MetCys: 0.468 ± 0.023
1.827MetAsp: 1.827 ± 0.043
1.659MetGlu: 1.659 ± 0.043
1.057MetPhe: 1.057 ± 0.038
2.294MetGly: 2.294 ± 0.055
0.597MetHis: 0.597 ± 0.026
1.255MetIle: 1.255 ± 0.037
1.298MetLys: 1.298 ± 0.042
2.816MetLeu: 2.816 ± 0.058
0.8MetMet: 0.8 ± 0.034
1.056MetAsn: 1.056 ± 0.04
1.639MetPro: 1.639 ± 0.041
0.968MetGln: 0.968 ± 0.036
1.803MetArg: 1.803 ± 0.048
1.726MetSer: 1.726 ± 0.048
1.734MetThr: 1.734 ± 0.046
2.103MetVal: 2.103 ± 0.056
0.254MetTrp: 0.254 ± 0.017
0.762MetTyr: 0.762 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.639AsnAla: 3.639 ± 0.07
0.5AsnCys: 0.5 ± 0.027
2.069AsnAsp: 2.069 ± 0.052
1.967AsnGlu: 1.967 ± 0.045
0.988AsnPhe: 0.988 ± 0.036
2.886AsnGly: 2.886 ± 0.077
0.61AsnHis: 0.61 ± 0.028
1.72AsnIle: 1.72 ± 0.043
1.123AsnLys: 1.123 ± 0.037
2.69AsnLeu: 2.69 ± 0.065
0.95AsnMet: 0.95 ± 0.034
1.108AsnAsn: 1.108 ± 0.043
2.121AsnPro: 2.121 ± 0.054
0.938AsnGln: 0.938 ± 0.036
1.812AsnArg: 1.812 ± 0.049
1.611AsnSer: 1.611 ± 0.051
1.779AsnThr: 1.779 ± 0.054
2.746AsnVal: 2.746 ± 0.061
0.392AsnTrp: 0.392 ± 0.019
1.035AsnTyr: 1.035 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
4.479ProAla: 4.479 ± 0.086
0.565ProCys: 0.565 ± 0.025
3.051ProAsp: 3.051 ± 0.068
4.057ProGlu: 4.057 ± 0.085
1.69ProPhe: 1.69 ± 0.048
3.077ProGly: 3.077 ± 0.066
0.787ProHis: 0.787 ± 0.03
2.014ProIle: 2.014 ± 0.048
1.743ProLys: 1.743 ± 0.045
3.444ProLeu: 3.444 ± 0.068
1.064ProMet: 1.064 ± 0.033
1.413ProAsn: 1.413 ± 0.04
1.076ProPro: 1.076 ± 0.038
1.556ProGln: 1.556 ± 0.055
1.845ProArg: 1.845 ± 0.046
2.443ProSer: 2.443 ± 0.056
2.265ProThr: 2.265 ± 0.05
3.566ProVal: 3.566 ± 0.068
0.508ProTrp: 0.508 ± 0.023
1.593ProTyr: 1.593 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.648GlnAla: 3.648 ± 0.073
0.343GlnCys: 0.343 ± 0.018
1.654GlnAsp: 1.654 ± 0.046
1.944GlnGlu: 1.944 ± 0.05
1.018GlnPhe: 1.018 ± 0.033
2.248GlnGly: 2.248 ± 0.05
0.541GlnHis: 0.541 ± 0.027
1.554GlnIle: 1.554 ± 0.039
1.264GlnLys: 1.264 ± 0.041
2.616GlnLeu: 2.616 ± 0.055
0.943GlnMet: 0.943 ± 0.034
1.001GlnAsn: 1.001 ± 0.033
1.316GlnPro: 1.316 ± 0.051
1.253GlnGln: 1.253 ± 0.049
1.826GlnArg: 1.826 ± 0.048
1.573GlnSer: 1.573 ± 0.045
1.802GlnThr: 1.802 ± 0.054
2.442GlnVal: 2.442 ± 0.052
0.356GlnTrp: 0.356 ± 0.017
0.912GlnTyr: 0.912 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
5.02ArgAla: 5.02 ± 0.096
0.823ArgCys: 0.823 ± 0.032
3.204ArgAsp: 3.204 ± 0.077
3.823ArgGlu: 3.823 ± 0.079
2.282ArgPhe: 2.282 ± 0.052
3.628ArgGly: 3.628 ± 0.071
1.147ArgHis: 1.147 ± 0.033
3.604ArgIle: 3.604 ± 0.069
2.6ArgLys: 2.6 ± 0.058
4.831ArgLeu: 4.831 ± 0.1
1.937ArgMet: 1.937 ± 0.046
1.96ArgAsn: 1.96 ± 0.052
2.029ArgPro: 2.029 ± 0.05
1.676ArgGln: 1.676 ± 0.047
3.607ArgArg: 3.607 ± 0.08
2.917ArgSer: 2.917 ± 0.07
2.924ArgThr: 2.924 ± 0.056
3.738ArgVal: 3.738 ± 0.067
0.555ArgTrp: 0.555 ± 0.028
1.802ArgTyr: 1.802 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.592SerAla: 5.592 ± 0.089
0.938SerCys: 0.938 ± 0.038
3.65SerAsp: 3.65 ± 0.064
3.565SerGlu: 3.565 ± 0.074
2.447SerPhe: 2.447 ± 0.059
5.208SerGly: 5.208 ± 0.095
1.069SerHis: 1.069 ± 0.036
3.111SerIle: 3.111 ± 0.066
2.258SerLys: 2.258 ± 0.06
4.822SerLeu: 4.822 ± 0.09
1.69SerMet: 1.69 ± 0.049
1.833SerAsn: 1.833 ± 0.052
2.104SerPro: 2.104 ± 0.05
1.797SerGln: 1.797 ± 0.049
3.09SerArg: 3.09 ± 0.068
3.601SerSer: 3.601 ± 0.109
2.996SerThr: 2.996 ± 0.067
4.325SerVal: 4.325 ± 0.071
0.767SerTrp: 0.767 ± 0.027
2.045SerTyr: 2.045 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
5.406ThrAla: 5.406 ± 0.123
0.975ThrCys: 0.975 ± 0.034
3.423ThrAsp: 3.423 ± 0.082
3.299ThrGlu: 3.299 ± 0.075
2.31ThrPhe: 2.31 ± 0.057
4.803ThrGly: 4.803 ± 0.089
1.041ThrHis: 1.041 ± 0.034
3.12ThrIle: 3.12 ± 0.082
2.062ThrLys: 2.062 ± 0.064
4.774ThrLeu: 4.774 ± 0.086
1.454ThrMet: 1.454 ± 0.043
1.691ThrAsn: 1.691 ± 0.075
2.879ThrPro: 2.879 ± 0.055
1.629ThrGln: 1.629 ± 0.042
2.542ThrArg: 2.542 ± 0.067
3.055ThrSer: 3.055 ± 0.072
3.05ThrThr: 3.05 ± 0.087
5.077ThrVal: 5.077 ± 0.122
0.758ThrTrp: 0.758 ± 0.03
2.001ThrTyr: 2.001 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
8.469ValAla: 8.469 ± 0.126
1.475ValCys: 1.475 ± 0.041
5.271ValAsp: 5.271 ± 0.085
5.251ValGlu: 5.251 ± 0.082
3.283ValPhe: 3.283 ± 0.075
5.577ValGly: 5.577 ± 0.084
1.304ValHis: 1.304 ± 0.046
4.214ValIle: 4.214 ± 0.082
2.955ValLys: 2.955 ± 0.062
7.305ValLeu: 7.305 ± 0.11
2.163ValMet: 2.163 ± 0.049
2.498ValAsn: 2.498 ± 0.057
3.5ValPro: 3.5 ± 0.072
2.119ValGln: 2.119 ± 0.053
4.22ValArg: 4.22 ± 0.076
4.827ValSer: 4.827 ± 0.077
4.509ValThr: 4.509 ± 0.156
6.896ValVal: 6.896 ± 0.124
0.851ValTrp: 0.851 ± 0.032
2.395ValTyr: 2.395 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.968TrpAla: 0.968 ± 0.037
0.25TrpCys: 0.25 ± 0.017
0.718TrpAsp: 0.718 ± 0.032
0.739TrpGlu: 0.739 ± 0.031
0.473TrpPhe: 0.473 ± 0.025
0.844TrpGly: 0.844 ± 0.036
0.27TrpHis: 0.27 ± 0.016
0.636TrpIle: 0.636 ± 0.027
0.48TrpLys: 0.48 ± 0.026
1.174TrpLeu: 1.174 ± 0.04
0.379TrpMet: 0.379 ± 0.019
0.463TrpAsn: 0.463 ± 0.026
0.385TrpPro: 0.385 ± 0.021
0.494TrpGln: 0.494 ± 0.028
0.676TrpArg: 0.676 ± 0.028
0.59TrpSer: 0.59 ± 0.026
0.648TrpThr: 0.648 ± 0.033
0.859TrpVal: 0.859 ± 0.038
0.157TrpTrp: 0.157 ± 0.015
0.525TrpTyr: 0.525 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.242TyrAla: 3.242 ± 0.063
0.53TyrCys: 0.53 ± 0.024
2.508TyrAsp: 2.508 ± 0.077
2.151TyrGlu: 2.151 ± 0.046
1.283TyrPhe: 1.283 ± 0.045
2.726TyrGly: 2.726 ± 0.054
0.624TyrHis: 0.624 ± 0.027
1.551TyrIle: 1.551 ± 0.042
1.113TyrLys: 1.113 ± 0.031
2.929TyrLeu: 2.929 ± 0.061
0.779TyrMet: 0.779 ± 0.03
1.128TyrAsn: 1.128 ± 0.043
1.368TyrPro: 1.368 ± 0.039
0.972TyrGln: 0.972 ± 0.036
1.869TyrArg: 1.869 ± 0.05
1.741TyrSer: 1.741 ± 0.048
1.937TyrThr: 1.937 ± 0.072
2.414TyrVal: 2.414 ± 0.048
0.408TyrTrp: 0.408 ± 0.024
1.362TyrTyr: 1.362 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2750 proteins (898832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski