Amino acid dipepetide frequency for Raspberry latent virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.982AlaAla: 2.982 ± 0.733
1.262AlaCys: 1.262 ± 0.286
2.982AlaAsp: 2.982 ± 0.371
3.785AlaGlu: 3.785 ± 0.498
2.179AlaPhe: 2.179 ± 0.448
3.441AlaGly: 3.441 ± 0.562
1.606AlaHis: 1.606 ± 0.296
4.244AlaIle: 4.244 ± 0.582
2.523AlaLys: 2.523 ± 0.407
5.735AlaLeu: 5.735 ± 0.831
1.72AlaMet: 1.72 ± 0.362
3.211AlaAsn: 3.211 ± 0.295
1.72AlaPro: 1.72 ± 0.274
2.294AlaGln: 2.294 ± 0.488
4.932AlaArg: 4.932 ± 0.601
5.62AlaSer: 5.62 ± 0.632
2.982AlaThr: 2.982 ± 0.6
3.9AlaVal: 3.9 ± 0.702
1.032AlaTrp: 1.032 ± 0.293
2.179AlaTyr: 2.179 ± 0.529
0.0AlaXaa: 0.0 ± 0.0
Cys
1.376CysAla: 1.376 ± 0.425
0.573CysCys: 0.573 ± 0.244
0.918CysAsp: 0.918 ± 0.258
1.835CysGlu: 1.835 ± 0.463
1.376CysPhe: 1.376 ± 0.439
1.376CysGly: 1.376 ± 0.323
0.229CysHis: 0.229 ± 0.173
0.688CysIle: 0.688 ± 0.241
0.459CysLys: 0.459 ± 0.173
0.918CysLeu: 0.918 ± 0.225
0.344CysMet: 0.344 ± 0.181
0.803CysAsn: 0.803 ± 0.273
0.918CysPro: 0.918 ± 0.269
0.573CysGln: 0.573 ± 0.23
0.803CysArg: 0.803 ± 0.274
1.491CysSer: 1.491 ± 0.539
0.688CysThr: 0.688 ± 0.302
1.032CysVal: 1.032 ± 0.472
0.115CysTrp: 0.115 ± 0.118
0.688CysTyr: 0.688 ± 0.498
0.0CysXaa: 0.0 ± 0.0
Asp
2.294AspAla: 2.294 ± 0.579
0.803AspCys: 0.803 ± 0.25
3.326AspAsp: 3.326 ± 0.828
3.441AspGlu: 3.441 ± 0.571
2.179AspPhe: 2.179 ± 0.632
3.441AspGly: 3.441 ± 0.623
1.262AspHis: 1.262 ± 0.265
3.326AspIle: 3.326 ± 0.518
2.638AspLys: 2.638 ± 0.506
5.62AspLeu: 5.62 ± 0.819
1.262AspMet: 1.262 ± 0.198
1.491AspAsn: 1.491 ± 0.347
3.326AspPro: 3.326 ± 0.594
3.441AspGln: 3.441 ± 0.752
2.523AspArg: 2.523 ± 0.483
4.244AspSer: 4.244 ± 0.839
2.982AspThr: 2.982 ± 0.563
4.244AspVal: 4.244 ± 0.708
0.459AspTrp: 0.459 ± 0.207
2.294AspTyr: 2.294 ± 0.234
0.0AspXaa: 0.0 ± 0.0
Glu
4.702GluAla: 4.702 ± 0.809
0.688GluCys: 0.688 ± 0.186
3.9GluAsp: 3.9 ± 0.645
4.014GluGlu: 4.014 ± 0.76
2.523GluPhe: 2.523 ± 0.339
4.129GluGly: 4.129 ± 0.811
0.803GluHis: 0.803 ± 0.29
4.358GluIle: 4.358 ± 0.675
2.753GluLys: 2.753 ± 0.59
5.046GluLeu: 5.046 ± 0.746
1.72GluMet: 1.72 ± 0.656
2.064GluAsn: 2.064 ± 0.504
2.523GluPro: 2.523 ± 0.725
2.179GluGln: 2.179 ± 0.436
3.9GluArg: 3.9 ± 0.814
3.097GluSer: 3.097 ± 0.731
2.982GluThr: 2.982 ± 0.508
5.276GluVal: 5.276 ± 0.769
0.459GluTrp: 0.459 ± 0.249
2.523GluTyr: 2.523 ± 0.491
0.0GluXaa: 0.0 ± 0.0
Phe
2.064PheAla: 2.064 ± 0.45
1.032PheCys: 1.032 ± 0.275
2.179PheAsp: 2.179 ± 0.412
2.982PheGlu: 2.982 ± 0.352
0.688PhePhe: 0.688 ± 0.194
2.753PheGly: 2.753 ± 0.608
1.606PheHis: 1.606 ± 0.347
1.491PheIle: 1.491 ± 0.267
2.179PheLys: 2.179 ± 0.574
3.441PheLeu: 3.441 ± 0.616
0.688PheMet: 0.688 ± 0.178
2.867PheAsn: 2.867 ± 0.522
1.95PhePro: 1.95 ± 0.532
2.294PheGln: 2.294 ± 0.409
1.376PheArg: 1.376 ± 0.386
3.785PheSer: 3.785 ± 0.481
4.129PheThr: 4.129 ± 0.546
2.294PheVal: 2.294 ± 0.443
0.115PheTrp: 0.115 ± 0.107
1.032PheTyr: 1.032 ± 0.325
0.0PheXaa: 0.0 ± 0.0
Gly
3.67GlyAla: 3.67 ± 0.461
0.344GlyCys: 0.344 ± 0.188
3.441GlyAsp: 3.441 ± 0.78
5.276GlyGlu: 5.276 ± 0.572
1.95GlyPhe: 1.95 ± 0.456
2.523GlyGly: 2.523 ± 0.718
0.573GlyHis: 0.573 ± 0.237
4.244GlyIle: 4.244 ± 0.662
2.523GlyLys: 2.523 ± 0.704
5.505GlyLeu: 5.505 ± 0.911
2.294GlyMet: 2.294 ± 0.442
2.064GlyAsn: 2.064 ± 0.66
1.606GlyPro: 1.606 ± 0.376
1.491GlyGln: 1.491 ± 0.404
3.555GlyArg: 3.555 ± 0.641
3.67GlySer: 3.67 ± 0.641
4.817GlyThr: 4.817 ± 0.347
3.097GlyVal: 3.097 ± 0.488
0.688GlyTrp: 0.688 ± 0.226
1.95GlyTyr: 1.95 ± 0.252
0.0GlyXaa: 0.0 ± 0.0
His
1.147HisAla: 1.147 ± 0.291
0.344HisCys: 0.344 ± 0.175
0.803HisAsp: 0.803 ± 0.274
1.262HisGlu: 1.262 ± 0.4
0.459HisPhe: 0.459 ± 0.235
1.147HisGly: 1.147 ± 0.329
0.688HisHis: 0.688 ± 0.301
0.918HisIle: 0.918 ± 0.319
0.344HisLys: 0.344 ± 0.154
1.835HisLeu: 1.835 ± 0.409
0.573HisMet: 0.573 ± 0.205
0.573HisAsn: 0.573 ± 0.256
2.179HisPro: 2.179 ± 0.557
1.032HisGln: 1.032 ± 0.247
1.491HisArg: 1.491 ± 0.339
2.064HisSer: 2.064 ± 0.554
1.147HisThr: 1.147 ± 0.454
1.147HisVal: 1.147 ± 0.435
0.344HisTrp: 0.344 ± 0.162
0.918HisTyr: 0.918 ± 0.257
0.0HisXaa: 0.0 ± 0.0
Ile
3.211IleAla: 3.211 ± 0.526
1.606IleCys: 1.606 ± 0.211
2.523IleAsp: 2.523 ± 0.334
2.179IleGlu: 2.179 ± 0.393
2.523IlePhe: 2.523 ± 0.466
3.785IleGly: 3.785 ± 0.5
1.376IleHis: 1.376 ± 0.232
3.785IleIle: 3.785 ± 0.6
2.523IleLys: 2.523 ± 0.411
6.193IleLeu: 6.193 ± 0.473
1.262IleMet: 1.262 ± 0.41
3.555IleAsn: 3.555 ± 0.429
5.046IlePro: 5.046 ± 0.547
2.179IleGln: 2.179 ± 0.517
3.9IleArg: 3.9 ± 0.628
4.473IleSer: 4.473 ± 0.81
3.785IleThr: 3.785 ± 0.573
4.129IleVal: 4.129 ± 0.575
0.918IleTrp: 0.918 ± 0.331
2.409IleTyr: 2.409 ± 0.462
0.0IleXaa: 0.0 ± 0.0
Lys
3.555LysAla: 3.555 ± 0.842
0.688LysCys: 0.688 ± 0.327
2.638LysAsp: 2.638 ± 0.503
1.835LysGlu: 1.835 ± 0.554
1.032LysPhe: 1.032 ± 0.285
2.523LysGly: 2.523 ± 0.68
0.918LysHis: 0.918 ± 0.283
4.129LysIle: 4.129 ± 0.429
2.638LysLys: 2.638 ± 0.649
3.785LysLeu: 3.785 ± 0.763
1.491LysMet: 1.491 ± 0.465
1.95LysAsn: 1.95 ± 0.409
2.294LysPro: 2.294 ± 0.498
1.376LysGln: 1.376 ± 0.431
2.294LysArg: 2.294 ± 0.376
2.867LysSer: 2.867 ± 0.849
2.753LysThr: 2.753 ± 0.391
4.473LysVal: 4.473 ± 0.74
0.918LysTrp: 0.918 ± 0.327
1.262LysTyr: 1.262 ± 0.361
0.0LysXaa: 0.0 ± 0.0
Leu
5.849LeuAla: 5.849 ± 1.008
1.147LeuCys: 1.147 ± 0.368
5.046LeuAsp: 5.046 ± 0.362
4.358LeuGlu: 4.358 ± 0.795
4.129LeuPhe: 4.129 ± 0.576
5.161LeuGly: 5.161 ± 0.689
1.72LeuHis: 1.72 ± 0.425
4.014LeuIle: 4.014 ± 0.473
5.046LeuLys: 5.046 ± 1.054
9.175LeuLeu: 9.175 ± 1.336
2.064LeuMet: 2.064 ± 0.517
2.982LeuAsn: 2.982 ± 0.339
5.62LeuPro: 5.62 ± 0.839
4.014LeuGln: 4.014 ± 0.946
6.079LeuArg: 6.079 ± 0.929
7.57LeuSer: 7.57 ± 1.0
5.505LeuThr: 5.505 ± 0.739
5.735LeuVal: 5.735 ± 0.704
0.688LeuTrp: 0.688 ± 0.32
2.523LeuTyr: 2.523 ± 0.415
0.0LeuXaa: 0.0 ± 0.0
Met
2.179MetAla: 2.179 ± 0.359
0.573MetCys: 0.573 ± 0.31
1.72MetAsp: 1.72 ± 0.585
1.491MetGlu: 1.491 ± 0.227
1.376MetPhe: 1.376 ± 0.373
0.459MetGly: 0.459 ± 0.209
0.229MetHis: 0.229 ± 0.122
1.376MetIle: 1.376 ± 0.376
0.918MetLys: 0.918 ± 0.261
2.638MetLeu: 2.638 ± 0.683
1.032MetMet: 1.032 ± 0.262
1.835MetAsn: 1.835 ± 0.46
0.918MetPro: 0.918 ± 0.344
0.688MetGln: 0.688 ± 0.207
2.179MetArg: 2.179 ± 0.323
2.179MetSer: 2.179 ± 0.433
1.95MetThr: 1.95 ± 0.569
2.867MetVal: 2.867 ± 0.47
0.573MetTrp: 0.573 ± 0.31
1.147MetTyr: 1.147 ± 0.352
0.0MetXaa: 0.0 ± 0.0
Asn
2.982AsnAla: 2.982 ± 0.6
0.918AsnCys: 0.918 ± 0.234
2.523AsnAsp: 2.523 ± 0.477
2.867AsnGlu: 2.867 ± 0.635
2.179AsnPhe: 2.179 ± 0.555
3.097AsnGly: 3.097 ± 0.713
1.262AsnHis: 1.262 ± 0.441
3.097AsnIle: 3.097 ± 0.547
1.72AsnLys: 1.72 ± 0.284
4.588AsnLeu: 4.588 ± 0.809
1.032AsnMet: 1.032 ± 0.335
0.803AsnAsn: 0.803 ± 0.188
3.555AsnPro: 3.555 ± 0.745
2.294AsnGln: 2.294 ± 0.369
2.638AsnArg: 2.638 ± 0.57
3.326AsnSer: 3.326 ± 0.487
2.409AsnThr: 2.409 ± 0.604
3.555AsnVal: 3.555 ± 0.557
0.344AsnTrp: 0.344 ± 0.165
1.835AsnTyr: 1.835 ± 0.579
0.0AsnXaa: 0.0 ± 0.0
Pro
2.753ProAla: 2.753 ± 0.565
0.688ProCys: 0.688 ± 0.362
3.097ProAsp: 3.097 ± 0.444
2.982ProGlu: 2.982 ± 0.581
2.638ProPhe: 2.638 ± 0.431
2.867ProGly: 2.867 ± 0.496
1.95ProHis: 1.95 ± 0.668
2.867ProIle: 2.867 ± 0.489
2.982ProLys: 2.982 ± 0.508
3.9ProLeu: 3.9 ± 0.62
1.147ProMet: 1.147 ± 0.344
3.441ProAsn: 3.441 ± 0.601
3.211ProPro: 3.211 ± 0.637
2.064ProGln: 2.064 ± 0.613
3.785ProArg: 3.785 ± 0.795
4.588ProSer: 4.588 ± 0.555
5.276ProThr: 5.276 ± 0.518
3.326ProVal: 3.326 ± 0.55
0.688ProTrp: 0.688 ± 0.26
1.262ProTyr: 1.262 ± 0.422
0.0ProXaa: 0.0 ± 0.0
Gln
2.753GlnAla: 2.753 ± 0.649
0.803GlnCys: 0.803 ± 0.182
2.179GlnAsp: 2.179 ± 0.52
1.95GlnGlu: 1.95 ± 0.31
1.491GlnPhe: 1.491 ± 0.367
2.294GlnGly: 2.294 ± 0.607
0.459GlnHis: 0.459 ± 0.293
3.211GlnIle: 3.211 ± 0.774
2.179GlnLys: 2.179 ± 0.462
2.982GlnLeu: 2.982 ± 0.821
1.376GlnMet: 1.376 ± 0.268
1.606GlnAsn: 1.606 ± 0.625
2.638GlnPro: 2.638 ± 0.541
1.032GlnGln: 1.032 ± 0.408
2.867GlnArg: 2.867 ± 0.632
4.014GlnSer: 4.014 ± 0.702
2.179GlnThr: 2.179 ± 0.39
3.211GlnVal: 3.211 ± 0.647
0.115GlnTrp: 0.115 ± 0.107
2.294GlnTyr: 2.294 ± 0.597
0.0GlnXaa: 0.0 ± 0.0
Arg
4.702ArgAla: 4.702 ± 0.724
0.918ArgCys: 0.918 ± 0.31
3.441ArgAsp: 3.441 ± 0.822
3.555ArgGlu: 3.555 ± 0.702
3.211ArgPhe: 3.211 ± 0.494
2.064ArgGly: 2.064 ± 0.531
1.262ArgHis: 1.262 ± 0.309
4.014ArgIle: 4.014 ± 0.452
2.867ArgLys: 2.867 ± 0.431
4.588ArgLeu: 4.588 ± 0.559
1.95ArgMet: 1.95 ± 0.622
3.326ArgAsn: 3.326 ± 1.112
2.064ArgPro: 2.064 ± 0.445
2.064ArgGln: 2.064 ± 0.532
4.244ArgArg: 4.244 ± 0.607
5.161ArgSer: 5.161 ± 0.796
3.097ArgThr: 3.097 ± 0.592
4.244ArgVal: 4.244 ± 0.493
1.147ArgTrp: 1.147 ± 0.4
2.294ArgTyr: 2.294 ± 0.435
0.0ArgXaa: 0.0 ± 0.0
Ser
3.9SerAla: 3.9 ± 0.766
2.294SerCys: 2.294 ± 0.464
5.62SerAsp: 5.62 ± 0.514
5.391SerGlu: 5.391 ± 0.935
3.211SerPhe: 3.211 ± 0.526
4.244SerGly: 4.244 ± 0.591
1.376SerHis: 1.376 ± 0.54
5.62SerIle: 5.62 ± 0.674
2.982SerLys: 2.982 ± 0.85
6.308SerLeu: 6.308 ± 0.685
2.753SerMet: 2.753 ± 0.512
4.244SerAsn: 4.244 ± 0.691
3.785SerPro: 3.785 ± 0.479
3.211SerGln: 3.211 ± 0.775
4.817SerArg: 4.817 ± 0.738
9.634SerSer: 9.634 ± 2.275
5.62SerThr: 5.62 ± 0.491
5.735SerVal: 5.735 ± 0.645
1.491SerTrp: 1.491 ± 0.399
1.95SerTyr: 1.95 ± 0.451
0.0SerXaa: 0.0 ± 0.0
Thr
4.129ThrAla: 4.129 ± 0.949
0.573ThrCys: 0.573 ± 0.36
1.95ThrAsp: 1.95 ± 0.429
3.211ThrGlu: 3.211 ± 0.523
3.211ThrPhe: 3.211 ± 0.78
3.67ThrGly: 3.67 ± 0.865
0.573ThrHis: 0.573 ± 0.269
3.67ThrIle: 3.67 ± 0.685
2.638ThrLys: 2.638 ± 0.606
5.62ThrLeu: 5.62 ± 1.033
1.262ThrMet: 1.262 ± 0.314
3.555ThrAsn: 3.555 ± 0.541
4.817ThrPro: 4.817 ± 0.743
2.523ThrGln: 2.523 ± 0.448
3.211ThrArg: 3.211 ± 0.511
6.308ThrSer: 6.308 ± 0.975
3.441ThrThr: 3.441 ± 0.793
4.244ThrVal: 4.244 ± 0.635
1.032ThrTrp: 1.032 ± 0.296
2.753ThrTyr: 2.753 ± 0.335
0.0ThrXaa: 0.0 ± 0.0
Val
3.555ValAla: 3.555 ± 0.657
1.147ValCys: 1.147 ± 0.386
4.014ValAsp: 4.014 ± 0.623
5.161ValGlu: 5.161 ± 0.701
2.638ValPhe: 2.638 ± 0.528
3.441ValGly: 3.441 ± 0.556
1.376ValHis: 1.376 ± 0.415
4.358ValIle: 4.358 ± 0.443
4.014ValLys: 4.014 ± 0.622
4.702ValLeu: 4.702 ± 0.754
2.867ValMet: 2.867 ± 0.65
3.67ValAsn: 3.67 ± 0.708
4.358ValPro: 4.358 ± 0.789
4.817ValGln: 4.817 ± 0.771
2.867ValArg: 2.867 ± 0.654
5.62ValSer: 5.62 ± 1.091
4.473ValThr: 4.473 ± 0.872
4.129ValVal: 4.129 ± 0.443
0.803ValTrp: 0.803 ± 0.252
1.262ValTyr: 1.262 ± 0.202
0.0ValXaa: 0.0 ± 0.0
Trp
0.573TrpAla: 0.573 ± 0.204
0.115TrpCys: 0.115 ± 0.103
0.573TrpAsp: 0.573 ± 0.219
0.803TrpGlu: 0.803 ± 0.328
0.344TrpPhe: 0.344 ± 0.249
0.688TrpGly: 0.688 ± 0.279
0.115TrpHis: 0.115 ± 0.107
0.688TrpIle: 0.688 ± 0.254
0.573TrpLys: 0.573 ± 0.134
1.606TrpLeu: 1.606 ± 0.482
0.573TrpMet: 0.573 ± 0.239
1.491TrpAsn: 1.491 ± 0.409
0.688TrpPro: 0.688 ± 0.182
0.344TrpGln: 0.344 ± 0.19
0.918TrpArg: 0.918 ± 0.181
0.573TrpSer: 0.573 ± 0.196
0.344TrpThr: 0.344 ± 0.195
0.573TrpVal: 0.573 ± 0.29
0.0TrpTrp: 0.0 ± 0.0
0.688TrpTyr: 0.688 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.95TyrAla: 1.95 ± 0.498
0.688TyrCys: 0.688 ± 0.282
1.72TyrAsp: 1.72 ± 0.457
1.262TyrGlu: 1.262 ± 0.349
1.606TyrPhe: 1.606 ± 0.319
2.294TyrGly: 2.294 ± 0.452
1.032TyrHis: 1.032 ± 0.294
1.262TyrIle: 1.262 ± 0.28
0.918TyrLys: 0.918 ± 0.25
4.244TyrLeu: 4.244 ± 0.389
0.803TyrMet: 0.803 ± 0.401
1.491TyrAsn: 1.491 ± 0.366
2.294TyrPro: 2.294 ± 0.538
1.72TyrGln: 1.72 ± 0.431
1.835TyrArg: 1.835 ± 0.508
3.9TyrSer: 3.9 ± 0.831
1.835TyrThr: 1.835 ± 0.348
2.064TyrVal: 2.064 ± 0.351
0.344TyrTrp: 0.344 ± 0.208
2.294TyrTyr: 2.294 ± 0.411
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (8720 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski