Amino acid dipepetide frequency for Lentibacter algarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.543AlaAla: 15.543 ± 0.198	1.125AlaCys: 1.125 ± 0.035	6.286AlaAsp: 6.286 ± 0.103	8.363AlaGlu: 8.363 ± 0.116	4.406AlaPhe: 4.406 ± 0.07	10.242AlaGly: 10.242 ± 0.136	2.394AlaHis: 2.394 ± 0.046	5.483AlaIle: 5.483 ± 0.083	4.755AlaLys: 4.755 ± 0.082	14.164AlaLeu: 14.164 ± 0.15	3.631AlaMet: 3.631 ± 0.061	2.942AlaAsn: 2.942 ± 0.064	5.316AlaPro: 5.316 ± 0.099	4.481AlaGln: 4.481 ± 0.075	7.768AlaArg: 7.768 ± 0.115	6.289AlaSer: 6.289 ± 0.079	5.851AlaThr: 5.851 ± 0.077	7.863AlaVal: 7.863 ± 0.1	1.314AlaTrp: 1.314 ± 0.037	2.718AlaTyr: 2.718 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.121CysAla: 1.121 ± 0.036	0.117CysCys: 0.117 ± 0.01	0.568CysAsp: 0.568 ± 0.026	0.54CysGlu: 0.54 ± 0.024	0.372CysPhe: 0.372 ± 0.019	0.915CysGly: 0.915 ± 0.037	0.276CysHis: 0.276 ± 0.017	0.419CysIle: 0.419 ± 0.02	0.279CysLys: 0.279 ± 0.017	0.889CysLeu: 0.889 ± 0.031	0.205CysMet: 0.205 ± 0.015	0.232CysAsn: 0.232 ± 0.015	0.464CysPro: 0.464 ± 0.024	0.241CysGln: 0.241 ± 0.018	0.447CysArg: 0.447 ± 0.019	0.5CysSer: 0.5 ± 0.024	0.449CysThr: 0.449 ± 0.021	0.629CysVal: 0.629 ± 0.028	0.091CysTrp: 0.091 ± 0.01	0.249CysTyr: 0.249 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.741AspAla: 6.741 ± 0.092	0.506AspCys: 0.506 ± 0.023	3.142AspAsp: 3.142 ± 0.114	3.628AspGlu: 3.628 ± 0.058	2.219AspPhe: 2.219 ± 0.047	5.073AspGly: 5.073 ± 0.105	1.167AspHis: 1.167 ± 0.036	3.373AspIle: 3.373 ± 0.067	2.032AspLys: 2.032 ± 0.041	5.481AspLeu: 5.481 ± 0.082	1.897AspMet: 1.897 ± 0.044	1.325AspAsn: 1.325 ± 0.035	2.802AspPro: 2.802 ± 0.061	1.623AspGln: 1.623 ± 0.043	2.97AspArg: 2.97 ± 0.059	2.188AspSer: 2.188 ± 0.07	3.119AspThr: 3.119 ± 0.115	4.518AspVal: 4.518 ± 0.068	1.016AspTrp: 1.016 ± 0.034	1.575AspTyr: 1.575 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	9.142GluAla: 9.142 ± 0.129	0.429GluCys: 0.429 ± 0.024	3.246GluAsp: 3.246 ± 0.066	4.034GluGlu: 4.034 ± 0.069	1.962GluPhe: 1.962 ± 0.045	5.311GluGly: 5.311 ± 0.071	1.337GluHis: 1.337 ± 0.034	3.852GluIle: 3.852 ± 0.07	2.498GluLys: 2.498 ± 0.058	5.847GluLeu: 5.847 ± 0.086	2.083GluMet: 2.083 ± 0.038	1.934GluAsn: 1.934 ± 0.05	2.485GluPro: 2.485 ± 0.06	2.099GluGln: 2.099 ± 0.052	4.553GluArg: 4.553 ± 0.074	2.505GluSer: 2.505 ± 0.055	3.903GluThr: 3.903 ± 0.064	4.314GluVal: 4.314 ± 0.071	0.704GluTrp: 0.704 ± 0.028	1.181GluTyr: 1.181 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.5PheAla: 4.5 ± 0.065	0.447PheCys: 0.447 ± 0.023	2.702PheAsp: 2.702 ± 0.06	2.717PheGlu: 2.717 ± 0.059	1.559PhePhe: 1.559 ± 0.043	3.821PheGly: 3.821 ± 0.063	0.723PheHis: 0.723 ± 0.028	1.812PheIle: 1.812 ± 0.049	1.264PheLys: 1.264 ± 0.038	3.484PheLeu: 3.484 ± 0.064	0.98PheMet: 0.98 ± 0.031	1.175PheAsn: 1.175 ± 0.038	1.492PhePro: 1.492 ± 0.041	1.1PheGln: 1.1 ± 0.035	1.856PheArg: 1.856 ± 0.049	2.358PheSer: 2.358 ± 0.047	2.12PheThr: 2.12 ± 0.05	2.879PheVal: 2.879 ± 0.056	0.587PheTrp: 0.587 ± 0.023	0.97PheTyr: 0.97 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.97GlyAla: 9.97 ± 0.115	0.862GlyCys: 0.862 ± 0.031	4.523GlyAsp: 4.523 ± 0.134	5.131GlyGlu: 5.131 ± 0.074	3.777GlyPhe: 3.777 ± 0.066	7.278GlyGly: 7.278 ± 0.144	1.905GlyHis: 1.905 ± 0.051	4.215GlyIle: 4.215 ± 0.071	3.579GlyLys: 3.579 ± 0.06	9.097GlyLeu: 9.097 ± 0.098	2.56GlyMet: 2.56 ± 0.056	2.258GlyAsn: 2.258 ± 0.085	3.223GlyPro: 3.223 ± 0.058	3.21GlyGln: 3.21 ± 0.061	5.024GlyArg: 5.024 ± 0.073	4.232GlySer: 4.232 ± 0.085	4.448GlyThr: 4.448 ± 0.074	6.316GlyVal: 6.316 ± 0.083	1.342GlyTrp: 1.342 ± 0.041	2.403GlyTyr: 2.403 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.263HisAla: 2.263 ± 0.06	0.223HisCys: 0.223 ± 0.016	1.217HisAsp: 1.217 ± 0.035	1.202HisGlu: 1.202 ± 0.04	0.908HisPhe: 0.908 ± 0.032	1.893HisGly: 1.893 ± 0.052	0.533HisHis: 0.533 ± 0.026	1.181HisIle: 1.181 ± 0.041	0.678HisLys: 0.678 ± 0.028	1.984HisLeu: 1.984 ± 0.045	0.583HisMet: 0.583 ± 0.025	0.543HisAsn: 0.543 ± 0.022	1.2HisPro: 1.2 ± 0.035	0.596HisGln: 0.596 ± 0.026	1.098HisArg: 1.098 ± 0.034	1.059HisSer: 1.059 ± 0.034	0.951HisThr: 0.951 ± 0.032	1.486HisVal: 1.486 ± 0.036	0.363HisTrp: 0.363 ± 0.018	0.563HisTyr: 0.563 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.716IleAla: 6.716 ± 0.096	0.662IleCys: 0.662 ± 0.025	3.328IleAsp: 3.328 ± 0.068	3.743IleGlu: 3.743 ± 0.062	1.826IlePhe: 1.826 ± 0.042	4.856IleGly: 4.856 ± 0.07	0.877IleHis: 0.877 ± 0.031	2.52IleIle: 2.52 ± 0.062	1.96IleLys: 1.96 ± 0.047	4.617IleLeu: 4.617 ± 0.068	1.316IleMet: 1.316 ± 0.037	1.629IleAsn: 1.629 ± 0.046	2.185IlePro: 2.185 ± 0.055	1.122IleGln: 1.122 ± 0.037	2.868IleArg: 2.868 ± 0.059	3.289IleSer: 3.289 ± 0.067	3.155IleThr: 3.155 ± 0.062	3.845IleVal: 3.845 ± 0.059	0.689IleTrp: 0.689 ± 0.028	1.229IleTyr: 1.229 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.936LysAla: 4.936 ± 0.071	0.213LysCys: 0.213 ± 0.015	2.156LysAsp: 2.156 ± 0.057	2.018LysGlu: 2.018 ± 0.056	1.188LysPhe: 1.188 ± 0.038	3.338LysGly: 3.338 ± 0.063	0.812LysHis: 0.812 ± 0.029	2.075LysIle: 2.075 ± 0.054	1.644LysLys: 1.644 ± 0.051	3.93LysLeu: 3.93 ± 0.059	1.062LysMet: 1.062 ± 0.034	1.091LysAsn: 1.091 ± 0.038	2.119LysPro: 2.119 ± 0.056	1.209LysGln: 1.209 ± 0.037	2.68LysArg: 2.68 ± 0.056	2.235LysSer: 2.235 ± 0.049	2.358LysThr: 2.358 ± 0.049	2.502LysVal: 2.502 ± 0.053	0.429LysTrp: 0.429 ± 0.018	0.76LysTyr: 0.76 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.713LeuAla: 12.713 ± 0.134	0.917LeuCys: 0.917 ± 0.031	5.37LeuAsp: 5.37 ± 0.08	6.113LeuGlu: 6.113 ± 0.09	3.732LeuPhe: 3.732 ± 0.064	8.579LeuGly: 8.579 ± 0.11	1.869LeuHis: 1.869 ± 0.044	5.181LeuIle: 5.181 ± 0.079	4.258LeuLys: 4.258 ± 0.065	9.048LeuLeu: 9.048 ± 0.13	2.921LeuMet: 2.921 ± 0.06	2.936LeuAsn: 2.936 ± 0.056	5.149LeuPro: 5.149 ± 0.08	2.867LeuGln: 2.867 ± 0.048	6.354LeuArg: 6.354 ± 0.088	6.93LeuSer: 6.93 ± 0.105	6.137LeuThr: 6.137 ± 0.083	6.741LeuVal: 6.741 ± 0.097	1.313LeuTrp: 1.313 ± 0.037	2.063LeuTyr: 2.063 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.47MetAla: 3.47 ± 0.065	0.222MetCys: 0.222 ± 0.015	1.431MetAsp: 1.431 ± 0.042	1.477MetGlu: 1.477 ± 0.043	0.899MetPhe: 0.899 ± 0.031	2.432MetGly: 2.432 ± 0.061	0.539MetHis: 0.539 ± 0.023	1.657MetIle: 1.657 ± 0.039	1.209MetLys: 1.209 ± 0.041	2.752MetLeu: 2.752 ± 0.055	0.893MetMet: 0.893 ± 0.035	0.937MetAsn: 0.937 ± 0.031	1.516MetPro: 1.516 ± 0.037	1.071MetGln: 1.071 ± 0.04	2.049MetArg: 2.049 ± 0.051	2.204MetSer: 2.204 ± 0.047	1.848MetThr: 1.848 ± 0.049	1.778MetVal: 1.778 ± 0.042	0.25MetTrp: 0.25 ± 0.016	0.349MetTyr: 0.349 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.38AsnAla: 3.38 ± 0.069	0.267AsnCys: 0.267 ± 0.017	1.625AsnAsp: 1.625 ± 0.077	1.492AsnGlu: 1.492 ± 0.037	1.105AsnPhe: 1.105 ± 0.035	2.506AsnGly: 2.506 ± 0.058	0.557AsnHis: 0.557 ± 0.023	1.642AsnIle: 1.642 ± 0.05	0.94AsnLys: 0.94 ± 0.032	2.651AsnLeu: 2.651 ± 0.05	0.802AsnMet: 0.802 ± 0.028	0.793AsnAsn: 0.793 ± 0.032	1.774AsnPro: 1.774 ± 0.041	0.74AsnGln: 0.74 ± 0.028	1.578AsnArg: 1.578 ± 0.035	1.38AsnSer: 1.38 ± 0.04	1.665AsnThr: 1.665 ± 0.041	2.081AsnVal: 2.081 ± 0.049	0.492AsnTrp: 0.492 ± 0.022	0.707AsnTyr: 0.707 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.826ProAla: 4.826 ± 0.082	0.345ProCys: 0.345 ± 0.019	3.246ProAsp: 3.246 ± 0.061	4.19ProGlu: 4.19 ± 0.077	1.9ProPhe: 1.9 ± 0.052	2.656ProGly: 2.656 ± 0.054	1.041ProHis: 1.041 ± 0.032	2.217ProIle: 2.217 ± 0.051	2.155ProLys: 2.155 ± 0.048	4.59ProLeu: 4.59 ± 0.07	1.311ProMet: 1.311 ± 0.035	1.427ProAsn: 1.427 ± 0.041	1.751ProPro: 1.751 ± 0.053	1.611ProGln: 1.611 ± 0.039	2.357ProArg: 2.357 ± 0.055	2.747ProSer: 2.747 ± 0.053	2.315ProThr: 2.315 ± 0.044	3.728ProVal: 3.728 ± 0.063	0.592ProTrp: 0.592 ± 0.024	1.209ProTyr: 1.209 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.894GlnAla: 3.894 ± 0.059	0.201GlnCys: 0.201 ± 0.013	1.807GlnAsp: 1.807 ± 0.038	1.628GlnGlu: 1.628 ± 0.047	1.14GlnPhe: 1.14 ± 0.038	2.676GlnGly: 2.676 ± 0.051	0.63GlnHis: 0.63 ± 0.023	2.09GlnIle: 2.09 ± 0.046	1.3GlnLys: 1.3 ± 0.042	2.972GlnLeu: 2.972 ± 0.056	1.11GlnMet: 1.11 ± 0.034	1.103GlnAsn: 1.103 ± 0.033	1.438GlnPro: 1.438 ± 0.04	0.983GlnGln: 0.983 ± 0.037	2.015GlnArg: 2.015 ± 0.051	2.056GlnSer: 2.056 ± 0.049	1.877GlnThr: 1.877 ± 0.046	2.113GlnVal: 2.113 ± 0.048	0.354GlnTrp: 0.354 ± 0.019	0.639GlnTyr: 0.639 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.295ArgAla: 7.295 ± 0.086	0.435ArgCys: 0.435 ± 0.02	3.543ArgAsp: 3.543 ± 0.061	3.859ArgGlu: 3.859 ± 0.076	2.589ArgPhe: 2.589 ± 0.063	4.156ArgGly: 4.156 ± 0.075	1.307ArgHis: 1.307 ± 0.042	3.278ArgIle: 3.278 ± 0.057	2.446ArgLys: 2.446 ± 0.056	6.618ArgLeu: 6.618 ± 0.088	1.776ArgMet: 1.776 ± 0.043	1.652ArgAsn: 1.652 ± 0.042	2.613ArgPro: 2.613 ± 0.056	1.999ArgGln: 1.999 ± 0.048	3.941ArgArg: 3.941 ± 0.086	3.079ArgSer: 3.079 ± 0.062	2.611ArgThr: 2.611 ± 0.05	4.323ArgVal: 4.323 ± 0.073	0.874ArgTrp: 0.874 ± 0.032	1.523ArgTyr: 1.523 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.325SerAla: 6.325 ± 0.094	0.508SerCys: 0.508 ± 0.026	3.363SerAsp: 3.363 ± 0.064	3.588SerGlu: 3.588 ± 0.068	2.591SerPhe: 2.591 ± 0.054	5.522SerGly: 5.522 ± 0.095	1.162SerHis: 1.162 ± 0.032	2.715SerIle: 2.715 ± 0.06	2.0SerLys: 2.0 ± 0.046	5.657SerLeu: 5.657 ± 0.085	1.467SerMet: 1.467 ± 0.036	1.636SerAsn: 1.636 ± 0.043	2.451SerPro: 2.451 ± 0.049	1.847SerGln: 1.847 ± 0.044	3.035SerArg: 3.035 ± 0.055	3.016SerSer: 3.016 ± 0.063	2.736SerThr: 2.736 ± 0.055	4.0SerVal: 4.0 ± 0.059	0.756SerTrp: 0.756 ± 0.027	1.506SerTyr: 1.506 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.083ThrAla: 6.083 ± 0.077	0.469ThrCys: 0.469 ± 0.022	2.889ThrAsp: 2.889 ± 0.067	3.069ThrGlu: 3.069 ± 0.056	1.935ThrPhe: 1.935 ± 0.046	5.461ThrGly: 5.461 ± 0.092	1.171ThrHis: 1.171 ± 0.038	2.699ThrIle: 2.699 ± 0.059	1.833ThrLys: 1.833 ± 0.046	6.171ThrLeu: 6.171 ± 0.079	1.266ThrMet: 1.266 ± 0.035	1.407ThrAsn: 1.407 ± 0.035	3.343ThrPro: 3.343 ± 0.062	1.726ThrGln: 1.726 ± 0.039	3.171ThrArg: 3.171 ± 0.052	2.979ThrSer: 2.979 ± 0.052	2.807ThrThr: 2.807 ± 0.062	4.135ThrVal: 4.135 ± 0.083	0.68ThrTrp: 0.68 ± 0.026	1.323ThrTyr: 1.323 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.081ValAla: 8.081 ± 0.096	0.667ValCys: 0.667 ± 0.026	3.642ValAsp: 3.642 ± 0.07	4.511ValGlu: 4.511 ± 0.076	2.918ValPhe: 2.918 ± 0.056	5.34ValGly: 5.34 ± 0.078	1.321ValHis: 1.321 ± 0.04	4.295ValIle: 4.295 ± 0.066	2.644ValLys: 2.644 ± 0.056	7.317ValLeu: 7.317 ± 0.1	2.168ValMet: 2.168 ± 0.048	2.1ValAsn: 2.1 ± 0.052	3.196ValPro: 3.196 ± 0.052	2.181ValGln: 2.181 ± 0.049	3.75ValArg: 3.75 ± 0.064	4.769ValSer: 4.769 ± 0.07	4.404ValThr: 4.404 ± 0.08	5.262ValVal: 5.262 ± 0.092	0.913ValTrp: 0.913 ± 0.031	1.493ValTyr: 1.493 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.354TrpAla: 1.354 ± 0.04	0.14TrpCys: 0.14 ± 0.012	0.707TrpAsp: 0.707 ± 0.029	0.654TrpGlu: 0.654 ± 0.025	0.555TrpPhe: 0.555 ± 0.023	1.056TrpGly: 1.056 ± 0.032	0.335TrpHis: 0.335 ± 0.019	0.605TrpIle: 0.605 ± 0.025	0.483TrpLys: 0.483 ± 0.024	1.648TrpLeu: 1.648 ± 0.045	0.394TrpMet: 0.394 ± 0.023	0.421TrpAsn: 0.421 ± 0.021	0.653TrpPro: 0.653 ± 0.026	0.581TrpGln: 0.581 ± 0.026	0.984TrpArg: 0.984 ± 0.035	0.761TrpSer: 0.761 ± 0.027	0.657TrpThr: 0.657 ± 0.028	0.871TrpVal: 0.871 ± 0.031	0.195TrpTrp: 0.195 ± 0.013	0.266TrpTyr: 0.266 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.047	0.249TyrCys: 0.249 ± 0.016	1.604TyrAsp: 1.604 ± 0.042	1.464TyrGlu: 1.464 ± 0.041	0.966TyrPhe: 0.966 ± 0.032	2.243TyrGly: 2.243 ± 0.057	0.567TyrHis: 0.567 ± 0.025	1.122TyrIle: 1.122 ± 0.034	0.801TyrLys: 0.801 ± 0.03	2.274TyrLeu: 2.274 ± 0.046	0.555TyrMet: 0.555 ± 0.025	0.636TyrAsn: 0.636 ± 0.023	1.044TyrPro: 1.044 ± 0.033	0.738TyrGln: 0.738 ± 0.029	1.419TyrArg: 1.419 ± 0.037	1.304TyrSer: 1.304 ± 0.039	1.204TyrThr: 1.204 ± 0.038	1.588TyrVal: 1.588 ± 0.04	0.365TyrTrp: 0.365 ± 0.02	0.624TyrTyr: 0.624 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3261 proteins (1000721 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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