Amino acid dipepetide frequency for Polyomavirus sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.016AlaAla: 6.016 ± 4.753
0.0AlaCys: 0.0 ± 0.0
1.337AlaAsp: 1.337 ± 1.253
5.348AlaGlu: 5.348 ± 2.397
2.674AlaPhe: 2.674 ± 1.417
2.005AlaGly: 2.005 ± 0.507
0.0AlaHis: 0.0 ± 0.0
5.348AlaIle: 5.348 ± 1.774
3.342AlaLys: 3.342 ± 1.991
8.69AlaLeu: 8.69 ± 5.038
0.668AlaMet: 0.668 ± 0.732
3.342AlaAsn: 3.342 ± 0.803
2.674AlaPro: 2.674 ± 1.119
4.679AlaGln: 4.679 ± 0.823
2.674AlaArg: 2.674 ± 2.016
2.674AlaSer: 2.674 ± 0.497
2.005AlaThr: 2.005 ± 0.796
6.684AlaVal: 6.684 ± 0.807
2.005AlaTrp: 2.005 ± 0.923
0.668AlaTyr: 0.668 ± 0.627
0.0AlaXaa: 0.0 ± 0.0
Cys
1.337CysAla: 1.337 ± 0.577
0.0CysCys: 0.0 ± 0.0
2.005CysAsp: 2.005 ± 1.279
1.337CysGlu: 1.337 ± 0.853
2.005CysPhe: 2.005 ± 1.892
1.337CysGly: 1.337 ± 0.853
0.0CysHis: 0.0 ± 0.0
0.668CysIle: 0.668 ± 1.002
3.342CysLys: 3.342 ± 1.099
3.342CysLeu: 3.342 ± 2.813
1.337CysMet: 1.337 ± 0.853
1.337CysAsn: 1.337 ± 0.577
0.0CysPro: 0.0 ± 0.0
0.668CysGln: 0.668 ± 0.426
0.668CysArg: 0.668 ± 0.426
0.668CysSer: 0.668 ± 0.426
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.668CysTrp: 0.668 ± 1.002
0.668CysTyr: 0.668 ± 1.002
0.0CysXaa: 0.0 ± 0.0
Asp
1.337AspAla: 1.337 ± 0.635
1.337AspCys: 1.337 ± 0.577
2.674AspAsp: 2.674 ± 1.706
4.679AspGlu: 4.679 ± 1.548
2.674AspPhe: 2.674 ± 1.119
4.011AspGly: 4.011 ± 1.352
4.011AspHis: 4.011 ± 1.327
3.342AspIle: 3.342 ± 1.678
2.005AspLys: 2.005 ± 1.055
5.348AspLeu: 5.348 ± 2.156
1.337AspMet: 1.337 ± 0.54
2.674AspAsn: 2.674 ± 1.143
2.674AspPro: 2.674 ± 0.947
0.668AspGln: 0.668 ± 0.426
0.668AspArg: 0.668 ± 0.732
7.353AspSer: 7.353 ± 2.2
2.005AspThr: 2.005 ± 0.799
4.011AspVal: 4.011 ± 1.014
1.337AspTrp: 1.337 ± 1.161
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
9.358GluAla: 9.358 ± 4.116
1.337GluCys: 1.337 ± 0.936
3.342GluAsp: 3.342 ± 1.529
7.353GluGlu: 7.353 ± 2.744
2.674GluPhe: 2.674 ± 1.706
4.011GluGly: 4.011 ± 1.014
1.337GluHis: 1.337 ± 0.635
2.674GluIle: 2.674 ± 1.155
4.011GluLys: 4.011 ± 1.592
5.348GluLeu: 5.348 ± 1.457
0.0GluMet: 0.0 ± 0.0
4.011GluAsn: 4.011 ± 1.834
1.337GluPro: 1.337 ± 1.253
6.016GluGln: 6.016 ± 2.707
2.005GluArg: 2.005 ± 0.796
2.674GluSer: 2.674 ± 0.91
3.342GluThr: 3.342 ± 1.914
5.348GluVal: 5.348 ± 1.813
0.668GluTrp: 0.668 ± 0.426
4.679GluTyr: 4.679 ± 1.737
0.0GluXaa: 0.0 ± 0.0
Phe
2.674PheAla: 2.674 ± 1.27
3.342PheCys: 3.342 ± 1.949
4.011PheAsp: 4.011 ± 1.905
4.679PheGlu: 4.679 ± 1.666
2.005PhePhe: 2.005 ± 0.799
2.005PheGly: 2.005 ± 0.923
0.668PheHis: 0.668 ± 0.627
4.011PheIle: 4.011 ± 1.259
1.337PheLys: 1.337 ± 0.853
6.016PheLeu: 6.016 ± 1.016
0.668PheMet: 0.668 ± 0.627
2.005PheAsn: 2.005 ± 0.799
3.342PhePro: 3.342 ± 1.055
0.668PheGln: 0.668 ± 0.426
2.674PheArg: 2.674 ± 1.782
3.342PheSer: 3.342 ± 1.023
3.342PheThr: 3.342 ± 0.514
1.337PheVal: 1.337 ± 0.936
0.668PheTrp: 0.668 ± 0.426
1.337PheTyr: 1.337 ± 1.105
0.0PheXaa: 0.0 ± 0.0
Gly
4.011GlyAla: 4.011 ± 1.014
0.668GlyCys: 0.668 ± 0.426
4.011GlyAsp: 4.011 ± 1.352
4.011GlyGlu: 4.011 ± 1.834
2.005GlyPhe: 2.005 ± 1.393
6.016GlyGly: 6.016 ± 0.991
0.0GlyHis: 0.0 ± 0.0
4.011GlyIle: 4.011 ± 0.87
1.337GlyLys: 1.337 ± 0.853
8.69GlyLeu: 8.69 ± 3.11
1.337GlyMet: 1.337 ± 0.794
6.016GlyAsn: 6.016 ± 1.299
3.342GlyPro: 3.342 ± 1.263
2.674GlyGln: 2.674 ± 1.155
2.005GlyArg: 2.005 ± 1.393
4.679GlySer: 4.679 ± 1.528
2.674GlyThr: 2.674 ± 0.764
4.679GlyVal: 4.679 ± 1.403
0.0GlyTrp: 0.0 ± 0.0
0.668GlyTyr: 0.668 ± 0.627
0.0GlyXaa: 0.0 ± 0.0
His
1.337HisAla: 1.337 ± 0.936
0.668HisCys: 0.668 ± 0.426
0.668HisAsp: 0.668 ± 0.426
0.0HisGlu: 0.0 ± 0.0
2.674HisPhe: 2.674 ± 1.155
0.668HisGly: 0.668 ± 0.426
1.337HisHis: 1.337 ± 0.635
0.668HisIle: 0.668 ± 0.732
1.337HisLys: 1.337 ± 0.853
2.005HisLeu: 2.005 ± 0.796
0.0HisMet: 0.0 ± 0.65
0.668HisAsn: 0.668 ± 0.627
2.005HisPro: 2.005 ± 0.952
0.0HisGln: 0.0 ± 0.0
2.005HisArg: 2.005 ± 1.055
2.005HisSer: 2.005 ± 1.127
0.0HisThr: 0.0 ± 0.0
0.668HisVal: 0.668 ± 0.732
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.342IleAla: 3.342 ± 2.817
1.337IleCys: 1.337 ± 0.936
4.011IleAsp: 4.011 ± 2.605
2.674IleGlu: 2.674 ± 1.782
2.005IlePhe: 2.005 ± 0.799
2.005IleGly: 2.005 ± 0.796
0.0IleHis: 0.0 ± 0.0
2.674IleIle: 2.674 ± 0.921
1.337IleLys: 1.337 ± 0.853
4.679IleLeu: 4.679 ± 1.551
0.668IleMet: 0.668 ± 0.825
2.674IleAsn: 2.674 ± 0.497
6.684IlePro: 6.684 ± 1.361
2.005IleGln: 2.005 ± 1.229
2.005IleArg: 2.005 ± 1.393
3.342IleSer: 3.342 ± 1.17
6.016IleThr: 6.016 ± 1.703
3.342IleVal: 3.342 ± 1.529
0.0IleTrp: 0.0 ± 0.0
3.342IleTyr: 3.342 ± 1.479
0.0IleXaa: 0.0 ± 0.0
Lys
1.337LysAla: 1.337 ± 0.853
1.337LysCys: 1.337 ± 0.936
2.674LysAsp: 2.674 ± 1.706
4.011LysGlu: 4.011 ± 1.389
0.668LysPhe: 0.668 ± 0.426
5.348LysGly: 5.348 ± 1.842
1.337LysHis: 1.337 ± 0.853
2.674LysIle: 2.674 ± 1.155
4.679LysLys: 4.679 ± 1.17
8.021LysLeu: 8.021 ± 3.784
2.005LysMet: 2.005 ± 0.799
4.011LysAsn: 4.011 ± 1.732
2.674LysPro: 2.674 ± 0.764
0.668LysGln: 0.668 ± 0.426
4.011LysArg: 4.011 ± 1.147
2.674LysSer: 2.674 ± 1.108
4.011LysThr: 4.011 ± 0.87
2.005LysVal: 2.005 ± 1.055
0.668LysTrp: 0.668 ± 0.426
1.337LysTyr: 1.337 ± 0.635
0.0LysXaa: 0.0 ± 0.0
Leu
8.69LeuAla: 8.69 ± 2.998
2.005LeuCys: 2.005 ± 0.799
3.342LeuAsp: 3.342 ± 1.529
10.027LeuGlu: 10.027 ± 3.075
5.348LeuPhe: 5.348 ± 0.676
5.348LeuGly: 5.348 ± 3.067
2.005LeuHis: 2.005 ± 1.055
6.016LeuIle: 6.016 ± 1.016
4.679LeuLys: 4.679 ± 1.528
12.701LeuLeu: 12.701 ± 2.085
4.679LeuMet: 4.679 ± 2.339
8.69LeuAsn: 8.69 ± 1.889
8.021LeuPro: 8.021 ± 2.544
3.342LeuGln: 3.342 ± 0.963
4.679LeuArg: 4.679 ± 1.794
4.011LeuSer: 4.011 ± 1.147
5.348LeuThr: 5.348 ± 1.393
4.679LeuVal: 4.679 ± 0.908
0.0LeuTrp: 0.0 ± 0.0
6.016LeuTyr: 6.016 ± 2.335
0.0LeuXaa: 0.0 ± 0.0
Met
2.674MetAla: 2.674 ± 0.947
0.0MetCys: 0.0 ± 0.0
1.337MetAsp: 1.337 ± 0.936
2.674MetGlu: 2.674 ± 0.921
0.668MetPhe: 0.668 ± 0.732
1.337MetGly: 1.337 ± 0.794
0.668MetHis: 0.668 ± 0.627
0.668MetIle: 0.668 ± 0.426
0.668MetLys: 0.668 ± 0.426
2.674MetLeu: 2.674 ± 0.947
0.0MetMet: 0.0 ± 0.0
0.668MetAsn: 0.668 ± 0.627
1.337MetPro: 1.337 ± 0.853
4.011MetGln: 4.011 ± 0.556
1.337MetArg: 1.337 ± 0.936
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
0.668MetVal: 0.668 ± 0.426
0.668MetTrp: 0.668 ± 0.627
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.011AsnAla: 4.011 ± 0.556
0.668AsnCys: 0.668 ± 0.426
2.005AsnAsp: 2.005 ± 0.923
4.011AsnGlu: 4.011 ± 2.254
4.679AsnPhe: 4.679 ± 1.737
2.674AsnGly: 2.674 ± 0.497
1.337AsnHis: 1.337 ± 0.577
4.679AsnIle: 4.679 ± 0.846
3.342AsnLys: 3.342 ± 2.132
4.011AsnLeu: 4.011 ± 0.983
2.674AsnMet: 2.674 ± 0.947
0.668AsnAsn: 0.668 ± 0.426
4.011AsnPro: 4.011 ± 1.515
2.674AsnGln: 2.674 ± 0.497
0.668AsnArg: 0.668 ± 0.426
0.668AsnSer: 0.668 ± 0.732
4.679AsnThr: 4.679 ± 2.852
4.011AsnVal: 4.011 ± 1.352
0.668AsnTrp: 0.668 ± 0.732
2.674AsnTyr: 2.674 ± 0.947
0.0AsnXaa: 0.0 ± 0.0
Pro
0.668ProAla: 0.668 ± 0.627
0.0ProCys: 0.0 ± 0.0
6.684ProAsp: 6.684 ± 2.095
2.674ProGlu: 2.674 ± 1.108
1.337ProPhe: 1.337 ± 0.936
4.011ProGly: 4.011 ± 0.983
0.668ProHis: 0.668 ± 0.732
2.674ProIle: 2.674 ± 2.08
2.674ProLys: 2.674 ± 0.921
6.684ProLeu: 6.684 ± 1.908
2.005ProMet: 2.005 ± 0.923
2.674ProAsn: 2.674 ± 1.417
5.348ProPro: 5.348 ± 0.676
1.337ProGln: 1.337 ± 0.635
4.679ProArg: 4.679 ± 2.852
3.342ProSer: 3.342 ± 1.523
3.342ProThr: 3.342 ± 1.263
3.342ProVal: 3.342 ± 1.678
0.0ProTrp: 0.0 ± 0.0
2.674ProTyr: 2.674 ± 1.155
0.0ProXaa: 0.0 ± 0.0
Gln
2.674GlnAla: 2.674 ± 0.91
2.005GlnCys: 2.005 ± 1.055
2.005GlnAsp: 2.005 ± 1.303
0.668GlnGlu: 0.668 ± 0.426
2.005GlnPhe: 2.005 ± 0.799
1.337GlnGly: 1.337 ± 0.577
0.0GlnHis: 0.0 ± 0.0
4.011GlnIle: 4.011 ± 1.637
3.342GlnLys: 3.342 ± 2.132
4.679GlnLeu: 4.679 ± 0.846
0.668GlnMet: 0.668 ± 0.627
3.342GlnAsn: 3.342 ± 1.327
1.337GlnPro: 1.337 ± 1.253
1.337GlnGln: 1.337 ± 0.577
2.005GlnArg: 2.005 ± 1.303
1.337GlnSer: 1.337 ± 0.936
0.0GlnThr: 0.0 ± 0.0
2.005GlnVal: 2.005 ± 1.491
0.668GlnTrp: 0.668 ± 0.426
2.005GlnTyr: 2.005 ± 0.952
0.0GlnXaa: 0.0 ± 0.0
Arg
1.337ArgAla: 1.337 ± 0.936
0.668ArgCys: 0.668 ± 0.426
4.011ArgAsp: 4.011 ± 1.513
3.342ArgGlu: 3.342 ± 0.514
4.011ArgPhe: 4.011 ± 1.592
2.005ArgGly: 2.005 ± 1.125
1.337ArgHis: 1.337 ± 0.635
1.337ArgIle: 1.337 ± 0.577
5.348ArgLys: 5.348 ± 0.676
2.674ArgLeu: 2.674 ± 1.73
0.668ArgMet: 0.668 ± 0.627
1.337ArgAsn: 1.337 ± 0.577
0.0ArgPro: 0.0 ± 0.0
0.0ArgGln: 0.0 ± 0.0
5.348ArgArg: 5.348 ± 2.644
2.674ArgSer: 2.674 ± 0.497
4.011ArgThr: 4.011 ± 1.834
3.342ArgVal: 3.342 ± 1.529
1.337ArgTrp: 1.337 ± 1.464
4.011ArgTyr: 4.011 ± 1.649
0.0ArgXaa: 0.0 ± 0.0
Ser
4.011SerAla: 4.011 ± 1.834
2.005SerCys: 2.005 ± 1.892
4.679SerAsp: 4.679 ± 1.597
1.337SerGlu: 1.337 ± 1.464
4.011SerPhe: 4.011 ± 1.733
2.674SerGly: 2.674 ± 1.782
1.337SerHis: 1.337 ± 0.936
1.337SerIle: 1.337 ± 0.577
4.679SerLys: 4.679 ± 1.403
6.016SerLeu: 6.016 ± 0.797
0.668SerMet: 0.668 ± 0.627
3.342SerAsn: 3.342 ± 1.529
2.005SerPro: 2.005 ± 1.393
2.674SerGln: 2.674 ± 1.706
2.005SerArg: 2.005 ± 0.796
2.674SerSer: 2.674 ± 1.27
2.674SerThr: 2.674 ± 0.91
4.679SerVal: 4.679 ± 1.597
2.005SerTrp: 2.005 ± 0.952
1.337SerTyr: 1.337 ± 0.794
0.0SerXaa: 0.0 ± 0.0
Thr
2.005ThrAla: 2.005 ± 2.197
2.005ThrCys: 2.005 ± 0.799
1.337ThrAsp: 1.337 ± 1.253
6.016ThrGlu: 6.016 ± 1.299
1.337ThrPhe: 1.337 ± 0.635
4.011ThrGly: 4.011 ± 1.014
0.668ThrHis: 0.668 ± 0.732
1.337ThrIle: 1.337 ± 0.577
1.337ThrLys: 1.337 ± 1.253
7.353ThrLeu: 7.353 ± 0.743
0.0ThrMet: 0.0 ± 0.0
4.011ThrAsn: 4.011 ± 1.649
6.016ThrPro: 6.016 ± 1.229
2.674ThrGln: 2.674 ± 0.947
4.011ThrArg: 4.011 ± 1.219
1.337ThrSer: 1.337 ± 0.635
4.679ThrThr: 4.679 ± 0.538
3.342ThrVal: 3.342 ± 2.147
0.0ThrTrp: 0.0 ± 0.0
1.337ThrTyr: 1.337 ± 1.105
0.0ThrXaa: 0.0 ± 0.0
Val
2.674ValAla: 2.674 ± 1.108
0.668ValCys: 0.668 ± 1.002
3.342ValAsp: 3.342 ± 2.132
4.011ValGlu: 4.011 ± 1.649
3.342ValPhe: 3.342 ± 0.514
6.684ValGly: 6.684 ± 2.729
1.337ValHis: 1.337 ± 1.253
2.674ValIle: 2.674 ± 0.764
6.016ValLys: 6.016 ± 0.994
5.348ValLeu: 5.348 ± 1.671
0.0ValMet: 0.0 ± 0.0
2.674ValAsn: 2.674 ± 1.706
1.337ValPro: 1.337 ± 0.794
0.0ValGln: 0.0 ± 0.0
2.674ValArg: 2.674 ± 0.947
7.353ValSer: 7.353 ± 0.762
4.011ValThr: 4.011 ± 1.352
2.005ValVal: 2.005 ± 0.799
0.668ValTrp: 0.668 ± 0.732
1.337ValTyr: 1.337 ± 0.577
0.0ValXaa: 0.0 ± 0.0
Trp
1.337TrpAla: 1.337 ± 1.464
0.668TrpCys: 0.668 ± 0.627
0.0TrpAsp: 0.0 ± 0.0
2.005TrpGlu: 2.005 ± 0.507
1.337TrpPhe: 1.337 ± 0.936
1.337TrpGly: 1.337 ± 1.161
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.337TrpLys: 1.337 ± 0.853
0.668TrpLeu: 0.668 ± 0.426
0.668TrpMet: 0.668 ± 0.732
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.337TrpGln: 1.337 ± 0.936
0.0TrpArg: 0.0 ± 0.0
0.668TrpSer: 0.668 ± 1.002
0.0TrpThr: 0.0 ± 0.0
0.668TrpVal: 0.668 ± 0.732
0.668TrpTrp: 0.668 ± 0.426
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.005TyrAla: 2.005 ± 0.796
0.668TyrCys: 0.668 ± 0.426
0.668TyrAsp: 0.668 ± 0.627
0.668TyrGlu: 0.668 ± 0.732
2.674TyrPhe: 2.674 ± 1.404
4.011TyrGly: 4.011 ± 0.698
1.337TyrHis: 1.337 ± 0.853
3.342TyrIle: 3.342 ± 1.27
0.0TyrLys: 0.0 ± 0.0
4.679TyrLeu: 4.679 ± 1.403
1.337TyrMet: 1.337 ± 0.79
0.668TyrAsn: 0.668 ± 0.426
2.674TyrPro: 2.674 ± 1.782
0.0TyrGln: 0.0 ± 0.0
2.674TyrArg: 2.674 ± 0.921
2.674TyrSer: 2.674 ± 0.947
2.674TyrThr: 2.674 ± 0.764
1.337TyrVal: 1.337 ± 1.464
0.0TyrTrp: 0.0 ± 0.0
2.674TyrTyr: 2.674 ± 0.497
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski