Amino acid dipepetide frequency for Diachasma alloeum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.654AlaAla: 4.654 ± 0.21
1.43AlaCys: 1.43 ± 0.08
2.425AlaAsp: 2.425 ± 0.118
3.345AlaGlu: 3.345 ± 0.165
3.189AlaPhe: 3.189 ± 0.145
3.241AlaGly: 3.241 ± 0.131
1.088AlaHis: 1.088 ± 0.092
4.868AlaIle: 4.868 ± 0.181
3.247AlaLys: 3.247 ± 0.165
6.633AlaLeu: 6.633 ± 0.197
2.061AlaMet: 2.061 ± 0.105
2.049AlaAsn: 2.049 ± 0.107
1.69AlaPro: 1.69 ± 0.118
2.049AlaGln: 2.049 ± 0.141
2.691AlaArg: 2.691 ± 0.143
4.358AlaSer: 4.358 ± 0.166
3.565AlaThr: 3.565 ± 0.132
4.711AlaVal: 4.711 ± 0.184
0.868AlaTrp: 0.868 ± 0.073
2.593AlaTyr: 2.593 ± 0.113
0.0AlaXaa: 0.0 ± 0.0
Cys
1.285CysAla: 1.285 ± 0.089
0.776CysCys: 0.776 ± 0.063
0.868CysAsp: 0.868 ± 0.067
0.932CysGlu: 0.932 ± 0.088
1.297CysPhe: 1.297 ± 0.092
1.441CysGly: 1.441 ± 0.103
0.55CysHis: 0.55 ± 0.061
1.725CysIle: 1.725 ± 0.101
0.608CysLys: 0.608 ± 0.057
2.338CysLeu: 2.338 ± 0.112
0.585CysMet: 0.585 ± 0.051
0.642CysAsn: 0.642 ± 0.059
0.59CysPro: 0.59 ± 0.067
0.839CysGln: 0.839 ± 0.077
0.99CysArg: 0.99 ± 0.074
1.256CysSer: 1.256 ± 0.094
1.187CysThr: 1.187 ± 0.076
1.482CysVal: 1.482 ± 0.103
0.417CysTrp: 0.417 ± 0.052
1.036CysTyr: 1.036 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
2.709AspAla: 2.709 ± 0.131
0.903AspCys: 0.903 ± 0.064
2.61AspAsp: 2.61 ± 0.145
2.969AspGlu: 2.969 ± 0.172
2.217AspPhe: 2.217 ± 0.113
2.24AspGly: 2.24 ± 0.12
0.909AspHis: 0.909 ± 0.068
3.027AspIle: 3.027 ± 0.119
2.35AspLys: 2.35 ± 0.111
4.214AspLeu: 4.214 ± 0.179
1.32AspMet: 1.32 ± 0.078
1.835AspAsn: 1.835 ± 0.094
1.563AspPro: 1.563 ± 0.093
1.325AspGln: 1.325 ± 0.099
1.997AspArg: 1.997 ± 0.103
2.859AspSer: 2.859 ± 0.118
2.309AspThr: 2.309 ± 0.11
2.987AspVal: 2.987 ± 0.135
0.932AspTrp: 0.932 ± 0.065
1.754AspTyr: 1.754 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
3.351GluAla: 3.351 ± 0.195
0.996GluCys: 0.996 ± 0.071
2.94GluAsp: 2.94 ± 0.15
4.642GluGlu: 4.642 ± 0.331
2.576GluPhe: 2.576 ± 0.122
2.304GluGly: 2.304 ± 0.167
1.314GluHis: 1.314 ± 0.099
4.474GluIle: 4.474 ± 0.172
4.318GluLys: 4.318 ± 0.275
5.447GluLeu: 5.447 ± 0.232
1.794GluMet: 1.794 ± 0.113
2.715GluAsn: 2.715 ± 0.115
1.459GluPro: 1.459 ± 0.13
1.69GluGln: 1.69 ± 0.138
3.479GluArg: 3.479 ± 0.21
3.936GluSer: 3.936 ± 0.174
3.259GluThr: 3.259 ± 0.144
3.351GluVal: 3.351 ± 0.172
0.828GluTrp: 0.828 ± 0.061
1.719GluTyr: 1.719 ± 0.098
0.0GluXaa: 0.0 ± 0.0
Phe
3.554PheAla: 3.554 ± 0.16
1.302PheCys: 1.302 ± 0.102
1.968PheAsp: 1.968 ± 0.1
2.61PheGlu: 2.61 ± 0.129
3.473PhePhe: 3.473 ± 0.18
3.131PheGly: 3.131 ± 0.143
1.331PheHis: 1.331 ± 0.1
4.439PheIle: 4.439 ± 0.207
2.628PheLys: 2.628 ± 0.156
5.394PheLeu: 5.394 ± 0.243
1.8PheMet: 1.8 ± 0.098
2.182PheAsn: 2.182 ± 0.109
1.956PhePro: 1.956 ± 0.097
1.806PheGln: 1.806 ± 0.106
2.327PheArg: 2.327 ± 0.115
4.399PheSer: 4.399 ± 0.165
4.115PheThr: 4.115 ± 0.177
4.086PheVal: 4.086 ± 0.174
0.845PheTrp: 0.845 ± 0.074
2.275PheTyr: 2.275 ± 0.123
0.006PheXaa: 0.006 ± 0.005
Gly
2.657GlyAla: 2.657 ± 0.153
0.972GlyCys: 0.972 ± 0.075
1.997GlyAsp: 1.997 ± 0.125
2.471GlyGlu: 2.471 ± 0.155
2.848GlyPhe: 2.848 ± 0.137
2.911GlyGly: 2.911 ± 0.146
1.036GlyHis: 1.036 ± 0.079
4.295GlyIle: 4.295 ± 0.156
2.911GlyLys: 2.911 ± 0.141
5.088GlyLeu: 5.088 ± 0.17
1.424GlyMet: 1.424 ± 0.088
2.159GlyAsn: 2.159 ± 0.12
1.447GlyPro: 1.447 ± 0.081
1.76GlyGln: 1.76 ± 0.098
2.471GlyArg: 2.471 ± 0.153
2.992GlySer: 2.992 ± 0.145
2.709GlyThr: 2.709 ± 0.129
3.513GlyVal: 3.513 ± 0.156
0.538GlyTrp: 0.538 ± 0.061
1.898GlyTyr: 1.898 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
1.239HisAla: 1.239 ± 0.081
0.475HisCys: 0.475 ± 0.06
0.868HisAsp: 0.868 ± 0.068
1.244HisGlu: 1.244 ± 0.092
1.21HisPhe: 1.21 ± 0.093
0.92HisGly: 0.92 ± 0.068
0.874HisHis: 0.874 ± 0.081
1.424HisIle: 1.424 ± 0.105
0.967HisLys: 0.967 ± 0.081
2.46HisLeu: 2.46 ± 0.125
0.642HisMet: 0.642 ± 0.064
0.845HisAsn: 0.845 ± 0.063
0.955HisPro: 0.955 ± 0.07
1.077HisGln: 1.077 ± 0.069
1.626HisArg: 1.626 ± 0.1
1.586HisSer: 1.586 ± 0.104
1.117HisThr: 1.117 ± 0.101
1.395HisVal: 1.395 ± 0.091
0.353HisTrp: 0.353 ± 0.044
1.036HisTyr: 1.036 ± 0.076
0.0HisXaa: 0.0 ± 0.0
Ile
4.63IleAla: 4.63 ± 0.18
2.032IleCys: 2.032 ± 0.138
3.363IleAsp: 3.363 ± 0.148
3.861IleGlu: 3.861 ± 0.171
5.198IlePhe: 5.198 ± 0.252
4.167IleGly: 4.167 ± 0.186
1.638IleHis: 1.638 ± 0.104
7.403IleIle: 7.403 ± 0.31
3.652IleLys: 3.652 ± 0.149
9.024IleLeu: 9.024 ± 0.288
2.605IleMet: 2.605 ± 0.144
3.073IleAsn: 3.073 ± 0.143
2.645IlePro: 2.645 ± 0.129
2.674IleGln: 2.674 ± 0.121
3.56IleArg: 3.56 ± 0.138
5.649IleSer: 5.649 ± 0.227
5.128IleThr: 5.128 ± 0.197
6.101IleVal: 6.101 ± 0.226
1.117IleTrp: 1.117 ± 0.082
3.34IleTyr: 3.34 ± 0.163
0.0IleXaa: 0.0 ± 0.0
Lys
3.039LysAla: 3.039 ± 0.153
1.187LysCys: 1.187 ± 0.094
2.558LysAsp: 2.558 ± 0.159
3.392LysGlu: 3.392 ± 0.264
2.9LysPhe: 2.9 ± 0.119
1.893LysGly: 1.893 ± 0.114
1.053LysHis: 1.053 ± 0.085
4.561LysIle: 4.561 ± 0.163
4.052LysLys: 4.052 ± 0.263
5.389LysLeu: 5.389 ± 0.198
1.783LysMet: 1.783 ± 0.103
3.102LysAsn: 3.102 ± 0.131
2.246LysPro: 2.246 ± 0.133
1.667LysGln: 1.667 ± 0.119
3.282LysArg: 3.282 ± 0.157
3.733LysSer: 3.733 ± 0.213
3.71LysThr: 3.71 ± 0.163
2.9LysVal: 2.9 ± 0.135
0.781LysTrp: 0.781 ± 0.065
2.414LysTyr: 2.414 ± 0.114
0.0LysXaa: 0.0 ± 0.0
Leu
6.048LeuAla: 6.048 ± 0.17
1.87LeuCys: 1.87 ± 0.129
3.872LeuAsp: 3.872 ± 0.159
5.58LeuGlu: 5.58 ± 0.271
5.585LeuPhe: 5.585 ± 0.203
4.949LeuGly: 4.949 ± 0.167
2.466LeuHis: 2.466 ± 0.117
8.74LeuIle: 8.74 ± 0.318
6.141LeuLys: 6.141 ± 0.226
11.402LeuLeu: 11.402 ± 0.334
3.658LeuMet: 3.658 ± 0.169
4.445LeuAsn: 4.445 ± 0.157
3.959LeuPro: 3.959 ± 0.145
4.416LeuGln: 4.416 ± 0.146
5.308LeuArg: 5.308 ± 0.15
8.121LeuSer: 8.121 ± 0.226
7.027LeuThr: 7.027 ± 0.197
6.616LeuVal: 6.616 ± 0.21
1.291LeuTrp: 1.291 ± 0.096
3.901LeuTyr: 3.901 ± 0.163
0.0LeuXaa: 0.0 ± 0.0
Met
1.991MetAla: 1.991 ± 0.098
0.515MetCys: 0.515 ± 0.052
1.412MetAsp: 1.412 ± 0.094
2.02MetGlu: 2.02 ± 0.091
1.383MetPhe: 1.383 ± 0.092
1.337MetGly: 1.337 ± 0.081
0.689MetHis: 0.689 ± 0.061
2.541MetIle: 2.541 ± 0.137
2.199MetLys: 2.199 ± 0.106
3.044MetLeu: 3.044 ± 0.141
1.534MetMet: 1.534 ± 0.103
1.516MetAsn: 1.516 ± 0.102
1.14MetPro: 1.14 ± 0.082
1.285MetGln: 1.285 ± 0.084
1.951MetArg: 1.951 ± 0.102
2.599MetSer: 2.599 ± 0.121
2.211MetThr: 2.211 ± 0.129
1.812MetVal: 1.812 ± 0.107
0.324MetTrp: 0.324 ± 0.046
0.972MetTyr: 0.972 ± 0.072
0.0MetXaa: 0.0 ± 0.0
Asn
2.362AsnAla: 2.362 ± 0.125
0.862AsnCys: 0.862 ± 0.072
2.159AsnAsp: 2.159 ± 0.114
2.558AsnGlu: 2.558 ± 0.116
2.807AsnPhe: 2.807 ± 0.124
1.858AsnGly: 1.858 ± 0.105
1.024AsnHis: 1.024 ± 0.081
3.34AsnIle: 3.34 ± 0.157
1.927AsnLys: 1.927 ± 0.121
4.347AsnLeu: 4.347 ± 0.154
1.459AsnMet: 1.459 ± 0.099
1.748AsnAsn: 1.748 ± 0.111
1.621AsnPro: 1.621 ± 0.093
1.21AsnGln: 1.21 ± 0.09
2.147AsnArg: 2.147 ± 0.093
3.288AsnSer: 3.288 ± 0.139
2.026AsnThr: 2.026 ± 0.101
2.836AsnVal: 2.836 ± 0.114
0.712AsnTrp: 0.712 ± 0.065
1.482AsnTyr: 1.482 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
1.991ProAla: 1.991 ± 0.119
0.764ProCys: 0.764 ± 0.063
1.621ProAsp: 1.621 ± 0.105
2.483ProGlu: 2.483 ± 0.17
2.182ProPhe: 2.182 ± 0.112
1.557ProGly: 1.557 ± 0.097
0.793ProHis: 0.793 ± 0.067
2.477ProIle: 2.477 ± 0.118
2.217ProLys: 2.217 ± 0.137
4.092ProLeu: 4.092 ± 0.125
1.007ProMet: 1.007 ± 0.09
1.464ProAsn: 1.464 ± 0.092
1.991ProPro: 1.991 ± 0.149
1.204ProGln: 1.204 ± 0.094
1.968ProArg: 1.968 ± 0.127
2.269ProSer: 2.269 ± 0.151
1.881ProThr: 1.881 ± 0.131
2.5ProVal: 2.5 ± 0.134
0.625ProTrp: 0.625 ± 0.056
1.337ProTyr: 1.337 ± 0.105
0.0ProXaa: 0.0 ± 0.0
Gln
1.754GlnAla: 1.754 ± 0.092
0.666GlnCys: 0.666 ± 0.063
1.169GlnAsp: 1.169 ± 0.088
2.084GlnGlu: 2.084 ± 0.116
2.003GlnPhe: 2.003 ± 0.106
1.285GlnGly: 1.285 ± 0.093
0.747GlnHis: 0.747 ± 0.058
2.593GlnIle: 2.593 ± 0.111
2.089GlnLys: 2.089 ± 0.144
4.196GlnLeu: 4.196 ± 0.177
1.198GlnMet: 1.198 ± 0.096
1.459GlnAsn: 1.459 ± 0.099
0.996GlnPro: 0.996 ± 0.088
1.493GlnGln: 1.493 ± 0.115
2.309GlnArg: 2.309 ± 0.133
2.443GlnSer: 2.443 ± 0.118
1.974GlnThr: 1.974 ± 0.091
2.165GlnVal: 2.165 ± 0.109
0.608GlnTrp: 0.608 ± 0.06
1.36GlnTyr: 1.36 ± 0.083
0.0GlnXaa: 0.0 ± 0.0
Arg
2.882ArgAla: 2.882 ± 0.15
0.967ArgCys: 0.967 ± 0.075
2.495ArgAsp: 2.495 ± 0.114
3.45ArgGlu: 3.45 ± 0.189
2.495ArgPhe: 2.495 ± 0.104
2.257ArgGly: 2.257 ± 0.13
1.563ArgHis: 1.563 ± 0.085
3.971ArgIle: 3.971 ± 0.133
3.421ArgLys: 3.421 ± 0.17
5.232ArgLeu: 5.232 ± 0.178
1.447ArgMet: 1.447 ± 0.102
2.379ArgAsn: 2.379 ± 0.119
2.055ArgPro: 2.055 ± 0.122
1.742ArgGln: 1.742 ± 0.092
3.762ArgArg: 3.762 ± 0.225
3.71ArgSer: 3.71 ± 0.17
2.616ArgThr: 2.616 ± 0.116
3.021ArgVal: 3.021 ± 0.128
0.631ArgTrp: 0.631 ± 0.06
1.615ArgTyr: 1.615 ± 0.103
0.0ArgXaa: 0.0 ± 0.0
Ser
4.341SerAla: 4.341 ± 0.15
1.331SerCys: 1.331 ± 0.095
3.16SerAsp: 3.16 ± 0.142
3.814SerGlu: 3.814 ± 0.157
4.138SerPhe: 4.138 ± 0.179
3.727SerGly: 3.727 ± 0.161
1.476SerHis: 1.476 ± 0.085
5.962SerIle: 5.962 ± 0.212
3.727SerLys: 3.727 ± 0.162
8.254SerLeu: 8.254 ± 0.234
2.408SerMet: 2.408 ± 0.133
2.639SerAsn: 2.639 ± 0.121
2.842SerPro: 2.842 ± 0.216
2.599SerGln: 2.599 ± 0.135
3.774SerArg: 3.774 ± 0.18
5.875SerSer: 5.875 ± 0.223
4.046SerThr: 4.046 ± 0.18
4.972SerVal: 4.972 ± 0.188
0.932SerTrp: 0.932 ± 0.071
2.888SerTyr: 2.888 ± 0.142
0.0SerXaa: 0.0 ± 0.0
Thr
4.827ThrAla: 4.827 ± 0.161
1.117ThrCys: 1.117 ± 0.08
1.927ThrAsp: 1.927 ± 0.113
2.778ThrGlu: 2.778 ± 0.124
3.392ThrPhe: 3.392 ± 0.15
2.853ThrGly: 2.853 ± 0.152
0.909ThrHis: 0.909 ± 0.071
5.203ThrIle: 5.203 ± 0.199
2.998ThrLys: 2.998 ± 0.159
6.211ThrLeu: 6.211 ± 0.229
1.864ThrMet: 1.864 ± 0.094
2.199ThrAsn: 2.199 ± 0.113
2.483ThrPro: 2.483 ± 0.177
1.997ThrGln: 1.997 ± 0.107
2.709ThrArg: 2.709 ± 0.136
4.468ThrSer: 4.468 ± 0.172
3.6ThrThr: 3.6 ± 0.17
4.792ThrVal: 4.792 ± 0.175
0.781ThrTrp: 0.781 ± 0.072
2.414ThrTyr: 2.414 ± 0.121
0.0ThrXaa: 0.0 ± 0.0
Val
4.329ValAla: 4.329 ± 0.167
1.435ValCys: 1.435 ± 0.092
3.224ValAsp: 3.224 ± 0.141
3.618ValGlu: 3.618 ± 0.191
3.502ValPhe: 3.502 ± 0.167
3.311ValGly: 3.311 ± 0.153
1.459ValHis: 1.459 ± 0.091
6.054ValIle: 6.054 ± 0.257
3.461ValLys: 3.461 ± 0.172
7.131ValLeu: 7.131 ± 0.241
2.431ValMet: 2.431 ± 0.132
2.593ValAsn: 2.593 ± 0.127
2.246ValPro: 2.246 ± 0.121
2.061ValGln: 2.061 ± 0.091
2.709ValArg: 2.709 ± 0.139
4.567ValSer: 4.567 ± 0.168
3.918ValThr: 3.918 ± 0.174
5.18ValVal: 5.18 ± 0.199
1.082ValTrp: 1.082 ± 0.104
2.68ValTyr: 2.68 ± 0.119
0.0ValXaa: 0.0 ± 0.0
Trp
0.718TrpAla: 0.718 ± 0.077
0.22TrpCys: 0.22 ± 0.035
0.556TrpAsp: 0.556 ± 0.057
0.729TrpGlu: 0.729 ± 0.059
0.706TrpPhe: 0.706 ± 0.067
0.66TrpGly: 0.66 ± 0.056
0.278TrpHis: 0.278 ± 0.039
1.32TrpIle: 1.32 ± 0.097
0.822TrpLys: 0.822 ± 0.064
1.366TrpLeu: 1.366 ± 0.095
0.399TrpMet: 0.399 ± 0.049
0.984TrpAsn: 0.984 ± 0.086
1.088TrpPro: 1.088 ± 0.084
0.376TrpGln: 0.376 ± 0.041
0.602TrpArg: 0.602 ± 0.067
1.053TrpSer: 1.053 ± 0.08
0.758TrpThr: 0.758 ± 0.069
0.538TrpVal: 0.538 ± 0.065
0.336TrpTrp: 0.336 ± 0.043
1.152TrpTyr: 1.152 ± 0.085
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.396TyrAla: 2.396 ± 0.116
1.024TyrCys: 1.024 ± 0.084
1.835TyrAsp: 1.835 ± 0.103
2.008TyrGlu: 2.008 ± 0.099
2.529TyrPhe: 2.529 ± 0.111
2.055TyrGly: 2.055 ± 0.131
1.117TyrHis: 1.117 ± 0.083
2.443TyrIle: 2.443 ± 0.126
1.904TyrLys: 1.904 ± 0.099
4.133TyrLeu: 4.133 ± 0.192
1.048TyrMet: 1.048 ± 0.091
1.742TyrAsn: 1.742 ± 0.114
1.453TyrPro: 1.453 ± 0.102
1.32TyrGln: 1.32 ± 0.093
2.055TyrArg: 2.055 ± 0.098
3.745TyrSer: 3.745 ± 0.164
2.367TyrThr: 2.367 ± 0.118
2.032TyrVal: 2.032 ± 0.114
0.66TyrTrp: 0.66 ± 0.067
1.927TyrTyr: 1.927 ± 0.121
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.006XaaMet: 0.006 ± 0.005
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.001
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 431 proteins (172772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski