Amino acid dipepetide frequency for Trypanosoma vivax (strain Y486)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.932AlaAla: 17.932 ± 0.191	2.853AlaCys: 2.853 ± 0.05	5.023AlaAsp: 5.023 ± 0.119	7.534AlaGlu: 7.534 ± 0.116	2.998AlaPhe: 2.998 ± 0.05	7.604AlaGly: 7.604 ± 0.099	3.3AlaHis: 3.3 ± 0.054	3.284AlaIle: 3.284 ± 0.048	6.288AlaLys: 6.288 ± 0.09	11.64AlaLeu: 11.64 ± 0.117	2.443AlaMet: 2.443 ± 0.046	3.866AlaAsn: 3.866 ± 0.057	4.647AlaPro: 4.647 ± 0.084	5.637AlaGln: 5.637 ± 0.072	9.805AlaArg: 9.805 ± 0.127	8.906AlaSer: 8.906 ± 0.112	8.623AlaThr: 8.623 ± 0.154	7.809AlaVal: 7.809 ± 0.098	1.671AlaTrp: 1.671 ± 0.033	1.21AlaTyr: 1.21 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	3.017CysAla: 3.017 ± 0.057	0.612CysCys: 0.612 ± 0.028	1.125CysAsp: 1.125 ± 0.027	1.567CysGlu: 1.567 ± 0.057	0.744CysPhe: 0.744 ± 0.024	2.251CysGly: 2.251 ± 0.045	0.54CysHis: 0.54 ± 0.027	1.12CysIle: 1.12 ± 0.033	0.955CysLys: 0.955 ± 0.029	2.032CysLeu: 2.032 ± 0.047	0.395CysMet: 0.395 ± 0.016	0.876CysAsn: 0.876 ± 0.026	1.329CysPro: 1.329 ± 0.038	0.599CysGln: 0.599 ± 0.02	1.653CysArg: 1.653 ± 0.04	1.923CysSer: 1.923 ± 0.043	1.929CysThr: 1.929 ± 0.076	1.867CysVal: 1.867 ± 0.043	0.188CysTrp: 0.188 ± 0.012	0.433CysTyr: 0.433 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.901AspAla: 6.901 ± 0.101	0.872AspCys: 0.872 ± 0.027	2.346AspAsp: 2.346 ± 0.053	3.431AspGlu: 3.431 ± 0.059	1.008AspPhe: 1.008 ± 0.028	4.107AspGly: 4.107 ± 0.066	0.794AspHis: 0.794 ± 0.036	1.671AspIle: 1.671 ± 0.034	2.477AspLys: 2.477 ± 0.043	2.85AspLeu: 2.85 ± 0.061	0.991AspMet: 0.991 ± 0.028	1.681AspAsn: 1.681 ± 0.04	1.235AspPro: 1.235 ± 0.037	1.062AspGln: 1.062 ± 0.033	2.227AspArg: 2.227 ± 0.046	3.046AspSer: 3.046 ± 0.053	3.656AspThr: 3.656 ± 0.075	3.766AspVal: 3.766 ± 0.091	0.447AspTrp: 0.447 ± 0.02	0.605AspTyr: 0.605 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.987GluAla: 7.987 ± 0.109	1.497GluCys: 1.497 ± 0.035	2.926GluAsp: 2.926 ± 0.048	5.321GluGlu: 5.321 ± 0.088	1.084GluPhe: 1.084 ± 0.031	4.176GluGly: 4.176 ± 0.073	1.68GluHis: 1.68 ± 0.033	1.87GluIle: 1.87 ± 0.042	4.666GluLys: 4.666 ± 0.084	4.767GluLeu: 4.767 ± 0.091	1.579GluMet: 1.579 ± 0.033	2.404GluAsn: 2.404 ± 0.044	1.678GluPro: 1.678 ± 0.054	2.907GluGln: 2.907 ± 0.048	5.74GluArg: 5.74 ± 0.101	4.059GluSer: 4.059 ± 0.09	4.036GluThr: 4.036 ± 0.076	4.059GluVal: 4.059 ± 0.064	0.779GluTrp: 0.779 ± 0.022	0.859GluTyr: 0.859 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	2.818PheAla: 2.818 ± 0.048	0.735PheCys: 0.735 ± 0.021	1.458PheAsp: 1.458 ± 0.034	1.386PheGlu: 1.386 ± 0.034	1.251PhePhe: 1.251 ± 0.032	1.814PheGly: 1.814 ± 0.055	0.513PheHis: 0.513 ± 0.023	1.126PheIle: 1.126 ± 0.033	0.832PheLys: 0.832 ± 0.025	2.385PheLeu: 2.385 ± 0.05	0.498PheMet: 0.498 ± 0.021	0.988PheAsn: 0.988 ± 0.025	1.101PhePro: 1.101 ± 0.037	0.636PheGln: 0.636 ± 0.02	1.504PheArg: 1.504 ± 0.036	2.335PheSer: 2.335 ± 0.048	1.306PheThr: 1.306 ± 0.032	2.213PheVal: 2.213 ± 0.045	0.425PheTrp: 0.425 ± 0.015	0.599PheTyr: 0.599 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.029GlyAla: 8.029 ± 0.104	1.689GlyCys: 1.689 ± 0.037	3.344GlyAsp: 3.344 ± 0.068	4.18GlyGlu: 4.18 ± 0.059	1.59GlyPhe: 1.59 ± 0.047	5.72GlyGly: 5.72 ± 0.094	1.833GlyHis: 1.833 ± 0.033	2.385GlyIle: 2.385 ± 0.072	4.176GlyLys: 4.176 ± 0.066	4.352GlyLeu: 4.352 ± 0.065	1.356GlyMet: 1.356 ± 0.035	3.003GlyAsn: 3.003 ± 0.065	2.425GlyPro: 2.425 ± 0.047	2.674GlyGln: 2.674 ± 0.053	5.14GlyArg: 5.14 ± 0.075	5.358GlySer: 5.358 ± 0.07	5.718GlyThr: 5.718 ± 0.078	4.631GlyVal: 4.631 ± 0.061	0.771GlyTrp: 0.771 ± 0.024	0.91GlyTyr: 0.91 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	3.801HisAla: 3.801 ± 0.063	0.832HisCys: 0.832 ± 0.053	1.165HisAsp: 1.165 ± 0.03	1.342HisGlu: 1.342 ± 0.034	0.735HisPhe: 0.735 ± 0.021	2.018HisGly: 2.018 ± 0.037	0.69HisHis: 0.69 ± 0.03	0.805HisIle: 0.805 ± 0.021	1.491HisLys: 1.491 ± 0.036	1.952HisLeu: 1.952 ± 0.044	0.601HisMet: 0.601 ± 0.02	0.924HisAsn: 0.924 ± 0.023	1.011HisPro: 1.011 ± 0.028	0.792HisGln: 0.792 ± 0.028	2.305HisArg: 2.305 ± 0.046	1.953HisSer: 1.953 ± 0.039	2.242HisThr: 2.242 ± 0.044	1.766HisVal: 1.766 ± 0.047	0.309HisTrp: 0.309 ± 0.026	0.493HisTyr: 0.493 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	3.612IleAla: 3.612 ± 0.055	0.776IleCys: 0.776 ± 0.029	1.569IleAsp: 1.569 ± 0.029	1.998IleGlu: 1.998 ± 0.041	1.015IlePhe: 1.015 ± 0.032	2.023IleGly: 2.023 ± 0.038	0.653IleHis: 0.653 ± 0.024	0.971IleIle: 0.971 ± 0.029	1.676IleLys: 1.676 ± 0.039	2.167IleLeu: 2.167 ± 0.043	0.53IleMet: 0.53 ± 0.017	1.332IleAsn: 1.332 ± 0.032	1.326IlePro: 1.326 ± 0.037	0.962IleGln: 0.962 ± 0.026	1.743IleArg: 1.743 ± 0.04	2.404IleSer: 2.404 ± 0.041	2.389IleThr: 2.389 ± 0.079	2.322IleVal: 2.322 ± 0.05	0.303IleTrp: 0.303 ± 0.014	0.63IleTyr: 0.63 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	6.184LysAla: 6.184 ± 0.094	1.055LysCys: 1.055 ± 0.029	2.567LysAsp: 2.567 ± 0.051	4.041LysGlu: 4.041 ± 0.067	0.953LysPhe: 0.953 ± 0.028	3.974LysGly: 3.974 ± 0.08	1.904LysHis: 1.904 ± 0.042	1.937LysIle: 1.937 ± 0.04	3.908LysLys: 3.908 ± 0.084	4.43LysLeu: 4.43 ± 0.077	1.357LysMet: 1.357 ± 0.034	2.181LysAsn: 2.181 ± 0.048	1.736LysPro: 1.736 ± 0.038	2.664LysGln: 2.664 ± 0.052	4.371LysArg: 4.371 ± 0.067	3.11LysSer: 3.11 ± 0.055	3.749LysThr: 3.749 ± 0.069	3.059LysVal: 3.059 ± 0.05	0.631LysTrp: 0.631 ± 0.02	0.748LysTyr: 0.748 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	9.461LeuAla: 9.461 ± 0.111	2.792LeuCys: 2.792 ± 0.048	3.438LeuAsp: 3.438 ± 0.062	4.914LeuGlu: 4.914 ± 0.08	2.693LeuPhe: 2.693 ± 0.054	4.83LeuGly: 4.83 ± 0.093	2.235LeuHis: 2.235 ± 0.049	2.03LeuIle: 2.03 ± 0.046	4.367LeuLys: 4.367 ± 0.074	8.489LeuLeu: 8.489 ± 0.11	1.568LeuMet: 1.568 ± 0.048	2.921LeuAsn: 2.921 ± 0.074	3.814LeuPro: 3.814 ± 0.094	3.221LeuGln: 3.221 ± 0.065	7.009LeuArg: 7.009 ± 0.093	7.236LeuSer: 7.236 ± 0.174	4.644LeuThr: 4.644 ± 0.069	5.27LeuVal: 5.27 ± 0.066	1.154LeuTrp: 1.154 ± 0.032	1.488LeuTyr: 1.488 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.24MetAla: 2.24 ± 0.045	0.58MetCys: 0.58 ± 0.019	0.966MetAsp: 0.966 ± 0.027	1.384MetGlu: 1.384 ± 0.034	0.446MetPhe: 0.446 ± 0.017	1.033MetGly: 1.033 ± 0.031	0.502MetHis: 0.502 ± 0.018	0.578MetIle: 0.578 ± 0.019	1.346MetLys: 1.346 ± 0.032	1.825MetLeu: 1.825 ± 0.037	0.368MetMet: 0.368 ± 0.018	0.659MetAsn: 0.659 ± 0.022	1.017MetPro: 1.017 ± 0.06	0.929MetGln: 0.929 ± 0.032	1.896MetArg: 1.896 ± 0.037	1.304MetSer: 1.304 ± 0.028	0.97MetThr: 0.97 ± 0.03	1.09MetVal: 1.09 ± 0.026	0.325MetTrp: 0.325 ± 0.014	0.393MetTyr: 0.393 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	5.121AsnAla: 5.121 ± 0.088	0.922AsnCys: 0.922 ± 0.028	1.68AsnAsp: 1.68 ± 0.037	2.993AsnGlu: 2.993 ± 0.063	0.954AsnPhe: 0.954 ± 0.03	2.794AsnGly: 2.794 ± 0.046	0.495AsnHis: 0.495 ± 0.018	1.472AsnIle: 1.472 ± 0.036	2.295AsnLys: 2.295 ± 0.044	2.019AsnLeu: 2.019 ± 0.052	0.74AsnMet: 0.74 ± 0.022	1.547AsnAsn: 1.547 ± 0.041	0.767AsnPro: 0.767 ± 0.027	0.788AsnGln: 0.788 ± 0.025	1.778AsnArg: 1.778 ± 0.036	2.682AsnSer: 2.682 ± 0.06	3.236AsnThr: 3.236 ± 0.053	2.829AsnVal: 2.829 ± 0.06	0.512AsnTrp: 0.512 ± 0.017	0.666AsnTyr: 0.666 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	3.953ProAla: 3.953 ± 0.07	1.056ProCys: 1.056 ± 0.033	1.564ProAsp: 1.564 ± 0.046	2.17ProGlu: 2.17 ± 0.042	1.285ProPhe: 1.285 ± 0.044	2.475ProGly: 2.475 ± 0.048	1.363ProHis: 1.363 ± 0.039	1.045ProIle: 1.045 ± 0.027	1.711ProLys: 1.711 ± 0.039	4.236ProLeu: 4.236 ± 0.109	0.632ProMet: 0.632 ± 0.021	1.233ProAsn: 1.233 ± 0.031	2.554ProPro: 2.554 ± 0.068	1.898ProGln: 1.898 ± 0.047	3.474ProArg: 3.474 ± 0.067	3.26ProSer: 3.26 ± 0.081	2.449ProThr: 2.449 ± 0.053	2.531ProVal: 2.531 ± 0.097	0.542ProTrp: 0.542 ± 0.019	0.612ProTyr: 0.612 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	4.341GlnAla: 4.341 ± 0.073	0.938GlnCys: 0.938 ± 0.063	1.52GlnAsp: 1.52 ± 0.037	2.443GlnGlu: 2.443 ± 0.066	0.751GlnPhe: 0.751 ± 0.019	2.764GlnGly: 2.764 ± 0.054	1.667GlnHis: 1.667 ± 0.042	1.0GlnIle: 1.0 ± 0.027	2.425GlnLys: 2.425 ± 0.044	3.697GlnLeu: 3.697 ± 0.065	0.726GlnMet: 0.726 ± 0.02	1.369GlnAsn: 1.369 ± 0.035	1.567GlnPro: 1.567 ± 0.035	2.756GlnGln: 2.756 ± 0.069	3.898GlnArg: 3.898 ± 0.067	2.385GlnSer: 2.385 ± 0.042	2.397GlnThr: 2.397 ± 0.048	1.957GlnVal: 1.957 ± 0.037	0.619GlnTrp: 0.619 ± 0.02	0.538GlnTyr: 0.538 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.232ArgAla: 9.232 ± 0.128	2.041ArgCys: 2.041 ± 0.049	3.414ArgAsp: 3.414 ± 0.05	5.281ArgGlu: 5.281 ± 0.073	1.508ArgPhe: 1.508 ± 0.033	5.372ArgGly: 5.372 ± 0.085	2.715ArgHis: 2.715 ± 0.055	2.053ArgIle: 2.053 ± 0.042	4.043ArgLys: 4.043 ± 0.076	6.021ArgLeu: 6.021 ± 0.098	1.7ArgMet: 1.7 ± 0.04	2.606ArgAsn: 2.606 ± 0.048	3.17ArgPro: 3.17 ± 0.063	3.313ArgGln: 3.313 ± 0.056	8.714ArgArg: 8.714 ± 0.161	5.054ArgSer: 5.054 ± 0.074	5.411ArgThr: 5.411 ± 0.082	5.051ArgVal: 5.051 ± 0.075	1.218ArgTrp: 1.218 ± 0.03	1.072ArgTyr: 1.072 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	9.603SerAla: 9.603 ± 0.101	1.787SerCys: 1.787 ± 0.043	3.543SerAsp: 3.543 ± 0.069	4.582SerGlu: 4.582 ± 0.077	2.275SerPhe: 2.275 ± 0.055	5.842SerGly: 5.842 ± 0.082	1.905SerHis: 1.905 ± 0.055	2.246SerIle: 2.246 ± 0.04	3.463SerLys: 3.463 ± 0.054	6.167SerLeu: 6.167 ± 0.1	1.211SerMet: 1.211 ± 0.027	2.638SerAsn: 2.638 ± 0.051	3.164SerPro: 3.164 ± 0.085	2.03SerGln: 2.03 ± 0.039	4.701SerArg: 4.701 ± 0.064	6.707SerSer: 6.707 ± 0.11	5.318SerThr: 5.318 ± 0.074	5.302SerVal: 5.302 ± 0.126	0.709SerTrp: 0.709 ± 0.024	1.069SerTyr: 1.069 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.472ThrAla: 8.472 ± 0.116	1.402ThrCys: 1.402 ± 0.034	3.067ThrAsp: 3.067 ± 0.085	4.025ThrGlu: 4.025 ± 0.059	1.617ThrPhe: 1.617 ± 0.033	4.784ThrGly: 4.784 ± 0.097	2.237ThrHis: 2.237 ± 0.043	1.896ThrIle: 1.896 ± 0.035	3.617ThrLys: 3.617 ± 0.063	6.032ThrLeu: 6.032 ± 0.095	1.111ThrMet: 1.111 ± 0.028	2.639ThrAsn: 2.639 ± 0.047	3.176ThrPro: 3.176 ± 0.063	3.577ThrGln: 3.577 ± 0.065	5.445ThrArg: 5.445 ± 0.1	5.199ThrSer: 5.199 ± 0.077	4.609ThrThr: 4.609 ± 0.108	3.942ThrVal: 3.942 ± 0.054	0.813ThrTrp: 0.813 ± 0.025	0.899ThrTyr: 0.899 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	7.984ValAla: 7.984 ± 0.124	1.888ValCys: 1.888 ± 0.041	3.083ValAsp: 3.083 ± 0.06	3.969ValGlu: 3.969 ± 0.06	2.129ValPhe: 2.129 ± 0.047	3.946ValGly: 3.946 ± 0.064	1.454ValHis: 1.454 ± 0.039	1.743ValIle: 1.743 ± 0.034	3.343ValLys: 3.343 ± 0.052	6.191ValLeu: 6.191 ± 0.092	1.34ValMet: 1.34 ± 0.062	2.141ValAsn: 2.141 ± 0.046	3.124ValPro: 3.124 ± 0.066	2.373ValGln: 2.373 ± 0.078	5.265ValArg: 5.265 ± 0.093	5.308ValSer: 5.308 ± 0.094	3.997ValThr: 3.997 ± 0.066	5.269ValVal: 5.269 ± 0.091	0.898ValTrp: 0.898 ± 0.026	0.933ValTyr: 0.933 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.017TrpAla: 1.017 ± 0.023	0.361TrpCys: 0.361 ± 0.017	0.574TrpAsp: 0.574 ± 0.021	0.664TrpGlu: 0.664 ± 0.026	0.269TrpPhe: 0.269 ± 0.014	0.834TrpGly: 0.834 ± 0.02	0.437TrpHis: 0.437 ± 0.025	0.341TrpIle: 0.341 ± 0.016	0.767TrpLys: 0.767 ± 0.021	1.138TrpLeu: 1.138 ± 0.028	0.289TrpMet: 0.289 ± 0.014	0.727TrpAsn: 0.727 ± 0.022	0.665TrpPro: 0.665 ± 0.023	0.527TrpGln: 0.527 ± 0.021	1.281TrpArg: 1.281 ± 0.029	0.946TrpSer: 0.946 ± 0.023	0.967TrpThr: 0.967 ± 0.027	0.462TrpVal: 0.462 ± 0.019	0.218TrpTrp: 0.218 ± 0.011	0.209TrpTyr: 0.209 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.367TyrAla: 1.367 ± 0.03	0.467TyrCys: 0.467 ± 0.027	0.802TyrAsp: 0.802 ± 0.024	0.849TyrGlu: 0.849 ± 0.026	0.62TyrPhe: 0.62 ± 0.023	0.923TyrGly: 0.923 ± 0.029	0.31TyrHis: 0.31 ± 0.016	0.827TyrIle: 0.827 ± 0.033	0.716TyrLys: 0.716 ± 0.021	1.184TyrLeu: 1.184 ± 0.031	0.417TyrMet: 0.417 ± 0.016	0.556TyrAsn: 0.556 ± 0.022	0.538TyrPro: 0.538 ± 0.022	0.412TyrGln: 0.412 ± 0.017	1.041TyrArg: 1.041 ± 0.029	1.088TyrSer: 1.088 ± 0.03	0.91TyrThr: 0.91 ± 0.022	1.182TyrVal: 1.182 ± 0.03	0.158TyrTrp: 0.158 ± 0.011	0.368TyrTyr: 0.368 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3778 proteins (1476553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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