Amino acid dipepetide frequency for Halostagnicola sp. A56

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.465AlaAla: 11.465 ± 0.173	0.743AlaCys: 0.743 ± 0.036	9.139AlaAsp: 9.139 ± 0.144	8.214AlaGlu: 8.214 ± 0.123	3.608AlaPhe: 3.608 ± 0.075	8.63AlaGly: 8.63 ± 0.143	1.79AlaHis: 1.79 ± 0.05	5.384AlaIle: 5.384 ± 0.102	1.894AlaLys: 1.894 ± 0.061	9.489AlaLeu: 9.489 ± 0.147	2.017AlaMet: 2.017 ± 0.06	2.544AlaAsn: 2.544 ± 0.053	3.294AlaPro: 3.294 ± 0.078	2.304AlaGln: 2.304 ± 0.061	5.717AlaArg: 5.717 ± 0.095	5.671AlaSer: 5.671 ± 0.095	6.788AlaThr: 6.788 ± 0.13	9.338AlaVal: 9.338 ± 0.15	0.915AlaTrp: 0.915 ± 0.04	2.551AlaTyr: 2.551 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.605CysAla: 0.605 ± 0.032	0.104CysCys: 0.104 ± 0.011	0.605CysAsp: 0.605 ± 0.032	0.675CysGlu: 0.675 ± 0.033	0.194CysPhe: 0.194 ± 0.017	0.856CysGly: 0.856 ± 0.039	0.19CysHis: 0.19 ± 0.016	0.307CysIle: 0.307 ± 0.021	0.123CysLys: 0.123 ± 0.014	0.649CysLeu: 0.649 ± 0.028	0.122CysMet: 0.122 ± 0.013	0.216CysAsn: 0.216 ± 0.019	0.547CysPro: 0.547 ± 0.031	0.19CysGln: 0.19 ± 0.017	0.48CysArg: 0.48 ± 0.026	0.497CysSer: 0.497 ± 0.025	0.404CysThr: 0.404 ± 0.024	0.465CysVal: 0.465 ± 0.026	0.094CysTrp: 0.094 ± 0.011	0.237CysTyr: 0.237 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.027AspAla: 9.027 ± 0.142	0.618AspCys: 0.618 ± 0.035	7.936AspAsp: 7.936 ± 0.144	8.747AspGlu: 8.747 ± 0.12	1.951AspPhe: 1.951 ± 0.056	8.072AspGly: 8.072 ± 0.146	1.705AspHis: 1.705 ± 0.054	3.698AspIle: 3.698 ± 0.085	1.02AspLys: 1.02 ± 0.036	7.051AspLeu: 7.051 ± 0.121	1.179AspMet: 1.179 ± 0.044	1.327AspAsn: 1.327 ± 0.045	4.322AspPro: 4.322 ± 0.081	1.858AspGln: 1.858 ± 0.054	6.532AspArg: 6.532 ± 0.129	4.468AspSer: 4.468 ± 0.09	3.884AspThr: 3.884 ± 0.091	7.369AspVal: 7.369 ± 0.085	0.917AspTrp: 0.917 ± 0.036	1.72AspTyr: 1.72 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	8.462GluAla: 8.462 ± 0.128	0.595GluCys: 0.595 ± 0.034	6.506GluAsp: 6.506 ± 0.122	7.098GluGlu: 7.098 ± 0.122	3.305GluPhe: 3.305 ± 0.071	5.435GluGly: 5.435 ± 0.107	2.214GluHis: 2.214 ± 0.06	4.61GluIle: 4.61 ± 0.091	2.084GluLys: 2.084 ± 0.06	8.017GluLeu: 8.017 ± 0.13	2.006GluMet: 2.006 ± 0.053	2.853GluAsn: 2.853 ± 0.066	4.253GluPro: 4.253 ± 0.085	3.054GluGln: 3.054 ± 0.074	7.795GluArg: 7.795 ± 0.121	6.632GluSer: 6.632 ± 0.125	7.732GluThr: 7.732 ± 0.125	5.591GluVal: 5.591 ± 0.086	1.2GluTrp: 1.2 ± 0.044	3.092GluTyr: 3.092 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	3.411PheAla: 3.411 ± 0.081	0.331PheCys: 0.331 ± 0.02	3.376PheAsp: 3.376 ± 0.078	3.473PheGlu: 3.473 ± 0.071	1.081PhePhe: 1.081 ± 0.042	3.145PheGly: 3.145 ± 0.066	0.65PheHis: 0.65 ± 0.03	1.169PheIle: 1.169 ± 0.041	0.491PheLys: 0.491 ± 0.029	2.803PheLeu: 2.803 ± 0.078	0.523PheMet: 0.523 ± 0.03	0.678PheAsn: 0.678 ± 0.034	1.36PhePro: 1.36 ± 0.042	0.845PheGln: 0.845 ± 0.039	1.692PheArg: 1.692 ± 0.05	1.815PheSer: 1.815 ± 0.051	1.761PheThr: 1.761 ± 0.049	3.31PheVal: 3.31 ± 0.078	0.357PheTrp: 0.357 ± 0.024	0.858PheTyr: 0.858 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.303GlyAla: 7.303 ± 0.127	0.67GlyCys: 0.67 ± 0.034	6.479GlyAsp: 6.479 ± 0.105	7.009GlyGlu: 7.009 ± 0.105	3.076GlyPhe: 3.076 ± 0.07	6.914GlyGly: 6.914 ± 0.13	1.554GlyHis: 1.554 ± 0.052	4.404GlyIle: 4.404 ± 0.092	1.922GlyLys: 1.922 ± 0.058	6.965GlyLeu: 6.965 ± 0.116	1.568GlyMet: 1.568 ± 0.046	2.03GlyAsn: 2.03 ± 0.062	3.233GlyPro: 3.233 ± 0.072	2.067GlyGln: 2.067 ± 0.06	4.458GlyArg: 4.458 ± 0.083	5.536GlySer: 5.536 ± 0.101	5.792GlyThr: 5.792 ± 0.107	7.134GlyVal: 7.134 ± 0.12	1.042GlyTrp: 1.042 ± 0.039	2.63GlyTyr: 2.63 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.932HisAla: 1.932 ± 0.056	0.192HisCys: 0.192 ± 0.016	1.779HisAsp: 1.779 ± 0.061	1.817HisGlu: 1.817 ± 0.055	0.562HisPhe: 0.562 ± 0.025	1.85HisGly: 1.85 ± 0.051	0.516HisHis: 0.516 ± 0.031	0.729HisIle: 0.729 ± 0.033	0.309HisLys: 0.309 ± 0.023	1.663HisLeu: 1.663 ± 0.046	0.303HisMet: 0.303 ± 0.02	0.426HisAsn: 0.426 ± 0.026	1.184HisPro: 1.184 ± 0.037	0.497HisGln: 0.497 ± 0.025	1.325HisArg: 1.325 ± 0.043	0.905HisSer: 0.905 ± 0.036	0.995HisThr: 0.995 ± 0.037	1.785HisVal: 1.785 ± 0.05	0.212HisTrp: 0.212 ± 0.018	0.544HisTyr: 0.544 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.379IleAla: 5.379 ± 0.099	0.357IleCys: 0.357 ± 0.022	4.935IleAsp: 4.935 ± 0.085	4.88IleGlu: 4.88 ± 0.099	1.136IlePhe: 1.136 ± 0.048	4.459IleGly: 4.459 ± 0.099	0.825IleHis: 0.825 ± 0.034	1.597IleIle: 1.597 ± 0.056	0.798IleLys: 0.798 ± 0.035	3.344IleLeu: 3.344 ± 0.081	0.599IleMet: 0.599 ± 0.032	1.115IleAsn: 1.115 ± 0.038	2.223IlePro: 2.223 ± 0.062	1.213IleGln: 1.213 ± 0.041	2.694IleArg: 2.694 ± 0.073	2.589IleSer: 2.589 ± 0.072	2.795IleThr: 2.795 ± 0.065	4.447IleVal: 4.447 ± 0.096	0.38IleTrp: 0.38 ± 0.024	1.018IleTyr: 1.018 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	1.709LysAla: 1.709 ± 0.055	0.122LysCys: 0.122 ± 0.014	1.07LysAsp: 1.07 ± 0.04	1.28LysGlu: 1.28 ± 0.052	0.553LysPhe: 0.553 ± 0.031	1.263LysGly: 1.263 ± 0.045	0.53LysHis: 0.53 ± 0.031	0.927LysIle: 0.927 ± 0.038	0.515LysLys: 0.515 ± 0.029	1.839LysLeu: 1.839 ± 0.058	0.407LysMet: 0.407 ± 0.023	0.63LysAsn: 0.63 ± 0.026	1.011LysPro: 1.011 ± 0.042	0.767LysGln: 0.767 ± 0.041	1.771LysArg: 1.771 ± 0.049	1.252LysSer: 1.252 ± 0.045	1.421LysThr: 1.421 ± 0.049	1.194LysVal: 1.194 ± 0.04	0.221LysTrp: 0.221 ± 0.017	0.618LysTyr: 0.618 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.88LeuAla: 9.88 ± 0.136	0.638LeuCys: 0.638 ± 0.026	5.619LeuAsp: 5.619 ± 0.09	12.44LeuGlu: 12.44 ± 0.146	3.065LeuPhe: 3.065 ± 0.07	6.828LeuGly: 6.828 ± 0.117	1.355LeuHis: 1.355 ± 0.051	3.322LeuIle: 3.322 ± 0.087	1.493LeuLys: 1.493 ± 0.048	8.108LeuLeu: 8.108 ± 0.14	1.274LeuMet: 1.274 ± 0.047	1.774LeuAsn: 1.774 ± 0.055	3.734LeuPro: 3.734 ± 0.075	1.954LeuGln: 1.954 ± 0.055	4.916LeuArg: 4.916 ± 0.097	5.663LeuSer: 5.663 ± 0.082	5.067LeuThr: 5.067 ± 0.101	7.777LeuVal: 7.777 ± 0.124	0.798LeuTrp: 0.798 ± 0.038	2.104LeuTyr: 2.104 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.054	0.111MetCys: 0.111 ± 0.012	1.299MetAsp: 1.299 ± 0.048	1.137MetGlu: 1.137 ± 0.042	0.529MetPhe: 0.529 ± 0.029	1.456MetGly: 1.456 ± 0.042	0.356MetHis: 0.356 ± 0.023	0.829MetIle: 0.829 ± 0.036	0.504MetLys: 0.504 ± 0.025	1.594MetLeu: 1.594 ± 0.051	0.386MetMet: 0.386 ± 0.024	0.681MetAsn: 0.681 ± 0.032	0.718MetPro: 0.718 ± 0.033	0.53MetGln: 0.53 ± 0.029	1.065MetArg: 1.065 ± 0.041	1.559MetSer: 1.559 ± 0.049	1.569MetThr: 1.569 ± 0.051	1.208MetVal: 1.208 ± 0.043	0.181MetTrp: 0.181 ± 0.018	0.407MetTyr: 0.407 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.811AsnAla: 2.811 ± 0.067	0.253AsnCys: 0.253 ± 0.021	1.818AsnAsp: 1.818 ± 0.06	2.168AsnGlu: 2.168 ± 0.061	0.682AsnPhe: 0.682 ± 0.03	2.219AsnGly: 2.219 ± 0.065	0.524AsnHis: 0.524 ± 0.029	1.005AsnIle: 1.005 ± 0.042	0.484AsnLys: 0.484 ± 0.025	1.973AsnLeu: 1.973 ± 0.049	0.511AsnMet: 0.511 ± 0.028	0.578AsnAsn: 0.578 ± 0.03	1.514AsnPro: 1.514 ± 0.043	0.693AsnGln: 0.693 ± 0.028	1.764AsnArg: 1.764 ± 0.054	1.292AsnSer: 1.292 ± 0.048	1.391AsnThr: 1.391 ± 0.049	2.347AsnVal: 2.347 ± 0.058	0.361AsnTrp: 0.361 ± 0.023	0.707AsnTyr: 0.707 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.339ProAla: 4.339 ± 0.087	0.253ProCys: 0.253 ± 0.018	4.58ProAsp: 4.58 ± 0.082	4.354ProGlu: 4.354 ± 0.08	1.532ProPhe: 1.532 ± 0.047	3.411ProGly: 3.411 ± 0.078	0.861ProHis: 0.861 ± 0.035	2.313ProIle: 2.313 ± 0.061	0.931ProLys: 0.931 ± 0.04	3.434ProLeu: 3.434 ± 0.073	0.789ProMet: 0.789 ± 0.035	1.245ProAsn: 1.245 ± 0.043	2.023ProPro: 2.023 ± 0.061	0.946ProGln: 0.946 ± 0.034	2.217ProArg: 2.217 ± 0.052	2.679ProSer: 2.679 ± 0.06	3.177ProThr: 3.177 ± 0.07	3.799ProVal: 3.799 ± 0.076	0.457ProTrp: 0.457 ± 0.027	1.094ProTyr: 1.094 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.435GlnAla: 2.435 ± 0.066	0.17GlnCys: 0.17 ± 0.015	1.418GlnAsp: 1.418 ± 0.046	1.796GlnGlu: 1.796 ± 0.064	1.111GlnPhe: 1.111 ± 0.041	1.613GlnGly: 1.613 ± 0.053	0.598GlnHis: 0.598 ± 0.031	1.377GlnIle: 1.377 ± 0.04	0.609GlnLys: 0.609 ± 0.03	2.362GlnLeu: 2.362 ± 0.06	0.63GlnMet: 0.63 ± 0.028	0.837GlnAsn: 0.837 ± 0.034	1.172GlnPro: 1.172 ± 0.04	1.103GlnGln: 1.103 ± 0.05	1.995GlnArg: 1.995 ± 0.058	1.849GlnSer: 1.849 ± 0.058	1.857GlnThr: 1.857 ± 0.048	1.778GlnVal: 1.778 ± 0.058	0.32GlnTrp: 0.32 ± 0.022	0.894GlnTyr: 0.894 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.096ArgAla: 6.096 ± 0.108	0.511ArgCys: 0.511 ± 0.03	4.845ArgAsp: 4.845 ± 0.081	6.365ArgGlu: 6.365 ± 0.107	2.305ArgPhe: 2.305 ± 0.054	4.22ArgGly: 4.22 ± 0.085	1.094ArgHis: 1.094 ± 0.049	3.189ArgIle: 3.189 ± 0.06	1.415ArgLys: 1.415 ± 0.053	5.995ArgLeu: 5.995 ± 0.098	1.327ArgMet: 1.327 ± 0.044	1.674ArgAsn: 1.674 ± 0.048	2.423ArgPro: 2.423 ± 0.058	1.709ArgGln: 1.709 ± 0.049	4.652ArgArg: 4.652 ± 0.104	4.065ArgSer: 4.065 ± 0.083	4.253ArgThr: 4.253 ± 0.092	4.848ArgVal: 4.848 ± 0.096	0.791ArgTrp: 0.791 ± 0.031	1.891ArgTyr: 1.891 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	5.692SerAla: 5.692 ± 0.094	0.357SerCys: 0.357 ± 0.024	4.993SerAsp: 4.993 ± 0.088	5.054SerGlu: 5.054 ± 0.102	2.102SerPhe: 2.102 ± 0.055	5.382SerGly: 5.382 ± 0.099	1.103SerHis: 1.103 ± 0.038	3.341SerIle: 3.341 ± 0.065	1.299SerLys: 1.299 ± 0.042	5.302SerLeu: 5.302 ± 0.077	1.303SerMet: 1.303 ± 0.042	1.7SerAsn: 1.7 ± 0.057	2.576SerPro: 2.576 ± 0.061	1.641SerGln: 1.641 ± 0.051	3.541SerArg: 3.541 ± 0.074	4.163SerSer: 4.163 ± 0.092	3.903SerThr: 3.903 ± 0.086	5.386SerVal: 5.386 ± 0.089	0.659SerTrp: 0.659 ± 0.031	1.572SerTyr: 1.572 ± 0.052	0.001SerXaa: 0.001 ± 0.001
Thr	6.925ThrAla: 6.925 ± 0.099	0.416ThrCys: 0.416 ± 0.024	5.862ThrAsp: 5.862 ± 0.101	4.985ThrGlu: 4.985 ± 0.075	2.103ThrPhe: 2.103 ± 0.057	5.813ThrGly: 5.813 ± 0.094	1.103ThrHis: 1.103 ± 0.039	3.635ThrIle: 3.635 ± 0.071	1.169ThrLys: 1.169 ± 0.044	5.764ThrLeu: 5.764 ± 0.106	1.083ThrMet: 1.083 ± 0.044	1.777ThrAsn: 1.777 ± 0.054	3.128ThrPro: 3.128 ± 0.072	1.494ThrGln: 1.494 ± 0.053	3.391ThrArg: 3.391 ± 0.069	3.236ThrSer: 3.236 ± 0.058	4.309ThrThr: 4.309 ± 0.1	6.704ThrVal: 6.704 ± 0.126	0.588ThrTrp: 0.588 ± 0.03	1.674ThrTyr: 1.674 ± 0.05	0.001ThrXaa: 0.001 ± 0.001
Val	8.704ValAla: 8.704 ± 0.141	0.725ValCys: 0.725 ± 0.032	7.675ValAsp: 7.675 ± 0.12	7.537ValGlu: 7.537 ± 0.119	2.955ValPhe: 2.955 ± 0.079	7.16ValGly: 7.16 ± 0.112	1.663ValHis: 1.663 ± 0.047	3.527ValIle: 3.527 ± 0.078	1.332ValLys: 1.332 ± 0.048	7.845ValLeu: 7.845 ± 0.14	1.27ValMet: 1.27 ± 0.043	1.977ValAsn: 1.977 ± 0.053	4.058ValPro: 4.058 ± 0.067	1.95ValGln: 1.95 ± 0.061	5.092ValArg: 5.092 ± 0.087	5.298ValSer: 5.298 ± 0.082	5.84ValThr: 5.84 ± 0.098	8.381ValVal: 8.381 ± 0.149	0.783ValTrp: 0.783 ± 0.035	2.122ValTyr: 2.122 ± 0.057	0.001ValXaa: 0.001 ± 0.001
Trp	0.823TrpAla: 0.823 ± 0.039	0.12TrpCys: 0.12 ± 0.014	0.721TrpAsp: 0.721 ± 0.037	0.851TrpGlu: 0.851 ± 0.038	0.436TrpPhe: 0.436 ± 0.025	0.769TrpGly: 0.769 ± 0.032	0.25TrpHis: 0.25 ± 0.022	0.618TrpIle: 0.618 ± 0.033	0.271TrpLys: 0.271 ± 0.02	1.171TrpLeu: 1.171 ± 0.042	0.241TrpMet: 0.241 ± 0.017	0.387TrpAsn: 0.387 ± 0.023	0.447TrpPro: 0.447 ± 0.027	0.34TrpGln: 0.34 ± 0.021	0.744TrpArg: 0.744 ± 0.033	0.592TrpSer: 0.592 ± 0.032	0.724TrpThr: 0.724 ± 0.033	0.743TrpVal: 0.743 ± 0.035	0.166TrpTrp: 0.166 ± 0.016	0.363TrpTyr: 0.363 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.701TyrAla: 2.701 ± 0.066	0.271TyrCys: 0.271 ± 0.019	2.746TyrAsp: 2.746 ± 0.069	2.652TyrGlu: 2.652 ± 0.073	0.844TyrPhe: 0.844 ± 0.033	2.29TyrGly: 2.29 ± 0.05	0.643TyrHis: 0.643 ± 0.034	0.804TyrIle: 0.804 ± 0.035	0.436TyrLys: 0.436 ± 0.024	2.441TyrLeu: 2.441 ± 0.065	0.376TyrMet: 0.376 ± 0.023	0.646TyrAsn: 0.646 ± 0.031	1.211TyrPro: 1.211 ± 0.046	0.768TyrGln: 0.768 ± 0.035	1.828TyrArg: 1.828 ± 0.053	1.31TyrSer: 1.31 ± 0.045	1.501TyrThr: 1.501 ± 0.046	2.293TyrVal: 2.293 ± 0.057	0.336TyrTrp: 0.336 ± 0.022	0.834TyrTyr: 0.834 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2711 proteins (722748 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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