Amino acid dipepetide frequency for Neisseria arctica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.922AlaAla: 12.922 ± 0.212
1.177AlaCys: 1.177 ± 0.044
5.9AlaAsp: 5.9 ± 0.117
7.115AlaGlu: 7.115 ± 0.123
3.653AlaPhe: 3.653 ± 0.089
7.536AlaGly: 7.536 ± 0.134
1.923AlaHis: 1.923 ± 0.058
4.874AlaIle: 4.874 ± 0.096
5.071AlaLys: 5.071 ± 0.088
10.864AlaLeu: 10.864 ± 0.146
2.667AlaMet: 2.667 ± 0.058
3.311AlaAsn: 3.311 ± 0.09
3.489AlaPro: 3.489 ± 0.084
4.498AlaGln: 4.498 ± 0.104
4.965AlaArg: 4.965 ± 0.101
4.795AlaSer: 4.795 ± 0.098
4.377AlaThr: 4.377 ± 0.107
8.314AlaVal: 8.314 ± 0.143
1.264AlaTrp: 1.264 ± 0.053
2.938AlaTyr: 2.938 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.902CysAla: 0.902 ± 0.04
0.165CysCys: 0.165 ± 0.016
0.513CysAsp: 0.513 ± 0.031
0.542CysGlu: 0.542 ± 0.031
0.321CysPhe: 0.321 ± 0.022
1.034CysGly: 1.034 ± 0.045
0.324CysHis: 0.324 ± 0.023
0.597CysIle: 0.597 ± 0.03
0.349CysLys: 0.349 ± 0.023
0.951CysLeu: 0.951 ± 0.045
0.23CysMet: 0.23 ± 0.021
0.38CysAsn: 0.38 ± 0.026
0.523CysPro: 0.523 ± 0.03
0.345CysGln: 0.345 ± 0.024
0.623CysArg: 0.623 ± 0.033
0.608CysSer: 0.608 ± 0.034
0.502CysThr: 0.502 ± 0.03
0.629CysVal: 0.629 ± 0.031
0.098CysTrp: 0.098 ± 0.015
0.314CysTyr: 0.314 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.711AspAla: 4.711 ± 0.092
0.464AspCys: 0.464 ± 0.027
2.341AspAsp: 2.341 ± 0.067
3.367AspGlu: 3.367 ± 0.077
2.449AspPhe: 2.449 ± 0.069
3.739AspGly: 3.739 ± 0.102
0.851AspHis: 0.851 ± 0.037
3.855AspIle: 3.855 ± 0.079
2.775AspLys: 2.775 ± 0.074
5.121AspLeu: 5.121 ± 0.086
1.455AspMet: 1.455 ± 0.047
2.187AspAsn: 2.187 ± 0.068
1.814AspPro: 1.814 ± 0.061
1.36AspGln: 1.36 ± 0.044
1.981AspArg: 1.981 ± 0.057
2.748AspSer: 2.748 ± 0.064
2.967AspThr: 2.967 ± 0.077
3.396AspVal: 3.396 ± 0.077
0.808AspTrp: 0.808 ± 0.036
1.95AspTyr: 1.95 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.477GluAla: 6.477 ± 0.111
0.486GluCys: 0.486 ± 0.026
2.521GluAsp: 2.521 ± 0.074
3.82GluGlu: 3.82 ± 0.102
1.996GluPhe: 1.996 ± 0.058
3.812GluGly: 3.812 ± 0.094
1.402GluHis: 1.402 ± 0.044
4.004GluIle: 4.004 ± 0.077
3.745GluLys: 3.745 ± 0.088
5.692GluLeu: 5.692 ± 0.116
1.688GluMet: 1.688 ± 0.054
3.064GluAsn: 3.064 ± 0.071
1.996GluPro: 1.996 ± 0.056
3.219GluGln: 3.219 ± 0.081
3.394GluArg: 3.394 ± 0.085
3.235GluSer: 3.235 ± 0.074
3.34GluThr: 3.34 ± 0.079
4.06GluVal: 4.06 ± 0.092
0.783GluTrp: 0.783 ± 0.037
1.836GluTyr: 1.836 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.928PheAla: 3.928 ± 0.092
0.478PheCys: 0.478 ± 0.03
2.506PheAsp: 2.506 ± 0.07
2.192PheGlu: 2.192 ± 0.068
1.758PhePhe: 1.758 ± 0.066
3.486PheGly: 3.486 ± 0.077
0.802PheHis: 0.802 ± 0.035
2.427PheIle: 2.427 ± 0.064
1.846PheLys: 1.846 ± 0.052
3.359PheLeu: 3.359 ± 0.091
0.937PheMet: 0.937 ± 0.042
1.782PheAsn: 1.782 ± 0.055
1.409PhePro: 1.409 ± 0.047
1.244PheGln: 1.244 ± 0.047
1.652PheArg: 1.652 ± 0.052
2.832PheSer: 2.832 ± 0.076
2.181PheThr: 2.181 ± 0.06
2.605PheVal: 2.605 ± 0.077
0.624PheTrp: 0.624 ± 0.032
1.255PheTyr: 1.255 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
6.177GlyAla: 6.177 ± 0.093
0.869GlyCys: 0.869 ± 0.043
3.458GlyAsp: 3.458 ± 0.095
4.447GlyGlu: 4.447 ± 0.089
3.458GlyPhe: 3.458 ± 0.082
5.884GlyGly: 5.884 ± 0.146
1.541GlyHis: 1.541 ± 0.055
5.113GlyIle: 5.113 ± 0.095
4.846GlyLys: 4.846 ± 0.101
7.848GlyLeu: 7.848 ± 0.125
2.281GlyMet: 2.281 ± 0.069
3.134GlyAsn: 3.134 ± 0.123
1.421GlyPro: 1.421 ± 0.05
2.864GlyGln: 2.864 ± 0.078
3.994GlyArg: 3.994 ± 0.094
4.646GlySer: 4.646 ± 0.112
3.567GlyThr: 3.567 ± 0.096
5.429GlyVal: 5.429 ± 0.117
1.074GlyTrp: 1.074 ± 0.051
2.46GlyTyr: 2.46 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.903HisAla: 1.903 ± 0.062
0.272HisCys: 0.272 ± 0.022
1.002HisAsp: 1.002 ± 0.041
1.296HisGlu: 1.296 ± 0.046
0.896HisPhe: 0.896 ± 0.041
1.709HisGly: 1.709 ± 0.05
0.673HisHis: 0.673 ± 0.039
1.607HisIle: 1.607 ± 0.055
0.969HisLys: 0.969 ± 0.038
2.081HisLeu: 2.081 ± 0.062
0.508HisMet: 0.508 ± 0.031
0.924HisAsn: 0.924 ± 0.04
1.274HisPro: 1.274 ± 0.05
0.864HisGln: 0.864 ± 0.037
1.051HisArg: 1.051 ± 0.036
1.164HisSer: 1.164 ± 0.043
1.406HisThr: 1.406 ± 0.053
1.205HisVal: 1.205 ± 0.048
0.334HisTrp: 0.334 ± 0.024
0.786HisTyr: 0.786 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.14IleAla: 6.14 ± 0.108
0.67IleCys: 0.67 ± 0.031
3.316IleAsp: 3.316 ± 0.079
4.015IleGlu: 4.015 ± 0.076
2.19IlePhe: 2.19 ± 0.063
5.16IleGly: 5.16 ± 0.094
1.267IleHis: 1.267 ± 0.046
3.427IleIle: 3.427 ± 0.078
2.74IleLys: 2.74 ± 0.073
5.529IleLeu: 5.529 ± 0.115
1.326IleMet: 1.326 ± 0.06
2.657IleAsn: 2.657 ± 0.077
2.551IlePro: 2.551 ± 0.063
2.166IleGln: 2.166 ± 0.058
3.385IleArg: 3.385 ± 0.082
3.763IleSer: 3.763 ± 0.072
3.62IleThr: 3.62 ± 0.078
3.899IleVal: 3.899 ± 0.08
0.678IleTrp: 0.678 ± 0.033
1.669IleTyr: 1.669 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.109LysAla: 5.109 ± 0.096
0.273LysCys: 0.273 ± 0.021
2.341LysAsp: 2.341 ± 0.073
2.935LysGlu: 2.935 ± 0.081
1.472LysPhe: 1.472 ± 0.047
3.329LysGly: 3.329 ± 0.073
1.169LysHis: 1.169 ± 0.045
3.286LysIle: 3.286 ± 0.083
2.827LysLys: 2.827 ± 0.079
5.084LysLeu: 5.084 ± 0.085
1.414LysMet: 1.414 ± 0.053
2.548LysAsn: 2.548 ± 0.067
2.49LysPro: 2.49 ± 0.068
2.857LysGln: 2.857 ± 0.069
2.702LysArg: 2.702 ± 0.07
2.571LysSer: 2.571 ± 0.066
2.938LysThr: 2.938 ± 0.079
3.334LysVal: 3.334 ± 0.092
0.561LysTrp: 0.561 ± 0.029
1.345LysTyr: 1.345 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
11.205LeuAla: 11.205 ± 0.182
1.043LeuCys: 1.043 ± 0.044
5.275LeuAsp: 5.275 ± 0.098
5.289LeuGlu: 5.289 ± 0.104
3.977LeuPhe: 3.977 ± 0.094
7.287LeuGly: 7.287 ± 0.127
2.263LeuHis: 2.263 ± 0.071
5.578LeuIle: 5.578 ± 0.128
5.533LeuLys: 5.533 ± 0.097
10.646LeuLeu: 10.646 ± 0.194
2.584LeuMet: 2.584 ± 0.079
4.606LeuAsn: 4.606 ± 0.106
5.899LeuPro: 5.899 ± 0.096
4.522LeuGln: 4.522 ± 0.086
4.881LeuArg: 4.881 ± 0.091
6.766LeuSer: 6.766 ± 0.11
5.333LeuThr: 5.333 ± 0.093
6.402LeuVal: 6.402 ± 0.121
1.28LeuTrp: 1.28 ± 0.052
2.733LeuTyr: 2.733 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.616MetAla: 2.616 ± 0.067
0.214MetCys: 0.214 ± 0.019
1.093MetAsp: 1.093 ± 0.039
1.136MetGlu: 1.136 ± 0.044
0.853MetPhe: 0.853 ± 0.042
1.904MetGly: 1.904 ± 0.063
0.545MetHis: 0.545 ± 0.029
1.323MetIle: 1.323 ± 0.051
1.455MetLys: 1.455 ± 0.044
2.962MetLeu: 2.962 ± 0.073
0.843MetMet: 0.843 ± 0.038
1.221MetAsn: 1.221 ± 0.041
1.372MetPro: 1.372 ± 0.044
1.398MetGln: 1.398 ± 0.045
1.407MetArg: 1.407 ± 0.054
1.653MetSer: 1.653 ± 0.052
1.313MetThr: 1.313 ± 0.046
1.804MetVal: 1.804 ± 0.053
0.238MetTrp: 0.238 ± 0.021
0.543MetTyr: 0.543 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.655AsnAla: 3.655 ± 0.101
0.348AsnCys: 0.348 ± 0.023
1.963AsnAsp: 1.963 ± 0.065
2.263AsnGlu: 2.263 ± 0.075
1.391AsnPhe: 1.391 ± 0.049
3.602AsnGly: 3.602 ± 0.103
1.032AsnHis: 1.032 ± 0.047
3.075AsnIle: 3.075 ± 0.084
2.017AsnLys: 2.017 ± 0.061
3.98AsnLeu: 3.98 ± 0.089
1.094AsnMet: 1.094 ± 0.042
1.992AsnAsn: 1.992 ± 0.082
2.451AsnPro: 2.451 ± 0.065
1.895AsnGln: 1.895 ± 0.073
2.401AsnArg: 2.401 ± 0.078
2.182AsnSer: 2.182 ± 0.094
2.581AsnThr: 2.581 ± 0.083
2.57AsnVal: 2.57 ± 0.087
0.608AsnTrp: 0.608 ± 0.032
1.185AsnTyr: 1.185 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
4.196ProAla: 4.196 ± 0.089
0.38ProCys: 0.38 ± 0.024
2.548ProAsp: 2.548 ± 0.066
3.593ProGlu: 3.593 ± 0.08
1.83ProPhe: 1.83 ± 0.057
2.459ProGly: 2.459 ± 0.069
0.993ProHis: 0.993 ± 0.044
2.104ProIle: 2.104 ± 0.068
2.239ProLys: 2.239 ± 0.048
4.347ProLeu: 4.347 ± 0.091
0.978ProMet: 0.978 ± 0.039
1.753ProAsn: 1.753 ± 0.045
1.563ProPro: 1.563 ± 0.053
2.004ProGln: 2.004 ± 0.059
1.676ProArg: 1.676 ± 0.054
2.308ProSer: 2.308 ± 0.061
2.039ProThr: 2.039 ± 0.052
3.529ProVal: 3.529 ± 0.088
0.478ProTrp: 0.478 ± 0.029
1.35ProTyr: 1.35 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
4.938GlnAla: 4.938 ± 0.105
0.318GlnCys: 0.318 ± 0.025
1.772GlnAsp: 1.772 ± 0.057
2.433GlnGlu: 2.433 ± 0.07
1.437GlnPhe: 1.437 ± 0.054
2.819GlnGly: 2.819 ± 0.079
1.064GlnHis: 1.064 ± 0.047
2.683GlnIle: 2.683 ± 0.058
2.251GlnLys: 2.251 ± 0.063
3.864GlnLeu: 3.864 ± 0.087
1.131GlnMet: 1.131 ± 0.04
2.155GlnAsn: 2.155 ± 0.072
1.796GlnPro: 1.796 ± 0.055
2.514GlnGln: 2.514 ± 0.107
2.214GlnArg: 2.214 ± 0.067
2.565GlnSer: 2.565 ± 0.083
2.933GlnThr: 2.933 ± 0.084
2.695GlnVal: 2.695 ± 0.069
0.646GlnTrp: 0.646 ± 0.033
1.409GlnTyr: 1.409 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
4.334ArgAla: 4.334 ± 0.082
0.418ArgCys: 0.418 ± 0.029
2.506ArgAsp: 2.506 ± 0.066
3.21ArgGlu: 3.21 ± 0.08
2.457ArgPhe: 2.457 ± 0.072
3.065ArgGly: 3.065 ± 0.073
1.321ArgHis: 1.321 ± 0.038
3.392ArgIle: 3.392 ± 0.075
2.544ArgLys: 2.544 ± 0.062
5.821ArgLeu: 5.821 ± 0.123
1.48ArgMet: 1.48 ± 0.049
2.298ArgAsn: 2.298 ± 0.069
2.096ArgPro: 2.096 ± 0.062
2.554ArgGln: 2.554 ± 0.067
3.197ArgArg: 3.197 ± 0.094
2.687ArgSer: 2.687 ± 0.074
2.325ArgThr: 2.325 ± 0.064
3.327ArgVal: 3.327 ± 0.081
0.642ArgTrp: 0.642 ± 0.037
2.041ArgTyr: 2.041 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.516SerAla: 5.516 ± 0.102
0.515SerCys: 0.515 ± 0.028
2.948SerAsp: 2.948 ± 0.072
3.535SerGlu: 3.535 ± 0.084
2.306SerPhe: 2.306 ± 0.069
5.578SerGly: 5.578 ± 0.117
1.28SerHis: 1.28 ± 0.048
3.237SerIle: 3.237 ± 0.06
2.587SerLys: 2.587 ± 0.063
5.905SerLeu: 5.905 ± 0.107
1.371SerMet: 1.371 ± 0.043
2.279SerAsn: 2.279 ± 0.073
2.359SerPro: 2.359 ± 0.062
2.174SerGln: 2.174 ± 0.066
3.207SerArg: 3.207 ± 0.067
3.386SerSer: 3.386 ± 0.09
2.756SerThr: 2.756 ± 0.082
4.02SerVal: 4.02 ± 0.095
0.754SerTrp: 0.754 ± 0.036
1.514SerTyr: 1.514 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
6.086ThrAla: 6.086 ± 0.13
0.478ThrCys: 0.478 ± 0.03
2.921ThrAsp: 2.921 ± 0.076
3.192ThrGlu: 3.192 ± 0.081
1.933ThrPhe: 1.933 ± 0.053
4.099ThrGly: 4.099 ± 0.1
1.088ThrHis: 1.088 ± 0.043
2.989ThrIle: 2.989 ± 0.08
1.769ThrLys: 1.769 ± 0.059
6.089ThrLeu: 6.089 ± 0.116
1.045ThrMet: 1.045 ± 0.042
1.804ThrAsn: 1.804 ± 0.088
2.957ThrPro: 2.957 ± 0.066
2.035ThrGln: 2.035 ± 0.063
2.441ThrArg: 2.441 ± 0.073
2.578ThrSer: 2.578 ± 0.068
2.668ThrThr: 2.668 ± 0.101
4.352ThrVal: 4.352 ± 0.107
0.524ThrTrp: 0.524 ± 0.032
1.367ThrTyr: 1.367 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
6.991ValAla: 6.991 ± 0.132
0.845ValCys: 0.845 ± 0.04
3.359ValAsp: 3.359 ± 0.076
4.058ValGlu: 4.058 ± 0.098
2.906ValPhe: 2.906 ± 0.082
4.866ValGly: 4.866 ± 0.107
1.252ValHis: 1.252 ± 0.049
4.152ValIle: 4.152 ± 0.081
3.311ValLys: 3.311 ± 0.086
7.8ValLeu: 7.8 ± 0.134
1.944ValMet: 1.944 ± 0.056
2.679ValAsn: 2.679 ± 0.077
2.932ValPro: 2.932 ± 0.072
2.478ValGln: 2.478 ± 0.058
3.631ValArg: 3.631 ± 0.073
4.596ValSer: 4.596 ± 0.093
3.369ValThr: 3.369 ± 0.102
5.229ValVal: 5.229 ± 0.112
0.942ValTrp: 0.942 ± 0.043
1.996ValTyr: 1.996 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
1.094TrpAla: 1.094 ± 0.044
0.149TrpCys: 0.149 ± 0.017
0.48TrpAsp: 0.48 ± 0.032
0.535TrpGlu: 0.535 ± 0.03
0.64TrpPhe: 0.64 ± 0.032
0.77TrpGly: 0.77 ± 0.039
0.41TrpHis: 0.41 ± 0.025
0.702TrpIle: 0.702 ± 0.032
0.518TrpLys: 0.518 ± 0.031
2.054TrpLeu: 2.054 ± 0.057
0.335TrpMet: 0.335 ± 0.024
0.415TrpAsn: 0.415 ± 0.026
0.492TrpPro: 0.492 ± 0.033
1.174TrpGln: 1.174 ± 0.047
0.866TrpArg: 0.866 ± 0.037
0.53TrpSer: 0.53 ± 0.031
0.422TrpThr: 0.422 ± 0.027
0.843TrpVal: 0.843 ± 0.039
0.203TrpTrp: 0.203 ± 0.02
0.365TrpTyr: 0.365 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.756TyrAla: 2.756 ± 0.077
0.389TyrCys: 0.389 ± 0.022
1.576TyrAsp: 1.576 ± 0.054
1.598TyrGlu: 1.598 ± 0.047
1.377TyrPhe: 1.377 ± 0.044
2.368TyrGly: 2.368 ± 0.067
0.723TyrHis: 0.723 ± 0.036
1.744TyrIle: 1.744 ± 0.059
1.193TyrLys: 1.193 ± 0.045
3.105TyrLeu: 3.105 ± 0.084
0.583TyrMet: 0.583 ± 0.032
1.096TyrAsn: 1.096 ± 0.041
1.482TyrPro: 1.482 ± 0.05
1.475TyrGln: 1.475 ± 0.054
2.052TyrArg: 2.052 ± 0.061
1.612TyrSer: 1.612 ± 0.056
1.779TyrThr: 1.779 ± 0.056
1.695TyrVal: 1.695 ± 0.051
0.457TyrTrp: 0.457 ± 0.025
0.956TyrTyr: 0.956 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2157 proteins (629626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski