Amino acid dipepetide frequency for Desulfovibrio gracilis DSM 16080

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.081AlaAla: 10.081 ± 0.132	1.373AlaCys: 1.373 ± 0.042	5.232AlaAsp: 5.232 ± 0.094	6.789AlaGlu: 6.789 ± 0.094	3.588AlaPhe: 3.588 ± 0.071	7.961AlaGly: 7.961 ± 0.104	1.944AlaHis: 1.944 ± 0.048	3.612AlaIle: 3.612 ± 0.074	3.614AlaLys: 3.614 ± 0.071	11.755AlaLeu: 11.755 ± 0.155	3.055AlaMet: 3.055 ± 0.073	2.216AlaAsn: 2.216 ± 0.055	4.075AlaPro: 4.075 ± 0.077	3.59AlaGln: 3.59 ± 0.054	6.787AlaArg: 6.787 ± 0.106	4.804AlaSer: 4.804 ± 0.077	4.179AlaThr: 4.179 ± 0.077	7.674AlaVal: 7.674 ± 0.101	1.279AlaTrp: 1.279 ± 0.042	2.32AlaTyr: 2.32 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.213CysAla: 1.213 ± 0.039	0.282CysCys: 0.282 ± 0.019	0.626CysAsp: 0.626 ± 0.024	0.654CysGlu: 0.654 ± 0.028	0.532CysPhe: 0.532 ± 0.022	1.485CysGly: 1.485 ± 0.045	0.432CysHis: 0.432 ± 0.035	0.559CysIle: 0.559 ± 0.026	0.363CysLys: 0.363 ± 0.021	1.369CysLeu: 1.369 ± 0.041	0.336CysMet: 0.336 ± 0.02	0.343CysAsn: 0.343 ± 0.018	0.991CysPro: 0.991 ± 0.041	0.325CysGln: 0.325 ± 0.019	1.126CysArg: 1.126 ± 0.036	0.804CysSer: 0.804 ± 0.03	0.612CysThr: 0.612 ± 0.027	1.003CysVal: 1.003 ± 0.04	0.166CysTrp: 0.166 ± 0.013	0.293CysTyr: 0.293 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.432AspAla: 5.432 ± 0.09	0.717AspCys: 0.717 ± 0.031	2.863AspAsp: 2.863 ± 0.082	3.836AspGlu: 3.836 ± 0.065	2.317AspPhe: 2.317 ± 0.047	4.209AspGly: 4.209 ± 0.081	1.319AspHis: 1.319 ± 0.035	3.108AspIle: 3.108 ± 0.06	2.144AspLys: 2.144 ± 0.052	5.987AspLeu: 5.987 ± 0.081	1.82AspMet: 1.82 ± 0.041	1.543AspAsn: 1.543 ± 0.053	3.338AspPro: 3.338 ± 0.067	2.188AspGln: 2.188 ± 0.05	3.625AspArg: 3.625 ± 0.067	2.684AspSer: 2.684 ± 0.068	2.575AspThr: 2.575 ± 0.064	4.451AspVal: 4.451 ± 0.073	0.805AspTrp: 0.805 ± 0.03	1.565AspTyr: 1.565 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.546GluAla: 6.546 ± 0.096	0.707GluCys: 0.707 ± 0.03	3.522GluAsp: 3.522 ± 0.071	5.007GluGlu: 5.007 ± 0.094	2.217GluPhe: 2.217 ± 0.052	4.184GluGly: 4.184 ± 0.084	1.761GluHis: 1.761 ± 0.039	3.43GluIle: 3.43 ± 0.066	3.034GluLys: 3.034 ± 0.066	7.202GluLeu: 7.202 ± 0.1	1.963GluMet: 1.963 ± 0.05	2.221GluAsn: 2.221 ± 0.045	2.782GluPro: 2.782 ± 0.065	3.613GluGln: 3.613 ± 0.067	5.401GluArg: 5.401 ± 0.083	3.398GluSer: 3.398 ± 0.068	3.411GluThr: 3.411 ± 0.059	4.445GluVal: 4.445 ± 0.075	0.68GluTrp: 0.68 ± 0.031	1.803GluTyr: 1.803 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.408PheAla: 3.408 ± 0.067	0.633PheCys: 0.633 ± 0.022	2.374PheAsp: 2.374 ± 0.048	2.265PheGlu: 2.265 ± 0.05	1.968PhePhe: 1.968 ± 0.057	3.256PheGly: 3.256 ± 0.065	0.921PheHis: 0.921 ± 0.032	1.656PheIle: 1.656 ± 0.052	1.225PheLys: 1.225 ± 0.039	4.449PheLeu: 4.449 ± 0.091	1.033PheMet: 1.033 ± 0.038	1.22PheAsn: 1.22 ± 0.038	1.805PhePro: 1.805 ± 0.045	1.424PheGln: 1.424 ± 0.042	2.431PheArg: 2.431 ± 0.057	2.555PheSer: 2.555 ± 0.058	2.17PheThr: 2.17 ± 0.052	2.707PheVal: 2.707 ± 0.057	0.594PheTrp: 0.594 ± 0.028	1.041PheTyr: 1.041 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.547GlyAla: 6.547 ± 0.103	1.262GlyCys: 1.262 ± 0.042	3.957GlyAsp: 3.957 ± 0.075	4.985GlyGlu: 4.985 ± 0.077	3.398GlyPhe: 3.398 ± 0.067	6.397GlyGly: 6.397 ± 0.122	1.805GlyHis: 1.805 ± 0.044	4.157GlyIle: 4.157 ± 0.077	3.751GlyLys: 3.751 ± 0.073	9.184GlyLeu: 9.184 ± 0.114	2.804GlyMet: 2.804 ± 0.064	2.375GlyAsn: 2.375 ± 0.055	3.109GlyPro: 3.109 ± 0.059	2.956GlyGln: 2.956 ± 0.065	5.636GlyArg: 5.636 ± 0.091	4.248GlySer: 4.248 ± 0.081	4.241GlyThr: 4.241 ± 0.082	6.372GlyVal: 6.372 ± 0.093	1.136GlyTrp: 1.136 ± 0.039	2.405GlyTyr: 2.405 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.168HisAla: 2.168 ± 0.045	0.406HisCys: 0.406 ± 0.019	1.32HisAsp: 1.32 ± 0.032	1.371HisGlu: 1.371 ± 0.041	0.989HisPhe: 0.989 ± 0.035	1.975HisGly: 1.975 ± 0.046	0.59HisHis: 0.59 ± 0.032	1.056HisIle: 1.056 ± 0.037	0.776HisLys: 0.776 ± 0.03	2.349HisLeu: 2.349 ± 0.052	0.516HisMet: 0.516 ± 0.024	0.623HisAsn: 0.623 ± 0.026	1.505HisPro: 1.505 ± 0.04	0.756HisGln: 0.756 ± 0.03	1.416HisArg: 1.416 ± 0.041	1.172HisSer: 1.172 ± 0.038	1.129HisThr: 1.129 ± 0.034	1.551HisVal: 1.551 ± 0.046	0.368HisTrp: 0.368 ± 0.019	0.573HisTyr: 0.573 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.101IleAla: 4.101 ± 0.071	0.659IleCys: 0.659 ± 0.029	2.224IleAsp: 2.224 ± 0.058	2.575IleGlu: 2.575 ± 0.056	1.866IlePhe: 1.866 ± 0.048	3.464IleGly: 3.464 ± 0.069	1.11IleHis: 1.11 ± 0.027	2.245IleIle: 2.245 ± 0.056	1.848IleLys: 1.848 ± 0.048	5.005IleLeu: 5.005 ± 0.076	1.274IleMet: 1.274 ± 0.037	1.503IleAsn: 1.503 ± 0.046	2.509IlePro: 2.509 ± 0.051	1.608IleGln: 1.608 ± 0.045	3.359IleArg: 3.359 ± 0.057	2.784IleSer: 2.784 ± 0.065	2.487IleThr: 2.487 ± 0.06	3.463IleVal: 3.463 ± 0.073	0.546IleTrp: 0.546 ± 0.026	1.135IleTyr: 1.135 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.926LysAla: 3.926 ± 0.078	0.367LysCys: 0.367 ± 0.022	2.254LysAsp: 2.254 ± 0.056	2.67LysGlu: 2.67 ± 0.066	1.115LysPhe: 1.115 ± 0.038	3.067LysGly: 3.067 ± 0.058	0.817LysHis: 0.817 ± 0.031	1.942LysIle: 1.942 ± 0.05	2.173LysLys: 2.173 ± 0.065	3.534LysLeu: 3.534 ± 0.076	1.031LysMet: 1.031 ± 0.033	1.379LysAsn: 1.379 ± 0.042	1.892LysPro: 1.892 ± 0.047	1.533LysGln: 1.533 ± 0.047	2.717LysArg: 2.717 ± 0.052	1.912LysSer: 1.912 ± 0.051	2.061LysThr: 2.061 ± 0.057	2.79LysVal: 2.79 ± 0.065	0.349LysTrp: 0.349 ± 0.019	1.021LysTyr: 1.021 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	11.719LeuAla: 11.719 ± 0.141	1.513LeuCys: 1.513 ± 0.041	6.785LeuAsp: 6.785 ± 0.102	7.617LeuGlu: 7.617 ± 0.106	4.329LeuPhe: 4.329 ± 0.09	8.887LeuGly: 8.887 ± 0.107	2.534LeuHis: 2.534 ± 0.051	4.113LeuIle: 4.113 ± 0.082	3.718LeuLys: 3.718 ± 0.071	12.373LeuLeu: 12.373 ± 0.185	2.335LeuMet: 2.335 ± 0.049	3.099LeuAsn: 3.099 ± 0.056	5.888LeuPro: 5.888 ± 0.096	3.785LeuGln: 3.785 ± 0.061	8.012LeuArg: 8.012 ± 0.11	6.285LeuSer: 6.285 ± 0.086	5.502LeuThr: 5.502 ± 0.079	7.756LeuVal: 7.756 ± 0.106	1.176LeuTrp: 1.176 ± 0.034	2.37LeuTyr: 2.37 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.955MetAla: 2.955 ± 0.058	0.234MetCys: 0.234 ± 0.018	1.907MetAsp: 1.907 ± 0.047	1.851MetGlu: 1.851 ± 0.052	0.804MetPhe: 0.804 ± 0.027	2.296MetGly: 2.296 ± 0.058	0.608MetHis: 0.608 ± 0.025	1.127MetIle: 1.127 ± 0.032	1.066MetLys: 1.066 ± 0.034	2.723MetLeu: 2.723 ± 0.059	0.527MetMet: 0.527 ± 0.023	0.92MetAsn: 0.92 ± 0.033	1.468MetPro: 1.468 ± 0.047	1.096MetGln: 1.096 ± 0.043	1.979MetArg: 1.979 ± 0.046	1.629MetSer: 1.629 ± 0.043	1.507MetThr: 1.507 ± 0.037	2.02MetVal: 2.02 ± 0.045	0.18MetTrp: 0.18 ± 0.014	0.501MetTyr: 0.501 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.011AsnAla: 3.011 ± 0.064	0.389AsnCys: 0.389 ± 0.022	1.505AsnAsp: 1.505 ± 0.049	1.598AsnGlu: 1.598 ± 0.042	1.069AsnPhe: 1.069 ± 0.039	2.429AsnGly: 2.429 ± 0.073	0.591AsnHis: 0.591 ± 0.024	1.67AsnIle: 1.67 ± 0.043	1.099AsnLys: 1.099 ± 0.037	3.081AsnLeu: 3.081 ± 0.066	0.885AsnMet: 0.885 ± 0.033	0.944AsnAsn: 0.944 ± 0.038	1.913AsnPro: 1.913 ± 0.044	0.965AsnGln: 0.965 ± 0.032	1.862AsnArg: 1.862 ± 0.042	1.419AsnSer: 1.419 ± 0.038	1.537AsnThr: 1.537 ± 0.046	2.293AsnVal: 2.293 ± 0.048	0.414AsnTrp: 0.414 ± 0.021	0.72AsnTyr: 0.72 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.555ProAla: 4.555 ± 0.087	0.672ProCys: 0.672 ± 0.031	3.766ProAsp: 3.766 ± 0.073	4.803ProGlu: 4.803 ± 0.08	1.996ProPhe: 1.996 ± 0.049	4.752ProGly: 4.752 ± 0.069	1.078ProHis: 1.078 ± 0.038	1.69ProIle: 1.69 ± 0.048	1.87ProLys: 1.87 ± 0.054	5.041ProLeu: 5.041 ± 0.092	1.218ProMet: 1.218 ± 0.038	1.263ProAsn: 1.263 ± 0.035	2.2ProPro: 2.2 ± 0.057	1.752ProGln: 1.752 ± 0.042	2.66ProArg: 2.66 ± 0.052	2.537ProSer: 2.537 ± 0.054	2.036ProThr: 2.036 ± 0.053	4.008ProVal: 4.008 ± 0.067	0.677ProTrp: 0.677 ± 0.028	1.154ProTyr: 1.154 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.324GlnAla: 4.324 ± 0.085	0.439GlnCys: 0.439 ± 0.022	2.015GlnAsp: 2.015 ± 0.042	2.737GlnGlu: 2.737 ± 0.064	1.093GlnPhe: 1.093 ± 0.038	3.43GlnGly: 3.43 ± 0.061	0.826GlnHis: 0.826 ± 0.029	1.585GlnIle: 1.585 ± 0.049	1.407GlnLys: 1.407 ± 0.042	3.37GlnLeu: 3.37 ± 0.066	0.92GlnMet: 0.92 ± 0.03	1.112GlnAsn: 1.112 ± 0.036	1.611GlnPro: 1.611 ± 0.045	1.493GlnGln: 1.493 ± 0.048	2.937GlnArg: 2.937 ± 0.062	1.97GlnSer: 1.97 ± 0.038	1.925GlnThr: 1.925 ± 0.049	2.504GlnVal: 2.504 ± 0.051	0.501GlnTrp: 0.501 ± 0.021	0.884GlnTyr: 0.884 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.851ArgAla: 5.851 ± 0.092	0.912ArgCys: 0.912 ± 0.032	3.92ArgAsp: 3.92 ± 0.065	5.345ArgGlu: 5.345 ± 0.093	3.052ArgPhe: 3.052 ± 0.06	4.503ArgGly: 4.503 ± 0.075	1.71ArgHis: 1.71 ± 0.041	3.937ArgIle: 3.937 ± 0.055	2.964ArgLys: 2.964 ± 0.064	7.952ArgLeu: 7.952 ± 0.121	1.976ArgMet: 1.976 ± 0.051	2.151ArgAsn: 2.151 ± 0.05	3.293ArgPro: 3.293 ± 0.07	2.636ArgGln: 2.636 ± 0.056	5.22ArgArg: 5.22 ± 0.105	3.827ArgSer: 3.827 ± 0.079	3.464ArgThr: 3.464 ± 0.065	5.027ArgVal: 5.027 ± 0.083	0.833ArgTrp: 0.833 ± 0.033	1.796ArgTyr: 1.796 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.874SerAla: 4.874 ± 0.072	0.697SerCys: 0.697 ± 0.025	2.775SerAsp: 2.775 ± 0.067	3.24SerGlu: 3.24 ± 0.057	2.199SerPhe: 2.199 ± 0.053	5.468SerGly: 5.468 ± 0.093	1.113SerHis: 1.113 ± 0.033	2.58SerIle: 2.58 ± 0.06	1.907SerLys: 1.907 ± 0.049	6.005SerLeu: 6.005 ± 0.083	1.687SerMet: 1.687 ± 0.043	1.375SerAsn: 1.375 ± 0.044	2.808SerPro: 2.808 ± 0.054	1.824SerGln: 1.824 ± 0.05	3.717SerArg: 3.717 ± 0.069	3.095SerSer: 3.095 ± 0.074	2.651SerThr: 2.651 ± 0.062	4.116SerVal: 4.116 ± 0.059	0.786SerTrp: 0.786 ± 0.031	1.266SerTyr: 1.266 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.901ThrAla: 4.901 ± 0.072	0.579ThrCys: 0.579 ± 0.027	2.686ThrAsp: 2.686 ± 0.064	2.758ThrGlu: 2.758 ± 0.061	1.888ThrPhe: 1.888 ± 0.046	4.788ThrGly: 4.788 ± 0.081	1.045ThrHis: 1.045 ± 0.037	2.385ThrIle: 2.385 ± 0.058	1.611ThrLys: 1.611 ± 0.045	5.714ThrLeu: 5.714 ± 0.088	1.351ThrMet: 1.351 ± 0.039	1.399ThrAsn: 1.399 ± 0.044	3.154ThrPro: 3.154 ± 0.065	1.514ThrGln: 1.514 ± 0.038	3.05ThrArg: 3.05 ± 0.06	2.634ThrSer: 2.634 ± 0.061	2.495ThrThr: 2.495 ± 0.063	4.003ThrVal: 4.003 ± 0.082	0.557ThrTrp: 0.557 ± 0.023	1.237ThrTyr: 1.237 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.921ValAla: 6.921 ± 0.096	1.087ValCys: 1.087 ± 0.035	4.546ValAsp: 4.546 ± 0.08	4.945ValGlu: 4.945 ± 0.084	3.089ValPhe: 3.089 ± 0.064	5.29ValGly: 5.29 ± 0.086	1.6ValHis: 1.6 ± 0.043	3.347ValIle: 3.347 ± 0.068	2.521ValLys: 2.521 ± 0.059	8.567ValLeu: 8.567 ± 0.118	1.746ValMet: 1.746 ± 0.05	2.423ValAsn: 2.423 ± 0.061	3.471ValPro: 3.471 ± 0.073	2.649ValGln: 2.649 ± 0.058	5.819ValArg: 5.819 ± 0.095	4.293ValSer: 4.293 ± 0.07	3.874ValThr: 3.874 ± 0.072	6.068ValVal: 6.068 ± 0.096	0.819ValTrp: 0.819 ± 0.032	1.738ValTyr: 1.738 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.993TrpAla: 0.993 ± 0.033	0.15TrpCys: 0.15 ± 0.013	0.719TrpAsp: 0.719 ± 0.032	0.762TrpGlu: 0.762 ± 0.029	0.557TrpPhe: 0.557 ± 0.024	0.891TrpGly: 0.891 ± 0.035	0.25TrpHis: 0.25 ± 0.016	0.632TrpIle: 0.632 ± 0.028	0.555TrpLys: 0.555 ± 0.024	1.408TrpLeu: 1.408 ± 0.043	0.346TrpMet: 0.346 ± 0.017	0.507TrpAsn: 0.507 ± 0.023	0.646TrpPro: 0.646 ± 0.027	0.491TrpGln: 0.491 ± 0.029	0.882TrpArg: 0.882 ± 0.031	0.682TrpSer: 0.682 ± 0.027	0.68TrpThr: 0.68 ± 0.026	0.788TrpVal: 0.788 ± 0.029	0.219TrpTrp: 0.219 ± 0.02	0.308TrpTyr: 0.308 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.405TyrAla: 2.405 ± 0.052	0.438TyrCys: 0.438 ± 0.022	1.528TyrAsp: 1.528 ± 0.047	1.517TyrGlu: 1.517 ± 0.041	1.068TyrPhe: 1.068 ± 0.034	1.991TyrGly: 1.991 ± 0.048	0.555TyrHis: 0.555 ± 0.027	0.935TyrIle: 0.935 ± 0.037	0.903TyrLys: 0.903 ± 0.032	2.727TyrLeu: 2.727 ± 0.057	0.575TyrMet: 0.575 ± 0.025	0.781TyrAsn: 0.781 ± 0.034	1.274TyrPro: 1.274 ± 0.045	0.884TyrGln: 0.884 ± 0.032	1.732TyrArg: 1.732 ± 0.045	1.449TyrSer: 1.449 ± 0.045	1.213TyrThr: 1.213 ± 0.039	1.776TyrVal: 1.776 ± 0.039	0.381TyrTrp: 0.381 ± 0.022	0.811TyrTyr: 0.811 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2871 proteins (934146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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