Amino acid dipepetide frequency for Oleiphilus messinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.59AlaAla: 7.59 ± 0.075
0.978AlaCys: 0.978 ± 0.024
4.665AlaAsp: 4.665 ± 0.068
5.853AlaGlu: 5.853 ± 0.063
3.448AlaPhe: 3.448 ± 0.045
6.05AlaGly: 6.05 ± 0.1
1.815AlaHis: 1.815 ± 0.031
5.47AlaIle: 5.47 ± 0.06
4.005AlaLys: 4.005 ± 0.058
9.917AlaLeu: 9.917 ± 0.095
2.319AlaMet: 2.319 ± 0.041
3.287AlaAsn: 3.287 ± 0.049
3.05AlaPro: 3.05 ± 0.054
3.994AlaGln: 3.994 ± 0.051
4.451AlaArg: 4.451 ± 0.063
5.288AlaSer: 5.288 ± 0.06
4.408AlaThr: 4.408 ± 0.061
5.887AlaVal: 5.887 ± 0.067
0.92AlaTrp: 0.92 ± 0.025
2.41AlaTyr: 2.41 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.891CysAla: 0.891 ± 0.023
0.153CysCys: 0.153 ± 0.01
0.573CysAsp: 0.573 ± 0.017
0.651CysGlu: 0.651 ± 0.019
0.474CysPhe: 0.474 ± 0.016
0.825CysGly: 0.825 ± 0.026
0.31CysHis: 0.31 ± 0.013
0.6CysIle: 0.6 ± 0.018
0.416CysLys: 0.416 ± 0.016
1.048CysLeu: 1.048 ± 0.023
0.206CysMet: 0.206 ± 0.011
0.368CysAsn: 0.368 ± 0.014
0.465CysPro: 0.465 ± 0.019
0.497CysGln: 0.497 ± 0.017
0.559CysArg: 0.559 ± 0.017
0.737CysSer: 0.737 ± 0.022
0.516CysThr: 0.516 ± 0.017
0.68CysVal: 0.68 ± 0.022
0.156CysTrp: 0.156 ± 0.009
0.307CysTyr: 0.307 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.595AspAla: 4.595 ± 0.06
0.578AspCys: 0.578 ± 0.019
3.164AspAsp: 3.164 ± 0.053
3.704AspGlu: 3.704 ± 0.049
2.549AspPhe: 2.549 ± 0.041
3.751AspGly: 3.751 ± 0.08
1.342AspHis: 1.342 ± 0.029
3.855AspIle: 3.855 ± 0.049
2.463AspLys: 2.463 ± 0.039
5.915AspLeu: 5.915 ± 0.068
1.268AspMet: 1.268 ± 0.024
2.243AspAsn: 2.243 ± 0.044
2.466AspPro: 2.466 ± 0.039
2.666AspGln: 2.666 ± 0.043
2.921AspArg: 2.921 ± 0.043
3.479AspSer: 3.479 ± 0.046
2.96AspThr: 2.96 ± 0.056
3.79AspVal: 3.79 ± 0.05
0.872AspTrp: 0.872 ± 0.023
2.048AspTyr: 2.048 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
5.614GluAla: 5.614 ± 0.065
0.537GluCys: 0.537 ± 0.018
3.048GluAsp: 3.048 ± 0.041
3.555GluGlu: 3.555 ± 0.062
2.572GluPhe: 2.572 ± 0.036
3.67GluGly: 3.67 ± 0.051
1.658GluHis: 1.658 ± 0.03
4.128GluIle: 4.128 ± 0.057
3.706GluLys: 3.706 ± 0.058
6.964GluLeu: 6.964 ± 0.069
1.56GluMet: 1.56 ± 0.03
2.894GluAsn: 2.894 ± 0.042
2.233GluPro: 2.233 ± 0.034
3.646GluGln: 3.646 ± 0.055
3.697GluArg: 3.697 ± 0.053
4.155GluSer: 4.155 ± 0.047
3.601GluThr: 3.601 ± 0.045
4.15GluVal: 4.15 ± 0.053
0.765GluTrp: 0.765 ± 0.02
1.803GluTyr: 1.803 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.426PheAla: 3.426 ± 0.048
0.527PheCys: 0.527 ± 0.017
2.692PheAsp: 2.692 ± 0.041
2.588PheGlu: 2.588 ± 0.041
1.705PhePhe: 1.705 ± 0.037
3.006PheGly: 3.006 ± 0.049
0.857PheHis: 0.857 ± 0.021
2.446PheIle: 2.446 ± 0.035
1.918PheLys: 1.918 ± 0.037
3.717PheLeu: 3.717 ± 0.052
0.98PheMet: 0.98 ± 0.027
1.876PheAsn: 1.876 ± 0.031
1.639PhePro: 1.639 ± 0.034
1.536PheGln: 1.536 ± 0.03
1.958PheArg: 1.958 ± 0.034
3.345PheSer: 3.345 ± 0.045
2.317PheThr: 2.317 ± 0.038
2.663PheVal: 2.663 ± 0.041
0.583PheTrp: 0.583 ± 0.019
1.302PheTyr: 1.302 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
5.478GlyAla: 5.478 ± 0.098
0.861GlyCys: 0.861 ± 0.024
3.784GlyAsp: 3.784 ± 0.069
4.188GlyGlu: 4.188 ± 0.052
3.176GlyPhe: 3.176 ± 0.043
4.683GlyGly: 4.683 ± 0.113
1.591GlyHis: 1.591 ± 0.029
4.611GlyIle: 4.611 ± 0.053
3.511GlyLys: 3.511 ± 0.046
7.068GlyLeu: 7.068 ± 0.069
1.896GlyMet: 1.896 ± 0.038
2.65GlyAsn: 2.65 ± 0.055
1.864GlyPro: 1.864 ± 0.038
2.93GlyGln: 2.93 ± 0.047
3.413GlyArg: 3.413 ± 0.043
4.312GlySer: 4.312 ± 0.08
3.729GlyThr: 3.729 ± 0.075
4.994GlyVal: 4.994 ± 0.062
0.948GlyTrp: 0.948 ± 0.024
2.419GlyTyr: 2.419 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.655HisAla: 1.655 ± 0.027
0.35HisCys: 0.35 ± 0.014
1.19HisAsp: 1.19 ± 0.028
1.354HisGlu: 1.354 ± 0.028
1.17HisPhe: 1.17 ± 0.027
1.581HisGly: 1.581 ± 0.03
0.76HisHis: 0.76 ± 0.023
1.371HisIle: 1.371 ± 0.026
0.933HisLys: 0.933 ± 0.024
2.376HisLeu: 2.376 ± 0.039
0.469HisMet: 0.469 ± 0.017
0.87HisAsn: 0.87 ± 0.022
1.316HisPro: 1.316 ± 0.028
1.11HisGln: 1.11 ± 0.023
1.333HisArg: 1.333 ± 0.033
1.482HisSer: 1.482 ± 0.029
1.119HisThr: 1.119 ± 0.03
1.255HisVal: 1.255 ± 0.027
0.395HisTrp: 0.395 ± 0.017
0.961HisTyr: 0.961 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.893IleAla: 5.893 ± 0.061
0.689IleCys: 0.689 ± 0.021
4.045IleAsp: 4.045 ± 0.056
4.499IleGlu: 4.499 ± 0.055
2.053IlePhe: 2.053 ± 0.034
4.246IleGly: 4.246 ± 0.053
1.276IleHis: 1.276 ± 0.026
3.363IleIle: 3.363 ± 0.046
3.002IleLys: 3.002 ± 0.043
5.423IleLeu: 5.423 ± 0.064
1.171IleMet: 1.171 ± 0.027
2.805IleAsn: 2.805 ± 0.045
2.918IlePro: 2.918 ± 0.045
2.638IleGln: 2.638 ± 0.041
3.424IleArg: 3.424 ± 0.04
4.424IleSer: 4.424 ± 0.049
3.529IleThr: 3.529 ± 0.054
4.058IleVal: 4.058 ± 0.055
0.629IleTrp: 0.629 ± 0.021
1.606IleTyr: 1.606 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.399LysAla: 4.399 ± 0.069
0.327LysCys: 0.327 ± 0.014
2.244LysAsp: 2.244 ± 0.041
2.63LysGlu: 2.63 ± 0.048
1.394LysPhe: 1.394 ± 0.028
3.014LysGly: 3.014 ± 0.042
1.162LysHis: 1.162 ± 0.028
2.847LysIle: 2.847 ± 0.044
2.61LysLys: 2.61 ± 0.049
5.05LysLeu: 5.05 ± 0.065
1.148LysMet: 1.148 ± 0.029
1.94LysAsn: 1.94 ± 0.035
2.272LysPro: 2.272 ± 0.042
2.47LysGln: 2.47 ± 0.041
2.859LysArg: 2.859 ± 0.043
3.231LysSer: 3.231 ± 0.045
2.832LysThr: 2.832 ± 0.045
3.189LysVal: 3.189 ± 0.049
0.532LysTrp: 0.532 ± 0.02
1.207LysTyr: 1.207 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
9.462LeuAla: 9.462 ± 0.081
1.097LeuCys: 1.097 ± 0.029
6.174LeuAsp: 6.174 ± 0.062
6.667LeuGlu: 6.667 ± 0.073
4.264LeuPhe: 4.264 ± 0.06
6.755LeuGly: 6.755 ± 0.061
2.18LeuHis: 2.18 ± 0.038
6.312LeuIle: 6.312 ± 0.065
5.61LeuLys: 5.61 ± 0.079
10.497LeuLeu: 10.497 ± 0.106
2.397LeuMet: 2.397 ± 0.041
4.735LeuAsn: 4.735 ± 0.055
4.876LeuPro: 4.876 ± 0.062
4.597LeuGln: 4.597 ± 0.056
5.158LeuArg: 5.158 ± 0.061
8.076LeuSer: 8.076 ± 0.082
5.832LeuThr: 5.832 ± 0.057
6.741LeuVal: 6.741 ± 0.067
1.101LeuTrp: 1.101 ± 0.028
2.664LeuTyr: 2.664 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.243MetAla: 2.243 ± 0.036
0.172MetCys: 0.172 ± 0.01
1.281MetAsp: 1.281 ± 0.026
1.254MetGlu: 1.254 ± 0.026
0.744MetPhe: 0.744 ± 0.022
1.629MetGly: 1.629 ± 0.034
0.494MetHis: 0.494 ± 0.015
1.308MetIle: 1.308 ± 0.032
1.189MetLys: 1.189 ± 0.03
2.469MetLeu: 2.469 ± 0.04
0.619MetMet: 0.619 ± 0.022
1.055MetAsn: 1.055 ± 0.023
1.166MetPro: 1.166 ± 0.029
0.998MetGln: 0.998 ± 0.025
1.13MetArg: 1.13 ± 0.026
1.754MetSer: 1.754 ± 0.034
1.389MetThr: 1.389 ± 0.028
1.61MetVal: 1.61 ± 0.034
0.177MetTrp: 0.177 ± 0.01
0.462MetTyr: 0.462 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.577AsnAla: 3.577 ± 0.051
0.407AsnCys: 0.407 ± 0.018
2.161AsnAsp: 2.161 ± 0.042
2.333AsnGlu: 2.333 ± 0.038
1.429AsnPhe: 1.429 ± 0.03
2.882AsnGly: 2.882 ± 0.059
0.966AsnHis: 0.966 ± 0.022
2.533AsnIle: 2.533 ± 0.041
1.745AsnLys: 1.745 ± 0.037
4.17AsnLeu: 4.17 ± 0.057
0.877AsnMet: 0.877 ± 0.023
1.719AsnAsn: 1.719 ± 0.037
2.309AsnPro: 2.309 ± 0.036
2.1AsnGln: 2.1 ± 0.034
2.462AsnArg: 2.462 ± 0.043
2.546AsnSer: 2.546 ± 0.045
2.352AsnThr: 2.352 ± 0.048
2.431AsnVal: 2.431 ± 0.042
0.601AsnTrp: 0.601 ± 0.016
1.266AsnTyr: 1.266 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
3.42ProAla: 3.42 ± 0.046
0.331ProCys: 0.331 ± 0.016
3.196ProAsp: 3.196 ± 0.048
4.03ProGlu: 4.03 ± 0.052
1.802ProPhe: 1.802 ± 0.038
3.198ProGly: 3.198 ± 0.049
0.858ProHis: 0.858 ± 0.022
2.355ProIle: 2.355 ± 0.038
1.835ProLys: 1.835 ± 0.037
4.243ProLeu: 4.243 ± 0.061
0.945ProMet: 0.945 ± 0.023
1.519ProAsn: 1.519 ± 0.033
1.616ProPro: 1.616 ± 0.033
1.555ProGln: 1.555 ± 0.029
1.623ProArg: 1.623 ± 0.034
2.451ProSer: 2.451 ± 0.037
2.025ProThr: 2.025 ± 0.046
3.608ProVal: 3.608 ± 0.051
0.558ProTrp: 0.558 ± 0.02
1.207ProTyr: 1.207 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.17GlnAla: 4.17 ± 0.053
0.454GlnCys: 0.454 ± 0.017
2.245GlnAsp: 2.245 ± 0.034
2.552GlnGlu: 2.552 ± 0.041
1.986GlnPhe: 1.986 ± 0.035
2.868GlnGly: 2.868 ± 0.047
1.185GlnHis: 1.185 ± 0.023
2.814GlnIle: 2.814 ± 0.038
2.233GlnLys: 2.233 ± 0.038
5.028GlnLeu: 5.028 ± 0.059
0.968GlnMet: 0.968 ± 0.026
1.895GlnAsn: 1.895 ± 0.042
1.704GlnPro: 1.704 ± 0.031
2.64GlnGln: 2.64 ± 0.045
2.639GlnArg: 2.639 ± 0.046
3.177GlnSer: 3.177 ± 0.047
2.38GlnThr: 2.38 ± 0.042
3.081GlnVal: 3.081 ± 0.046
0.64GlnTrp: 0.64 ± 0.019
1.432GlnTyr: 1.432 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
3.991ArgAla: 3.991 ± 0.045
0.545ArgCys: 0.545 ± 0.019
2.867ArgAsp: 2.867 ± 0.042
3.502ArgGlu: 3.502 ± 0.057
2.682ArgPhe: 2.682 ± 0.042
2.808ArgGly: 2.808 ± 0.039
1.331ArgHis: 1.331 ± 0.027
3.474ArgIle: 3.474 ± 0.04
2.705ArgLys: 2.705 ± 0.05
6.018ArgLeu: 6.018 ± 0.076
1.339ArgMet: 1.339 ± 0.028
2.223ArgAsn: 2.223 ± 0.031
1.903ArgPro: 1.903 ± 0.034
2.487ArgGln: 2.487 ± 0.042
2.827ArgArg: 2.827 ± 0.049
3.172ArgSer: 3.172 ± 0.046
2.462ArgThr: 2.462 ± 0.035
3.622ArgVal: 3.622 ± 0.043
0.803ArgTrp: 0.803 ± 0.02
2.08ArgTyr: 2.08 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.021SerAla: 6.021 ± 0.076
0.606SerCys: 0.606 ± 0.019
3.901SerAsp: 3.901 ± 0.061
4.458SerGlu: 4.458 ± 0.053
2.66SerPhe: 2.66 ± 0.044
5.685SerGly: 5.685 ± 0.103
1.521SerHis: 1.521 ± 0.029
4.213SerIle: 4.213 ± 0.049
2.754SerLys: 2.754 ± 0.04
6.844SerLeu: 6.844 ± 0.063
1.492SerMet: 1.492 ± 0.031
2.544SerAsn: 2.544 ± 0.046
2.893SerPro: 2.893 ± 0.042
2.761SerGln: 2.761 ± 0.044
3.482SerArg: 3.482 ± 0.047
4.537SerSer: 4.537 ± 0.072
3.537SerThr: 3.537 ± 0.061
4.722SerVal: 4.722 ± 0.058
0.858SerTrp: 0.858 ± 0.022
1.855SerTyr: 1.855 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.491ThrAla: 4.491 ± 0.059
0.51ThrCys: 0.51 ± 0.018
3.018ThrAsp: 3.018 ± 0.057
3.465ThrGlu: 3.465 ± 0.048
2.125ThrPhe: 2.125 ± 0.04
4.389ThrGly: 4.389 ± 0.067
1.211ThrHis: 1.211 ± 0.028
3.21ThrIle: 3.21 ± 0.048
1.876ThrLys: 1.876 ± 0.041
6.432ThrLeu: 6.432 ± 0.068
1.0ThrMet: 1.0 ± 0.024
1.849ThrAsn: 1.849 ± 0.038
2.989ThrPro: 2.989 ± 0.052
2.358ThrGln: 2.358 ± 0.034
2.787ThrArg: 2.787 ± 0.038
3.218ThrSer: 3.218 ± 0.044
2.994ThrThr: 2.994 ± 0.049
3.855ThrVal: 3.855 ± 0.066
0.58ThrTrp: 0.58 ± 0.018
1.463ThrTyr: 1.463 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
5.942ValAla: 5.942 ± 0.06
0.786ValCys: 0.786 ± 0.023
4.167ValAsp: 4.167 ± 0.059
4.371ValGlu: 4.371 ± 0.055
2.779ValPhe: 2.779 ± 0.041
4.147ValGly: 4.147 ± 0.062
1.353ValHis: 1.353 ± 0.028
4.462ValIle: 4.462 ± 0.048
3.231ValLys: 3.231 ± 0.048
6.959ValLeu: 6.959 ± 0.072
1.638ValMet: 1.638 ± 0.031
2.886ValAsn: 2.886 ± 0.051
2.786ValPro: 2.786 ± 0.038
2.529ValGln: 2.529 ± 0.044
3.365ValArg: 3.365 ± 0.045
5.092ValSer: 5.092 ± 0.064
3.828ValThr: 3.828 ± 0.056
5.074ValVal: 5.074 ± 0.066
0.773ValTrp: 0.773 ± 0.022
1.782ValTyr: 1.782 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
0.799TrpAla: 0.799 ± 0.024
0.144TrpCys: 0.144 ± 0.008
0.608TrpAsp: 0.608 ± 0.018
0.606TrpGlu: 0.606 ± 0.018
0.612TrpPhe: 0.612 ± 0.02
0.801TrpGly: 0.801 ± 0.021
0.372TrpHis: 0.372 ± 0.014
0.727TrpIle: 0.727 ± 0.021
0.534TrpLys: 0.534 ± 0.018
1.718TrpLeu: 1.718 ± 0.042
0.308TrpMet: 0.308 ± 0.013
0.458TrpAsn: 0.458 ± 0.016
0.503TrpPro: 0.503 ± 0.015
0.825TrpGln: 0.825 ± 0.021
0.746TrpArg: 0.746 ± 0.022
0.857TrpSer: 0.857 ± 0.026
0.499TrpThr: 0.499 ± 0.018
0.842TrpVal: 0.842 ± 0.024
0.173TrpTrp: 0.173 ± 0.011
0.398TrpTyr: 0.398 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.147TyrAla: 2.147 ± 0.041
0.378TyrCys: 0.378 ± 0.016
1.605TyrAsp: 1.605 ± 0.032
1.701TyrGlu: 1.701 ± 0.033
1.455TyrPhe: 1.455 ± 0.033
2.121TyrGly: 2.121 ± 0.035
0.808TyrHis: 0.808 ± 0.022
1.591TyrIle: 1.591 ± 0.028
1.079TyrLys: 1.079 ± 0.022
3.34TyrLeu: 3.34 ± 0.048
0.545TyrMet: 0.545 ± 0.015
1.05TyrAsn: 1.05 ± 0.03
1.407TyrPro: 1.407 ± 0.028
1.754TyrGln: 1.754 ± 0.036
2.008TyrArg: 2.008 ± 0.038
2.012TyrSer: 2.012 ± 0.032
1.508TyrThr: 1.508 ± 0.031
1.696TyrVal: 1.696 ± 0.033
0.466TyrTrp: 0.466 ± 0.019
1.072TyrTyr: 1.072 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5456 proteins (1829888 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski