Amino acid dipepetide frequency for Geodermatophilus sp. TF02-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.974AlaAla: 24.974 ± 0.244
1.043AlaCys: 1.043 ± 0.029
9.347AlaAsp: 9.347 ± 0.097
9.042AlaGlu: 9.042 ± 0.11
3.318AlaPhe: 3.318 ± 0.047
15.042AlaGly: 15.042 ± 0.127
2.729AlaHis: 2.729 ± 0.043
3.288AlaIle: 3.288 ± 0.056
1.58AlaLys: 1.58 ± 0.039
15.155AlaLeu: 15.155 ± 0.144
2.258AlaMet: 2.258 ± 0.043
1.594AlaAsn: 1.594 ± 0.036
7.697AlaPro: 7.697 ± 0.099
3.741AlaGln: 3.741 ± 0.064
11.841AlaArg: 11.841 ± 0.132
5.444AlaSer: 5.444 ± 0.068
7.488AlaThr: 7.488 ± 0.085
15.023AlaVal: 15.023 ± 0.129
1.914AlaTrp: 1.914 ± 0.039
2.151AlaTyr: 2.151 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.983CysAla: 0.983 ± 0.025
0.099CysCys: 0.099 ± 0.009
0.466CysAsp: 0.466 ± 0.019
0.337CysGlu: 0.337 ± 0.016
0.212CysPhe: 0.212 ± 0.011
0.926CysGly: 0.926 ± 0.028
0.168CysHis: 0.168 ± 0.012
0.155CysIle: 0.155 ± 0.011
0.077CysLys: 0.077 ± 0.008
0.662CysLeu: 0.662 ± 0.022
0.088CysMet: 0.088 ± 0.008
0.098CysAsn: 0.098 ± 0.009
0.483CysPro: 0.483 ± 0.023
0.143CysGln: 0.143 ± 0.011
0.661CysArg: 0.661 ± 0.025
0.396CysSer: 0.396 ± 0.018
0.506CysThr: 0.506 ± 0.022
0.633CysVal: 0.633 ± 0.022
0.131CysTrp: 0.131 ± 0.01
0.137CysTyr: 0.137 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
8.473AspAla: 8.473 ± 0.083
0.369AspCys: 0.369 ± 0.017
4.243AspAsp: 4.243 ± 0.065
3.904AspGlu: 3.904 ± 0.065
1.358AspPhe: 1.358 ± 0.033
6.626AspGly: 6.626 ± 0.071
1.159AspHis: 1.159 ± 0.032
1.214AspIle: 1.214 ± 0.033
0.638AspLys: 0.638 ± 0.025
7.166AspLeu: 7.166 ± 0.079
0.627AspMet: 0.627 ± 0.022
0.638AspAsn: 0.638 ± 0.026
5.182AspPro: 5.182 ± 0.068
1.482AspGln: 1.482 ± 0.036
5.779AspArg: 5.779 ± 0.068
2.11AspSer: 2.11 ± 0.042
2.922AspThr: 2.922 ± 0.049
6.703AspVal: 6.703 ± 0.07
0.946AspTrp: 0.946 ± 0.028
0.967AspTyr: 0.967 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.935GluAla: 6.935 ± 0.08
0.303GluCys: 0.303 ± 0.015
3.084GluAsp: 3.084 ± 0.053
3.391GluGlu: 3.391 ± 0.057
1.31GluPhe: 1.31 ± 0.032
4.118GluGly: 4.118 ± 0.062
1.613GluHis: 1.613 ± 0.036
1.731GluIle: 1.731 ± 0.04
0.8GluLys: 0.8 ± 0.029
6.861GluLeu: 6.861 ± 0.086
0.76GluMet: 0.76 ± 0.022
0.722GluAsn: 0.722 ± 0.021
3.304GluPro: 3.304 ± 0.055
2.469GluGln: 2.469 ± 0.046
5.536GluArg: 5.536 ± 0.069
1.975GluSer: 1.975 ± 0.041
2.537GluThr: 2.537 ± 0.043
5.727GluVal: 5.727 ± 0.073
0.719GluTrp: 0.719 ± 0.023
0.905GluTyr: 0.905 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.576PheAla: 3.576 ± 0.053
0.266PheCys: 0.266 ± 0.014
1.905PheAsp: 1.905 ± 0.041
1.226PheGlu: 1.226 ± 0.028
0.796PhePhe: 0.796 ± 0.027
2.821PheGly: 2.821 ± 0.049
0.475PheHis: 0.475 ± 0.021
0.583PheIle: 0.583 ± 0.024
0.283PheLys: 0.283 ± 0.017
2.54PheLeu: 2.54 ± 0.053
0.29PheMet: 0.29 ± 0.012
0.422PheAsn: 0.422 ± 0.02
1.292PhePro: 1.292 ± 0.032
0.534PheGln: 0.534 ± 0.025
1.665PheArg: 1.665 ± 0.032
1.22PheSer: 1.22 ± 0.031
1.75PheThr: 1.75 ± 0.039
2.432PheVal: 2.432 ± 0.037
0.397PheTrp: 0.397 ± 0.018
0.529PheTyr: 0.529 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
11.993GlyAla: 11.993 ± 0.12
0.848GlyCys: 0.848 ± 0.026
5.511GlyAsp: 5.511 ± 0.062
5.208GlyGlu: 5.208 ± 0.064
2.683GlyPhe: 2.683 ± 0.041
9.124GlyGly: 9.124 ± 0.117
2.026GlyHis: 2.026 ± 0.042
3.033GlyIle: 3.033 ± 0.052
1.454GlyLys: 1.454 ± 0.039
9.947GlyLeu: 9.947 ± 0.097
1.912GlyMet: 1.912 ± 0.044
1.414GlyAsn: 1.414 ± 0.036
5.497GlyPro: 5.497 ± 0.08
2.792GlyGln: 2.792 ± 0.044
8.92GlyArg: 8.92 ± 0.098
5.384GlySer: 5.384 ± 0.064
6.021GlyThr: 6.021 ± 0.071
8.827GlyVal: 8.827 ± 0.098
1.821GlyTrp: 1.821 ± 0.039
2.217GlyTyr: 2.217 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.483HisAla: 2.483 ± 0.042
0.202HisCys: 0.202 ± 0.013
1.228HisAsp: 1.228 ± 0.034
1.109HisGlu: 1.109 ± 0.029
0.506HisPhe: 0.506 ± 0.019
2.236HisGly: 2.236 ± 0.043
0.564HisHis: 0.564 ± 0.021
0.385HisIle: 0.385 ± 0.019
0.203HisLys: 0.203 ± 0.013
2.449HisLeu: 2.449 ± 0.044
0.245HisMet: 0.245 ± 0.014
0.263HisAsn: 0.263 ± 0.017
1.771HisPro: 1.771 ± 0.042
0.524HisGln: 0.524 ± 0.022
2.055HisArg: 2.055 ± 0.041
0.804HisSer: 0.804 ± 0.022
1.008HisThr: 1.008 ± 0.028
2.049HisVal: 2.049 ± 0.039
0.325HisTrp: 0.325 ± 0.014
0.403HisTyr: 0.403 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.035IleAla: 4.035 ± 0.056
0.237IleCys: 0.237 ± 0.013
1.916IleAsp: 1.916 ± 0.043
1.59IleGlu: 1.59 ± 0.039
0.422IlePhe: 0.422 ± 0.018
3.141IleGly: 3.141 ± 0.051
0.379IleHis: 0.379 ± 0.016
0.578IleIle: 0.578 ± 0.027
0.36IleLys: 0.36 ± 0.017
1.657IleLeu: 1.657 ± 0.042
0.304IleMet: 0.304 ± 0.015
0.486IleAsn: 0.486 ± 0.02
1.445IlePro: 1.445 ± 0.038
0.515IleGln: 0.515 ± 0.021
1.942IleArg: 1.942 ± 0.039
1.301IleSer: 1.301 ± 0.032
1.683IleThr: 1.683 ± 0.036
2.396IleVal: 2.396 ± 0.048
0.278IleTrp: 0.278 ± 0.015
0.34IleTyr: 0.34 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
1.676LysAla: 1.676 ± 0.041
0.059LysCys: 0.059 ± 0.008
0.678LysAsp: 0.678 ± 0.027
0.62LysGlu: 0.62 ± 0.026
0.243LysPhe: 0.243 ± 0.015
1.023LysGly: 1.023 ± 0.035
0.26LysHis: 0.26 ± 0.015
0.409LysIle: 0.409 ± 0.019
0.313LysLys: 0.313 ± 0.021
1.168LysLeu: 1.168 ± 0.031
0.199LysMet: 0.199 ± 0.01
0.245LysAsn: 0.245 ± 0.015
0.761LysPro: 0.761 ± 0.023
0.414LysGln: 0.414 ± 0.019
1.006LysArg: 1.006 ± 0.025
0.554LysSer: 0.554 ± 0.022
0.779LysThr: 0.779 ± 0.025
1.187LysVal: 1.187 ± 0.033
0.139LysTrp: 0.139 ± 0.011
0.242LysTyr: 0.242 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
17.191LeuAla: 17.191 ± 0.153
0.693LeuCys: 0.693 ± 0.023
7.032LeuAsp: 7.032 ± 0.078
4.854LeuGlu: 4.854 ± 0.059
2.504LeuPhe: 2.504 ± 0.046
9.876LeuGly: 9.876 ± 0.101
2.136LeuHis: 2.136 ± 0.041
2.21LeuIle: 2.21 ± 0.047
1.069LeuLys: 1.069 ± 0.028
11.962LeuLeu: 11.962 ± 0.128
1.284LeuMet: 1.284 ± 0.033
1.234LeuAsn: 1.234 ± 0.036
7.059LeuPro: 7.059 ± 0.08
2.556LeuGln: 2.556 ± 0.052
8.899LeuArg: 8.899 ± 0.095
4.847LeuSer: 4.847 ± 0.07
6.737LeuThr: 6.737 ± 0.071
11.264LeuVal: 11.264 ± 0.114
1.204LeuTrp: 1.204 ± 0.027
1.498LeuTyr: 1.498 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.187MetAla: 2.187 ± 0.039
0.12MetCys: 0.12 ± 0.009
0.781MetAsp: 0.781 ± 0.022
0.567MetGlu: 0.567 ± 0.024
0.293MetPhe: 0.293 ± 0.017
1.225MetGly: 1.225 ± 0.03
0.306MetHis: 0.306 ± 0.016
0.459MetIle: 0.459 ± 0.02
0.229MetLys: 0.229 ± 0.013
1.304MetLeu: 1.304 ± 0.034
0.204MetMet: 0.204 ± 0.012
0.274MetAsn: 0.274 ± 0.014
1.003MetPro: 1.003 ± 0.027
0.399MetGln: 0.399 ± 0.018
1.292MetArg: 1.292 ± 0.032
1.176MetSer: 1.176 ± 0.032
1.514MetThr: 1.514 ± 0.032
1.275MetVal: 1.275 ± 0.026
0.17MetTrp: 0.17 ± 0.012
0.208MetTyr: 0.208 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
1.734AsnAla: 1.734 ± 0.039
0.122AsnCys: 0.122 ± 0.01
0.702AsnAsp: 0.702 ± 0.026
0.597AsnGlu: 0.597 ± 0.02
0.385AsnPhe: 0.385 ± 0.02
1.322AsnGly: 1.322 ± 0.038
0.284AsnHis: 0.284 ± 0.016
0.394AsnIle: 0.394 ± 0.018
0.199AsnLys: 0.199 ± 0.013
1.395AsnLeu: 1.395 ± 0.034
0.209AsnMet: 0.209 ± 0.013
0.279AsnAsn: 0.279 ± 0.014
1.102AsnPro: 1.102 ± 0.029
0.387AsnGln: 0.387 ± 0.016
1.061AsnArg: 1.061 ± 0.031
0.602AsnSer: 0.602 ± 0.025
0.816AsnThr: 0.816 ± 0.025
1.227AsnVal: 1.227 ± 0.032
0.234AsnTrp: 0.234 ± 0.016
0.289AsnTyr: 0.289 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
9.923ProAla: 9.923 ± 0.118
0.317ProCys: 0.317 ± 0.015
4.898ProAsp: 4.898 ± 0.058
4.181ProGlu: 4.181 ± 0.058
1.499ProPhe: 1.499 ± 0.035
7.191ProGly: 7.191 ± 0.082
1.306ProHis: 1.306 ± 0.031
1.25ProIle: 1.25 ± 0.033
0.661ProLys: 0.661 ± 0.023
5.56ProLeu: 5.56 ± 0.067
0.996ProMet: 0.996 ± 0.027
0.719ProAsn: 0.719 ± 0.021
4.245ProPro: 4.245 ± 0.075
1.627ProGln: 1.627 ± 0.036
4.622ProArg: 4.622 ± 0.069
3.082ProSer: 3.082 ± 0.053
3.736ProThr: 3.736 ± 0.055
6.503ProVal: 6.503 ± 0.078
0.971ProTrp: 0.971 ± 0.026
1.103ProTyr: 1.103 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.768GlnAla: 3.768 ± 0.06
0.138GlnCys: 0.138 ± 0.009
1.227GlnAsp: 1.227 ± 0.03
1.267GlnGlu: 1.267 ± 0.031
0.666GlnPhe: 0.666 ± 0.021
1.915GlnGly: 1.915 ± 0.046
0.599GlnHis: 0.599 ± 0.022
0.86GlnIle: 0.86 ± 0.027
0.38GlnLys: 0.38 ± 0.018
3.349GlnLeu: 3.349 ± 0.05
0.44GlnMet: 0.44 ± 0.017
0.363GlnAsn: 0.363 ± 0.019
1.734GlnPro: 1.734 ± 0.035
1.141GlnGln: 1.141 ± 0.034
2.63GlnArg: 2.63 ± 0.05
0.999GlnSer: 0.999 ± 0.027
1.438GlnThr: 1.438 ± 0.036
2.959GlnVal: 2.959 ± 0.047
0.372GlnTrp: 0.372 ± 0.015
0.529GlnTyr: 0.529 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
11.296ArgAla: 11.296 ± 0.117
0.649ArgCys: 0.649 ± 0.026
4.546ArgAsp: 4.546 ± 0.06
4.705ArgGlu: 4.705 ± 0.067
2.32ArgPhe: 2.32 ± 0.041
6.663ArgGly: 6.663 ± 0.066
1.911ArgHis: 1.911 ± 0.038
2.656ArgIle: 2.656 ± 0.043
0.953ArgLys: 0.953 ± 0.026
9.534ArgLeu: 9.534 ± 0.1
1.807ArgMet: 1.807 ± 0.037
1.106ArgAsn: 1.106 ± 0.029
6.117ArgPro: 6.117 ± 0.076
2.414ArgGln: 2.414 ± 0.041
9.652ArgArg: 9.652 ± 0.12
4.404ArgSer: 4.404 ± 0.06
5.314ArgThr: 5.314 ± 0.064
7.326ArgVal: 7.326 ± 0.085
1.596ArgTrp: 1.596 ± 0.037
1.853ArgTyr: 1.853 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.379SerAla: 6.379 ± 0.074
0.374SerCys: 0.374 ± 0.017
2.474SerAsp: 2.474 ± 0.046
1.973SerGlu: 1.973 ± 0.046
1.316SerPhe: 1.316 ± 0.034
5.34SerGly: 5.34 ± 0.063
0.802SerHis: 0.802 ± 0.024
1.3SerIle: 1.3 ± 0.034
0.516SerLys: 0.516 ± 0.023
4.342SerLeu: 4.342 ± 0.062
0.947SerMet: 0.947 ± 0.029
0.664SerAsn: 0.664 ± 0.022
3.189SerPro: 3.189 ± 0.047
1.01SerGln: 1.01 ± 0.031
3.761SerArg: 3.761 ± 0.049
2.762SerSer: 2.762 ± 0.052
2.918SerThr: 2.918 ± 0.051
4.238SerVal: 4.238 ± 0.061
0.843SerTrp: 0.843 ± 0.025
0.932SerTyr: 0.932 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
8.986ThrAla: 8.986 ± 0.083
0.432ThrCys: 0.432 ± 0.02
3.57ThrAsp: 3.57 ± 0.056
2.916ThrGlu: 2.916 ± 0.058
1.482ThrPhe: 1.482 ± 0.036
6.623ThrGly: 6.623 ± 0.08
1.089ThrHis: 1.089 ± 0.026
1.559ThrIle: 1.559 ± 0.04
0.69ThrLys: 0.69 ± 0.026
5.423ThrLeu: 5.423 ± 0.061
0.835ThrMet: 0.835 ± 0.029
0.815ThrAsn: 0.815 ± 0.023
4.273ThrPro: 4.273 ± 0.059
1.232ThrGln: 1.232 ± 0.034
4.226ThrArg: 4.226 ± 0.061
2.948ThrSer: 2.948 ± 0.047
3.851ThrThr: 3.851 ± 0.052
6.326ThrVal: 6.326 ± 0.068
0.906ThrTrp: 0.906 ± 0.027
1.071ThrTyr: 1.071 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
13.911ValAla: 13.911 ± 0.129
0.802ValCys: 0.802 ± 0.024
6.828ValAsp: 6.828 ± 0.072
5.707ValGlu: 5.707 ± 0.076
2.694ValPhe: 2.694 ± 0.052
8.463ValGly: 8.463 ± 0.078
2.321ValHis: 2.321 ± 0.048
2.224ValIle: 2.224 ± 0.047
1.144ValLys: 1.144 ± 0.03
11.849ValLeu: 11.849 ± 0.108
1.19ValMet: 1.19 ± 0.03
1.49ValAsn: 1.49 ± 0.033
6.439ValPro: 6.439 ± 0.076
2.396ValGln: 2.396 ± 0.042
8.14ValArg: 8.14 ± 0.079
4.334ValSer: 4.334 ± 0.057
6.159ValThr: 6.159 ± 0.074
11.979ValVal: 11.979 ± 0.113
1.235ValTrp: 1.235 ± 0.033
1.674ValTyr: 1.674 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.766TrpAla: 1.766 ± 0.036
0.139TrpCys: 0.139 ± 0.009
0.808TrpAsp: 0.808 ± 0.029
0.638TrpGlu: 0.638 ± 0.023
0.48TrpPhe: 0.48 ± 0.02
1.065TrpGly: 1.065 ± 0.029
0.369TrpHis: 0.369 ± 0.02
0.386TrpIle: 0.386 ± 0.017
0.187TrpLys: 0.187 ± 0.01
1.839TrpLeu: 1.839 ± 0.042
0.225TrpMet: 0.225 ± 0.013
0.268TrpAsn: 0.268 ± 0.015
0.857TrpPro: 0.857 ± 0.027
0.505TrpGln: 0.505 ± 0.021
1.473TrpArg: 1.473 ± 0.031
0.9TrpSer: 0.9 ± 0.028
1.03TrpThr: 1.03 ± 0.025
1.249TrpVal: 1.249 ± 0.029
0.333TrpTrp: 0.333 ± 0.017
0.285TrpTyr: 0.285 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.399TyrAla: 2.399 ± 0.051
0.147TyrCys: 0.147 ± 0.01
1.264TyrAsp: 1.264 ± 0.03
0.968TyrGlu: 0.968 ± 0.031
0.517TyrPhe: 0.517 ± 0.024
1.891TyrGly: 1.891 ± 0.045
0.32TyrHis: 0.32 ± 0.017
0.332TyrIle: 0.332 ± 0.016
0.237TyrLys: 0.237 ± 0.013
1.946TyrLeu: 1.946 ± 0.039
0.165TyrMet: 0.165 ± 0.012
0.246TyrAsn: 0.246 ± 0.014
0.942TyrPro: 0.942 ± 0.028
0.491TyrGln: 0.491 ± 0.02
1.661TyrArg: 1.661 ± 0.037
0.839TyrSer: 0.839 ± 0.027
1.046TyrThr: 1.046 ± 0.029
1.654TyrVal: 1.654 ± 0.036
0.269TyrTrp: 0.269 ± 0.014
0.356TyrTyr: 0.356 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4244 proteins (1348583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski