Amino acid dipepetide frequency for Angiostrongylus costaricensis (Nematode worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.432AlaAla: 5.432 ± 0.052	1.314AlaCys: 1.314 ± 0.019	3.324AlaAsp: 3.324 ± 0.034	4.15AlaGlu: 4.15 ± 0.038	2.91AlaPhe: 2.91 ± 0.029	3.57AlaGly: 3.57 ± 0.035	1.601AlaHis: 1.601 ± 0.02	3.979AlaIle: 3.979 ± 0.033	3.562AlaLys: 3.562 ± 0.033	6.409AlaLeu: 6.409 ± 0.046	1.76AlaMet: 1.76 ± 0.02	2.604AlaAsn: 2.604 ± 0.026	2.924AlaPro: 2.924 ± 0.032	2.394AlaGln: 2.394 ± 0.03	3.73AlaArg: 3.73 ± 0.033	4.819AlaSer: 4.819 ± 0.035	3.623AlaThr: 3.623 ± 0.033	5.171AlaVal: 5.171 ± 0.035	0.641AlaTrp: 0.641 ± 0.011	1.8AlaTyr: 1.8 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.445CysAla: 1.445 ± 0.022	0.642CysCys: 0.642 ± 0.017	1.323CysAsp: 1.323 ± 0.025	1.345CysGlu: 1.345 ± 0.022	1.119CysPhe: 1.119 ± 0.017	1.515CysGly: 1.515 ± 0.023	0.593CysHis: 0.593 ± 0.014	1.236CysIle: 1.236 ± 0.021	1.037CysLys: 1.037 ± 0.019	2.066CysLeu: 2.066 ± 0.027	0.541CysMet: 0.541 ± 0.011	0.896CysAsn: 0.896 ± 0.017	1.169CysPro: 1.169 ± 0.031	0.815CysGln: 0.815 ± 0.018	1.434CysArg: 1.434 ± 0.025	2.035CysSer: 2.035 ± 0.026	1.145CysThr: 1.145 ± 0.017	1.551CysVal: 1.551 ± 0.024	0.264CysTrp: 0.264 ± 0.008	0.704CysTyr: 0.704 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.34AspAla: 3.34 ± 0.03	1.129AspCys: 1.129 ± 0.022	3.852AspAsp: 3.852 ± 0.048	4.359AspGlu: 4.359 ± 0.039	2.461AspPhe: 2.461 ± 0.023	3.66AspGly: 3.66 ± 0.043	1.248AspHis: 1.248 ± 0.018	3.154AspIle: 3.154 ± 0.028	2.573AspLys: 2.573 ± 0.024	4.692AspLeu: 4.692 ± 0.034	1.3AspMet: 1.3 ± 0.019	2.022AspAsn: 2.022 ± 0.025	2.323AspPro: 2.323 ± 0.026	1.721AspGln: 1.721 ± 0.021	3.071AspArg: 3.071 ± 0.026	3.866AspSer: 3.866 ± 0.033	2.375AspThr: 2.375 ± 0.022	4.062AspVal: 4.062 ± 0.037	0.674AspTrp: 0.674 ± 0.012	1.75AspTyr: 1.75 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	4.102GluAla: 4.102 ± 0.039	1.363GluCys: 1.363 ± 0.025	3.565GluAsp: 3.565 ± 0.035	5.363GluGlu: 5.363 ± 0.062	2.463GluPhe: 2.463 ± 0.023	2.955GluGly: 2.955 ± 0.028	1.544GluHis: 1.544 ± 0.023	3.609GluIle: 3.609 ± 0.034	4.752GluLys: 4.752 ± 0.042	5.878GluLeu: 5.878 ± 0.048	1.867GluMet: 1.867 ± 0.023	3.119GluAsn: 3.119 ± 0.032	2.162GluPro: 2.162 ± 0.027	2.697GluGln: 2.697 ± 0.031	4.33GluArg: 4.33 ± 0.045	4.12GluSer: 4.12 ± 0.034	3.172GluThr: 3.172 ± 0.031	4.006GluVal: 4.006 ± 0.034	0.847GluTrp: 0.847 ± 0.016	1.881GluTyr: 1.881 ± 0.02	0.001GluXaa: 0.001 ± 0.001
Phe	2.916PheAla: 2.916 ± 0.026	1.163PheCys: 1.163 ± 0.019	2.605PheAsp: 2.605 ± 0.024	2.573PheGlu: 2.573 ± 0.027	2.484PhePhe: 2.484 ± 0.029	2.759PheGly: 2.759 ± 0.03	1.197PheHis: 1.197 ± 0.018	2.653PheIle: 2.653 ± 0.03	2.004PheLys: 2.004 ± 0.022	4.441PheLeu: 4.441 ± 0.036	1.109PheMet: 1.109 ± 0.014	1.876PheAsn: 1.876 ± 0.02	1.92PhePro: 1.92 ± 0.023	1.57PheGln: 1.57 ± 0.018	2.55PheArg: 2.55 ± 0.023	3.776PheSer: 3.776 ± 0.03	2.459PheThr: 2.459 ± 0.022	3.345PheVal: 3.345 ± 0.031	0.541PheTrp: 0.541 ± 0.011	1.692PheTyr: 1.692 ± 0.023	0.001PheXaa: 0.001 ± 0.001
Gly	3.544GlyAla: 3.544 ± 0.038	1.269GlyCys: 1.269 ± 0.026	3.107GlyAsp: 3.107 ± 0.032	3.49GlyGlu: 3.49 ± 0.037	2.634GlyPhe: 2.634 ± 0.027	3.957GlyGly: 3.957 ± 0.056	1.346GlyHis: 1.346 ± 0.02	3.255GlyIle: 3.255 ± 0.031	3.311GlyLys: 3.311 ± 0.031	4.715GlyLeu: 4.715 ± 0.053	1.426GlyMet: 1.426 ± 0.02	2.454GlyAsn: 2.454 ± 0.025	2.381GlyPro: 2.381 ± 0.049	2.063GlyGln: 2.063 ± 0.027	3.637GlyArg: 3.637 ± 0.035	4.272GlySer: 4.272 ± 0.04	3.137GlyThr: 3.137 ± 0.032	3.986GlyVal: 3.986 ± 0.038	0.72GlyTrp: 0.72 ± 0.015	1.955GlyTyr: 1.955 ± 0.027	0.001GlyXaa: 0.001 ± 0.0
His	1.472HisAla: 1.472 ± 0.019	0.647HisCys: 0.647 ± 0.014	1.178HisAsp: 1.178 ± 0.016	1.429HisGlu: 1.429 ± 0.021	1.229HisPhe: 1.229 ± 0.016	1.502HisGly: 1.502 ± 0.019	0.796HisHis: 0.796 ± 0.018	1.448HisIle: 1.448 ± 0.018	1.135HisLys: 1.135 ± 0.016	2.554HisLeu: 2.554 ± 0.028	0.623HisMet: 0.623 ± 0.012	0.955HisAsn: 0.955 ± 0.015	1.333HisPro: 1.333 ± 0.02	0.912HisGln: 0.912 ± 0.015	1.607HisArg: 1.607 ± 0.02	1.977HisSer: 1.977 ± 0.025	1.206HisThr: 1.206 ± 0.018	1.701HisVal: 1.701 ± 0.019	0.328HisTrp: 0.328 ± 0.009	0.919HisTyr: 0.919 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.039IleAla: 4.039 ± 0.034	1.443IleCys: 1.443 ± 0.022	3.31IleAsp: 3.31 ± 0.03	3.493IleGlu: 3.493 ± 0.031	2.657IlePhe: 2.657 ± 0.031	3.537IleGly: 3.537 ± 0.035	1.479IleHis: 1.479 ± 0.018	3.101IleIle: 3.101 ± 0.032	2.622IleLys: 2.622 ± 0.027	5.09IleLeu: 5.09 ± 0.037	1.311IleMet: 1.311 ± 0.019	2.276IleAsn: 2.276 ± 0.022	2.855IlePro: 2.855 ± 0.028	2.012IleGln: 2.012 ± 0.022	3.609IleArg: 3.609 ± 0.034	4.699IleSer: 4.699 ± 0.034	3.172IleThr: 3.172 ± 0.034	4.104IleVal: 4.104 ± 0.032	0.659IleTrp: 0.659 ± 0.013	1.838IleTyr: 1.838 ± 0.022	0.001IleXaa: 0.001 ± 0.001
Lys	3.504LysAla: 3.504 ± 0.035	1.212LysCys: 1.212 ± 0.021	2.846LysAsp: 2.846 ± 0.029	4.048LysGlu: 4.048 ± 0.04	2.136LysPhe: 2.136 ± 0.022	2.657LysGly: 2.657 ± 0.03	1.305LysHis: 1.305 ± 0.018	3.155LysIle: 3.155 ± 0.029	4.201LysLys: 4.201 ± 0.044	4.98LysLeu: 4.98 ± 0.038	1.522LysMet: 1.522 ± 0.018	2.51LysAsn: 2.51 ± 0.026	2.331LysPro: 2.331 ± 0.03	2.191LysGln: 2.191 ± 0.024	3.697LysArg: 3.697 ± 0.034	3.718LysSer: 3.718 ± 0.03	3.0LysThr: 3.0 ± 0.027	3.596LysVal: 3.596 ± 0.031	0.715LysTrp: 0.715 ± 0.014	1.837LysTyr: 1.837 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	6.37LeuAla: 6.37 ± 0.048	2.228LeuCys: 2.228 ± 0.027	4.751LeuAsp: 4.751 ± 0.034	5.674LeuGlu: 5.674 ± 0.058	4.5LeuPhe: 4.5 ± 0.04	4.502LeuGly: 4.502 ± 0.036	2.495LeuHis: 2.495 ± 0.023	5.103LeuIle: 5.103 ± 0.042	5.219LeuLys: 5.219 ± 0.04	9.57LeuLeu: 9.57 ± 0.069	2.378LeuMet: 2.378 ± 0.025	4.045LeuAsn: 4.045 ± 0.029	4.718LeuPro: 4.718 ± 0.044	3.788LeuGln: 3.788 ± 0.034	6.055LeuArg: 6.055 ± 0.042	7.77LeuSer: 7.77 ± 0.046	5.002LeuThr: 5.002 ± 0.037	5.956LeuVal: 5.956 ± 0.042	1.084LeuTrp: 1.084 ± 0.017	2.822LeuTyr: 2.822 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.755MetAla: 1.755 ± 0.018	0.561MetCys: 0.561 ± 0.011	1.424MetAsp: 1.424 ± 0.019	1.725MetGlu: 1.725 ± 0.019	1.19MetPhe: 1.19 ± 0.019	1.296MetGly: 1.296 ± 0.022	0.584MetHis: 0.584 ± 0.012	1.373MetIle: 1.373 ± 0.019	1.623MetLys: 1.623 ± 0.017	2.445MetLeu: 2.445 ± 0.025	0.784MetMet: 0.784 ± 0.018	1.234MetAsn: 1.234 ± 0.017	1.112MetPro: 1.112 ± 0.017	0.992MetGln: 0.992 ± 0.015	1.615MetArg: 1.615 ± 0.016	1.982MetSer: 1.982 ± 0.019	1.439MetThr: 1.439 ± 0.022	1.703MetVal: 1.703 ± 0.022	0.311MetTrp: 0.311 ± 0.008	0.704MetTyr: 0.704 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.772AsnAla: 2.772 ± 0.024	0.929AsnCys: 0.929 ± 0.017	2.372AsnAsp: 2.372 ± 0.027	2.889AsnGlu: 2.889 ± 0.028	1.86AsnPhe: 1.86 ± 0.023	2.905AsnGly: 2.905 ± 0.031	0.986AsnHis: 0.986 ± 0.015	2.64AsnIle: 2.64 ± 0.028	2.093AsnLys: 2.093 ± 0.023	3.679AsnLeu: 3.679 ± 0.03	1.102AsnMet: 1.102 ± 0.018	1.806AsnAsn: 1.806 ± 0.022	2.006AsnPro: 2.006 ± 0.024	1.408AsnGln: 1.408 ± 0.016	2.46AsnArg: 2.46 ± 0.025	3.196AsnSer: 3.196 ± 0.029	2.221AsnThr: 2.221 ± 0.023	3.159AsnVal: 3.159 ± 0.025	0.49AsnTrp: 0.49 ± 0.012	1.451AsnTyr: 1.451 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	2.779ProAla: 2.779 ± 0.032	0.867ProCys: 0.867 ± 0.016	2.306ProAsp: 2.306 ± 0.026	2.744ProGlu: 2.744 ± 0.027	2.102ProPhe: 2.102 ± 0.023	2.96ProGly: 2.96 ± 0.108	1.162ProHis: 1.162 ± 0.016	2.507ProIle: 2.507 ± 0.026	2.279ProLys: 2.279 ± 0.025	4.232ProLeu: 4.232 ± 0.04	1.024ProMet: 1.024 ± 0.015	1.953ProAsn: 1.953 ± 0.022	3.612ProPro: 3.612 ± 0.061	1.766ProGln: 1.766 ± 0.025	2.463ProArg: 2.463 ± 0.028	4.244ProSer: 4.244 ± 0.042	2.837ProThr: 2.837 ± 0.038	3.104ProVal: 3.104 ± 0.034	0.474ProTrp: 0.474 ± 0.012	1.462ProTyr: 1.462 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.353GlnAla: 2.353 ± 0.028	0.942GlnCys: 0.942 ± 0.023	1.404GlnAsp: 1.404 ± 0.022	2.084GlnGlu: 2.084 ± 0.027	1.65GlnPhe: 1.65 ± 0.02	1.677GlnGly: 1.677 ± 0.023	1.038GlnHis: 1.038 ± 0.017	2.154GlnIle: 2.154 ± 0.022	2.217GlnLys: 2.217 ± 0.022	4.184GlnLeu: 4.184 ± 0.039	1.17GlnMet: 1.17 ± 0.018	1.599GlnAsn: 1.599 ± 0.022	1.801GlnPro: 1.801 ± 0.027	2.174GlnGln: 2.174 ± 0.057	2.522GlnArg: 2.522 ± 0.025	2.596GlnSer: 2.596 ± 0.029	1.905GlnThr: 1.905 ± 0.021	2.38GlnVal: 2.38 ± 0.024	0.522GlnTrp: 0.522 ± 0.015	1.208GlnTyr: 1.208 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	3.682ArgAla: 3.682 ± 0.03	1.437ArgCys: 1.437 ± 0.023	2.984ArgAsp: 2.984 ± 0.031	3.845ArgGlu: 3.845 ± 0.037	2.761ArgPhe: 2.761 ± 0.026	3.062ArgGly: 3.062 ± 0.032	1.631ArgHis: 1.631 ± 0.021	3.657ArgIle: 3.657 ± 0.027	3.965ArgLys: 3.965 ± 0.035	5.985ArgLeu: 5.985 ± 0.041	1.631ArgMet: 1.631 ± 0.019	2.815ArgAsn: 2.815 ± 0.025	2.679ArgPro: 2.679 ± 0.027	2.493ArgGln: 2.493 ± 0.026	5.012ArgArg: 5.012 ± 0.046	4.609ArgSer: 4.609 ± 0.034	3.311ArgThr: 3.311 ± 0.028	3.694ArgVal: 3.694 ± 0.033	0.764ArgTrp: 0.764 ± 0.014	1.907ArgTyr: 1.907 ± 0.022	0.001ArgXaa: 0.001 ± 0.0
Ser	5.108SerAla: 5.108 ± 0.041	1.754SerCys: 1.754 ± 0.025	4.157SerAsp: 4.157 ± 0.034	4.642SerGlu: 4.642 ± 0.04	3.626SerPhe: 3.626 ± 0.034	4.632SerGly: 4.632 ± 0.039	1.853SerHis: 1.853 ± 0.02	4.443SerIle: 4.443 ± 0.039	3.815SerLys: 3.815 ± 0.032	7.342SerLeu: 7.342 ± 0.048	1.924SerMet: 1.924 ± 0.02	3.133SerAsn: 3.133 ± 0.029	3.764SerPro: 3.764 ± 0.049	2.723SerGln: 2.723 ± 0.028	4.542SerArg: 4.542 ± 0.036	7.698SerSer: 7.698 ± 0.071	4.868SerThr: 4.868 ± 0.045	5.35SerVal: 5.35 ± 0.038	0.86SerTrp: 0.86 ± 0.016	2.259SerTyr: 2.259 ± 0.023	0.001SerXaa: 0.001 ± 0.001
Thr	3.813ThrAla: 3.813 ± 0.03	1.229ThrCys: 1.229 ± 0.022	2.642ThrAsp: 2.642 ± 0.029	3.037ThrGlu: 3.037 ± 0.028	2.452ThrPhe: 2.452 ± 0.025	3.103ThrGly: 3.103 ± 0.028	1.239ThrHis: 1.239 ± 0.02	3.276ThrIle: 3.276 ± 0.033	2.86ThrLys: 2.86 ± 0.027	5.008ThrLeu: 5.008 ± 0.036	1.439ThrMet: 1.439 ± 0.019	2.296ThrAsn: 2.296 ± 0.024	2.767ThrPro: 2.767 ± 0.034	1.79ThrGln: 1.79 ± 0.021	2.903ThrArg: 2.903 ± 0.028	4.627ThrSer: 4.627 ± 0.042	3.571ThrThr: 3.571 ± 0.05	4.208ThrVal: 4.208 ± 0.035	0.604ThrTrp: 0.604 ± 0.011	1.607ThrTyr: 1.607 ± 0.022	0.001ThrXaa: 0.001 ± 0.0
Val	4.639ValAla: 4.639 ± 0.031	1.654ValCys: 1.654 ± 0.024	4.06ValAsp: 4.06 ± 0.033	4.337ValGlu: 4.337 ± 0.034	3.279ValPhe: 3.279 ± 0.032	3.817ValGly: 3.817 ± 0.035	1.743ValHis: 1.743 ± 0.019	4.097ValIle: 4.097 ± 0.029	3.603ValLys: 3.603 ± 0.033	6.672ValLeu: 6.672 ± 0.041	1.724ValMet: 1.724 ± 0.02	2.904ValAsn: 2.904 ± 0.027	3.162ValPro: 3.162 ± 0.029	2.496ValGln: 2.496 ± 0.023	3.903ValArg: 3.903 ± 0.034	5.163ValSer: 5.163 ± 0.038	3.729ValThr: 3.729 ± 0.033	5.434ValVal: 5.434 ± 0.047	0.759ValTrp: 0.759 ± 0.014	2.083ValTyr: 2.083 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.684TrpAla: 0.684 ± 0.013	0.259TrpCys: 0.259 ± 0.008	0.607TrpAsp: 0.607 ± 0.013	0.654TrpGlu: 0.654 ± 0.012	0.554TrpPhe: 0.554 ± 0.012	0.505TrpGly: 0.505 ± 0.013	0.273TrpHis: 0.273 ± 0.009	0.771TrpIle: 0.771 ± 0.016	0.775TrpLys: 0.775 ± 0.014	1.17TrpLeu: 1.17 ± 0.017	0.391TrpMet: 0.391 ± 0.009	0.614TrpAsn: 0.614 ± 0.013	0.469TrpPro: 0.469 ± 0.011	0.46TrpGln: 0.46 ± 0.009	0.795TrpArg: 0.795 ± 0.015	0.95TrpSer: 0.95 ± 0.014	0.715TrpThr: 0.715 ± 0.013	0.655TrpVal: 0.655 ± 0.012	0.179TrpTrp: 0.179 ± 0.006	0.378TrpTyr: 0.378 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.967TyrAla: 1.967 ± 0.022	0.836TyrCys: 0.836 ± 0.016	1.815TyrAsp: 1.815 ± 0.022	1.914TyrGlu: 1.914 ± 0.023	1.566TyrPhe: 1.566 ± 0.02	2.086TyrGly: 2.086 ± 0.029	0.839TyrHis: 0.839 ± 0.016	1.696TyrIle: 1.696 ± 0.024	1.515TyrLys: 1.515 ± 0.022	2.917TyrLeu: 2.917 ± 0.024	0.826TyrMet: 0.826 ± 0.014	1.316TyrAsn: 1.316 ± 0.019	1.389TyrPro: 1.389 ± 0.019	1.111TyrGln: 1.111 ± 0.018	1.99TyrArg: 1.99 ± 0.023	2.376TyrSer: 2.376 ± 0.028	1.583TyrThr: 1.583 ± 0.02	2.094TyrVal: 2.094 ± 0.024	0.419TyrTrp: 0.419 ± 0.01	1.224TyrTyr: 1.224 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.005

Statistics based on 13350 proteins (4341050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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