Amino acid dipepetide frequency for Facklamia sp. 252

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.05AlaAla: 6.05 ± 0.255
0.376AlaCys: 0.376 ± 0.028
3.61AlaAsp: 3.61 ± 0.098
5.061AlaGlu: 5.061 ± 0.134
3.068AlaPhe: 3.068 ± 0.081
4.723AlaGly: 4.723 ± 0.105
1.37AlaHis: 1.37 ± 0.048
6.601AlaIle: 6.601 ± 0.152
5.117AlaLys: 5.117 ± 0.249
7.591AlaLeu: 7.591 ± 0.119
2.215AlaMet: 2.215 ± 0.067
3.447AlaAsn: 3.447 ± 0.082
2.257AlaPro: 2.257 ± 0.089
3.281AlaGln: 3.281 ± 0.093
2.649AlaArg: 2.649 ± 0.079
3.947AlaSer: 3.947 ± 0.089
4.433AlaThr: 4.433 ± 0.107
4.995AlaVal: 4.995 ± 0.13
0.567AlaTrp: 0.567 ± 0.035
2.669AlaTyr: 2.669 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.372CysAla: 0.372 ± 0.028
0.062CysCys: 0.062 ± 0.011
0.319CysAsp: 0.319 ± 0.023
0.344CysGlu: 0.344 ± 0.025
0.25CysPhe: 0.25 ± 0.02
0.526CysGly: 0.526 ± 0.035
0.197CysHis: 0.197 ± 0.02
0.412CysIle: 0.412 ± 0.028
0.215CysLys: 0.215 ± 0.02
0.556CysLeu: 0.556 ± 0.034
0.125CysMet: 0.125 ± 0.015
0.212CysAsn: 0.212 ± 0.019
0.22CysPro: 0.22 ± 0.021
0.302CysGln: 0.302 ± 0.027
0.235CysArg: 0.235 ± 0.021
0.357CysSer: 0.357 ± 0.024
0.255CysThr: 0.255 ± 0.019
0.377CysVal: 0.377 ± 0.025
0.055CysTrp: 0.055 ± 0.009
0.234CysTyr: 0.234 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.042AspAla: 4.042 ± 0.14
0.335AspCys: 0.335 ± 0.024
2.697AspAsp: 2.697 ± 0.091
4.745AspGlu: 4.745 ± 0.114
2.572AspPhe: 2.572 ± 0.067
3.472AspGly: 3.472 ± 0.091
0.806AspHis: 0.806 ± 0.045
4.108AspIle: 4.108 ± 0.095
3.657AspLys: 3.657 ± 0.127
4.742AspLeu: 4.742 ± 0.106
1.284AspMet: 1.284 ± 0.058
2.639AspAsn: 2.639 ± 0.075
1.632AspPro: 1.632 ± 0.154
1.45AspGln: 1.45 ± 0.055
1.724AspArg: 1.724 ± 0.06
2.894AspSer: 2.894 ± 0.072
3.148AspThr: 3.148 ± 0.104
3.84AspVal: 3.84 ± 0.08
0.669AspTrp: 0.669 ± 0.037
2.699AspTyr: 2.699 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
5.369GluAla: 5.369 ± 0.166
0.389GluCys: 0.389 ± 0.026
3.58GluAsp: 3.58 ± 0.115
5.82GluGlu: 5.82 ± 0.153
2.507GluPhe: 2.507 ± 0.073
3.518GluGly: 3.518 ± 0.113
1.557GluHis: 1.557 ± 0.056
5.474GluIle: 5.474 ± 0.106
5.306GluLys: 5.306 ± 0.125
7.184GluLeu: 7.184 ± 0.121
2.278GluMet: 2.278 ± 0.059
3.912GluAsn: 3.912 ± 0.077
2.061GluPro: 2.061 ± 0.076
4.224GluGln: 4.224 ± 0.11
3.408GluArg: 3.408 ± 0.083
3.854GluSer: 3.854 ± 0.088
4.315GluThr: 4.315 ± 0.122
5.459GluVal: 5.459 ± 0.13
0.804GluTrp: 0.804 ± 0.042
2.519GluTyr: 2.519 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
2.959PheAla: 2.959 ± 0.07
0.287PheCys: 0.287 ± 0.022
2.924PheAsp: 2.924 ± 0.077
3.058PheGlu: 3.058 ± 0.077
1.956PhePhe: 1.956 ± 0.07
3.073PheGly: 3.073 ± 0.082
0.716PheHis: 0.716 ± 0.033
3.41PheIle: 3.41 ± 0.09
2.529PheLys: 2.529 ± 0.076
3.689PheLeu: 3.689 ± 0.093
1.105PheMet: 1.105 ± 0.047
2.338PheAsn: 2.338 ± 0.073
1.415PhePro: 1.415 ± 0.049
1.379PheGln: 1.379 ± 0.054
1.425PheArg: 1.425 ± 0.051
3.056PheSer: 3.056 ± 0.083
2.327PheThr: 2.327 ± 0.065
2.934PheVal: 2.934 ± 0.076
0.409PheTrp: 0.409 ± 0.026
1.829PheTyr: 1.829 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.343GlyAla: 4.343 ± 0.107
0.407GlyCys: 0.407 ± 0.028
3.118GlyAsp: 3.118 ± 0.076
4.355GlyGlu: 4.355 ± 0.113
3.033GlyPhe: 3.033 ± 0.089
4.134GlyGly: 4.134 ± 0.127
1.315GlyHis: 1.315 ± 0.057
5.127GlyIle: 5.127 ± 0.117
4.123GlyLys: 4.123 ± 0.099
5.952GlyLeu: 5.952 ± 0.129
1.854GlyMet: 1.854 ± 0.068
2.956GlyAsn: 2.956 ± 0.086
1.258GlyPro: 1.258 ± 0.05
2.45GlyGln: 2.45 ± 0.069
2.534GlyArg: 2.534 ± 0.08
3.445GlySer: 3.445 ± 0.082
3.947GlyThr: 3.947 ± 0.119
4.844GlyVal: 4.844 ± 0.094
0.629GlyTrp: 0.629 ± 0.034
2.839GlyTyr: 2.839 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.29HisAla: 1.29 ± 0.049
0.174HisCys: 0.174 ± 0.02
1.065HisAsp: 1.065 ± 0.054
1.41HisGlu: 1.41 ± 0.056
1.08HisPhe: 1.08 ± 0.039
1.15HisGly: 1.15 ± 0.046
0.731HisHis: 0.731 ± 0.044
1.449HisIle: 1.449 ± 0.046
0.831HisLys: 0.831 ± 0.038
2.108HisLeu: 2.108 ± 0.07
0.359HisMet: 0.359 ± 0.03
0.816HisAsn: 0.816 ± 0.04
0.875HisPro: 0.875 ± 0.045
1.193HisGln: 1.193 ± 0.047
0.91HisArg: 0.91 ± 0.033
1.162HisSer: 1.162 ± 0.046
1.05HisThr: 1.05 ± 0.041
1.173HisVal: 1.173 ± 0.047
0.225HisTrp: 0.225 ± 0.022
1.22HisTyr: 1.22 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.276IleAla: 6.276 ± 0.108
0.544IleCys: 0.544 ± 0.03
4.707IleAsp: 4.707 ± 0.134
6.231IleGlu: 6.231 ± 0.106
3.256IlePhe: 3.256 ± 0.084
5.303IleGly: 5.303 ± 0.13
1.512IleHis: 1.512 ± 0.054
5.872IleIle: 5.872 ± 0.138
4.361IleLys: 4.361 ± 0.094
6.873IleLeu: 6.873 ± 0.143
1.793IleMet: 1.793 ± 0.063
3.739IleAsn: 3.739 ± 0.085
3.018IlePro: 3.018 ± 0.077
3.423IleGln: 3.423 ± 0.092
3.008IleArg: 3.008 ± 0.078
4.85IleSer: 4.85 ± 0.102
4.274IleThr: 4.274 ± 0.103
5.503IleVal: 5.503 ± 0.106
0.613IleTrp: 0.613 ± 0.037
2.557IleTyr: 2.557 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.665LysAla: 4.665 ± 0.262
0.24LysCys: 0.24 ± 0.024
3.41LysAsp: 3.41 ± 0.133
5.526LysGlu: 5.526 ± 0.158
1.928LysPhe: 1.928 ± 0.063
3.762LysGly: 3.762 ± 0.085
1.148LysHis: 1.148 ± 0.046
4.301LysIle: 4.301 ± 0.096
4.083LysLys: 4.083 ± 0.113
5.209LysLeu: 5.209 ± 0.098
1.883LysMet: 1.883 ± 0.06
3.038LysAsn: 3.038 ± 0.076
2.053LysPro: 2.053 ± 0.102
3.316LysGln: 3.316 ± 0.093
2.834LysArg: 2.834 ± 0.08
3.111LysSer: 3.111 ± 0.081
3.36LysThr: 3.36 ± 0.085
4.54LysVal: 4.54 ± 0.095
0.661LysTrp: 0.661 ± 0.042
2.125LysTyr: 2.125 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
7.567LeuAla: 7.567 ± 0.127
0.576LeuCys: 0.576 ± 0.032
5.069LeuAsp: 5.069 ± 0.095
6.354LeuGlu: 6.354 ± 0.123
4.353LeuPhe: 4.353 ± 0.115
5.875LeuGly: 5.875 ± 0.112
1.697LeuHis: 1.697 ± 0.056
7.207LeuIle: 7.207 ± 0.166
5.792LeuLys: 5.792 ± 0.111
9.797LeuLeu: 9.797 ± 0.215
2.792LeuMet: 2.792 ± 0.068
4.98LeuAsn: 4.98 ± 0.109
3.956LeuPro: 3.956 ± 0.087
3.46LeuGln: 3.46 ± 0.083
3.547LeuArg: 3.547 ± 0.09
7.207LeuSer: 7.207 ± 0.137
5.867LeuThr: 5.867 ± 0.11
6.634LeuVal: 6.634 ± 0.114
0.788LeuTrp: 0.788 ± 0.042
3.206LeuTyr: 3.206 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.055MetAla: 2.055 ± 0.071
0.129MetCys: 0.129 ± 0.015
1.282MetAsp: 1.282 ± 0.045
1.661MetGlu: 1.661 ± 0.062
0.86MetPhe: 0.86 ± 0.041
1.627MetGly: 1.627 ± 0.055
0.414MetHis: 0.414 ± 0.029
2.325MetIle: 2.325 ± 0.073
2.048MetLys: 2.048 ± 0.069
2.288MetLeu: 2.288 ± 0.072
0.918MetMet: 0.918 ± 0.048
1.599MetAsn: 1.599 ± 0.053
0.971MetPro: 0.971 ± 0.038
1.138MetGln: 1.138 ± 0.044
1.203MetArg: 1.203 ± 0.049
1.814MetSer: 1.814 ± 0.062
1.848MetThr: 1.848 ± 0.055
1.737MetVal: 1.737 ± 0.06
0.209MetTrp: 0.209 ± 0.019
0.738MetTyr: 0.738 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.408AsnAla: 3.408 ± 0.083
0.25AsnCys: 0.25 ± 0.023
2.5AsnAsp: 2.5 ± 0.077
3.557AsnGlu: 3.557 ± 0.085
1.964AsnPhe: 1.964 ± 0.062
3.557AsnGly: 3.557 ± 0.097
1.208AsnHis: 1.208 ± 0.04
3.62AsnIle: 3.62 ± 0.091
2.756AsnLys: 2.756 ± 0.084
4.313AsnLeu: 4.313 ± 0.106
1.107AsnMet: 1.107 ± 0.043
2.348AsnAsn: 2.348 ± 0.077
2.27AsnPro: 2.27 ± 0.097
2.941AsnGln: 2.941 ± 0.083
2.35AsnArg: 2.35 ± 0.069
2.392AsnSer: 2.392 ± 0.078
2.51AsnThr: 2.51 ± 0.083
3.226AsnVal: 3.226 ± 0.075
0.569AsnTrp: 0.569 ± 0.034
1.968AsnTyr: 1.968 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.252ProAla: 2.252 ± 0.072
0.155ProCys: 0.155 ± 0.018
1.681ProAsp: 1.681 ± 0.068
2.943ProGlu: 2.943 ± 0.118
1.612ProPhe: 1.612 ± 0.053
2.001ProGly: 2.001 ± 0.117
0.658ProHis: 0.658 ± 0.042
2.864ProIle: 2.864 ± 0.068
2.191ProLys: 2.191 ± 0.094
3.071ProLeu: 3.071 ± 0.089
0.855ProMet: 0.855 ± 0.041
1.979ProAsn: 1.979 ± 0.079
0.743ProPro: 0.743 ± 0.064
1.322ProGln: 1.322 ± 0.047
1.01ProArg: 1.01 ± 0.041
2.175ProSer: 2.175 ± 0.118
2.484ProThr: 2.484 ± 0.121
2.789ProVal: 2.789 ± 0.107
0.265ProTrp: 0.265 ± 0.023
1.505ProTyr: 1.505 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
3.909GlnAla: 3.909 ± 0.116
0.2GlnCys: 0.2 ± 0.021
1.904GlnAsp: 1.904 ± 0.049
3.026GlnGlu: 3.026 ± 0.083
1.993GlnPhe: 1.993 ± 0.071
2.24GlnGly: 2.24 ± 0.06
1.04GlnHis: 1.04 ± 0.048
3.046GlnIle: 3.046 ± 0.069
2.504GlnLys: 2.504 ± 0.073
5.511GlnLeu: 5.511 ± 0.152
1.26GlnMet: 1.26 ± 0.041
1.896GlnAsn: 1.896 ± 0.07
1.602GlnPro: 1.602 ± 0.099
2.757GlnGln: 2.757 ± 0.101
1.991GlnArg: 1.991 ± 0.071
2.547GlnSer: 2.547 ± 0.083
2.532GlnThr: 2.532 ± 0.077
2.983GlnVal: 2.983 ± 0.075
0.581GlnTrp: 0.581 ± 0.035
1.974GlnTyr: 1.974 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
2.432ArgAla: 2.432 ± 0.064
0.187ArgCys: 0.187 ± 0.018
1.99ArgAsp: 1.99 ± 0.063
2.993ArgGlu: 2.993 ± 0.091
1.904ArgPhe: 1.904 ± 0.058
2.098ArgGly: 2.098 ± 0.065
0.855ArgHis: 0.855 ± 0.037
3.24ArgIle: 3.24 ± 0.071
2.504ArgLys: 2.504 ± 0.067
4.214ArgLeu: 4.214 ± 0.097
1.192ArgMet: 1.192 ± 0.051
1.858ArgAsn: 1.858 ± 0.068
1.252ArgPro: 1.252 ± 0.045
2.16ArgGln: 2.16 ± 0.072
1.928ArgArg: 1.928 ± 0.074
1.859ArgSer: 1.859 ± 0.062
1.983ArgThr: 1.983 ± 0.057
2.774ArgVal: 2.774 ± 0.081
0.376ArgTrp: 0.376 ± 0.029
1.838ArgTyr: 1.838 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.049SerAla: 4.049 ± 0.096
0.292SerCys: 0.292 ± 0.024
3.15SerAsp: 3.15 ± 0.075
4.286SerGlu: 4.286 ± 0.125
2.741SerPhe: 2.741 ± 0.068
4.079SerGly: 4.079 ± 0.09
1.27SerHis: 1.27 ± 0.052
4.852SerIle: 4.852 ± 0.11
3.368SerLys: 3.368 ± 0.076
5.743SerLeu: 5.743 ± 0.124
1.584SerMet: 1.584 ± 0.047
2.744SerAsn: 2.744 ± 0.071
1.869SerPro: 1.869 ± 0.061
2.547SerGln: 2.547 ± 0.075
2.16SerArg: 2.16 ± 0.068
3.442SerSer: 3.442 ± 0.077
3.298SerThr: 3.298 ± 0.082
4.363SerVal: 4.363 ± 0.101
0.541SerTrp: 0.541 ± 0.033
2.263SerTyr: 2.263 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
4.32ThrAla: 4.32 ± 0.127
0.234ThrCys: 0.234 ± 0.021
3.15ThrAsp: 3.15 ± 0.084
3.567ThrGlu: 3.567 ± 0.104
2.377ThrPhe: 2.377 ± 0.073
4.017ThrGly: 4.017 ± 0.078
1.263ThrHis: 1.263 ± 0.051
4.855ThrIle: 4.855 ± 0.106
3.24ThrLys: 3.24 ± 0.069
5.92ThrLeu: 5.92 ± 0.118
1.307ThrMet: 1.307 ± 0.053
2.742ThrAsn: 2.742 ± 0.084
2.767ThrPro: 2.767 ± 0.158
2.542ThrGln: 2.542 ± 0.093
1.921ThrArg: 1.921 ± 0.066
3.188ThrSer: 3.188 ± 0.08
3.704ThrThr: 3.704 ± 0.114
4.48ThrVal: 4.48 ± 0.096
0.557ThrTrp: 0.557 ± 0.03
2.248ThrTyr: 2.248 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
5.481ValAla: 5.481 ± 0.112
0.422ValCys: 0.422 ± 0.026
4.208ValAsp: 4.208 ± 0.108
5.508ValGlu: 5.508 ± 0.139
2.796ValPhe: 2.796 ± 0.068
4.572ValGly: 4.572 ± 0.1
1.233ValHis: 1.233 ± 0.055
5.588ValIle: 5.588 ± 0.093
4.223ValLys: 4.223 ± 0.104
6.534ValLeu: 6.534 ± 0.121
1.909ValMet: 1.909 ± 0.054
3.378ValAsn: 3.378 ± 0.083
2.674ValPro: 2.674 ± 0.089
2.639ValGln: 2.639 ± 0.065
2.47ValArg: 2.47 ± 0.065
4.577ValSer: 4.577 ± 0.092
4.572ValThr: 4.572 ± 0.105
5.351ValVal: 5.351 ± 0.129
0.588ValTrp: 0.588 ± 0.026
2.447ValTyr: 2.447 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.541TrpAla: 0.541 ± 0.032
0.083TrpCys: 0.083 ± 0.013
0.489TrpAsp: 0.489 ± 0.028
0.552TrpGlu: 0.552 ± 0.032
0.431TrpPhe: 0.431 ± 0.029
0.579TrpGly: 0.579 ± 0.035
0.279TrpHis: 0.279 ± 0.026
0.751TrpIle: 0.751 ± 0.036
0.519TrpLys: 0.519 ± 0.032
1.25TrpLeu: 1.25 ± 0.058
0.257TrpMet: 0.257 ± 0.022
0.506TrpAsn: 0.506 ± 0.028
0.23TrpPro: 0.23 ± 0.021
0.634TrpGln: 0.634 ± 0.043
0.431TrpArg: 0.431 ± 0.028
0.531TrpSer: 0.531 ± 0.031
0.486TrpThr: 0.486 ± 0.033
0.623TrpVal: 0.623 ± 0.04
0.117TrpTrp: 0.117 ± 0.015
0.344TrpTyr: 0.344 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.647TyrAla: 2.647 ± 0.076
0.284TyrCys: 0.284 ± 0.022
2.305TyrAsp: 2.305 ± 0.071
2.545TyrGlu: 2.545 ± 0.073
2.138TyrPhe: 2.138 ± 0.063
2.357TyrGly: 2.357 ± 0.068
1.0TyrHis: 1.0 ± 0.044
2.609TyrIle: 2.609 ± 0.076
1.828TyrLys: 1.828 ± 0.068
4.179TyrLeu: 4.179 ± 0.098
0.786TyrMet: 0.786 ± 0.037
1.687TyrAsn: 1.687 ± 0.058
1.43TyrPro: 1.43 ± 0.05
2.337TyrGln: 2.337 ± 0.08
1.896TyrArg: 1.896 ± 0.057
2.233TyrSer: 2.233 ± 0.075
2.008TyrThr: 2.008 ± 0.058
2.542TyrVal: 2.542 ± 0.103
0.409TyrTrp: 0.409 ± 0.028
1.848TyrTyr: 1.848 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1842 proteins (599143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski