Amino acid dipepetide frequency for Sharpea azabuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.542AlaAla: 4.542 ± 0.107	0.959AlaCys: 0.959 ± 0.042	3.319AlaAsp: 3.319 ± 0.079	3.065AlaGlu: 3.065 ± 0.085	3.243AlaPhe: 3.243 ± 0.066	4.58AlaGly: 4.58 ± 0.087	1.722AlaHis: 1.722 ± 0.046	6.544AlaIle: 6.544 ± 0.115	5.565AlaLys: 5.565 ± 0.106	7.555AlaLeu: 7.555 ± 0.106	2.303AlaMet: 2.303 ± 0.061	3.239AlaAsn: 3.239 ± 0.077	1.834AlaPro: 1.834 ± 0.061	2.029AlaGln: 2.029 ± 0.051	2.597AlaArg: 2.597 ± 0.059	4.631AlaSer: 4.631 ± 0.08	3.482AlaThr: 3.482 ± 0.084	4.307AlaVal: 4.307 ± 0.098	0.479AlaTrp: 0.479 ± 0.026	3.159AlaTyr: 3.159 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	0.831CysAla: 0.831 ± 0.034	0.188CysCys: 0.188 ± 0.017	0.802CysAsp: 0.802 ± 0.035	0.688CysGlu: 0.688 ± 0.028	0.62CysPhe: 0.62 ± 0.029	1.027CysGly: 1.027 ± 0.041	0.442CysHis: 0.442 ± 0.03	1.007CysIle: 1.007 ± 0.04	0.647CysLys: 0.647 ± 0.027	1.045CysLeu: 1.045 ± 0.042	0.355CysMet: 0.355 ± 0.024	0.508CysAsn: 0.508 ± 0.028	0.542CysPro: 0.542 ± 0.028	0.377CysGln: 0.377 ± 0.022	0.372CysArg: 0.372 ± 0.022	0.636CysSer: 0.636 ± 0.031	0.593CysThr: 0.593 ± 0.032	0.786CysVal: 0.786 ± 0.034	0.082CysTrp: 0.082 ± 0.011	0.438CysTyr: 0.438 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.074AspAla: 4.074 ± 0.086	0.673AspCys: 0.673 ± 0.029	4.001AspAsp: 4.001 ± 0.096	5.342AspGlu: 5.342 ± 0.094	2.89AspPhe: 2.89 ± 0.078	3.957AspGly: 3.957 ± 0.086	1.817AspHis: 1.817 ± 0.057	5.23AspIle: 5.23 ± 0.099	3.666AspLys: 3.666 ± 0.075	5.388AspLeu: 5.388 ± 0.112	1.949AspMet: 1.949 ± 0.06	2.543AspAsn: 2.543 ± 0.068	1.891AspPro: 1.891 ± 0.052	2.051AspGln: 2.051 ± 0.067	2.034AspArg: 2.034 ± 0.059	2.645AspSer: 2.645 ± 0.061	2.777AspThr: 2.777 ± 0.066	4.394AspVal: 4.394 ± 0.08	0.445AspTrp: 0.445 ± 0.028	3.603AspTyr: 3.603 ± 0.079	0.0AspXaa: 0.0 ± 0.0
Glu	5.221GluAla: 5.221 ± 0.092	0.698GluCys: 0.698 ± 0.032	4.442GluAsp: 4.442 ± 0.084	6.157GluGlu: 6.157 ± 0.102	2.274GluPhe: 2.274 ± 0.054	3.991GluGly: 3.991 ± 0.077	1.586GluHis: 1.586 ± 0.054	5.128GluIle: 5.128 ± 0.091	5.935GluLys: 5.935 ± 0.108	5.959GluLeu: 5.959 ± 0.104	2.26GluMet: 2.26 ± 0.068	3.784GluAsn: 3.784 ± 0.08	1.392GluPro: 1.392 ± 0.051	1.977GluGln: 1.977 ± 0.059	2.981GluArg: 2.981 ± 0.069	2.943GluSer: 2.943 ± 0.067	3.2GluThr: 3.2 ± 0.074	4.593GluVal: 4.593 ± 0.087	0.517GluTrp: 0.517 ± 0.028	2.655GluTyr: 2.655 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.787PheAla: 2.787 ± 0.068	0.503PheCys: 0.503 ± 0.028	3.045PheAsp: 3.045 ± 0.074	2.699PheGlu: 2.699 ± 0.064	1.909PhePhe: 1.909 ± 0.07	2.839PheGly: 2.839 ± 0.078	1.024PheHis: 1.024 ± 0.043	3.581PheIle: 3.581 ± 0.088	2.958PheLys: 2.958 ± 0.057	3.631PheLeu: 3.631 ± 0.081	1.276PheMet: 1.276 ± 0.044	2.12PheAsn: 2.12 ± 0.054	1.303PhePro: 1.303 ± 0.042	1.039PheGln: 1.039 ± 0.043	1.335PheArg: 1.335 ± 0.043	2.726PheSer: 2.726 ± 0.075	2.375PheThr: 2.375 ± 0.057	3.113PheVal: 3.113 ± 0.081	0.293PheTrp: 0.293 ± 0.021	2.032PheTyr: 2.032 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	4.44GlyAla: 4.44 ± 0.1	1.041GlyCys: 1.041 ± 0.04	3.329GlyAsp: 3.329 ± 0.066	3.664GlyGlu: 3.664 ± 0.077	2.954GlyPhe: 2.954 ± 0.073	4.185GlyGly: 4.185 ± 0.105	1.68GlyHis: 1.68 ± 0.044	5.622GlyIle: 5.622 ± 0.101	5.06GlyLys: 5.06 ± 0.096	5.793GlyLeu: 5.793 ± 0.101	2.187GlyMet: 2.187 ± 0.063	2.739GlyAsn: 2.739 ± 0.073	1.277GlyPro: 1.277 ± 0.052	1.891GlyGln: 1.891 ± 0.057	2.424GlyArg: 2.424 ± 0.061	3.362GlySer: 3.362 ± 0.077	3.594GlyThr: 3.594 ± 0.081	4.458GlyVal: 4.458 ± 0.083	0.517GlyTrp: 0.517 ± 0.031	3.363GlyTyr: 3.363 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.497HisAla: 1.497 ± 0.048	0.354HisCys: 0.354 ± 0.021	1.633HisAsp: 1.633 ± 0.051	1.559HisGlu: 1.559 ± 0.045	1.31HisPhe: 1.31 ± 0.041	1.422HisGly: 1.422 ± 0.049	0.935HisHis: 0.935 ± 0.049	2.178HisIle: 2.178 ± 0.062	1.477HisLys: 1.477 ± 0.051	2.415HisLeu: 2.415 ± 0.059	0.783HisMet: 0.783 ± 0.032	1.154HisAsn: 1.154 ± 0.04	1.134HisPro: 1.134 ± 0.044	1.059HisGln: 1.059 ± 0.04	0.874HisArg: 0.874 ± 0.041	1.219HisSer: 1.219 ± 0.038	1.292HisThr: 1.292 ± 0.047	1.706HisVal: 1.706 ± 0.044	0.186HisTrp: 0.186 ± 0.019	1.429HisTyr: 1.429 ± 0.046	0.0HisXaa: 0.0 ± 0.0
Ile	6.392IleAla: 6.392 ± 0.107	1.038IleCys: 1.038 ± 0.041	5.318IleAsp: 5.318 ± 0.098	5.166IleGlu: 5.166 ± 0.099	3.198IlePhe: 3.198 ± 0.081	5.223IleGly: 5.223 ± 0.103	1.987IleHis: 1.987 ± 0.055	6.375IleIle: 6.375 ± 0.117	5.734IleLys: 5.734 ± 0.084	6.992IleLeu: 6.992 ± 0.117	2.246IleMet: 2.246 ± 0.063	4.026IleAsn: 4.026 ± 0.075	2.95IlePro: 2.95 ± 0.069	2.233IleGln: 2.233 ± 0.053	2.995IleArg: 2.995 ± 0.076	4.652IleSer: 4.652 ± 0.097	4.526IleThr: 4.526 ± 0.091	5.745IleVal: 5.745 ± 0.111	0.486IleTrp: 0.486 ± 0.025	3.219IleTyr: 3.219 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.568LysAla: 5.568 ± 0.099	0.666LysCys: 0.666 ± 0.033	4.972LysAsp: 4.972 ± 0.09	6.783LysGlu: 6.783 ± 0.125	1.953LysPhe: 1.953 ± 0.051	4.382LysGly: 4.382 ± 0.084	1.804LysHis: 1.804 ± 0.056	5.22LysIle: 5.22 ± 0.098	7.353LysLys: 7.353 ± 0.133	5.839LysLeu: 5.839 ± 0.092	2.464LysMet: 2.464 ± 0.057	4.41LysAsn: 4.41 ± 0.081	2.059LysPro: 2.059 ± 0.057	2.777LysGln: 2.777 ± 0.07	3.461LysArg: 3.461 ± 0.072	3.681LysSer: 3.681 ± 0.07	4.222LysThr: 4.222 ± 0.081	4.707LysVal: 4.707 ± 0.072	0.574LysTrp: 0.574 ± 0.031	3.236LysTyr: 3.236 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	6.541LeuAla: 6.541 ± 0.114	1.134LeuCys: 1.134 ± 0.037	5.706LeuAsp: 5.706 ± 0.095	6.106LeuGlu: 6.106 ± 0.096	3.974LeuPhe: 3.974 ± 0.097	5.734LeuGly: 5.734 ± 0.104	2.082LeuHis: 2.082 ± 0.061	6.606LeuIle: 6.606 ± 0.12	7.336LeuLys: 7.336 ± 0.114	8.27LeuLeu: 8.27 ± 0.148	2.832LeuMet: 2.832 ± 0.06	4.516LeuAsn: 4.516 ± 0.088	3.239LeuPro: 3.239 ± 0.075	2.314LeuGln: 2.314 ± 0.049	3.314LeuArg: 3.314 ± 0.076	6.407LeuSer: 6.407 ± 0.116	4.908LeuThr: 4.908 ± 0.085	5.881LeuVal: 5.881 ± 0.104	0.551LeuTrp: 0.551 ± 0.03	3.624LeuTyr: 3.624 ± 0.084	0.0LeuXaa: 0.0 ± 0.0
Met	2.216MetAla: 2.216 ± 0.062	0.306MetCys: 0.306 ± 0.017	1.803MetAsp: 1.803 ± 0.051	1.701MetGlu: 1.701 ± 0.046	1.061MetPhe: 1.061 ± 0.038	1.837MetGly: 1.837 ± 0.06	0.813MetHis: 0.813 ± 0.034	2.536MetIle: 2.536 ± 0.062	2.902MetLys: 2.902 ± 0.064	2.719MetLeu: 2.719 ± 0.068	1.112MetMet: 1.112 ± 0.047	1.985MetAsn: 1.985 ± 0.05	1.154MetPro: 1.154 ± 0.046	1.092MetGln: 1.092 ± 0.04	1.326MetArg: 1.326 ± 0.042	1.893MetSer: 1.893 ± 0.054	1.706MetThr: 1.706 ± 0.049	1.682MetVal: 1.682 ± 0.042	0.22MetTrp: 0.22 ± 0.018	0.967MetTyr: 0.967 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.543AsnAla: 3.543 ± 0.074	0.515AsnCys: 0.515 ± 0.031	3.162AsnAsp: 3.162 ± 0.079	3.566AsnGlu: 3.566 ± 0.078	1.705AsnPhe: 1.705 ± 0.056	3.427AsnGly: 3.427 ± 0.075	1.269AsnHis: 1.269 ± 0.044	3.836AsnIle: 3.836 ± 0.077	4.077AsnLys: 4.077 ± 0.093	3.901AsnLeu: 3.901 ± 0.073	1.552AsnMet: 1.552 ± 0.043	2.63AsnAsn: 2.63 ± 0.072	1.879AsnPro: 1.879 ± 0.053	1.793AsnGln: 1.793 ± 0.053	1.964AsnArg: 1.964 ± 0.056	2.249AsnSer: 2.249 ± 0.058	2.603AsnThr: 2.603 ± 0.066	3.249AsnVal: 3.249 ± 0.072	0.394AsnTrp: 0.394 ± 0.027	2.379AsnTyr: 2.379 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	2.024ProAla: 2.024 ± 0.062	0.307ProCys: 0.307 ± 0.024	1.997ProAsp: 1.997 ± 0.062	2.447ProGlu: 2.447 ± 0.056	1.527ProPhe: 1.527 ± 0.042	1.845ProGly: 1.845 ± 0.066	0.881ProHis: 0.881 ± 0.04	2.4ProIle: 2.4 ± 0.057	1.796ProLys: 1.796 ± 0.05	2.844ProLeu: 2.844 ± 0.067	0.824ProMet: 0.824 ± 0.036	1.311ProAsn: 1.311 ± 0.042	0.548ProPro: 0.548 ± 0.025	0.988ProGln: 0.988 ± 0.037	1.028ProArg: 1.028 ± 0.039	1.757ProSer: 1.757 ± 0.045	1.801ProThr: 1.801 ± 0.052	2.361ProVal: 2.361 ± 0.063	0.262ProTrp: 0.262 ± 0.02	1.588ProTyr: 1.588 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	2.48GlnAla: 2.48 ± 0.051	0.32GlnCys: 0.32 ± 0.024	1.786GlnAsp: 1.786 ± 0.061	2.484GlnGlu: 2.484 ± 0.069	1.371GlnPhe: 1.371 ± 0.047	1.766GlnGly: 1.766 ± 0.053	0.671GlnHis: 0.671 ± 0.032	2.195GlnIle: 2.195 ± 0.063	2.352GlnLys: 2.352 ± 0.055	3.011GlnLeu: 3.011 ± 0.071	1.031GlnMet: 1.031 ± 0.038	1.396GlnAsn: 1.396 ± 0.052	0.905GlnPro: 0.905 ± 0.036	1.182GlnGln: 1.182 ± 0.052	1.192GlnArg: 1.192 ± 0.045	1.765GlnSer: 1.765 ± 0.057	1.477GlnThr: 1.477 ± 0.048	2.012GlnVal: 2.012 ± 0.048	0.272GlnTrp: 0.272 ± 0.022	1.699GlnTyr: 1.699 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	2.158ArgAla: 2.158 ± 0.061	0.49ArgCys: 0.49 ± 0.03	2.213ArgAsp: 2.213 ± 0.062	2.764ArgGlu: 2.764 ± 0.078	1.765ArgPhe: 1.765 ± 0.045	2.082ArgGly: 2.082 ± 0.058	1.044ArgHis: 1.044 ± 0.039	3.322ArgIle: 3.322 ± 0.064	3.268ArgLys: 3.268 ± 0.078	3.332ArgLeu: 3.332 ± 0.075	1.318ArgMet: 1.318 ± 0.043	1.942ArgAsn: 1.942 ± 0.051	1.059ArgPro: 1.059 ± 0.042	1.367ArgGln: 1.367 ± 0.043	1.663ArgArg: 1.663 ± 0.055	1.981ArgSer: 1.981 ± 0.064	1.861ArgThr: 1.861 ± 0.056	2.456ArgVal: 2.456 ± 0.058	0.279ArgTrp: 0.279 ± 0.021	2.072ArgTyr: 2.072 ± 0.067	0.0ArgXaa: 0.0 ± 0.0
Ser	3.597SerAla: 3.597 ± 0.079	0.642SerCys: 0.642 ± 0.029	3.082SerAsp: 3.082 ± 0.067	3.226SerGlu: 3.226 ± 0.066	2.937SerPhe: 2.937 ± 0.068	3.809SerGly: 3.809 ± 0.073	1.412SerHis: 1.412 ± 0.048	4.576SerIle: 4.576 ± 0.088	3.775SerLys: 3.775 ± 0.077	5.725SerLeu: 5.725 ± 0.087	1.668SerMet: 1.668 ± 0.05	2.579SerAsn: 2.579 ± 0.066	1.586SerPro: 1.586 ± 0.041	1.912SerGln: 1.912 ± 0.05	2.236SerArg: 2.236 ± 0.062	3.572SerSer: 3.572 ± 0.085	2.999SerThr: 2.999 ± 0.074	3.523SerVal: 3.523 ± 0.081	0.469SerTrp: 0.469 ± 0.031	2.818SerTyr: 2.818 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	3.274ThrAla: 3.274 ± 0.08	0.565ThrCys: 0.565 ± 0.029	2.781ThrAsp: 2.781 ± 0.068	2.437ThrGlu: 2.437 ± 0.065	2.403ThrPhe: 2.403 ± 0.063	3.707ThrGly: 3.707 ± 0.075	1.265ThrHis: 1.265 ± 0.045	4.754ThrIle: 4.754 ± 0.089	3.944ThrLys: 3.944 ± 0.092	5.305ThrLeu: 5.305 ± 0.096	1.416ThrMet: 1.416 ± 0.045	2.757ThrAsn: 2.757 ± 0.064	2.069ThrPro: 2.069 ± 0.051	1.508ThrGln: 1.508 ± 0.049	1.871ThrArg: 1.871 ± 0.054	3.283ThrSer: 3.283 ± 0.076	3.118ThrThr: 3.118 ± 0.085	3.494ThrVal: 3.494 ± 0.079	0.358ThrTrp: 0.358 ± 0.026	2.593ThrTyr: 2.593 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.631ValAla: 4.631 ± 0.086	0.871ValCys: 0.871 ± 0.041	4.315ValAsp: 4.315 ± 0.072	4.442ValGlu: 4.442 ± 0.081	2.917ValPhe: 2.917 ± 0.062	4.396ValGly: 4.396 ± 0.082	1.439ValHis: 1.439 ± 0.047	5.594ValIle: 5.594 ± 0.092	4.7ValLys: 4.7 ± 0.094	6.252ValLeu: 6.252 ± 0.095	1.959ValMet: 1.959 ± 0.05	3.338ValAsn: 3.338 ± 0.066	2.062ValPro: 2.062 ± 0.065	1.522ValGln: 1.522 ± 0.047	2.468ValArg: 2.468 ± 0.057	4.043ValSer: 4.043 ± 0.083	3.795ValThr: 3.795 ± 0.074	5.058ValVal: 5.058 ± 0.107	0.404ValTrp: 0.404 ± 0.026	2.613ValTyr: 2.613 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.483TrpAla: 0.483 ± 0.023	0.108TrpCys: 0.108 ± 0.013	0.453TrpAsp: 0.453 ± 0.027	0.377TrpGlu: 0.377 ± 0.025	0.368TrpPhe: 0.368 ± 0.026	0.517TrpGly: 0.517 ± 0.032	0.232TrpHis: 0.232 ± 0.018	0.53TrpIle: 0.53 ± 0.028	0.501TrpLys: 0.501 ± 0.029	0.695TrpLeu: 0.695 ± 0.034	0.236TrpMet: 0.236 ± 0.019	0.429TrpAsn: 0.429 ± 0.026	0.214TrpPro: 0.214 ± 0.018	0.313TrpGln: 0.313 ± 0.024	0.234TrpArg: 0.234 ± 0.018	0.37TrpSer: 0.37 ± 0.024	0.287TrpThr: 0.287 ± 0.023	0.402TrpVal: 0.402 ± 0.021	0.093TrpTrp: 0.093 ± 0.012	0.361TrpTyr: 0.361 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.854TyrAla: 2.854 ± 0.063	0.61TyrCys: 0.61 ± 0.03	3.21TyrAsp: 3.21 ± 0.071	3.021TyrGlu: 3.021 ± 0.076	2.211TyrPhe: 2.211 ± 0.064	2.855TyrGly: 2.855 ± 0.071	1.512TyrHis: 1.512 ± 0.048	3.266TyrIle: 3.266 ± 0.073	3.082TyrLys: 3.082 ± 0.065	4.403TyrLeu: 4.403 ± 0.086	1.258TyrMet: 1.258 ± 0.04	2.287TyrAsn: 2.287 ± 0.056	1.439TyrPro: 1.439 ± 0.043	1.943TyrGln: 1.943 ± 0.057	2.066TyrArg: 2.066 ± 0.055	2.33TyrSer: 2.33 ± 0.057	2.284TyrThr: 2.284 ± 0.055	2.892TyrVal: 2.892 ± 0.06	0.326TyrTrp: 0.326 ± 0.022	2.325TyrTyr: 2.325 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2425 proteins (706142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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