Amino acid dipepetide frequency for Arthrobacter phage Bridgette

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.597AlaAla: 18.597 ± 1.741
1.09AlaCys: 1.09 ± 0.278
7.264AlaAsp: 7.264 ± 0.852
6.175AlaGlu: 6.175 ± 0.825
2.906AlaPhe: 2.906 ± 0.394
13.729AlaGly: 13.729 ± 2.139
2.034AlaHis: 2.034 ± 0.44
4.504AlaIle: 4.504 ± 0.648
5.303AlaLys: 5.303 ± 0.686
10.315AlaLeu: 10.315 ± 1.127
2.107AlaMet: 2.107 ± 0.551
3.995AlaAsn: 3.995 ± 0.853
7.119AlaPro: 7.119 ± 1.29
4.867AlaGln: 4.867 ± 0.572
7.119AlaArg: 7.119 ± 0.899
5.739AlaSer: 5.739 ± 0.636
7.555AlaThr: 7.555 ± 0.79
6.32AlaVal: 6.32 ± 0.795
1.961AlaTrp: 1.961 ± 0.389
1.889AlaTyr: 1.889 ± 0.457
0.0AlaXaa: 0.0 ± 0.0
Cys
0.944CysAla: 0.944 ± 0.294
0.145CysCys: 0.145 ± 0.105
0.363CysAsp: 0.363 ± 0.161
0.581CysGlu: 0.581 ± 0.231
0.073CysPhe: 0.073 ± 0.078
1.308CysGly: 1.308 ± 0.327
0.291CysHis: 0.291 ± 0.142
0.508CysIle: 0.508 ± 0.21
0.363CysLys: 0.363 ± 0.156
0.363CysLeu: 0.363 ± 0.175
0.0CysMet: 0.0 ± 0.0
0.363CysAsn: 0.363 ± 0.228
1.235CysPro: 1.235 ± 0.34
0.581CysGln: 0.581 ± 0.234
0.581CysArg: 0.581 ± 0.256
0.799CysSer: 0.799 ± 0.226
0.508CysThr: 0.508 ± 0.232
0.291CysVal: 0.291 ± 0.144
0.073CysTrp: 0.073 ± 0.075
0.291CysTyr: 0.291 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
7.119AspAla: 7.119 ± 0.85
0.436AspCys: 0.436 ± 0.166
3.632AspAsp: 3.632 ± 0.594
3.414AspGlu: 3.414 ± 0.467
2.47AspPhe: 2.47 ± 0.394
5.957AspGly: 5.957 ± 0.691
1.162AspHis: 1.162 ± 0.352
2.542AspIle: 2.542 ± 0.346
2.615AspLys: 2.615 ± 0.398
4.068AspLeu: 4.068 ± 0.477
1.453AspMet: 1.453 ± 0.298
1.525AspAsn: 1.525 ± 0.381
4.431AspPro: 4.431 ± 0.718
2.397AspGln: 2.397 ± 0.327
4.213AspArg: 4.213 ± 0.52
3.051AspSer: 3.051 ± 0.605
2.542AspThr: 2.542 ± 0.443
3.487AspVal: 3.487 ± 0.525
1.09AspTrp: 1.09 ± 0.237
1.017AspTyr: 1.017 ± 0.249
0.0AspXaa: 0.0 ± 0.0
Glu
7.41GluAla: 7.41 ± 0.883
0.508GluCys: 0.508 ± 0.177
3.196GluAsp: 3.196 ± 0.448
3.923GluGlu: 3.923 ± 0.584
0.944GluPhe: 0.944 ± 0.23
3.85GluGly: 3.85 ± 0.525
1.09GluHis: 1.09 ± 0.262
2.47GluIle: 2.47 ± 0.341
2.034GluLys: 2.034 ± 0.487
5.666GluLeu: 5.666 ± 0.552
1.598GluMet: 1.598 ± 0.329
1.09GluAsn: 1.09 ± 0.282
2.688GluPro: 2.688 ± 0.535
2.978GluGln: 2.978 ± 0.432
3.85GluArg: 3.85 ± 0.532
3.051GluSer: 3.051 ± 0.42
3.487GluThr: 3.487 ± 0.417
3.85GluVal: 3.85 ± 0.466
1.525GluTrp: 1.525 ± 0.431
1.816GluTyr: 1.816 ± 0.422
0.0GluXaa: 0.0 ± 0.0
Phe
3.269PheAla: 3.269 ± 0.499
0.508PheCys: 0.508 ± 0.228
2.325PheAsp: 2.325 ± 0.365
0.944PheGlu: 0.944 ± 0.218
0.581PhePhe: 0.581 ± 0.228
2.107PheGly: 2.107 ± 0.338
0.799PheHis: 0.799 ± 0.242
1.162PheIle: 1.162 ± 0.251
1.671PheLys: 1.671 ± 0.418
1.743PheLeu: 1.743 ± 0.383
0.726PheMet: 0.726 ± 0.238
0.581PheAsn: 0.581 ± 0.191
1.235PhePro: 1.235 ± 0.335
0.799PheGln: 0.799 ± 0.182
1.525PheArg: 1.525 ± 0.322
1.09PheSer: 1.09 ± 0.302
1.961PheThr: 1.961 ± 0.377
1.162PheVal: 1.162 ± 0.277
0.363PheTrp: 0.363 ± 0.165
0.726PheTyr: 0.726 ± 0.213
0.0PheXaa: 0.0 ± 0.0
Gly
8.427GlyAla: 8.427 ± 1.207
0.872GlyCys: 0.872 ± 0.255
5.085GlyAsp: 5.085 ± 0.458
3.995GlyGlu: 3.995 ± 0.53
2.325GlyPhe: 2.325 ± 0.341
7.627GlyGly: 7.627 ± 1.011
1.961GlyHis: 1.961 ± 0.372
3.995GlyIle: 3.995 ± 0.682
4.504GlyLys: 4.504 ± 0.565
7.482GlyLeu: 7.482 ± 0.777
2.47GlyMet: 2.47 ± 0.423
2.76GlyAsn: 2.76 ± 0.461
3.196GlyPro: 3.196 ± 0.523
3.269GlyGln: 3.269 ± 0.446
5.376GlyArg: 5.376 ± 0.731
5.23GlySer: 5.23 ± 0.835
7.337GlyThr: 7.337 ± 0.828
6.175GlyVal: 6.175 ± 0.763
2.615GlyTrp: 2.615 ± 0.508
2.47GlyTyr: 2.47 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
2.252HisAla: 2.252 ± 0.475
0.218HisCys: 0.218 ± 0.12
1.235HisAsp: 1.235 ± 0.27
1.38HisGlu: 1.38 ± 0.265
0.508HisPhe: 0.508 ± 0.192
1.453HisGly: 1.453 ± 0.416
0.581HisHis: 0.581 ± 0.246
0.363HisIle: 0.363 ± 0.189
0.799HisLys: 0.799 ± 0.214
1.525HisLeu: 1.525 ± 0.363
0.363HisMet: 0.363 ± 0.176
0.436HisAsn: 0.436 ± 0.159
1.162HisPro: 1.162 ± 0.281
0.726HisGln: 0.726 ± 0.228
1.453HisArg: 1.453 ± 0.405
1.162HisSer: 1.162 ± 0.332
1.598HisThr: 1.598 ± 0.358
1.09HisVal: 1.09 ± 0.267
0.291HisTrp: 0.291 ± 0.139
0.581HisTyr: 0.581 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
5.158IleAla: 5.158 ± 0.636
0.363IleCys: 0.363 ± 0.149
2.978IleAsp: 2.978 ± 0.545
3.269IleGlu: 3.269 ± 0.426
0.799IlePhe: 0.799 ± 0.23
2.906IleGly: 2.906 ± 0.388
0.944IleHis: 0.944 ± 0.336
1.743IleIle: 1.743 ± 0.433
1.671IleLys: 1.671 ± 0.286
1.889IleLeu: 1.889 ± 0.356
0.726IleMet: 0.726 ± 0.236
1.235IleAsn: 1.235 ± 0.304
3.196IlePro: 3.196 ± 0.535
1.525IleGln: 1.525 ± 0.318
3.124IleArg: 3.124 ± 0.408
2.833IleSer: 2.833 ± 0.502
4.068IleThr: 4.068 ± 0.591
2.47IleVal: 2.47 ± 0.497
0.291IleTrp: 0.291 ± 0.143
1.308IleTyr: 1.308 ± 0.233
0.0IleXaa: 0.0 ± 0.0
Lys
6.828LysAla: 6.828 ± 0.841
0.291LysCys: 0.291 ± 0.14
2.47LysAsp: 2.47 ± 0.439
2.179LysGlu: 2.179 ± 0.375
1.017LysPhe: 1.017 ± 0.27
3.051LysGly: 3.051 ± 0.567
1.162LysHis: 1.162 ± 0.302
1.671LysIle: 1.671 ± 0.359
2.107LysLys: 2.107 ± 0.294
3.414LysLeu: 3.414 ± 0.575
1.162LysMet: 1.162 ± 0.281
1.889LysAsn: 1.889 ± 0.334
3.124LysPro: 3.124 ± 0.406
1.816LysGln: 1.816 ± 0.458
2.107LysArg: 2.107 ± 0.375
2.615LysSer: 2.615 ± 0.498
2.833LysThr: 2.833 ± 0.335
3.487LysVal: 3.487 ± 0.475
0.363LysTrp: 0.363 ± 0.148
1.453LysTyr: 1.453 ± 0.334
0.0LysXaa: 0.0 ± 0.0
Leu
9.153LeuAla: 9.153 ± 0.832
0.872LeuCys: 0.872 ± 0.261
5.666LeuAsp: 5.666 ± 0.656
4.431LeuGlu: 4.431 ± 0.535
1.889LeuPhe: 1.889 ± 0.36
6.683LeuGly: 6.683 ± 0.659
1.38LeuHis: 1.38 ± 0.388
3.559LeuIle: 3.559 ± 0.537
4.359LeuLys: 4.359 ± 0.68
5.158LeuLeu: 5.158 ± 0.581
1.816LeuMet: 1.816 ± 0.331
2.179LeuAsn: 2.179 ± 0.319
5.085LeuPro: 5.085 ± 0.656
3.196LeuGln: 3.196 ± 0.513
5.376LeuArg: 5.376 ± 0.689
4.504LeuSer: 4.504 ± 0.574
5.811LeuThr: 5.811 ± 0.709
4.94LeuVal: 4.94 ± 0.685
0.872LeuTrp: 0.872 ± 0.265
1.453LeuTyr: 1.453 ± 0.257
0.0LeuXaa: 0.0 ± 0.0
Met
2.615MetAla: 2.615 ± 0.413
0.073MetCys: 0.073 ± 0.074
1.38MetAsp: 1.38 ± 0.301
0.799MetGlu: 0.799 ± 0.243
0.436MetPhe: 0.436 ± 0.232
1.598MetGly: 1.598 ± 0.275
0.073MetHis: 0.073 ± 0.078
0.654MetIle: 0.654 ± 0.224
0.363MetLys: 0.363 ± 0.145
1.816MetLeu: 1.816 ± 0.431
0.073MetMet: 0.073 ± 0.071
0.726MetAsn: 0.726 ± 0.218
1.453MetPro: 1.453 ± 0.429
0.872MetGln: 0.872 ± 0.249
1.235MetArg: 1.235 ± 0.31
2.325MetSer: 2.325 ± 0.472
2.76MetThr: 2.76 ± 0.426
0.872MetVal: 0.872 ± 0.239
0.291MetTrp: 0.291 ± 0.141
0.581MetTyr: 0.581 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
3.196AsnAla: 3.196 ± 0.492
0.291AsnCys: 0.291 ± 0.141
1.38AsnAsp: 1.38 ± 0.281
1.017AsnGlu: 1.017 ± 0.287
0.581AsnPhe: 0.581 ± 0.189
3.487AsnGly: 3.487 ± 0.536
0.726AsnHis: 0.726 ± 0.247
1.816AsnIle: 1.816 ± 0.345
0.944AsnLys: 0.944 ± 0.252
1.889AsnLeu: 1.889 ± 0.35
0.436AsnMet: 0.436 ± 0.214
0.799AsnAsn: 0.799 ± 0.312
2.833AsnPro: 2.833 ± 0.581
1.671AsnGln: 1.671 ± 0.353
1.308AsnArg: 1.308 ± 0.28
1.816AsnSer: 1.816 ± 0.486
2.179AsnThr: 2.179 ± 0.495
2.397AsnVal: 2.397 ± 0.33
0.436AsnTrp: 0.436 ± 0.2
0.872AsnTyr: 0.872 ± 0.202
0.0AsnXaa: 0.0 ± 0.0
Pro
6.828ProAla: 6.828 ± 0.974
0.581ProCys: 0.581 ± 0.215
3.196ProAsp: 3.196 ± 0.563
4.504ProGlu: 4.504 ± 0.667
1.816ProPhe: 1.816 ± 0.367
4.94ProGly: 4.94 ± 0.727
0.872ProHis: 0.872 ± 0.253
2.179ProIle: 2.179 ± 0.442
2.034ProLys: 2.034 ± 0.386
4.141ProLeu: 4.141 ± 0.747
1.09ProMet: 1.09 ± 0.274
1.889ProAsn: 1.889 ± 0.434
3.559ProPro: 3.559 ± 0.8
2.252ProGln: 2.252 ± 0.609
3.923ProArg: 3.923 ± 0.683
3.487ProSer: 3.487 ± 0.48
4.141ProThr: 4.141 ± 0.599
5.376ProVal: 5.376 ± 0.878
0.944ProTrp: 0.944 ± 0.3
1.671ProTyr: 1.671 ± 0.349
0.0ProXaa: 0.0 ± 0.0
Gln
4.94GlnAla: 4.94 ± 0.909
0.218GlnCys: 0.218 ± 0.117
2.325GlnAsp: 2.325 ± 0.408
1.961GlnGlu: 1.961 ± 0.297
1.453GlnPhe: 1.453 ± 0.32
3.051GlnGly: 3.051 ± 0.421
0.581GlnHis: 0.581 ± 0.213
1.525GlnIle: 1.525 ± 0.361
1.525GlnLys: 1.525 ± 0.354
3.487GlnLeu: 3.487 ± 0.584
1.017GlnMet: 1.017 ± 0.269
0.726GlnAsn: 0.726 ± 0.19
2.252GlnPro: 2.252 ± 0.668
3.196GlnGln: 3.196 ± 1.336
3.051GlnArg: 3.051 ± 0.573
2.47GlnSer: 2.47 ± 0.463
3.051GlnThr: 3.051 ± 0.528
2.542GlnVal: 2.542 ± 0.456
0.436GlnTrp: 0.436 ± 0.196
1.453GlnTyr: 1.453 ± 0.403
0.0GlnXaa: 0.0 ± 0.0
Arg
7.046ArgAla: 7.046 ± 0.673
0.799ArgCys: 0.799 ± 0.317
3.342ArgAsp: 3.342 ± 0.383
3.632ArgGlu: 3.632 ± 0.535
1.09ArgPhe: 1.09 ± 0.28
5.23ArgGly: 5.23 ± 0.628
1.38ArgHis: 1.38 ± 0.403
2.833ArgIle: 2.833 ± 0.401
3.487ArgLys: 3.487 ± 0.563
6.029ArgLeu: 6.029 ± 0.716
2.034ArgMet: 2.034 ± 0.297
2.034ArgAsn: 2.034 ± 0.354
3.487ArgPro: 3.487 ± 0.556
1.598ArgGln: 1.598 ± 0.324
4.576ArgArg: 4.576 ± 0.649
3.85ArgSer: 3.85 ± 0.47
4.068ArgThr: 4.068 ± 0.514
4.867ArgVal: 4.867 ± 0.688
2.252ArgTrp: 2.252 ± 0.455
1.235ArgTyr: 1.235 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
5.593SerAla: 5.593 ± 0.832
0.581SerCys: 0.581 ± 0.191
3.559SerAsp: 3.559 ± 0.482
3.414SerGlu: 3.414 ± 0.546
1.525SerPhe: 1.525 ± 0.33
5.666SerGly: 5.666 ± 0.7
0.944SerHis: 0.944 ± 0.261
2.906SerIle: 2.906 ± 0.633
3.414SerLys: 3.414 ± 0.586
3.559SerLeu: 3.559 ± 0.552
1.09SerMet: 1.09 ± 0.287
1.38SerAsn: 1.38 ± 0.302
2.542SerPro: 2.542 ± 0.396
2.47SerGln: 2.47 ± 0.426
3.777SerArg: 3.777 ± 0.599
1.961SerSer: 1.961 ± 0.453
3.995SerThr: 3.995 ± 0.409
4.286SerVal: 4.286 ± 0.597
1.162SerTrp: 1.162 ± 0.307
1.816SerTyr: 1.816 ± 0.294
0.0SerXaa: 0.0 ± 0.0
Thr
8.572ThrAla: 8.572 ± 0.827
0.436ThrCys: 0.436 ± 0.22
3.559ThrAsp: 3.559 ± 0.453
3.995ThrGlu: 3.995 ± 0.66
2.397ThrPhe: 2.397 ± 0.474
6.901ThrGly: 6.901 ± 0.797
1.453ThrHis: 1.453 ± 0.328
3.124ThrIle: 3.124 ± 0.55
2.179ThrLys: 2.179 ± 0.462
6.247ThrLeu: 6.247 ± 0.635
1.017ThrMet: 1.017 ± 0.229
2.325ThrAsn: 2.325 ± 0.499
4.94ThrPro: 4.94 ± 0.658
2.179ThrGln: 2.179 ± 0.391
4.359ThrArg: 4.359 ± 0.619
3.559ThrSer: 3.559 ± 0.67
5.957ThrThr: 5.957 ± 0.787
6.247ThrVal: 6.247 ± 0.735
1.09ThrTrp: 1.09 ± 0.246
2.397ThrTyr: 2.397 ± 0.396
0.0ThrXaa: 0.0 ± 0.0
Val
7.918ValAla: 7.918 ± 0.913
0.436ValCys: 0.436 ± 0.169
3.124ValAsp: 3.124 ± 0.409
4.649ValGlu: 4.649 ± 0.675
1.308ValPhe: 1.308 ± 0.296
4.722ValGly: 4.722 ± 0.688
1.235ValHis: 1.235 ± 0.305
3.196ValIle: 3.196 ± 0.552
3.777ValLys: 3.777 ± 0.494
5.158ValLeu: 5.158 ± 0.725
0.944ValMet: 0.944 ± 0.218
2.252ValAsn: 2.252 ± 0.42
3.995ValPro: 3.995 ± 0.631
2.252ValGln: 2.252 ± 0.53
4.867ValArg: 4.867 ± 0.609
4.286ValSer: 4.286 ± 0.596
5.811ValThr: 5.811 ± 0.666
4.431ValVal: 4.431 ± 0.626
1.308ValTrp: 1.308 ± 0.29
1.816ValTyr: 1.816 ± 0.405
0.0ValXaa: 0.0 ± 0.0
Trp
2.107TrpAla: 2.107 ± 0.439
0.508TrpCys: 0.508 ± 0.158
1.162TrpAsp: 1.162 ± 0.25
1.017TrpGlu: 1.017 ± 0.316
0.654TrpPhe: 0.654 ± 0.2
1.162TrpGly: 1.162 ± 0.266
0.363TrpHis: 0.363 ± 0.166
0.799TrpIle: 0.799 ± 0.217
0.726TrpLys: 0.726 ± 0.25
1.961TrpLeu: 1.961 ± 0.458
0.363TrpMet: 0.363 ± 0.131
0.799TrpAsn: 0.799 ± 0.2
0.581TrpPro: 0.581 ± 0.208
0.872TrpGln: 0.872 ± 0.193
1.017TrpArg: 1.017 ± 0.293
0.872TrpSer: 0.872 ± 0.248
1.09TrpThr: 1.09 ± 0.301
1.525TrpVal: 1.525 ± 0.399
0.654TrpTrp: 0.654 ± 0.231
0.145TrpTyr: 0.145 ± 0.1
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.615TyrAla: 2.615 ± 0.402
0.436TyrCys: 0.436 ± 0.187
1.38TyrAsp: 1.38 ± 0.297
1.743TyrGlu: 1.743 ± 0.263
0.508TyrPhe: 0.508 ± 0.215
1.743TyrGly: 1.743 ± 0.331
0.145TyrHis: 0.145 ± 0.096
0.944TyrIle: 0.944 ± 0.259
1.162TyrLys: 1.162 ± 0.245
2.47TyrLeu: 2.47 ± 0.488
0.436TyrMet: 0.436 ± 0.147
1.09TyrAsn: 1.09 ± 0.323
1.308TyrPro: 1.308 ± 0.349
1.743TyrGln: 1.743 ± 0.362
2.107TyrArg: 2.107 ± 0.364
0.944TyrSer: 0.944 ± 0.197
2.179TyrThr: 2.179 ± 0.376
1.671TyrVal: 1.671 ± 0.293
0.363TyrTrp: 0.363 ± 0.156
0.508TyrTyr: 0.508 ± 0.169
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (13767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski