Amino acid dipepetide frequency for Vagococcus carniphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.875AlaAla: 3.875 ± 0.092	0.487AlaCys: 0.487 ± 0.023	3.105AlaAsp: 3.105 ± 0.058	3.935AlaGlu: 3.935 ± 0.083	2.767AlaPhe: 2.767 ± 0.061	4.08AlaGly: 4.08 ± 0.089	0.99AlaHis: 0.99 ± 0.033	5.446AlaIle: 5.446 ± 0.092	4.899AlaLys: 4.899 ± 0.088	5.824AlaLeu: 5.824 ± 0.087	1.768AlaMet: 1.768 ± 0.049	2.826AlaAsn: 2.826 ± 0.059	1.779AlaPro: 1.779 ± 0.053	1.92AlaGln: 1.92 ± 0.06	1.948AlaArg: 1.948 ± 0.055	3.863AlaSer: 3.863 ± 0.077	3.723AlaThr: 3.723 ± 0.076	4.22AlaVal: 4.22 ± 0.077	0.445AlaTrp: 0.445 ± 0.022	2.095AlaTyr: 2.095 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.317CysAla: 0.317 ± 0.018	0.081CysCys: 0.081 ± 0.01	0.337CysAsp: 0.337 ± 0.022	0.373CysGlu: 0.373 ± 0.022	0.305CysPhe: 0.305 ± 0.02	0.535CysGly: 0.535 ± 0.025	0.214CysHis: 0.214 ± 0.016	0.429CysIle: 0.429 ± 0.023	0.226CysLys: 0.226 ± 0.015	0.771CysLeu: 0.771 ± 0.03	0.134CysMet: 0.134 ± 0.011	0.202CysAsn: 0.202 ± 0.015	0.259CysPro: 0.259 ± 0.019	0.282CysGln: 0.282 ± 0.019	0.209CysArg: 0.209 ± 0.015	0.442CysSer: 0.442 ± 0.021	0.29CysThr: 0.29 ± 0.017	0.405CysVal: 0.405 ± 0.018	0.041CysTrp: 0.041 ± 0.007	0.265CysTyr: 0.265 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.002AspAla: 3.002 ± 0.076	0.32AspCys: 0.32 ± 0.018	2.77AspAsp: 2.77 ± 0.068	4.609AspGlu: 4.609 ± 0.09	2.867AspPhe: 2.867 ± 0.058	3.44AspGly: 3.44 ± 0.094	0.824AspHis: 0.824 ± 0.029	4.501AspIle: 4.501 ± 0.075	4.307AspLys: 4.307 ± 0.079	5.279AspLeu: 5.279 ± 0.082	1.453AspMet: 1.453 ± 0.045	2.655AspAsn: 2.655 ± 0.055	1.518AspPro: 1.518 ± 0.041	1.671AspGln: 1.671 ± 0.042	1.652AspArg: 1.652 ± 0.047	3.299AspSer: 3.299 ± 0.069	2.734AspThr: 2.734 ± 0.062	4.0AspVal: 4.0 ± 0.07	0.559AspTrp: 0.559 ± 0.028	2.61AspTyr: 2.61 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.259GluAla: 5.259 ± 0.093	0.36GluCys: 0.36 ± 0.022	3.938GluAsp: 3.938 ± 0.075	7.578GluGlu: 7.578 ± 0.116	2.804GluPhe: 2.804 ± 0.056	4.035GluGly: 4.035 ± 0.072	1.188GluHis: 1.188 ± 0.039	6.193GluIle: 6.193 ± 0.094	8.11GluLys: 8.11 ± 0.117	7.694GluLeu: 7.694 ± 0.117	2.467GluMet: 2.467 ± 0.062	4.343GluAsn: 4.343 ± 0.071	1.834GluPro: 1.834 ± 0.049	2.748GluGln: 2.748 ± 0.065	2.755GluArg: 2.755 ± 0.07	4.141GluSer: 4.141 ± 0.072	4.825GluThr: 4.825 ± 0.087	5.513GluVal: 5.513 ± 0.083	0.683GluTrp: 0.683 ± 0.025	2.262GluTyr: 2.262 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.38PheAla: 2.38 ± 0.054	0.349PheCys: 0.349 ± 0.02	2.786PheAsp: 2.786 ± 0.059	3.252PheGlu: 3.252 ± 0.064	2.626PhePhe: 2.626 ± 0.062	2.961PheGly: 2.961 ± 0.067	0.724PheHis: 0.724 ± 0.025	3.965PheIle: 3.965 ± 0.085	3.199PheLys: 3.199 ± 0.054	4.721PheLeu: 4.721 ± 0.09	1.145PheMet: 1.145 ± 0.039	2.618PheAsn: 2.618 ± 0.057	1.409PhePro: 1.409 ± 0.04	1.371PheGln: 1.371 ± 0.039	1.302PheArg: 1.302 ± 0.04	4.022PheSer: 4.022 ± 0.072	2.432PheThr: 2.432 ± 0.054	3.099PheVal: 3.099 ± 0.064	0.387PheTrp: 0.387 ± 0.022	1.972PheTyr: 1.972 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.117GlyAla: 4.117 ± 0.094	0.457GlyCys: 0.457 ± 0.021	3.01GlyAsp: 3.01 ± 0.063	4.12GlyGlu: 4.12 ± 0.075	3.191GlyPhe: 3.191 ± 0.064	4.074GlyGly: 4.074 ± 0.102	1.082GlyHis: 1.082 ± 0.033	5.717GlyIle: 5.717 ± 0.087	5.066GlyLys: 5.066 ± 0.082	6.028GlyLeu: 6.028 ± 0.09	1.913GlyMet: 1.913 ± 0.047	2.973GlyAsn: 2.973 ± 0.064	1.362GlyPro: 1.362 ± 0.044	2.042GlyGln: 2.042 ± 0.047	2.116GlyArg: 2.116 ± 0.059	3.972GlySer: 3.972 ± 0.106	3.899GlyThr: 3.899 ± 0.075	4.522GlyVal: 4.522 ± 0.079	0.554GlyTrp: 0.554 ± 0.021	2.626GlyTyr: 2.626 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	0.89HisAla: 0.89 ± 0.028	0.109HisCys: 0.109 ± 0.011	0.848HisAsp: 0.848 ± 0.032	1.106HisGlu: 1.106 ± 0.035	1.004HisPhe: 1.004 ± 0.035	1.124HisGly: 1.124 ± 0.032	0.459HisHis: 0.459 ± 0.025	1.202HisIle: 1.202 ± 0.036	0.834HisLys: 0.834 ± 0.032	1.94HisLeu: 1.94 ± 0.049	0.411HisMet: 0.411 ± 0.02	0.605HisAsn: 0.605 ± 0.023	0.84HisPro: 0.84 ± 0.027	0.813HisGln: 0.813 ± 0.031	0.678HisArg: 0.678 ± 0.026	1.039HisSer: 1.039 ± 0.038	0.847HisThr: 0.847 ± 0.034	1.135HisVal: 1.135 ± 0.034	0.144HisTrp: 0.144 ± 0.013	0.863HisTyr: 0.863 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.218IleAla: 5.218 ± 0.084	0.626IleCys: 0.626 ± 0.024	4.799IleAsp: 4.799 ± 0.089	6.338IleGlu: 6.338 ± 0.09	3.84IlePhe: 3.84 ± 0.081	5.713IleGly: 5.713 ± 0.098	1.337IleHis: 1.337 ± 0.033	6.45IleIle: 6.45 ± 0.116	5.941IleLys: 5.941 ± 0.078	7.647IleLeu: 7.647 ± 0.131	1.876IleMet: 1.876 ± 0.058	4.276IleAsn: 4.276 ± 0.082	3.131IlePro: 3.131 ± 0.063	2.783IleGln: 2.783 ± 0.062	2.569IleArg: 2.569 ± 0.066	5.815IleSer: 5.815 ± 0.091	4.277IleThr: 4.277 ± 0.075	5.488IleVal: 5.488 ± 0.07	0.565IleTrp: 0.565 ± 0.028	2.663IleTyr: 2.663 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.543LysAla: 4.543 ± 0.094	0.292LysCys: 0.292 ± 0.019	4.743LysAsp: 4.743 ± 0.09	9.567LysGlu: 9.567 ± 0.139	2.217LysPhe: 2.217 ± 0.05	4.351LysGly: 4.351 ± 0.083	1.143LysHis: 1.143 ± 0.034	5.999LysIle: 5.999 ± 0.082	8.503LysLys: 8.503 ± 0.117	6.168LysLeu: 6.168 ± 0.09	2.633LysMet: 2.633 ± 0.055	4.902LysAsn: 4.902 ± 0.078	2.233LysPro: 2.233 ± 0.049	3.45LysGln: 3.45 ± 0.068	3.122LysArg: 3.122 ± 0.067	4.227LysSer: 4.227 ± 0.07	4.416LysThr: 4.416 ± 0.074	4.967LysVal: 4.967 ± 0.09	0.724LysTrp: 0.724 ± 0.028	2.537LysTyr: 2.537 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.5LeuAla: 6.5 ± 0.086	0.579LeuCys: 0.579 ± 0.026	5.201LeuAsp: 5.201 ± 0.085	7.172LeuGlu: 7.172 ± 0.116	4.902LeuPhe: 4.902 ± 0.1	6.085LeuGly: 6.085 ± 0.106	1.316LeuHis: 1.316 ± 0.039	7.93LeuIle: 7.93 ± 0.13	7.448LeuLys: 7.448 ± 0.093	9.83LeuLeu: 9.83 ± 0.16	2.614LeuMet: 2.614 ± 0.052	5.179LeuAsn: 5.179 ± 0.068	3.66LeuPro: 3.66 ± 0.061	2.553LeuGln: 2.553 ± 0.053	2.942LeuArg: 2.942 ± 0.057	7.317LeuSer: 7.317 ± 0.09	6.105LeuThr: 6.105 ± 0.085	6.606LeuVal: 6.606 ± 0.083	0.636LeuTrp: 0.636 ± 0.028	3.006LeuTyr: 3.006 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.799MetAla: 1.799 ± 0.046	0.133MetCys: 0.133 ± 0.012	1.444MetAsp: 1.444 ± 0.039	1.707MetGlu: 1.707 ± 0.047	1.044MetPhe: 1.044 ± 0.038	1.69MetGly: 1.69 ± 0.056	0.323MetHis: 0.323 ± 0.02	2.359MetIle: 2.359 ± 0.051	2.551MetLys: 2.551 ± 0.048	2.454MetLeu: 2.454 ± 0.056	0.952MetMet: 0.952 ± 0.041	1.608MetAsn: 1.608 ± 0.045	0.903MetPro: 0.903 ± 0.029	0.698MetGln: 0.698 ± 0.024	0.915MetArg: 0.915 ± 0.031	1.948MetSer: 1.948 ± 0.047	2.079MetThr: 2.079 ± 0.05	1.701MetVal: 1.701 ± 0.045	0.167MetTrp: 0.167 ± 0.013	0.743MetTyr: 0.743 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.587AsnAla: 2.587 ± 0.054	0.306AsnCys: 0.306 ± 0.016	2.71AsnAsp: 2.71 ± 0.065	4.118AsnGlu: 4.118 ± 0.064	2.231AsnPhe: 2.231 ± 0.051	3.325AsnGly: 3.325 ± 0.075	1.139AsnHis: 1.139 ± 0.04	3.862AsnIle: 3.862 ± 0.064	4.092AsnLys: 4.092 ± 0.085	4.74AsnLeu: 4.74 ± 0.071	1.33AsnMet: 1.33 ± 0.036	2.782AsnAsn: 2.782 ± 0.07	2.02AsnPro: 2.02 ± 0.05	3.048AsnGln: 3.048 ± 0.066	1.942AsnArg: 1.942 ± 0.046	2.81AsnSer: 2.81 ± 0.061	2.398AsnThr: 2.398 ± 0.057	3.178AsnVal: 3.178 ± 0.059	0.569AsnTrp: 0.569 ± 0.035	2.266AsnTyr: 2.266 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.697ProAla: 1.697 ± 0.042	0.158ProCys: 0.158 ± 0.014	1.77ProAsp: 1.77 ± 0.044	2.708ProGlu: 2.708 ± 0.064	1.748ProPhe: 1.748 ± 0.046	1.823ProGly: 1.823 ± 0.045	0.556ProHis: 0.556 ± 0.028	2.732ProIle: 2.732 ± 0.061	2.503ProLys: 2.503 ± 0.048	3.053ProLeu: 3.053 ± 0.062	0.75ProMet: 0.75 ± 0.028	1.795ProAsn: 1.795 ± 0.048	0.569ProPro: 0.569 ± 0.027	0.942ProGln: 0.942 ± 0.035	0.816ProArg: 0.816 ± 0.03	2.002ProSer: 2.002 ± 0.053	2.114ProThr: 2.114 ± 0.05	2.479ProVal: 2.479 ± 0.052	0.265ProTrp: 0.265 ± 0.018	1.182ProTyr: 1.182 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.395GlnAla: 2.395 ± 0.068	0.143GlnCys: 0.143 ± 0.013	1.554GlnAsp: 1.554 ± 0.046	2.967GlnGlu: 2.967 ± 0.067	1.528GlnPhe: 1.528 ± 0.041	1.951GlnGly: 1.951 ± 0.052	0.613GlnHis: 0.613 ± 0.026	2.752GlnIle: 2.752 ± 0.057	3.021GlnLys: 3.021 ± 0.069	4.052GlnLeu: 4.052 ± 0.09	1.09GlnMet: 1.09 ± 0.041	1.708GlnAsn: 1.708 ± 0.04	1.102GlnPro: 1.102 ± 0.031	1.621GlnGln: 1.621 ± 0.05	1.118GlnArg: 1.118 ± 0.036	2.049GlnSer: 2.049 ± 0.052	2.174GlnThr: 2.174 ± 0.049	2.664GlnVal: 2.664 ± 0.06	0.28GlnTrp: 0.28 ± 0.019	1.146GlnTyr: 1.146 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.709ArgAla: 1.709 ± 0.043	0.176ArgCys: 0.176 ± 0.015	1.718ArgAsp: 1.718 ± 0.046	2.66ArgGlu: 2.66 ± 0.057	1.589ArgPhe: 1.589 ± 0.042	1.95ArgGly: 1.95 ± 0.05	0.622ArgHis: 0.622 ± 0.028	2.615ArgIle: 2.615 ± 0.06	2.817ArgLys: 2.817 ± 0.061	3.305ArgLeu: 3.305 ± 0.073	0.979ArgMet: 0.979 ± 0.035	1.708ArgAsn: 1.708 ± 0.044	1.05ArgPro: 1.05 ± 0.033	1.368ArgGln: 1.368 ± 0.046	1.418ArgArg: 1.418 ± 0.041	1.638ArgSer: 1.638 ± 0.044	1.6ArgThr: 1.6 ± 0.045	2.325ArgVal: 2.325 ± 0.054	0.268ArgTrp: 0.268 ± 0.018	1.39ArgTyr: 1.39 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.34SerAla: 3.34 ± 0.061	0.366SerCys: 0.366 ± 0.02	3.535SerAsp: 3.535 ± 0.081	4.618SerGlu: 4.618 ± 0.079	3.63SerPhe: 3.63 ± 0.072	4.392SerGly: 4.392 ± 0.077	1.271SerHis: 1.271 ± 0.046	5.438SerIle: 5.438 ± 0.076	4.952SerLys: 4.952 ± 0.083	6.879SerLeu: 6.879 ± 0.094	1.588SerMet: 1.588 ± 0.05	3.193SerAsn: 3.193 ± 0.071	1.818SerPro: 1.818 ± 0.051	2.393SerGln: 2.393 ± 0.057	2.001SerArg: 2.001 ± 0.046	4.411SerSer: 4.411 ± 0.089	3.514SerThr: 3.514 ± 0.075	4.308SerVal: 4.308 ± 0.063	0.56SerTrp: 0.56 ± 0.027	2.646SerTyr: 2.646 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.336ThrAla: 3.336 ± 0.066	0.368ThrCys: 0.368 ± 0.023	3.151ThrAsp: 3.151 ± 0.065	3.792ThrGlu: 3.792 ± 0.069	2.922ThrPhe: 2.922 ± 0.056	3.947ThrGly: 3.947 ± 0.083	1.084ThrHis: 1.084 ± 0.036	5.069ThrIle: 5.069 ± 0.077	4.429ThrLys: 4.429 ± 0.091	5.67ThrLeu: 5.67 ± 0.103	1.331ThrMet: 1.331 ± 0.038	2.859ThrAsn: 2.859 ± 0.063	2.253ThrPro: 2.253 ± 0.054	1.868ThrGln: 1.868 ± 0.046	1.593ThrArg: 1.593 ± 0.051	3.849ThrSer: 3.849 ± 0.078	3.522ThrThr: 3.522 ± 0.071	3.897ThrVal: 3.897 ± 0.082	0.466ThrTrp: 0.466 ± 0.023	2.254ThrTyr: 2.254 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.68ValAla: 4.68 ± 0.085	0.499ValCys: 0.499 ± 0.021	3.986ValAsp: 3.986 ± 0.07	4.945ValGlu: 4.945 ± 0.093	2.956ValPhe: 2.956 ± 0.06	4.48ValGly: 4.48 ± 0.075	0.973ValHis: 0.973 ± 0.033	5.653ValIle: 5.653 ± 0.088	5.037ValLys: 5.037 ± 0.083	6.505ValLeu: 6.505 ± 0.088	1.799ValMet: 1.799 ± 0.049	3.227ValAsn: 3.227 ± 0.058	2.406ValPro: 2.406 ± 0.052	1.811ValGln: 1.811 ± 0.046	2.058ValArg: 2.058 ± 0.049	5.089ValSer: 5.089 ± 0.082	4.476ValThr: 4.476 ± 0.072	5.098ValVal: 5.098 ± 0.092	0.494ValTrp: 0.494 ± 0.025	2.199ValTyr: 2.199 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.373TrpAla: 0.373 ± 0.023	0.055TrpCys: 0.055 ± 0.009	0.428TrpAsp: 0.428 ± 0.019	0.561TrpGlu: 0.561 ± 0.024	0.425TrpPhe: 0.425 ± 0.024	0.502TrpGly: 0.502 ± 0.026	0.2TrpHis: 0.2 ± 0.015	0.62TrpIle: 0.62 ± 0.024	0.613TrpLys: 0.613 ± 0.029	1.011TrpLeu: 1.011 ± 0.037	0.213TrpMet: 0.213 ± 0.014	0.432TrpAsn: 0.432 ± 0.023	0.171TrpPro: 0.171 ± 0.014	0.475TrpGln: 0.475 ± 0.03	0.287TrpArg: 0.287 ± 0.019	0.535TrpSer: 0.535 ± 0.024	0.39TrpThr: 0.39 ± 0.021	0.502TrpVal: 0.502 ± 0.028	0.081TrpTrp: 0.081 ± 0.01	0.328TrpTyr: 0.328 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.975TyrAla: 1.975 ± 0.055	0.256TyrCys: 0.256 ± 0.018	2.236TyrAsp: 2.236 ± 0.062	2.607TyrGlu: 2.607 ± 0.07	2.123TyrPhe: 2.123 ± 0.052	2.385TyrGly: 2.385 ± 0.057	0.832TyrHis: 0.832 ± 0.035	2.42TyrIle: 2.42 ± 0.058	2.189TyrLys: 2.189 ± 0.057	4.01TyrLeu: 4.01 ± 0.074	0.77TyrMet: 0.77 ± 0.029	1.56TyrAsn: 1.56 ± 0.051	1.344TyrPro: 1.344 ± 0.034	2.067TyrGln: 2.067 ± 0.065	1.466TyrArg: 1.466 ± 0.045	2.388TyrSer: 2.388 ± 0.055	1.844TyrThr: 1.844 ± 0.05	2.265TyrVal: 2.265 ± 0.047	0.315TyrTrp: 0.315 ± 0.017	1.66TyrTyr: 1.66 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2902 proteins (910394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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