Amino acid dipepetide frequency for Streptococcus phage 2167

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.34AlaAla: 2.34 ± 0.854
0.374AlaCys: 0.374 ± 0.198
6.458AlaAsp: 6.458 ± 0.708
6.552AlaGlu: 6.552 ± 0.846
2.995AlaPhe: 2.995 ± 0.791
4.961AlaGly: 4.961 ± 1.0
0.374AlaHis: 0.374 ± 0.2
4.68AlaIle: 4.68 ± 0.959
5.429AlaLys: 5.429 ± 0.804
5.803AlaLeu: 5.803 ± 0.879
2.246AlaMet: 2.246 ± 0.486
3.37AlaAsn: 3.37 ± 0.577
1.778AlaPro: 1.778 ± 0.364
2.714AlaGln: 2.714 ± 0.466
3.182AlaArg: 3.182 ± 0.534
1.778AlaSer: 1.778 ± 0.452
4.306AlaThr: 4.306 ± 0.771
5.429AlaVal: 5.429 ± 0.965
1.685AlaTrp: 1.685 ± 0.472
1.966AlaTyr: 1.966 ± 0.386
0.0AlaXaa: 0.0 ± 0.0
Cys
0.374CysAla: 0.374 ± 0.164
0.187CysCys: 0.187 ± 0.132
0.562CysAsp: 0.562 ± 0.231
0.562CysGlu: 0.562 ± 0.23
0.281CysPhe: 0.281 ± 0.174
0.468CysGly: 0.468 ± 0.29
0.187CysHis: 0.187 ± 0.134
0.468CysIle: 0.468 ± 0.246
0.749CysLys: 0.749 ± 0.262
0.468CysLeu: 0.468 ± 0.216
0.187CysMet: 0.187 ± 0.156
0.187CysAsn: 0.187 ± 0.164
0.187CysPro: 0.187 ± 0.135
0.281CysGln: 0.281 ± 0.162
0.468CysArg: 0.468 ± 0.162
0.281CysSer: 0.281 ± 0.151
0.281CysThr: 0.281 ± 0.19
0.094CysVal: 0.094 ± 0.083
0.094CysTrp: 0.094 ± 0.082
0.374CysTyr: 0.374 ± 0.193
0.0CysXaa: 0.0 ± 0.0
Asp
3.37AspAla: 3.37 ± 0.705
0.655AspCys: 0.655 ± 0.25
3.276AspAsp: 3.276 ± 0.685
5.148AspGlu: 5.148 ± 1.042
2.902AspPhe: 2.902 ± 0.6
4.493AspGly: 4.493 ± 0.489
0.281AspHis: 0.281 ± 0.132
4.773AspIle: 4.773 ± 0.621
5.148AspLys: 5.148 ± 0.947
5.335AspLeu: 5.335 ± 0.652
2.153AspMet: 2.153 ± 0.423
3.37AspAsn: 3.37 ± 0.503
1.966AspPro: 1.966 ± 0.454
1.778AspGln: 1.778 ± 0.37
2.995AspArg: 2.995 ± 0.592
3.65AspSer: 3.65 ± 0.513
3.182AspThr: 3.182 ± 0.482
3.557AspVal: 3.557 ± 0.538
1.498AspTrp: 1.498 ± 0.374
3.182AspTyr: 3.182 ± 0.649
0.0AspXaa: 0.0 ± 0.0
Glu
6.552GluAla: 6.552 ± 0.827
0.562GluCys: 0.562 ± 0.216
4.212GluAsp: 4.212 ± 0.909
7.113GluGlu: 7.113 ± 1.375
4.212GluPhe: 4.212 ± 0.743
2.995GluGly: 2.995 ± 0.629
1.31GluHis: 1.31 ± 0.352
6.552GluIle: 6.552 ± 0.673
6.645GluLys: 6.645 ± 1.038
9.641GluLeu: 9.641 ± 1.3
1.966GluMet: 1.966 ± 0.51
4.306GluAsn: 4.306 ± 0.669
1.778GluPro: 1.778 ± 0.396
4.212GluGln: 4.212 ± 0.709
5.148GluArg: 5.148 ± 0.686
5.054GluSer: 5.054 ± 0.679
3.37GluThr: 3.37 ± 0.497
5.897GluVal: 5.897 ± 0.768
1.123GluTrp: 1.123 ± 0.308
2.995GluTyr: 2.995 ± 0.535
0.0GluXaa: 0.0 ± 0.0
Phe
2.434PheAla: 2.434 ± 0.603
0.187PheCys: 0.187 ± 0.159
4.118PheAsp: 4.118 ± 0.531
4.399PheGlu: 4.399 ± 0.777
1.591PhePhe: 1.591 ± 0.427
2.059PheGly: 2.059 ± 0.664
0.187PheHis: 0.187 ± 0.121
2.995PheIle: 2.995 ± 0.482
3.089PheLys: 3.089 ± 0.462
2.527PheLeu: 2.527 ± 0.42
0.936PheMet: 0.936 ± 0.299
2.714PheAsn: 2.714 ± 0.559
0.562PhePro: 0.562 ± 0.246
1.966PheGln: 1.966 ± 0.372
1.123PheArg: 1.123 ± 0.263
3.838PheSer: 3.838 ± 0.824
2.808PheThr: 2.808 ± 0.374
1.591PheVal: 1.591 ± 0.347
0.655PheTrp: 0.655 ± 0.275
1.872PheTyr: 1.872 ± 0.415
0.0PheXaa: 0.0 ± 0.0
Gly
3.463GlyAla: 3.463 ± 0.542
0.094GlyCys: 0.094 ± 0.105
3.557GlyAsp: 3.557 ± 0.551
5.335GlyGlu: 5.335 ± 0.817
2.808GlyPhe: 2.808 ± 0.676
5.241GlyGly: 5.241 ± 1.365
0.749GlyHis: 0.749 ± 0.226
3.557GlyIle: 3.557 ± 0.653
5.522GlyLys: 5.522 ± 0.602
5.616GlyLeu: 5.616 ± 1.238
1.966GlyMet: 1.966 ± 0.369
3.37GlyAsn: 3.37 ± 0.492
1.03GlyPro: 1.03 ± 0.331
4.025GlyGln: 4.025 ± 0.504
3.557GlyArg: 3.557 ± 0.616
4.118GlySer: 4.118 ± 0.832
2.714GlyThr: 2.714 ± 0.518
4.773GlyVal: 4.773 ± 0.733
0.749GlyTrp: 0.749 ± 0.193
2.995GlyTyr: 2.995 ± 0.564
0.0GlyXaa: 0.0 ± 0.0
His
1.03HisAla: 1.03 ± 0.327
0.094HisCys: 0.094 ± 0.098
0.749HisAsp: 0.749 ± 0.237
1.217HisGlu: 1.217 ± 0.338
0.936HisPhe: 0.936 ± 0.256
0.749HisGly: 0.749 ± 0.225
0.281HisHis: 0.281 ± 0.212
0.562HisIle: 0.562 ± 0.281
0.468HisLys: 0.468 ± 0.208
1.03HisLeu: 1.03 ± 0.285
0.187HisMet: 0.187 ± 0.141
1.03HisAsn: 1.03 ± 0.315
0.655HisPro: 0.655 ± 0.179
0.655HisGln: 0.655 ± 0.249
0.749HisArg: 0.749 ± 0.265
0.842HisSer: 0.842 ± 0.267
0.655HisThr: 0.655 ± 0.253
0.749HisVal: 0.749 ± 0.168
0.281HisTrp: 0.281 ± 0.158
0.655HisTyr: 0.655 ± 0.295
0.0HisXaa: 0.0 ± 0.0
Ile
4.961IleAla: 4.961 ± 0.812
0.468IleCys: 0.468 ± 0.157
3.182IleAsp: 3.182 ± 0.537
5.616IleGlu: 5.616 ± 0.68
2.808IlePhe: 2.808 ± 0.638
4.961IleGly: 4.961 ± 0.853
0.842IleHis: 0.842 ± 0.312
3.557IleIle: 3.557 ± 0.545
6.084IleLys: 6.084 ± 0.743
4.212IleLeu: 4.212 ± 0.546
1.498IleMet: 1.498 ± 0.412
4.399IleAsn: 4.399 ± 0.533
1.404IlePro: 1.404 ± 0.364
2.808IleGln: 2.808 ± 0.419
2.902IleArg: 2.902 ± 0.502
5.616IleSer: 5.616 ± 0.685
4.493IleThr: 4.493 ± 0.609
2.902IleVal: 2.902 ± 0.461
0.281IleTrp: 0.281 ± 0.163
1.966IleTyr: 1.966 ± 0.533
0.0IleXaa: 0.0 ± 0.0
Lys
5.522LysAla: 5.522 ± 0.833
0.749LysCys: 0.749 ± 0.343
5.803LysAsp: 5.803 ± 0.51
7.956LysGlu: 7.956 ± 0.822
2.714LysPhe: 2.714 ± 0.468
4.586LysGly: 4.586 ± 0.554
0.936LysHis: 0.936 ± 0.256
5.616LysIle: 5.616 ± 0.896
5.897LysLys: 5.897 ± 0.525
7.581LysLeu: 7.581 ± 0.76
2.621LysMet: 2.621 ± 0.549
4.118LysAsn: 4.118 ± 0.504
2.527LysPro: 2.527 ± 0.573
2.995LysGln: 2.995 ± 0.652
3.276LysArg: 3.276 ± 0.413
3.744LysSer: 3.744 ± 0.415
4.118LysThr: 4.118 ± 0.558
6.833LysVal: 6.833 ± 0.677
0.842LysTrp: 0.842 ± 0.319
2.902LysTyr: 2.902 ± 0.469
0.0LysXaa: 0.0 ± 0.0
Leu
5.897LeuAla: 5.897 ± 1.116
0.749LeuCys: 0.749 ± 0.294
6.458LeuAsp: 6.458 ± 0.825
8.143LeuGlu: 8.143 ± 1.08
2.808LeuPhe: 2.808 ± 0.468
6.833LeuGly: 6.833 ± 1.438
1.31LeuHis: 1.31 ± 0.353
4.399LeuIle: 4.399 ± 0.548
6.833LeuLys: 6.833 ± 0.758
7.488LeuLeu: 7.488 ± 1.035
2.34LeuMet: 2.34 ± 0.464
4.212LeuAsn: 4.212 ± 0.591
2.246LeuPro: 2.246 ± 0.517
2.902LeuGln: 2.902 ± 0.522
4.306LeuArg: 4.306 ± 0.732
4.399LeuSer: 4.399 ± 0.702
3.931LeuThr: 3.931 ± 0.588
3.838LeuVal: 3.838 ± 0.485
0.655LeuTrp: 0.655 ± 0.252
2.246LeuTyr: 2.246 ± 0.332
0.0LeuXaa: 0.0 ± 0.0
Met
2.34MetAla: 2.34 ± 0.509
0.094MetCys: 0.094 ± 0.095
1.591MetAsp: 1.591 ± 0.288
2.246MetGlu: 2.246 ± 0.504
1.123MetPhe: 1.123 ± 0.264
1.685MetGly: 1.685 ± 0.455
0.374MetHis: 0.374 ± 0.233
1.966MetIle: 1.966 ± 0.397
2.714MetLys: 2.714 ± 0.531
1.591MetLeu: 1.591 ± 0.399
0.374MetMet: 0.374 ± 0.189
1.591MetAsn: 1.591 ± 0.433
0.936MetPro: 0.936 ± 0.344
0.936MetGln: 0.936 ± 0.311
1.03MetArg: 1.03 ± 0.273
1.217MetSer: 1.217 ± 0.313
1.778MetThr: 1.778 ± 0.409
0.936MetVal: 0.936 ± 0.237
0.187MetTrp: 0.187 ± 0.138
0.749MetTyr: 0.749 ± 0.211
0.0MetXaa: 0.0 ± 0.0
Asn
4.68AsnAla: 4.68 ± 1.022
0.374AsnCys: 0.374 ± 0.177
2.714AsnAsp: 2.714 ± 0.417
3.463AsnGlu: 3.463 ± 0.715
1.591AsnPhe: 1.591 ± 0.453
3.65AsnGly: 3.65 ± 0.517
0.936AsnHis: 0.936 ± 0.278
3.276AsnIle: 3.276 ± 0.565
4.212AsnLys: 4.212 ± 0.544
3.838AsnLeu: 3.838 ± 0.642
1.123AsnMet: 1.123 ± 0.388
1.685AsnAsn: 1.685 ± 0.438
2.153AsnPro: 2.153 ± 0.458
2.808AsnGln: 2.808 ± 0.569
2.527AsnArg: 2.527 ± 0.629
3.37AsnSer: 3.37 ± 0.711
3.276AsnThr: 3.276 ± 0.711
3.744AsnVal: 3.744 ± 0.52
0.749AsnTrp: 0.749 ± 0.191
1.685AsnTyr: 1.685 ± 0.326
0.0AsnXaa: 0.0 ± 0.0
Pro
2.059ProAla: 2.059 ± 0.463
0.094ProCys: 0.094 ± 0.083
2.153ProAsp: 2.153 ± 0.485
3.182ProGlu: 3.182 ± 0.445
1.404ProPhe: 1.404 ± 0.445
1.03ProGly: 1.03 ± 0.256
0.562ProHis: 0.562 ± 0.201
1.966ProIle: 1.966 ± 0.53
2.621ProLys: 2.621 ± 0.389
1.31ProLeu: 1.31 ± 0.332
0.468ProMet: 0.468 ± 0.208
1.404ProAsn: 1.404 ± 0.455
0.749ProPro: 0.749 ± 0.263
1.03ProGln: 1.03 ± 0.391
1.591ProArg: 1.591 ± 0.351
0.842ProSer: 0.842 ± 0.341
0.842ProThr: 0.842 ± 0.28
1.778ProVal: 1.778 ± 0.365
0.468ProTrp: 0.468 ± 0.212
1.404ProTyr: 1.404 ± 0.423
0.0ProXaa: 0.0 ± 0.0
Gln
3.089GlnAla: 3.089 ± 0.483
0.281GlnCys: 0.281 ± 0.137
1.966GlnAsp: 1.966 ± 0.359
4.118GlnGlu: 4.118 ± 0.783
1.123GlnPhe: 1.123 ± 0.34
2.434GlnGly: 2.434 ± 0.501
0.187GlnHis: 0.187 ± 0.128
3.744GlnIle: 3.744 ± 0.571
3.744GlnLys: 3.744 ± 0.582
3.276GlnLeu: 3.276 ± 0.471
0.842GlnMet: 0.842 ± 0.261
1.872GlnAsn: 1.872 ± 0.443
1.123GlnPro: 1.123 ± 0.292
2.153GlnGln: 2.153 ± 0.486
2.527GlnArg: 2.527 ± 0.51
2.621GlnSer: 2.621 ± 0.439
2.059GlnThr: 2.059 ± 0.468
4.212GlnVal: 4.212 ± 0.718
0.468GlnTrp: 0.468 ± 0.163
1.123GlnTyr: 1.123 ± 0.378
0.0GlnXaa: 0.0 ± 0.0
Arg
3.182ArgAla: 3.182 ± 0.471
0.187ArgCys: 0.187 ± 0.11
2.246ArgAsp: 2.246 ± 0.483
3.557ArgGlu: 3.557 ± 0.693
2.153ArgPhe: 2.153 ± 0.541
2.527ArgGly: 2.527 ± 0.526
0.655ArgHis: 0.655 ± 0.248
3.276ArgIle: 3.276 ± 0.437
3.931ArgLys: 3.931 ± 0.705
5.522ArgLeu: 5.522 ± 0.751
1.872ArgMet: 1.872 ± 0.332
2.434ArgAsn: 2.434 ± 0.576
0.936ArgPro: 0.936 ± 0.267
2.902ArgGln: 2.902 ± 0.549
2.714ArgArg: 2.714 ± 0.629
2.246ArgSer: 2.246 ± 0.483
2.902ArgThr: 2.902 ± 0.518
2.995ArgVal: 2.995 ± 0.545
0.281ArgTrp: 0.281 ± 0.164
1.778ArgTyr: 1.778 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
5.148SerAla: 5.148 ± 1.063
0.374SerCys: 0.374 ± 0.276
3.65SerAsp: 3.65 ± 0.632
3.838SerGlu: 3.838 ± 0.584
1.872SerPhe: 1.872 ± 0.403
5.148SerGly: 5.148 ± 0.75
1.123SerHis: 1.123 ± 0.386
3.838SerIle: 3.838 ± 0.669
4.493SerLys: 4.493 ± 0.55
4.118SerLeu: 4.118 ± 0.599
1.404SerMet: 1.404 ± 0.377
2.621SerAsn: 2.621 ± 0.642
1.498SerPro: 1.498 ± 0.347
2.714SerGln: 2.714 ± 0.435
3.276SerArg: 3.276 ± 0.611
3.557SerSer: 3.557 ± 0.882
4.025SerThr: 4.025 ± 0.643
3.089SerVal: 3.089 ± 0.606
1.123SerTrp: 1.123 ± 0.392
2.714SerTyr: 2.714 ± 0.656
0.0SerXaa: 0.0 ± 0.0
Thr
4.586ThrAla: 4.586 ± 0.667
0.187ThrCys: 0.187 ± 0.144
3.744ThrAsp: 3.744 ± 0.515
3.65ThrGlu: 3.65 ± 0.593
3.089ThrPhe: 3.089 ± 0.662
3.557ThrGly: 3.557 ± 0.62
1.03ThrHis: 1.03 ± 0.354
3.744ThrIle: 3.744 ± 0.544
3.557ThrLys: 3.557 ± 0.697
4.68ThrLeu: 4.68 ± 0.715
0.936ThrMet: 0.936 ± 0.256
2.714ThrAsn: 2.714 ± 0.39
1.404ThrPro: 1.404 ± 0.358
2.902ThrGln: 2.902 ± 0.529
1.31ThrArg: 1.31 ± 0.299
4.025ThrSer: 4.025 ± 0.625
4.306ThrThr: 4.306 ± 0.722
4.586ThrVal: 4.586 ± 0.812
0.842ThrTrp: 0.842 ± 0.303
2.34ThrTyr: 2.34 ± 0.524
0.0ThrXaa: 0.0 ± 0.0
Val
4.773ValAla: 4.773 ± 0.577
0.281ValCys: 0.281 ± 0.17
3.37ValAsp: 3.37 ± 0.647
5.616ValGlu: 5.616 ± 0.598
2.621ValPhe: 2.621 ± 0.436
4.867ValGly: 4.867 ± 0.942
0.936ValHis: 0.936 ± 0.381
2.808ValIle: 2.808 ± 0.413
5.522ValLys: 5.522 ± 0.712
4.212ValLeu: 4.212 ± 0.614
1.31ValMet: 1.31 ± 0.375
4.025ValAsn: 4.025 ± 0.87
2.246ValPro: 2.246 ± 0.331
1.217ValGln: 1.217 ± 0.328
2.714ValArg: 2.714 ± 0.313
5.054ValSer: 5.054 ± 0.702
5.616ValThr: 5.616 ± 0.619
4.493ValVal: 4.493 ± 0.763
0.655ValTrp: 0.655 ± 0.251
2.808ValTyr: 2.808 ± 0.625
0.0ValXaa: 0.0 ± 0.0
Trp
1.217TrpAla: 1.217 ± 0.356
0.187TrpCys: 0.187 ± 0.124
0.842TrpAsp: 0.842 ± 0.295
0.842TrpGlu: 0.842 ± 0.336
1.123TrpPhe: 1.123 ± 0.493
0.749TrpGly: 0.749 ± 0.263
0.281TrpHis: 0.281 ± 0.172
0.749TrpIle: 0.749 ± 0.291
0.842TrpLys: 0.842 ± 0.278
0.842TrpLeu: 0.842 ± 0.366
0.374TrpMet: 0.374 ± 0.166
1.217TrpAsn: 1.217 ± 0.415
0.094TrpPro: 0.094 ± 0.09
0.468TrpGln: 0.468 ± 0.317
0.655TrpArg: 0.655 ± 0.238
0.562TrpSer: 0.562 ± 0.208
0.749TrpThr: 0.749 ± 0.279
0.936TrpVal: 0.936 ± 0.313
0.281TrpTrp: 0.281 ± 0.154
0.187TrpTyr: 0.187 ± 0.121
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.404TyrAla: 1.404 ± 0.289
0.562TyrCys: 0.562 ± 0.301
2.059TyrAsp: 2.059 ± 0.365
3.089TyrGlu: 3.089 ± 0.636
1.498TyrPhe: 1.498 ± 0.372
2.246TyrGly: 2.246 ± 0.391
1.03TyrHis: 1.03 ± 0.269
2.527TyrIle: 2.527 ± 0.601
3.838TyrLys: 3.838 ± 0.683
2.902TyrLeu: 2.902 ± 0.492
0.562TyrMet: 0.562 ± 0.284
1.217TyrAsn: 1.217 ± 0.276
1.685TyrPro: 1.685 ± 0.519
1.498TyrGln: 1.498 ± 0.479
2.246TyrArg: 2.246 ± 0.646
2.808TyrSer: 2.808 ± 0.593
1.778TyrThr: 1.778 ± 0.376
2.714TyrVal: 2.714 ± 0.515
0.281TyrTrp: 0.281 ± 0.151
1.123TyrTyr: 1.123 ± 0.446
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (10685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski