Amino acid dipepetide frequency for Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.065AlaAla: 20.065 ± 0.121	1.099AlaCys: 1.099 ± 0.022	7.678AlaAsp: 7.678 ± 0.056	8.673AlaGlu: 8.673 ± 0.077	3.698AlaPhe: 3.698 ± 0.04	13.999AlaGly: 13.999 ± 0.08	2.566AlaHis: 2.566 ± 0.031	4.223AlaIle: 4.223 ± 0.045	2.539AlaLys: 2.539 ± 0.038	14.293AlaLeu: 14.293 ± 0.09	2.692AlaMet: 2.692 ± 0.028	1.802AlaAsn: 1.802 ± 0.027	6.556AlaPro: 6.556 ± 0.059	3.359AlaGln: 3.359 ± 0.036	10.005AlaArg: 10.005 ± 0.06	5.775AlaSer: 5.775 ± 0.052	6.835AlaThr: 6.835 ± 0.06	12.096AlaVal: 12.096 ± 0.082	1.902AlaTrp: 1.902 ± 0.029	2.587AlaTyr: 2.587 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.018	0.09CysCys: 0.09 ± 0.006	0.492CysAsp: 0.492 ± 0.014	0.427CysGlu: 0.427 ± 0.013	0.221CysPhe: 0.221 ± 0.01	0.926CysGly: 0.926 ± 0.021	0.207CysHis: 0.207 ± 0.009	0.145CysIle: 0.145 ± 0.007	0.106CysLys: 0.106 ± 0.006	0.802CysLeu: 0.802 ± 0.016	0.137CysMet: 0.137 ± 0.008	0.116CysAsn: 0.116 ± 0.006	0.506CysPro: 0.506 ± 0.015	0.167CysGln: 0.167 ± 0.007	0.583CysArg: 0.583 ± 0.015	0.42CysSer: 0.42 ± 0.012	0.413CysThr: 0.413 ± 0.011	0.673CysVal: 0.673 ± 0.016	0.112CysTrp: 0.112 ± 0.007	0.158CysTyr: 0.158 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.519AspAla: 6.519 ± 0.053	0.376AspCys: 0.376 ± 0.012	3.459AspAsp: 3.459 ± 0.038	3.462AspGlu: 3.462 ± 0.04	1.582AspPhe: 1.582 ± 0.021	6.151AspGly: 6.151 ± 0.048	1.383AspHis: 1.383 ± 0.023	1.858AspIle: 1.858 ± 0.026	1.014AspLys: 1.014 ± 0.021	6.641AspLeu: 6.641 ± 0.053	0.872AspMet: 0.872 ± 0.014	0.921AspAsn: 0.921 ± 0.02	4.545AspPro: 4.545 ± 0.045	1.517AspGln: 1.517 ± 0.026	5.01AspArg: 5.01 ± 0.047	2.323AspSer: 2.323 ± 0.027	2.676AspThr: 2.676 ± 0.029	4.716AspVal: 4.716 ± 0.044	0.909AspTrp: 0.909 ± 0.017	1.247AspTyr: 1.247 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.021GluAla: 7.021 ± 0.054	0.354GluCys: 0.354 ± 0.011	2.641GluAsp: 2.641 ± 0.033	3.551GluGlu: 3.551 ± 0.041	1.53GluPhe: 1.53 ± 0.023	4.143GluGly: 4.143 ± 0.039	1.538GluHis: 1.538 ± 0.025	2.663GluIle: 2.663 ± 0.03	1.21GluLys: 1.21 ± 0.02	6.755GluLeu: 6.755 ± 0.048	0.992GluMet: 0.992 ± 0.02	0.961GluAsn: 0.961 ± 0.02	3.31GluPro: 3.31 ± 0.039	2.05GluGln: 2.05 ± 0.03	5.56GluArg: 5.56 ± 0.051	2.512GluSer: 2.512 ± 0.035	2.916GluThr: 2.916 ± 0.034	4.799GluVal: 4.799 ± 0.048	0.835GluTrp: 0.835 ± 0.018	1.024GluTyr: 1.024 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.818PheAla: 3.818 ± 0.037	0.275PheCys: 0.275 ± 0.01	2.045PheAsp: 2.045 ± 0.028	1.442PheGlu: 1.442 ± 0.026	0.928PhePhe: 0.928 ± 0.019	3.074PheGly: 3.074 ± 0.039	0.627PheHis: 0.627 ± 0.016	0.789PheIle: 0.789 ± 0.018	0.509PheLys: 0.509 ± 0.015	2.735PheLeu: 2.735 ± 0.036	0.467PheMet: 0.467 ± 0.013	0.606PheAsn: 0.606 ± 0.014	1.437PhePro: 1.437 ± 0.025	0.721PheGln: 0.721 ± 0.014	1.919PheArg: 1.919 ± 0.026	1.529PheSer: 1.529 ± 0.024	2.06PheThr: 2.06 ± 0.03	2.303PheVal: 2.303 ± 0.029	0.465PheTrp: 0.465 ± 0.013	0.623PheTyr: 0.623 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.847GlyAla: 10.847 ± 0.064	0.834GlyCys: 0.834 ± 0.017	5.366GlyAsp: 5.366 ± 0.049	5.366GlyGlu: 5.366 ± 0.047	2.988GlyPhe: 2.988 ± 0.037	9.06GlyGly: 9.06 ± 0.087	2.3GlyHis: 2.3 ± 0.031	3.484GlyIle: 3.484 ± 0.033	2.319GlyLys: 2.319 ± 0.036	10.025GlyLeu: 10.025 ± 0.069	2.184GlyMet: 2.184 ± 0.028	1.715GlyAsn: 1.715 ± 0.029	5.313GlyPro: 5.313 ± 0.053	2.706GlyGln: 2.706 ± 0.033	8.275GlyArg: 8.275 ± 0.056	5.196GlySer: 5.196 ± 0.053	5.849GlyThr: 5.849 ± 0.06	8.07GlyVal: 8.07 ± 0.06	1.809GlyTrp: 1.809 ± 0.024	2.414GlyTyr: 2.414 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.577HisAla: 2.577 ± 0.036	0.195HisCys: 0.195 ± 0.008	1.352HisAsp: 1.352 ± 0.023	1.165HisGlu: 1.165 ± 0.021	0.597HisPhe: 0.597 ± 0.017	2.241HisGly: 2.241 ± 0.03	0.633HisHis: 0.633 ± 0.016	0.679HisIle: 0.679 ± 0.015	0.305HisLys: 0.305 ± 0.011	2.413HisLeu: 2.413 ± 0.03	0.356HisMet: 0.356 ± 0.011	0.368HisAsn: 0.368 ± 0.013	1.721HisPro: 1.721 ± 0.024	0.555HisGln: 0.555 ± 0.015	2.022HisArg: 2.022 ± 0.028	0.955HisSer: 0.955 ± 0.018	1.068HisThr: 1.068 ± 0.019	1.78HisVal: 1.78 ± 0.022	0.351HisTrp: 0.351 ± 0.011	0.472HisTyr: 0.472 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.231IleAla: 5.231 ± 0.047	0.328IleCys: 0.328 ± 0.011	2.38IleAsp: 2.38 ± 0.026	2.202IleGlu: 2.202 ± 0.031	0.901IlePhe: 0.901 ± 0.02	3.937IleGly: 3.937 ± 0.043	0.678IleHis: 0.678 ± 0.016	1.136IleIle: 1.136 ± 0.026	0.796IleLys: 0.796 ± 0.018	2.894IleLeu: 2.894 ± 0.033	0.616IleMet: 0.616 ± 0.013	0.738IleAsn: 0.738 ± 0.019	2.007IlePro: 2.007 ± 0.026	0.792IleGln: 0.792 ± 0.015	2.653IleArg: 2.653 ± 0.031	2.007IleSer: 2.007 ± 0.026	2.48IleThr: 2.48 ± 0.032	3.27IleVal: 3.27 ± 0.038	0.485IleTrp: 0.485 ± 0.013	0.653IleTyr: 0.653 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.503LysAla: 2.503 ± 0.035	0.12LysCys: 0.12 ± 0.007	1.138LysAsp: 1.138 ± 0.022	1.055LysGlu: 1.055 ± 0.023	0.451LysPhe: 0.451 ± 0.014	1.648LysGly: 1.648 ± 0.029	0.405LysHis: 0.405 ± 0.013	1.027LysIle: 1.027 ± 0.021	0.658LysLys: 0.658 ± 0.016	1.972LysLeu: 1.972 ± 0.03	0.369LysMet: 0.369 ± 0.011	0.467LysAsn: 0.467 ± 0.014	1.194LysPro: 1.194 ± 0.025	0.588LysGln: 0.588 ± 0.015	1.321LysArg: 1.321 ± 0.022	1.013LysSer: 1.013 ± 0.02	1.193LysThr: 1.193 ± 0.025	1.872LysVal: 1.872 ± 0.028	0.262LysTrp: 0.262 ± 0.009	0.417LysTyr: 0.417 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.819LeuAla: 15.819 ± 0.105	0.797LeuCys: 0.797 ± 0.018	6.433LeuAsp: 6.433 ± 0.052	4.901LeuGlu: 4.901 ± 0.048	2.682LeuPhe: 2.682 ± 0.037	9.73LeuGly: 9.73 ± 0.066	2.083LeuHis: 2.083 ± 0.028	3.916LeuIle: 3.916 ± 0.04	1.904LeuLys: 1.904 ± 0.029	11.405LeuLeu: 11.405 ± 0.086	1.754LeuMet: 1.754 ± 0.023	1.866LeuAsn: 1.866 ± 0.028	6.617LeuPro: 6.617 ± 0.059	2.136LeuGln: 2.136 ± 0.026	9.003LeuArg: 9.003 ± 0.069	5.857LeuSer: 5.857 ± 0.042	6.772LeuThr: 6.772 ± 0.053	8.972LeuVal: 8.972 ± 0.07	1.385LeuTrp: 1.385 ± 0.025	1.876LeuTyr: 1.876 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.407MetAla: 2.407 ± 0.028	0.139MetCys: 0.139 ± 0.007	0.933MetAsp: 0.933 ± 0.017	0.825MetGlu: 0.825 ± 0.018	0.532MetPhe: 0.532 ± 0.012	1.372MetGly: 1.372 ± 0.024	0.349MetHis: 0.349 ± 0.01	0.976MetIle: 0.976 ± 0.02	0.434MetLys: 0.434 ± 0.012	1.976MetLeu: 1.976 ± 0.025	0.353MetMet: 0.353 ± 0.011	0.48MetAsn: 0.48 ± 0.012	1.155MetPro: 1.155 ± 0.02	0.415MetGln: 0.415 ± 0.013	1.691MetArg: 1.691 ± 0.026	1.388MetSer: 1.388 ± 0.021	1.628MetThr: 1.628 ± 0.026	1.497MetVal: 1.497 ± 0.021	0.232MetTrp: 0.232 ± 0.009	0.303MetTyr: 0.303 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.073AsnAla: 2.073 ± 0.027	0.158AsnCys: 0.158 ± 0.009	0.917AsnAsp: 0.917 ± 0.019	0.776AsnGlu: 0.776 ± 0.016	0.473AsnPhe: 0.473 ± 0.013	1.849AsnGly: 1.849 ± 0.035	0.39AsnHis: 0.39 ± 0.011	0.631AsnIle: 0.631 ± 0.015	0.351AsnLys: 0.351 ± 0.011	1.821AsnLeu: 1.821 ± 0.026	0.305AsnMet: 0.305 ± 0.011	0.428AsnAsn: 0.428 ± 0.023	1.385AsnPro: 1.385 ± 0.025	0.475AsnGln: 0.475 ± 0.014	1.343AsnArg: 1.343 ± 0.024	0.83AsnSer: 0.83 ± 0.017	1.05AsnThr: 1.05 ± 0.022	1.458AsnVal: 1.458 ± 0.025	0.302AsnTrp: 0.302 ± 0.01	0.406AsnTyr: 0.406 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.743ProAla: 8.743 ± 0.067	0.337ProCys: 0.337 ± 0.012	4.218ProAsp: 4.218 ± 0.042	4.267ProGlu: 4.267 ± 0.044	1.615ProPhe: 1.615 ± 0.024	7.054ProGly: 7.054 ± 0.061	1.241ProHis: 1.241 ± 0.022	1.738ProIle: 1.738 ± 0.024	1.092ProLys: 1.092 ± 0.023	5.408ProLeu: 5.408 ± 0.05	1.114ProMet: 1.114 ± 0.02	0.885ProAsn: 0.885 ± 0.019	3.774ProPro: 3.774 ± 0.056	1.556ProGln: 1.556 ± 0.025	4.015ProArg: 4.015 ± 0.042	3.316ProSer: 3.316 ± 0.038	2.914ProThr: 2.914 ± 0.043	5.444ProVal: 5.444 ± 0.046	0.951ProTrp: 0.951 ± 0.019	1.468ProTyr: 1.468 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.856GlnAla: 3.856 ± 0.042	0.14GlnCys: 0.14 ± 0.007	1.222GlnAsp: 1.222 ± 0.021	1.411GlnGlu: 1.411 ± 0.023	0.645GlnPhe: 0.645 ± 0.013	2.141GlnGly: 2.141 ± 0.03	0.512GlnHis: 0.512 ± 0.012	1.185GlnIle: 1.185 ± 0.022	0.489GlnLys: 0.489 ± 0.015	2.591GlnLeu: 2.591 ± 0.03	0.49GlnMet: 0.49 ± 0.013	0.445GlnAsn: 0.445 ± 0.015	1.614GlnPro: 1.614 ± 0.028	0.917GlnGln: 0.917 ± 0.027	2.246GlnArg: 2.246 ± 0.029	1.168GlnSer: 1.168 ± 0.022	1.311GlnThr: 1.311 ± 0.024	2.57GlnVal: 2.57 ± 0.034	0.441GlnTrp: 0.441 ± 0.013	0.471GlnTyr: 0.471 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	9.664ArgAla: 9.664 ± 0.071	0.587ArgCys: 0.587 ± 0.014	4.454ArgAsp: 4.454 ± 0.047	4.868ArgGlu: 4.868 ± 0.044	2.535ArgPhe: 2.535 ± 0.031	5.985ArgGly: 5.985 ± 0.045	2.133ArgHis: 2.133 ± 0.029	3.354ArgIle: 3.354 ± 0.035	1.576ArgLys: 1.576 ± 0.025	9.712ArgLeu: 9.712 ± 0.083	1.934ArgMet: 1.934 ± 0.024	1.34ArgAsn: 1.34 ± 0.021	5.153ArgPro: 5.153 ± 0.053	2.397ArgGln: 2.397 ± 0.029	8.157ArgArg: 8.157 ± 0.068	4.203ArgSer: 4.203 ± 0.045	4.684ArgThr: 4.684 ± 0.041	6.15ArgVal: 6.15 ± 0.05	1.451ArgTrp: 1.451 ± 0.025	1.843ArgTyr: 1.843 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.657SerAla: 6.657 ± 0.046	0.391SerCys: 0.391 ± 0.012	2.526SerAsp: 2.526 ± 0.031	2.388SerGlu: 2.388 ± 0.031	1.608SerPhe: 1.608 ± 0.023	6.069SerGly: 6.069 ± 0.051	1.049SerHis: 1.049 ± 0.022	1.713SerIle: 1.713 ± 0.024	0.95SerLys: 0.95 ± 0.023	4.934SerLeu: 4.934 ± 0.046	1.156SerMet: 1.156 ± 0.02	0.782SerAsn: 0.782 ± 0.018	3.503SerPro: 3.503 ± 0.042	1.239SerGln: 1.239 ± 0.023	4.031SerArg: 4.031 ± 0.039	2.779SerSer: 2.779 ± 0.041	2.897SerThr: 2.897 ± 0.041	4.234SerVal: 4.234 ± 0.035	0.951SerTrp: 0.951 ± 0.019	1.177SerTyr: 1.177 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	7.997ThrAla: 7.997 ± 0.061	0.438ThrCys: 0.438 ± 0.015	3.005ThrAsp: 3.005 ± 0.036	2.816ThrGlu: 2.816 ± 0.032	1.674ThrPhe: 1.674 ± 0.028	6.592ThrGly: 6.592 ± 0.062	1.059ThrHis: 1.059 ± 0.017	1.994ThrIle: 1.994 ± 0.028	0.96ThrLys: 0.96 ± 0.023	5.857ThrLeu: 5.857 ± 0.054	1.086ThrMet: 1.086 ± 0.017	0.905ThrAsn: 0.905 ± 0.019	4.103ThrPro: 4.103 ± 0.053	1.217ThrGln: 1.217 ± 0.022	3.992ThrArg: 3.992 ± 0.038	3.109ThrSer: 3.109 ± 0.04	3.45ThrThr: 3.45 ± 0.047	5.853ThrVal: 5.853 ± 0.064	0.96ThrTrp: 0.96 ± 0.02	1.255ThrTyr: 1.255 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	11.439ValAla: 11.439 ± 0.069	0.706ValCys: 0.706 ± 0.017	4.743ValAsp: 4.743 ± 0.04	4.873ValGlu: 4.873 ± 0.045	2.541ValPhe: 2.541 ± 0.031	6.63ValGly: 6.63 ± 0.055	1.823ValHis: 1.823 ± 0.021	3.479ValIle: 3.479 ± 0.039	1.747ValLys: 1.747 ± 0.029	9.527ValLeu: 9.527 ± 0.069	1.584ValMet: 1.584 ± 0.025	1.767ValAsn: 1.767 ± 0.025	5.299ValPro: 5.299 ± 0.052	1.922ValGln: 1.922 ± 0.025	7.036ValArg: 7.036 ± 0.055	4.652ValSer: 4.652 ± 0.039	5.977ValThr: 5.977 ± 0.058	8.088ValVal: 8.088 ± 0.068	1.149ValTrp: 1.149 ± 0.021	1.664ValTyr: 1.664 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.668TrpAla: 1.668 ± 0.027	0.148TrpCys: 0.148 ± 0.007	0.828TrpAsp: 0.828 ± 0.018	0.765TrpGlu: 0.765 ± 0.013	0.518TrpPhe: 0.518 ± 0.014	1.065TrpGly: 1.065 ± 0.018	0.412TrpHis: 0.412 ± 0.012	0.643TrpIle: 0.643 ± 0.016	0.366TrpLys: 0.366 ± 0.013	1.882TrpLeu: 1.882 ± 0.031	0.329TrpMet: 0.329 ± 0.011	0.417TrpAsn: 0.417 ± 0.013	0.844TrpPro: 0.844 ± 0.018	0.552TrpGln: 0.552 ± 0.015	1.442TrpArg: 1.442 ± 0.023	1.024TrpSer: 1.024 ± 0.022	1.009TrpThr: 1.009 ± 0.024	1.047TrpVal: 1.047 ± 0.018	0.346TrpTrp: 0.346 ± 0.013	0.36TrpTyr: 0.36 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.544TyrAla: 2.544 ± 0.029	0.184TyrCys: 0.184 ± 0.008	1.351TyrAsp: 1.351 ± 0.02	1.133TyrGlu: 1.133 ± 0.021	0.652TyrPhe: 0.652 ± 0.016	2.454TyrGly: 2.454 ± 0.035	0.42TyrHis: 0.42 ± 0.011	0.551TyrIle: 0.551 ± 0.014	0.347TyrLys: 0.347 ± 0.012	2.262TyrLeu: 2.262 ± 0.029	0.292TyrMet: 0.292 ± 0.011	0.41TyrAsn: 0.41 ± 0.013	1.115TyrPro: 1.115 ± 0.021	0.586TyrGln: 0.586 ± 0.013	1.873TyrArg: 1.873 ± 0.024	0.981TyrSer: 0.981 ± 0.02	1.14TyrThr: 1.14 ± 0.024	1.757TyrVal: 1.757 ± 0.025	0.366TyrTrp: 0.366 ± 0.013	0.465TyrTyr: 0.465 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8955 proteins (2950138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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