Amino acid dipepetide frequency for Sphingosinicella microcystinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.123AlaAla: 20.123 ± 0.201	1.027AlaCys: 1.027 ± 0.032	7.813AlaAsp: 7.813 ± 0.084	8.328AlaGlu: 8.328 ± 0.092	4.7AlaPhe: 4.7 ± 0.065	11.327AlaGly: 11.327 ± 0.143	2.417AlaHis: 2.417 ± 0.051	6.497AlaIle: 6.497 ± 0.069	4.235AlaLys: 4.235 ± 0.062	14.123AlaLeu: 14.123 ± 0.139	3.698AlaMet: 3.698 ± 0.063	3.08AlaAsn: 3.08 ± 0.064	6.196AlaPro: 6.196 ± 0.081	3.671AlaGln: 3.671 ± 0.054	9.712AlaArg: 9.712 ± 0.107	6.424AlaSer: 6.424 ± 0.079	5.877AlaThr: 5.877 ± 0.074	9.051AlaVal: 9.051 ± 0.09	1.647AlaTrp: 1.647 ± 0.04	2.75AlaTyr: 2.75 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.011CysAla: 1.011 ± 0.029	0.102CysCys: 0.102 ± 0.008	0.49CysAsp: 0.49 ± 0.02	0.407CysGlu: 0.407 ± 0.019	0.287CysPhe: 0.287 ± 0.016	0.911CysGly: 0.911 ± 0.03	0.189CysHis: 0.189 ± 0.012	0.381CysIle: 0.381 ± 0.019	0.162CysLys: 0.162 ± 0.012	0.722CysLeu: 0.722 ± 0.024	0.143CysMet: 0.143 ± 0.011	0.195CysAsn: 0.195 ± 0.013	0.423CysPro: 0.423 ± 0.02	0.167CysGln: 0.167 ± 0.013	0.582CysArg: 0.582 ± 0.022	0.437CysSer: 0.437 ± 0.019	0.408CysThr: 0.408 ± 0.017	0.539CysVal: 0.539 ± 0.022	0.109CysTrp: 0.109 ± 0.009	0.19CysTyr: 0.19 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.788AspAla: 7.788 ± 0.085	0.466AspCys: 0.466 ± 0.021	3.188AspAsp: 3.188 ± 0.061	3.34AspGlu: 3.34 ± 0.052	2.302AspPhe: 2.302 ± 0.046	5.407AspGly: 5.407 ± 0.099	1.196AspHis: 1.196 ± 0.032	3.2AspIle: 3.2 ± 0.055	1.549AspLys: 1.549 ± 0.042	5.55AspLeu: 5.55 ± 0.075	1.399AspMet: 1.399 ± 0.029	1.326AspAsn: 1.326 ± 0.035	3.476AspPro: 3.476 ± 0.054	1.447AspGln: 1.447 ± 0.037	4.538AspArg: 4.538 ± 0.062	2.301AspSer: 2.301 ± 0.042	2.901AspThr: 2.901 ± 0.048	4.526AspVal: 4.526 ± 0.072	1.093AspTrp: 1.093 ± 0.032	1.665AspTyr: 1.665 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.211GluAla: 8.211 ± 0.103	0.312GluCys: 0.312 ± 0.016	2.876GluAsp: 2.876 ± 0.052	2.8GluGlu: 2.8 ± 0.057	1.598GluPhe: 1.598 ± 0.035	4.621GluGly: 4.621 ± 0.07	1.104GluHis: 1.104 ± 0.03	3.227GluIle: 3.227 ± 0.06	1.996GluLys: 1.996 ± 0.049	4.881GluLeu: 4.881 ± 0.065	1.457GluMet: 1.457 ± 0.036	1.58GluAsn: 1.58 ± 0.039	2.51GluPro: 2.51 ± 0.045	1.756GluGln: 1.756 ± 0.041	5.027GluArg: 5.027 ± 0.073	2.372GluSer: 2.372 ± 0.047	3.883GluThr: 3.883 ± 0.05	3.783GluVal: 3.783 ± 0.059	0.751GluTrp: 0.751 ± 0.024	1.076GluTyr: 1.076 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.785PheAla: 4.785 ± 0.062	0.37PheCys: 0.37 ± 0.017	2.753PheAsp: 2.753 ± 0.05	2.241PheGlu: 2.241 ± 0.042	1.292PhePhe: 1.292 ± 0.038	3.8PheGly: 3.8 ± 0.05	0.756PheHis: 0.756 ± 0.026	1.563PheIle: 1.563 ± 0.035	0.973PheLys: 0.973 ± 0.028	3.23PheLeu: 3.23 ± 0.055	0.808PheMet: 0.808 ± 0.028	1.086PheAsn: 1.086 ± 0.036	1.542PhePro: 1.542 ± 0.038	0.893PheGln: 0.893 ± 0.028	2.301PheArg: 2.301 ± 0.054	2.2PheSer: 2.2 ± 0.051	2.133PheThr: 2.133 ± 0.051	2.718PheVal: 2.718 ± 0.045	0.505PheTrp: 0.505 ± 0.022	0.954PheTyr: 0.954 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.296GlyAla: 10.296 ± 0.128	0.803GlyCys: 0.803 ± 0.031	4.893GlyAsp: 4.893 ± 0.09	5.018GlyGlu: 5.018 ± 0.075	3.798GlyPhe: 3.798 ± 0.055	8.385GlyGly: 8.385 ± 0.154	1.859GlyHis: 1.859 ± 0.035	4.805GlyIle: 4.805 ± 0.071	3.505GlyLys: 3.505 ± 0.06	8.816GlyLeu: 8.816 ± 0.098	2.194GlyMet: 2.194 ± 0.051	2.311GlyAsn: 2.311 ± 0.069	3.59GlyPro: 3.59 ± 0.057	2.54GlyGln: 2.54 ± 0.053	6.353GlyArg: 6.353 ± 0.075	4.792GlySer: 4.792 ± 0.086	5.138GlyThr: 5.138 ± 0.13	6.484GlyVal: 6.484 ± 0.083	1.548GlyTrp: 1.548 ± 0.038	2.511GlyTyr: 2.511 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.385HisAla: 2.385 ± 0.048	0.232HisCys: 0.232 ± 0.013	1.133HisAsp: 1.133 ± 0.031	0.998HisGlu: 0.998 ± 0.029	0.891HisPhe: 0.891 ± 0.029	1.914HisGly: 1.914 ± 0.048	0.504HisHis: 0.504 ± 0.02	1.001HisIle: 1.001 ± 0.027	0.461HisLys: 0.461 ± 0.021	1.803HisLeu: 1.803 ± 0.038	0.497HisMet: 0.497 ± 0.025	0.501HisAsn: 0.501 ± 0.022	1.202HisPro: 1.202 ± 0.03	0.534HisGln: 0.534 ± 0.022	1.395HisArg: 1.395 ± 0.041	0.922HisSer: 0.922 ± 0.03	0.859HisThr: 0.859 ± 0.029	1.508HisVal: 1.508 ± 0.035	0.319HisTrp: 0.319 ± 0.016	0.56HisTyr: 0.56 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.769IleAla: 7.769 ± 0.085	0.42IleCys: 0.42 ± 0.018	3.903IleAsp: 3.903 ± 0.067	3.649IleGlu: 3.649 ± 0.062	1.551IlePhe: 1.551 ± 0.039	5.08IleGly: 5.08 ± 0.071	0.847IleHis: 0.847 ± 0.028	2.143IleIle: 2.143 ± 0.052	1.217IleLys: 1.217 ± 0.036	3.914IleLeu: 3.914 ± 0.069	0.862IleMet: 0.862 ± 0.025	1.314IleAsn: 1.314 ± 0.038	2.207IlePro: 2.207 ± 0.049	1.01IleGln: 1.01 ± 0.031	3.157IleArg: 3.157 ± 0.048	2.829IleSer: 2.829 ± 0.051	2.64IleThr: 2.64 ± 0.046	4.284IleVal: 4.284 ± 0.069	0.523IleTrp: 0.523 ± 0.023	1.117IleTyr: 1.117 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.452LysAla: 4.452 ± 0.077	0.162LysCys: 0.162 ± 0.012	1.674LysAsp: 1.674 ± 0.037	1.262LysGlu: 1.262 ± 0.037	0.827LysPhe: 0.827 ± 0.029	2.733LysGly: 2.733 ± 0.051	0.549LysHis: 0.549 ± 0.022	1.441LysIle: 1.441 ± 0.039	1.056LysLys: 1.056 ± 0.033	3.166LysLeu: 3.166 ± 0.063	0.742LysMet: 0.742 ± 0.028	0.742LysAsn: 0.742 ± 0.026	2.098LysPro: 2.098 ± 0.056	0.901LysGln: 0.901 ± 0.026	2.431LysArg: 2.431 ± 0.051	1.725LysSer: 1.725 ± 0.041	1.998LysThr: 1.998 ± 0.043	2.322LysVal: 2.322 ± 0.048	0.367LysTrp: 0.367 ± 0.019	0.594LysTyr: 0.594 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.815LeuAla: 13.815 ± 0.136	0.761LeuCys: 0.761 ± 0.026	5.757LeuAsp: 5.757 ± 0.069	4.911LeuGlu: 4.911 ± 0.081	3.569LeuPhe: 3.569 ± 0.058	8.703LeuGly: 8.703 ± 0.095	1.776LeuHis: 1.776 ± 0.04	4.536LeuIle: 4.536 ± 0.075	3.368LeuLys: 3.368 ± 0.061	8.993LeuLeu: 8.993 ± 0.124	2.212LeuMet: 2.212 ± 0.048	2.437LeuAsn: 2.437 ± 0.052	5.516LeuPro: 5.516 ± 0.078	2.386LeuGln: 2.386 ± 0.045	6.746LeuArg: 6.746 ± 0.097	6.172LeuSer: 6.172 ± 0.07	5.534LeuThr: 5.534 ± 0.076	7.201LeuVal: 7.201 ± 0.081	1.178LeuTrp: 1.178 ± 0.032	2.002LeuTyr: 2.002 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.027MetAla: 3.027 ± 0.055	0.15MetCys: 0.15 ± 0.011	1.082MetAsp: 1.082 ± 0.03	1.051MetGlu: 1.051 ± 0.028	0.765MetPhe: 0.765 ± 0.025	1.829MetGly: 1.829 ± 0.041	0.477MetHis: 0.477 ± 0.018	1.298MetIle: 1.298 ± 0.032	0.982MetLys: 0.982 ± 0.033	2.505MetLeu: 2.505 ± 0.046	0.636MetMet: 0.636 ± 0.026	0.713MetAsn: 0.713 ± 0.024	1.442MetPro: 1.442 ± 0.037	0.809MetGln: 0.809 ± 0.026	1.839MetArg: 1.839 ± 0.046	1.559MetSer: 1.559 ± 0.04	1.766MetThr: 1.766 ± 0.037	1.558MetVal: 1.558 ± 0.035	0.238MetTrp: 0.238 ± 0.016	0.326MetTyr: 0.326 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.488AsnAla: 3.488 ± 0.069	0.22AsnCys: 0.22 ± 0.015	1.389AsnAsp: 1.389 ± 0.043	1.11AsnGlu: 1.11 ± 0.027	0.964AsnPhe: 0.964 ± 0.03	2.391AsnGly: 2.391 ± 0.069	0.465AsnHis: 0.465 ± 0.02	1.394AsnIle: 1.394 ± 0.036	0.596AsnLys: 0.596 ± 0.025	2.475AsnLeu: 2.475 ± 0.049	0.582AsnMet: 0.582 ± 0.02	0.692AsnAsn: 0.692 ± 0.031	1.782AsnPro: 1.782 ± 0.038	0.635AsnGln: 0.635 ± 0.022	1.822AsnArg: 1.822 ± 0.045	1.192AsnSer: 1.192 ± 0.037	1.338AsnThr: 1.338 ± 0.044	2.044AsnVal: 2.044 ± 0.047	0.424AsnTrp: 0.424 ± 0.02	0.74AsnTyr: 0.74 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.771ProAla: 6.771 ± 0.097	0.322ProCys: 0.322 ± 0.017	3.488ProAsp: 3.488 ± 0.065	3.767ProGlu: 3.767 ± 0.065	1.917ProPhe: 1.917 ± 0.043	4.737ProGly: 4.737 ± 0.067	1.05ProHis: 1.05 ± 0.031	2.389ProIle: 2.389 ± 0.049	1.685ProLys: 1.685 ± 0.046	4.838ProLeu: 4.838 ± 0.072	1.202ProMet: 1.202 ± 0.032	1.235ProAsn: 1.235 ± 0.031	2.568ProPro: 2.568 ± 0.072	1.54ProGln: 1.54 ± 0.032	2.969ProArg: 2.969 ± 0.047	2.68ProSer: 2.68 ± 0.048	2.489ProThr: 2.489 ± 0.051	4.309ProVal: 4.309 ± 0.068	0.67ProTrp: 0.67 ± 0.027	1.148ProTyr: 1.148 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.491GlnAla: 3.491 ± 0.06	0.198GlnCys: 0.198 ± 0.012	1.31GlnAsp: 1.31 ± 0.032	1.22GlnGlu: 1.22 ± 0.032	1.003GlnPhe: 1.003 ± 0.031	2.193GlnGly: 2.193 ± 0.043	0.557GlnHis: 0.557 ± 0.021	1.574GlnIle: 1.574 ± 0.042	0.929GlnLys: 0.929 ± 0.027	2.716GlnLeu: 2.716 ± 0.045	0.742GlnMet: 0.742 ± 0.026	0.769GlnAsn: 0.769 ± 0.025	1.643GlnPro: 1.643 ± 0.039	0.975GlnGln: 0.975 ± 0.029	2.241GlnArg: 2.241 ± 0.042	1.581GlnSer: 1.581 ± 0.04	1.56GlnThr: 1.56 ± 0.04	1.91GlnVal: 1.91 ± 0.044	0.375GlnTrp: 0.375 ± 0.018	0.605GlnTyr: 0.605 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.626ArgAla: 8.626 ± 0.104	0.536ArgCys: 0.536 ± 0.025	4.021ArgAsp: 4.021 ± 0.062	4.086ArgGlu: 4.086 ± 0.064	3.152ArgPhe: 3.152 ± 0.054	5.206ArgGly: 5.206 ± 0.07	1.582ArgHis: 1.582 ± 0.038	4.203ArgIle: 4.203 ± 0.054	2.239ArgLys: 2.239 ± 0.048	8.059ArgLeu: 8.059 ± 0.093	1.932ArgMet: 1.932 ± 0.042	1.765ArgAsn: 1.765 ± 0.039	3.423ArgPro: 3.423 ± 0.054	2.362ArgGln: 2.362 ± 0.054	5.654ArgArg: 5.654 ± 0.081	3.612ArgSer: 3.612 ± 0.055	3.689ArgThr: 3.689 ± 0.059	5.089ArgVal: 5.089 ± 0.071	1.201ArgTrp: 1.201 ± 0.03	1.933ArgTyr: 1.933 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.706SerAla: 6.706 ± 0.081	0.415SerCys: 0.415 ± 0.019	3.149SerAsp: 3.149 ± 0.049	2.69SerGlu: 2.69 ± 0.053	2.237SerPhe: 2.237 ± 0.043	5.772SerGly: 5.772 ± 0.104	1.002SerHis: 1.002 ± 0.033	2.665SerIle: 2.665 ± 0.05	1.486SerLys: 1.486 ± 0.042	5.126SerLeu: 5.126 ± 0.069	1.195SerMet: 1.195 ± 0.032	1.389SerAsn: 1.389 ± 0.041	2.774SerPro: 2.774 ± 0.052	1.324SerGln: 1.324 ± 0.036	3.577SerArg: 3.577 ± 0.057	2.771SerSer: 2.771 ± 0.054	2.6SerThr: 2.6 ± 0.054	3.941SerVal: 3.941 ± 0.062	0.74SerTrp: 0.74 ± 0.025	1.412SerTyr: 1.412 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.781ThrAla: 6.781 ± 0.081	0.402ThrCys: 0.402 ± 0.019	3.017ThrAsp: 3.017 ± 0.044	2.601ThrGlu: 2.601 ± 0.045	2.013ThrPhe: 2.013 ± 0.037	5.506ThrGly: 5.506 ± 0.112	1.078ThrHis: 1.078 ± 0.031	2.908ThrIle: 2.908 ± 0.063	1.356ThrLys: 1.356 ± 0.039	5.921ThrLeu: 5.921 ± 0.1	1.217ThrMet: 1.217 ± 0.031	1.376ThrAsn: 1.376 ± 0.042	3.495ThrPro: 3.495 ± 0.06	1.413ThrGln: 1.413 ± 0.038	3.473ThrArg: 3.473 ± 0.051	2.708ThrSer: 2.708 ± 0.053	2.825ThrThr: 2.825 ± 0.053	4.167ThrVal: 4.167 ± 0.062	0.688ThrTrp: 0.688 ± 0.026	1.294ThrTyr: 1.294 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.0ValAla: 9.0 ± 0.098	0.633ValCys: 0.633 ± 0.02	4.462ValAsp: 4.462 ± 0.064	4.447ValGlu: 4.447 ± 0.062	2.563ValPhe: 2.563 ± 0.049	5.882ValGly: 5.882 ± 0.088	1.36ValHis: 1.36 ± 0.031	3.66ValIle: 3.66 ± 0.058	2.318ValLys: 2.318 ± 0.053	6.887ValLeu: 6.887 ± 0.09	1.701ValMet: 1.701 ± 0.041	2.133ValAsn: 2.133 ± 0.054	4.111ValPro: 4.111 ± 0.062	1.988ValGln: 1.988 ± 0.037	5.39ValArg: 5.39 ± 0.064	4.515ValSer: 4.515 ± 0.067	4.495ValThr: 4.495 ± 0.067	5.553ValVal: 5.553 ± 0.085	0.928ValTrp: 0.928 ± 0.031	1.524ValTyr: 1.524 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.35TrpAla: 1.35 ± 0.032	0.117TrpCys: 0.117 ± 0.01	0.665TrpAsp: 0.665 ± 0.027	0.614TrpGlu: 0.614 ± 0.025	0.542TrpPhe: 0.542 ± 0.022	0.916TrpGly: 0.916 ± 0.031	0.353TrpHis: 0.353 ± 0.018	0.643TrpIle: 0.643 ± 0.024	0.472TrpLys: 0.472 ± 0.021	1.703TrpLeu: 1.703 ± 0.044	0.378TrpMet: 0.378 ± 0.017	0.447TrpAsn: 0.447 ± 0.019	0.689TrpPro: 0.689 ± 0.026	0.538TrpGln: 0.538 ± 0.024	1.294TrpArg: 1.294 ± 0.033	0.915TrpSer: 0.915 ± 0.028	0.853TrpThr: 0.853 ± 0.026	0.842TrpVal: 0.842 ± 0.031	0.225TrpTrp: 0.225 ± 0.014	0.314TrpTyr: 0.314 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.826TyrAla: 2.826 ± 0.046	0.206TyrCys: 0.206 ± 0.013	1.594TyrAsp: 1.594 ± 0.039	1.279TyrGlu: 1.279 ± 0.033	0.931TyrPhe: 0.931 ± 0.028	2.326TyrGly: 2.326 ± 0.045	0.5TyrHis: 0.5 ± 0.02	0.907TyrIle: 0.907 ± 0.03	0.652TyrLys: 0.652 ± 0.028	2.147TyrLeu: 2.147 ± 0.046	0.455TyrMet: 0.455 ± 0.021	0.656TyrAsn: 0.656 ± 0.023	1.087TyrPro: 1.087 ± 0.033	0.702TyrGln: 0.702 ± 0.025	1.871TyrArg: 1.871 ± 0.041	1.263TyrSer: 1.263 ± 0.032	1.254TyrThr: 1.254 ± 0.037	1.72TyrVal: 1.72 ± 0.039	0.338TyrTrp: 0.338 ± 0.016	0.679TyrTyr: 0.679 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3645 proteins (1206989 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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